MPD: JaxKOMP-EAP genotype: Rab11b<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Rab11b^em1(IMPC)J -/- Gene Rab11b

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	3.5417	1.1196	0.76987	0.145	0.00643
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	1.0417	1.2971	0.23233	0.826	0.434
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	6.5957	2.9054	1.0024	0.284	0.0384
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	6.0224	3.9119	0.82806	0.509	0.145
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	9.3750	2.9092	1.4204	0.110	0.00570
body composition	body length	0.10563	0.048331	1.4997	0.182	0.0341
body composition	body weight (at time of DXA)	1.6295	0.66881	1.4621	0.0870	0.0188
body composition	bone area, whole body scan, head excluded	0.064758	0.16718	0.45028	0.863	0.700
body composition	bone mineral content of whole body scan, head excluded	0.0068525	0.012688	0.51939	0.804	0.592
body composition	bone mineral content to body weight ratio	0.00017911	0.00044978	0.39948	0.846	0.692
body composition	bone mineral density of whole body scan, head excluded	0.00040182	0.00062690	0.45585	0.763	0.525
body composition	fat tissue mass of whole body scan, head excluded	0.55533	0.42152	0.82079	0.433	0.194
body composition	fat tissue mass to body weight ratio	0.014191	0.013592	0.67792	0.545	0.302
body composition	lean tissue mass of whole body scan, head excluded	0.030976	0.43934	-0.077899	0.986	0.944
body composition	lean tissue mass to body weight ratio	-0.00089887	0.012066	-0.089593	0.973	0.941
body composition	percent fat, whole body scan, head excluded	0.96434	1.2699	0.53351	0.679	0.452
body composition	ratio of soft-tissue attenuation coefficients	-0.0010731	0.0014111	-0.53479	0.681	0.451
body composition	tissue area	0.054897	0.25276	0.37929	0.945	0.829
body composition	total tissue mass, whole body scan, head excluded	0.64738	0.40487	1.0977	0.325	0.117
clinical blood chemistry	alanine transaminase (plasma ALT)	8.9078	5.9146	0.67672	0.510	0.142
clinical blood chemistry	albumin (plasma Alb)	-0.022463	0.35766	0.021389	0.989	0.950
clinical blood chemistry	alkaline phosphatase (plasma ALP)	2.5988	4.9299	-0.090100	0.791	0.602
clinical blood chemistry	aspartate transaminase (plasma AST)	4.9163	26.163	0.24048	0.960	0.852
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.56205	0.48613	-1.5642	0.654	0.256
clinical blood chemistry	blood urea nitrogen (BUN)	3.4252	1.9909	1.3145	0.306	0.0947
clinical blood chemistry	calcium (plasma Ca)	-0.13736	0.072070	-0.64052	0.222	0.0654
clinical blood chemistry	creatinine (plasma)	-0.029171	0.040407	-0.56972	0.704	0.476
clinical blood chemistry	glucose (plasma GLU, no fast)	-9.0747	13.118	-0.060739	0.691	0.494
clinical blood chemistry	HDL cholesterol (plasma HDL)	3.0608	2.9591	0.40855	0.614	0.309
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.00024115	0.013437	-0.14642	0.999	0.986
clinical blood chemistry	phosphorus (plasma phosphate)	-0.62020	0.32450	-1.0240	0.261	0.0647
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0094253	0.014090	-0.70237	0.785	0.508
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	4.9059	3.6745	0.61971	0.489	0.191
clinical blood chemistry	total protein (plasma TP)	-0.17378	0.68259	-0.19683	0.907	0.801
clinical blood chemistry	triglyceride (plasma TG, no fast)	10.851	12.844	0.80428	0.677	0.404
EKG	duration of PQ interval	0.20242	0.65345	0.33884	0.941	0.769
EKG	duration of PR interval	-0.16734	0.71174	-0.072603	0.959	0.823
EKG	duration of QRS interval	-0.22742	0.37860	-0.75783	0.945	0.574
EKG	duration of QT interval	0.26109	0.92291	0.40143	0.960	0.789
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.47036	0.92971	0.57170	0.939	0.634
EKG	duration of RR interval	0.078069	1.6020	0.27756	0.981	0.963
EKG	duration of ST interval	0.46149	0.90149	0.70517	0.908	0.631
EKG	heart rate coefficient of variation (signal intensity)	-0.027056	1.1485	0.10700	0.990	0.982
EKG	heart rate variability, mean of differences between sequential beats; beats per min	0.10101	8.3799	0.11916	0.998	0.991
EKG	heart rate, beats per min	-1.1090	14.101	-0.32953	0.981	0.940
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.040769	0.13375	-0.44478	0.925	0.773
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.050706	0.10804	-0.39413	0.868	0.659
EKG	number of signals	-1.2554	9.2243	-0.30278	0.981	0.897
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-0.37736	4.6710	-0.0020346	0.990	0.939
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-1.2629	4.6598	-0.34739	0.977	0.797
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-0.69931	5.5800	-0.17007	0.986	0.905
EKG	root mean square of successive differences of neighboring RR intervals	1.1172	1.4721	0.71034	0.897	0.482
glucose tolerance test	amount glucose injected	-0.91411	2.7582	0.077766	0.918	0.743
glucose tolerance test	plasma glucose, 0min	9.3017	5.3324	0.71379	0.244	0.0913
glucose tolerance test	plasma glucose, 15min	25.991	24.406	0.85381	0.625	0.295
glucose tolerance test	plasma glucose, 30min	63.012	22.018	1.8042	0.0982	0.00760
glucose tolerance test	plasma glucose, 60min	22.756	17.082	1.0153	0.516	0.193
glucose tolerance test	plasma glucose, 120min	16.195	12.698	0.94860	0.523	0.212
grip strength	body weight (at time of grip strength test)	0.18349	0.48976	0.37877	0.831	0.710
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-24.215	6.5128	-1.4496	0.00773	0.000565
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.0857	0.29697	-1.3492	0.00975	0.000680
grip strength	forelimb and hindlimb grip strength by trial, trial1	-24.488	8.8440	-1.3601	0.0745	0.00814
grip strength	forelimb and hindlimb grip strength by trial, trial2	-21.468	8.6703	-1.1084	0.110	0.0171
grip strength	forelimb and hindlimb grip strength by trial, trial3	-24.939	8.2363	-1.3349	0.0454	0.00411
grip strength	forelimb grip strength (mean of trials), average	-13.602	3.3104	-1.3456	0.00639	0.000170
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.59276	0.14249	-1.1870	0.00659	0.000145
grip strength	forelimb grip strength by trial, trial1	-13.302	3.8451	-1.1988	0.0395	0.00121
grip strength	forelimb grip strength by trial, trial2	-13.443	4.0398	-1.1696	0.0423	0.00178
grip strength	forelimb grip strength by trial, trial3	-14.497	4.7948	-1.2169	0.0703	0.00416
heart weight	heart weight, normalized to body weight	-0.0019621	0.15778	-0.45657	0.993	0.990
heart weight	heart weight, weight	-1.0610	4.5735	-0.50665	0.902	0.819
hematology	basophil differential (percent of total WBC)	-0.029508	0.048539	-0.43023	0.847	0.551
hematology	calculated hemoglobin (cHGB)	-0.79621	0.14471	-1.9151	0.00248	0.0000483
hematology	eosinophil differential (percent of total WBC)	0.40929	0.30746	1.2168	0.594	0.201
hematology	hematocrit (HCT)	-1.6192	0.62069	-1.6277	0.145	0.0183
hematology	hemoglobin concentration distribution width (HDW)	0.0033741	0.029164	0.078303	0.954	0.909
hematology	large unstained cells (percent of total WBC)	-0.052699	0.049741	-0.34272	0.641	0.304
hematology	lymphocyte differential (percent of total WBC)	-0.51245	0.95472	-0.26834	0.779	0.599
hematology	mean corpuscular hemoglobin (CHr)	-1.0730	0.081977	-2.5417	1.91e-8	2.64e-10
hematology	mean platelet volume (MPV)	0.13576	0.056197	0.67751	0.112	0.0272
hematology	mean RBC corpuscular hemoglobin (MCH)	-1.0581	0.24497	-1.6651	0.0163	0.000465
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.78863	0.48391	-1.1339	0.453	0.122
hematology	mean RBC corpuscular volume (MCV)	-2.2826	0.31268	-2.3771	0.0000569	0.00000124
hematology	measured hemoglobin (mHGB)	-0.77302	0.31176	-1.4491	0.193	0.0247
hematology	monocyte differential (percent of total WBC)	0.090844	0.11483	0.52628	0.743	0.440
hematology	neutrophil differential (percent of total WBC)	-0.13006	0.79365	-0.042382	0.940	0.872
hematology	platelet count (PLT; units per volume x 10³)	-19.462	41.781	-0.22466	0.865	0.647
hematology	RBC corpuscular distribution width (RDW)	0.81795	0.19965	1.9302	0.0192	0.000842
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-1.0306	0.17394	-2.1628	0.000920	0.0000166
hematology	red blood cell count (RBC; per volume x 10⁶)	0.24215	0.13958	0.70750	0.343	0.102
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-22.918	18.850	-0.89570	0.638	0.241
hematology	reticulocyte differential (percent of total RBC)	-0.29636	0.20856	-1.0320	0.527	0.173
hematology	white blood cell count (WBC; units per volume x 10³)	-1.6780	0.36437	-0.97107	0.00477	0.000252
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.99732	0.93847	-0.95270	0.739	0.293
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.68463	0.54313	-0.93950	0.729	0.213
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.17814	0.49991	-0.21518	0.937	0.723
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.4442	0.54796	-1.3646	0.283	0.0112
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.19557	0.70021	0.41964	0.954	0.781
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.096674	0.26813	-0.25753	0.957	0.720
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.28589	0.31218	-0.77964	0.865	0.364
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.45401	0.43196	-0.66025	0.790	0.298
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.42115	0.39804	-0.65762	0.772	0.295
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.31047	0.22971	-0.82107	0.746	0.183
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.67500	0.30841	-1.7776	0.562	0.0333
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.13435	0.37333	-0.12175	0.947	0.720
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.0250	0.73647	-0.91660	0.584	0.170
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.22677	0.37360	-0.25404	0.859	0.547
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.43171	0.34498	0.74948	0.669	0.217
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.0082974	0.80213	0.035431	0.998	0.992
holeboard	total number of hole pokes, 20 min test	-6.1055	4.1368	-0.76521	0.418	0.146
light / dark	fecal boli count, 20 min test	-0.68013	0.54199	-0.71058	0.621	0.216
light / dark	latency to enter dark zone, 20 min test	37.157	44.005	0.57345	0.770	0.403
light / dark	number of transitions between light and dark zones, 20 min test	1.5698	8.1844	0.26117	0.940	0.849
light / dark	percentage of total time in dark zone, 20 min test	-0.77271	4.2536	-0.0054081	0.959	0.857
light / dark	percentage of total time in light zone, 20 min test	0.77271	4.2536	0.0027040	0.960	0.857
light / dark	time mobile in dark zone, 20 min test	7.2546	11.554	0.37645	0.786	0.533
light / dark	time mobile in light zone, 20 min test	7.8121	11.549	0.27378	0.741	0.502
light / dark	time spent in dark zone, 20 min test	-45.163	58.758	-0.47114	0.800	0.446
light / dark	time spent in light zone, 20 min test	45.163	58.758	0.47114	0.800	0.446
open field	average speed in center of arena, 20 min test	-0.97334	0.51505	-1.8731	0.340	0.0673
open field	average speed in periphery of arena, 20 min test	0.16726	0.14465	0.14891	0.476	0.256
open field	distance traveled habituation ratio, 20 min test	9.3361	6.4810	0.76092	0.473	0.159
open field	distance traveled in center of arena, 20 min test	146.57	109.02	0.57294	0.439	0.188
open field	distance traveled in periphery of arena, 20 min test	47.138	140.75	-0.24476	0.867	0.740
open field	distance traveled slope, 20 min test	6.3879	6.1395	0.59523	0.628	0.305
open field	distance traveled, 20 min test, 1st 5min	35.814	74.722	-0.036930	0.831	0.635
open field	distance traveled, 20 min test, 2nd 5min	64.481	51.395	0.21306	0.452	0.218
open field	distance traveled, 20 min test, 3rd 5min	3.6798	64.542	-0.37875	0.989	0.955
open field	distance traveled, 20 min test, 4th 5min	96.197	50.310	0.57452	0.230	0.0646
open field	number of clockwise revolution episodes, 20 min test	-0.49137	1.3107	-0.70087	0.896	0.710
open field	number of counter-clockwise revolution episodes, 20 min test	3.4568	1.6785	1.3508	0.232	0.0472
open field	number of fecal boli, 20 min test	-1.0143	0.75752	-0.54516	0.514	0.190
open field	number of rears in 5 min bins, 20 min test, 1st 5min	4.8486	2.2757	1.0930	0.193	0.0404
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	5.1397	2.9477	0.97856	0.326	0.0903
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	9.9262	3.2958	1.7425	0.0568	0.00487
open field	number of rears in 5 min bins, 20 min test, 4th 5min	6.1837	3.9176	1.0229	0.368	0.124
open field	percentage of total time in center of arena, 20 min test	5.2081	3.4130	0.92781	0.439	0.136
open field	percentage of total time in center of arena, slope, 20 min test	1.0564	1.6284	0.72552	0.867	0.521
open field	percentage of total time in center, habituation ratio, 20 min test	0.76926	1.7521	0.54313	0.901	0.663
open field	percentage of total time in corners of arena, 20 min test	-8.5032	4.9931	-1.2537	0.381	0.0977
open field	percentage of total time in corners, habituation ratio, 20 min test	0.51819	1.8042	-0.042304	0.959	0.776
open field	percentage of total time in corners, slope, 20 min test	0.65994	1.7547	0.035586	0.937	0.709
open field	permanence time in center of arena, 20 min test	62.487	40.954	0.92987	0.439	0.136
open field	permanence time in corners of arena, 20 min test	-102.02	59.917	-1.2537	0.381	0.0978
open field	permanence time in periphery of arena, 20 min test	-62.482	40.959	-0.92987	0.439	0.136
open field	total distance traveled, 20 min test	198.04	202.06	0.10019	0.558	0.334
open field	total number of rears, 20 min test	26.101	11.138	1.3643	0.133	0.0251
open field	whole arena average speed, 20 min test	0.16578	0.16876	0.10019	0.557	0.333
open field	whole arena resting time, 20 min test	-27.596	18.438	-0.22681	0.315	0.144
open field	whole arena time spent mobile, 20 min test	27.623	18.433	0.48038	0.319	0.143
open field	whole arena time spent vertical, 20 min test	17.134	9.2393	1.2391	0.311	0.0724
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.1580	1.3793	0.67310	0.688	0.406
startle / PPI	average baseline movement during background noise	-0.80920	1.7536	-0.55471	0.922	0.647
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.17744	0.058528	1.4246	0.124	0.00456
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.17010	0.057910	1.5465	0.124	0.00582
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	4.6269	6.4259	0.56783	0.891	0.476
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	14.738	7.0486	1.4809	0.320	0.0439
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	37.987	7.6258	2.9333	0.00250	0.0000182
startle / PPI	average startle response to full pulse (120 dB)	-141.85	38.457	-1.8781	0.0104	0.000783
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-151.36	34.694	-2.0288	0.00259	0.000113
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-142.58	29.801	-2.1532	0.00109	0.0000326
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-193.56	64.890	-3.2590	0.0420	0.00517
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.90333	1.2494	-0.59604	0.864	0.474
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.83233	1.5131	0.55144	0.913	0.586
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	3.7833	3.2377	1.2749	0.683	0.250
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.048662	0.069648	0.50314	0.903	0.489
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.19161	0.076442	1.5558	0.206	0.0170
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.31397	0.073190	2.0285	0.00736	0.000140
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-140.96	39.086	-1.8237	0.0125	0.000985
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-150.52	35.155	-1.9867	0.00313	0.000143
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-143.13	30.334	-2.1677	0.00116	0.0000397
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-122.91	25.271	-2.2477	0.00107	0.0000258
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.026976	0.077657	0.26726	0.954	0.730
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.21749	0.074042	1.6204	0.135	0.00582
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.32794	0.071032	1.9477	0.00335	0.0000536
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-519.12	142.24	-1.9118	0.0112	0.000873
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-551.08	127.01	-2.0179	0.00265	0.000121
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-480.05	106.54	-1.9767	0.00182	0.0000744
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-373.43	81.400	-1.8164	0.00173	0.0000585
startle / PPI	maximum baseline movement during background noise	-0.55525	3.8124	-0.059583	0.973	0.885
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	2.5808	7.3168	0.30082	0.958	0.726
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	18.434	7.0524	1.6638	0.199	0.0131
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	24.106	6.5718	2.0512	0.0273	0.000829
startle / PPI	maximum startle response to full pulse (120 dB)	-521.05	141.15	-1.9296	0.0101	0.000776
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-545.23	127.01	-2.0073	0.00289	0.000139
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-537.30	112.00	-2.2140	0.00102	0.0000314
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-455.61	94.138	-2.2305	0.000990	0.0000277
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.8803	3.2005	-0.50632	0.882	0.561
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	1.4779	3.4354	0.45909	0.934	0.670
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	7.9110	4.4328	1.0640	0.447	0.0830

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	12.0 %	0.175
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	6.0 %	0.248
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	12.0 %	0.0594
eye morphology	lacrimation	both	6.0 %	0.106
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	36.0 %	0.00894
eye morphology	persistence of hyaloid vascular system	males	11.0 %	0.333
eye morphology	persistence of hyaloid vascular system	both	22.0 %	0.0125
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	7.0 %	0.610
eye morphology	retina	both	7.0 %	0.801
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	25.0 %	0.0775
eye morphology	retinal pigmentation	males	22.0 %	0.145
eye morphology	retinal pigmentation	both	18.0 %	0.0446
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	1.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	36.0 %	0.000414
SHIRPA	tail elevation	both	17.0 %	0.00147
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Rab11b^em1(IMPC)J -/- with genotype: