MPD: JaxKOMP-EAP genotype: Serp2<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Serp2^em1(IMPC)J -/- Gene Serp2

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.2070	1.8793	0.086543	0.854	0.549
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	2.9167	2.3265	0.65725	0.720	0.265
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	3.9583	2.3866	0.61891	0.515	0.158
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	4.7917	3.8385	0.64172	0.651	0.267
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	6.6667	3.2684	1.0250	0.456	0.0969
body composition	body length	-0.027490	0.031648	-0.12878	0.678	0.389
body composition	body weight (at time of DXA)	-0.85720	0.55604	-0.53240	0.312	0.129
body composition	bone area, whole body scan, head excluded	-0.17110	0.14244	-0.51160	0.506	0.235
body composition	bone mineral content of whole body scan, head excluded	-0.0049461	0.0099840	-0.15627	0.822	0.622
body composition	bone mineral content to body weight ratio	-0.000089175	0.00039208	0.032772	0.927	0.821
body composition	bone mineral density of whole body scan, head excluded	0.00034867	0.00045983	0.39453	0.727	0.451
body composition	fat tissue mass of whole body scan, head excluded	0.071637	0.28770	0.11631	0.906	0.804
body composition	fat tissue mass to body weight ratio	0.0034561	0.0099626	0.22581	0.872	0.730
body composition	lean tissue mass of whole body scan, head excluded	-0.10490	0.25692	-0.38033	0.873	0.685
body composition	lean tissue mass to body weight ratio	0.0013374	0.0087936	0.015710	0.936	0.880
body composition	percent fat, whole body scan, head excluded	0.27096	0.96093	0.22441	0.900	0.779
body composition	ratio of soft-tissue attenuation coefficients	-0.00028092	0.0010683	-0.22210	0.912	0.794
body composition	tissue area	-0.0030761	0.18170	0.18279	0.998	0.987
body composition	total tissue mass, whole body scan, head excluded	-0.013565	0.15995	-0.24265	0.967	0.933
clinical blood chemistry	alanine transaminase (plasma ALT)	5.0132	6.9511	0.39626	0.792	0.479
clinical blood chemistry	albumin (plasma Alb)	-0.34360	0.74936	-0.43386	0.863	0.651
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-4.1472	4.5924	-1.2528	0.624	0.377
clinical blood chemistry	aspartate transaminase (plasma AST)	2.5360	23.953	0.13510	0.980	0.917
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.45489	0.38405	-1.3267	0.647	0.249
clinical blood chemistry	blood urea nitrogen (BUN)	-0.62351	1.5353	-0.27204	0.849	0.689
clinical blood chemistry	calcium (plasma Ca)	-0.10639	0.12433	-0.38693	0.639	0.402
clinical blood chemistry	creatinine (plasma)	0.0088234	0.033386	0.30390	0.892	0.794
clinical blood chemistry	glucose (plasma GLU, no fast)	-6.5756	14.285	0.045006	0.803	0.650
clinical blood chemistry	HDL cholesterol (plasma HDL)	-3.0698	4.4506	-0.98530	0.763	0.498
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.0018185	0.017373	-0.26424	0.981	0.918
clinical blood chemistry	phosphorus (plasma phosphate)	-0.18852	0.31129	-0.35882	0.784	0.551
clinical blood chemistry	total bilirubin (plasma TBIL)	0.029771	0.010207	1.5989	0.105	0.00853
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-3.3782	5.2707	-0.80491	0.794	0.528
clinical blood chemistry	total protein (plasma TP)	0.68416	2.6193	0.45962	0.906	0.797
clinical blood chemistry	triglyceride (plasma TG, no fast)	-6.2592	8.8855	-0.13345	0.737	0.490
EKG	duration of PQ interval	2.5141	0.96828	2.2553	0.416	0.0177
EKG	duration of PR interval	2.9714	0.88100	2.5347	0.211	0.00339
EKG	duration of QRS interval	0.48625	0.33767	1.2652	0.885	0.166
EKG	duration of QT interval	0.93625	0.92042	1.0524	0.789	0.322
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.59500	0.91152	0.72337	0.924	0.522
EKG	duration of RR interval	1.3877	1.3867	0.96207	0.742	0.330
EKG	duration of ST interval	0.45000	0.99204	0.68975	0.915	0.655
EKG	heart rate coefficient of variation (signal intensity)	-0.38212	0.96154	-0.21730	0.950	0.695
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-3.4075	6.8363	-0.30489	0.931	0.624
EKG	heart rate, beats per min	-13.472	12.492	-1.1402	0.704	0.294
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.18450	0.11235	1.3158	0.456	0.117
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.10888	0.16025	0.53577	0.781	0.505
EKG	number of signals	1.7791	6.5858	0.31970	0.955	0.790
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	2.1444	3.5813	0.47734	0.893	0.556
EKG	QT dispersion, measured as inter-lead variability of QT intervals	0.45000	2.0103	0.18030	0.979	0.825
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-0.10000	1.9241	-0.028213	0.987	0.959
EKG	root mean square of successive differences of neighboring RR intervals	-1.9031	1.8487	-0.97820	0.850	0.316
glucose tolerance test	amount glucose injected	-5.2386	2.3422	-1.0908	0.286	0.0382
glucose tolerance test	plasma glucose, 0min	30.172	5.7426	2.1338	0.00140	0.0000452
glucose tolerance test	plasma glucose, 15min	43.675	28.641	1.2866	0.445	0.144
glucose tolerance test	plasma glucose, 30min	100.56	36.718	2.3114	0.129	0.0131
glucose tolerance test	plasma glucose, 60min	58.931	18.152	2.0953	0.0776	0.00425
glucose tolerance test	plasma glucose, 120min	12.786	9.2212	0.75514	0.493	0.182
grip strength	body weight (at time of grip strength test)	-0.28282	0.44859	-0.060963	0.708	0.532
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-16.749	6.7059	-0.89065	0.0783	0.0171
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.92893	0.31481	-1.1084	0.0405	0.00547
grip strength	forelimb and hindlimb grip strength by trial, trial1	-14.802	8.6544	-0.71986	0.322	0.0956
grip strength	forelimb and hindlimb grip strength by trial, trial2	-13.248	8.0901	-0.60760	0.314	0.110
grip strength	forelimb and hindlimb grip strength by trial, trial3	-20.950	7.5083	-1.1031	0.0717	0.00828
grip strength	forelimb grip strength (mean of trials), average	-15.764	4.8559	-1.5723	0.0311	0.00249
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.78946	0.22664	-1.5430	0.0232	0.00126
grip strength	forelimb grip strength by trial, trial1	-17.660	5.8903	-1.6190	0.0817	0.00477
grip strength	forelimb grip strength by trial, trial2	-16.729	5.9376	-1.4707	0.0965	0.00764
grip strength	forelimb grip strength by trial, trial3	-13.973	5.4952	-1.1724	0.145	0.0153
heart weight	heart weight, normalized to body weight	-0.10253	0.087820	-0.83970	0.473	0.253
heart weight	heart weight, weight	-2.3650	2.1400	-0.69284	0.487	0.278
hematology	basophil differential (percent of total WBC)	-0.014076	0.059619	-0.20879	0.952	0.816
hematology	calculated hemoglobin (cHGB)	0.027916	0.16574	-0.19771	0.948	0.868
hematology	eosinophil differential (percent of total WBC)	-0.23571	0.25266	-0.57999	0.746	0.362
hematology	hematocrit (HCT)	0.32619	0.40165	-0.027339	0.682	0.426
hematology	hemoglobin concentration distribution width (HDW)	-0.036038	0.022298	-0.99366	0.391	0.122
hematology	large unstained cells (percent of total WBC)	-0.097565	0.11250	-0.67831	0.714	0.397
hematology	lymphocyte differential (percent of total WBC)	0.90142	1.6316	0.33703	0.772	0.587
hematology	mean corpuscular hemoglobin (CHr)	-0.21382	0.083505	-1.5446	0.0892	0.0186
hematology	mean platelet volume (MPV)	-0.21180	0.068860	-1.2775	0.0389	0.00622
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.15364	0.10554	-0.58268	0.505	0.161
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.077053	0.22489	0.20553	0.908	0.736
hematology	mean RBC corpuscular volume (MCV)	-0.19113	0.31037	-0.35589	0.746	0.545
hematology	measured hemoglobin (mHGB)	0.20067	0.18433	0.28625	0.595	0.289
hematology	monocyte differential (percent of total WBC)	-0.10238	0.17040	-0.13848	0.818	0.555
hematology	neutrophil differential (percent of total WBC)	-0.27489	1.4220	-0.11644	0.927	0.849
hematology	platelet count (PLT; units per volume x 10³)	18.799	50.890	0.28253	0.895	0.716
hematology	RBC corpuscular distribution width (RDW)	0.18084	0.17407	0.63752	0.571	0.311
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.17545	0.21979	-0.52240	0.687	0.434
hematology	red blood cell count (RBC; per volume x 10⁶)	0.061453	0.13150	-0.076697	0.822	0.645
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-3.9323	13.478	-0.092844	0.937	0.774
hematology	reticulocyte differential (percent of total RBC)	-0.044557	0.13800	0.032180	0.905	0.750
hematology	white blood cell count (WBC; units per volume x 10³)	0.048333	0.73675	0.22185	0.975	0.948
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.83133	0.47901	0.83682	0.557	0.0893
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.61712	0.32912	1.1108	0.567	0.0671
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.44176	0.30909	0.80141	0.684	0.160
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.81485	0.49333	0.86838	0.561	0.105
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.98091	0.41861	1.5063	0.392	0.0235
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.23379	0.22275	0.66499	0.855	0.299
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.014907	0.17055	0.039731	1.00	0.931
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.20438	0.45521	0.46808	0.935	0.656
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.95082	0.47315	1.4904	0.453	0.0504
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.10800	0.30871	0.36120	0.951	0.728
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.45412	0.24642	1.0857	0.653	0.0718
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.76617	0.41000	1.2000	0.497	0.0680
holeboard	number of hole pokes by individual hole number, 20 min test, 13	2.0580	0.92455	1.8120	0.380	0.0310
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.58504	0.42434	0.93733	0.609	0.175
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.30335	0.42684	0.54542	0.852	0.481
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.24925	0.78387	0.25404	0.933	0.752
holeboard	total number of hole pokes, 20 min test	9.9202	3.5131	1.2994	0.0850	0.00699
light / dark	fecal boli count, 20 min test	-0.19865	0.68716	-0.19594	0.927	0.774
light / dark	latency to enter dark zone, 20 min test	-1.8533	48.600	-0.14108	0.990	0.970
light / dark	number of transitions between light and dark zones, 20 min test	16.544	6.3423	1.4994	0.128	0.0116
light / dark	percentage of total time in dark zone, 20 min test	-3.8578	4.9708	-0.57185	0.745	0.441
light / dark	percentage of total time in light zone, 20 min test	3.8578	4.9708	0.57026	0.743	0.441
light / dark	time mobile in dark zone, 20 min test	41.700	12.210	1.6922	0.0217	0.00119
light / dark	time mobile in light zone, 20 min test	28.789	10.563	1.2467	0.0717	0.00855
light / dark	time spent in dark zone, 20 min test	-57.180	55.769	-0.63512	0.708	0.310
light / dark	time spent in light zone, 20 min test	57.180	55.769	0.63512	0.708	0.310
open field	average speed in center of arena, 20 min test	0.17306	0.41933	0.21169	0.878	0.681
open field	average speed in periphery of arena, 20 min test	0.26197	0.13828	0.48944	0.192	0.0633
open field	distance traveled habituation ratio, 20 min test	15.408	7.9746	1.2596	0.293	0.0585
open field	distance traveled in center of arena, 20 min test	166.20	74.151	0.68591	0.140	0.0290
open field	distance traveled in periphery of arena, 20 min test	199.05	144.02	0.35720	0.391	0.172
open field	distance traveled slope, 20 min test	13.532	7.2772	1.1698	0.317	0.0682
open field	distance traveled, 20 min test, 1st 5min	10.305	80.034	-0.26140	0.955	0.898
open field	distance traveled, 20 min test, 2nd 5min	99.252	50.718	0.58724	0.204	0.0553
open field	distance traveled, 20 min test, 3rd 5min	98.335	48.229	0.63580	0.182	0.0462
open field	distance traveled, 20 min test, 4th 5min	149.25	42.076	1.1081	0.0112	0.000796
open field	number of clockwise revolution episodes, 20 min test	2.0356	1.1740	0.76591	0.386	0.0885
open field	number of counter-clockwise revolution episodes, 20 min test	2.2561	1.1506	0.74488	0.254	0.0549
open field	number of fecal boli, 20 min test	0.61995	0.86902	0.70956	0.750	0.479
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-2.7377	2.0286	-0.95040	0.438	0.183
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	0.80945	2.2222	-0.14483	0.865	0.717
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	3.5259	2.4234	0.52764	0.410	0.151
open field	number of rears in 5 min bins, 20 min test, 4th 5min	5.6189	2.7006	0.87736	0.216	0.0421
open field	percentage of total time in center of arena, 20 min test	1.7343	2.2438	0.20346	0.734	0.443
open field	percentage of total time in center of arena, slope, 20 min test	-0.56672	1.7623	-0.20072	0.946	0.749
open field	percentage of total time in center, habituation ratio, 20 min test	-0.42091	1.8857	-0.10829	0.957	0.824
open field	percentage of total time in corners of arena, 20 min test	-1.7005	2.5680	-0.010070	0.771	0.511
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.086868	2.0880	-0.34150	0.996	0.967
open field	percentage of total time in corners, slope, 20 min test	0.032900	1.9697	-0.25168	1.00	0.987
open field	permanence time in center of arena, 20 min test	20.812	26.925	0.20483	0.734	0.443
open field	permanence time in corners of arena, 20 min test	-20.411	30.815	-0.011412	0.771	0.511
open field	permanence time in periphery of arena, 20 min test	-20.758	26.926	-0.20346	0.734	0.444
open field	total distance traveled, 20 min test	363.40	187.21	0.55093	0.181	0.0573
open field	total number of rears, 20 min test	7.0376	7.7203	0.14483	0.613	0.366
open field	whole arena average speed, 20 min test	0.30291	0.15594	0.55249	0.182	0.0571
open field	whole arena resting time, 20 min test	-35.741	16.830	-0.43122	0.135	0.0381
open field	whole arena time spent mobile, 20 min test	35.643	16.830	0.67575	0.137	0.0386
open field	whole arena time spent vertical, 20 min test	-4.1233	8.4115	-0.46237	0.846	0.626
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.9193	1.5694	0.99484	0.547	0.229
startle / PPI	average baseline movement during background noise	2.4537	1.7494	1.3797	0.718	0.170
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.11064	0.11303	0.91968	0.679	0.335
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.044055	0.077657	0.35445	0.833	0.574
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	11.762	12.440	1.3797	0.879	0.351
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	1.7846	7.8070	0.13987	0.947	0.821
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	1.6051	5.5992	0.055373	0.912	0.776
startle / PPI	average startle response to full pulse (120 dB)	-15.705	42.327	-0.13845	0.875	0.713
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-29.831	41.458	-0.41744	0.696	0.477
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-7.8512	34.749	0.011910	0.896	0.823
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.27208	26.620	0.18245	0.997	0.992
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.49477	1.4333	0.42050	0.953	0.732
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.43375	1.3387	-0.29203	0.956	0.748
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-0.095827	1.9325	-0.23833	0.990	0.961
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.093039	0.14538	0.91541	0.918	0.526
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.0082583	0.089994	-0.014729	0.980	0.927
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.047925	0.068345	0.22622	0.731	0.488
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-18.100	42.483	-0.19672	0.851	0.673
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-31.092	41.321	-0.43124	0.679	0.457
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-7.4175	34.651	0.031531	0.902	0.832
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-0.19396	26.113	0.19101	0.997	0.994
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.36986	0.26513	2.2140	0.807	0.172
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.11688	0.13679	-0.98549	0.707	0.399
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.018452	0.068518	-0.036458	0.915	0.789
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-46.071	152.41	-0.080653	0.902	0.764
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-107.31	155.52	-0.42203	0.703	0.495
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-29.212	127.36	0.021719	0.896	0.820
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	8.0210	95.041	0.24843	0.961	0.933
startle / PPI	maximum baseline movement during background noise	3.1831	3.5233	0.92396	0.808	0.373
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	14.076	13.170	1.5066	0.888	0.293
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.41941	9.2271	-0.051164	0.987	0.964
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	1.8948	6.4198	0.034335	0.908	0.770
startle / PPI	maximum startle response to full pulse (120 dB)	-42.625	152.15	-0.062391	0.910	0.781
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-102.84	155.72	-0.40220	0.718	0.513
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-29.257	127.44	0.020318	0.895	0.820
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	5.1556	95.961	0.23113	0.976	0.957
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-0.54454	3.3860	-0.044150	0.970	0.873
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.044792	3.4020	0.0091075	0.996	0.990
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-2.9484	4.2076	-0.78658	0.811	0.488

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value

eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	1.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.00
eye morphology	eyes (present, absent)	0.0 %	1.00
eye morphology	fusion between cornea and lens	3.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.0
eye morphology	lacrimation	3.0 %	1.00
eye morphology	lens	9.0 %	1.00
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.00
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	9.0 %	1.00
eye morphology	pupil dilation	2.0 %	1.00
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	3.0 %	1.0
eye morphology	retina	13.0 %	1.00
eye morphology	retinal blood vessels	3.0 %	1.00
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.0
eye morphology	retinal pigmentation	37.0 %	0.00111
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	6.0 %	0.101
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	6.0 %	0.00883
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	7.0 %	0.624
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	42.0 %	1.02e-9
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Serp2^em1(IMPC)J -/- with genotype: