MPD: JaxKOMP-EAP genotype: Ssx2ip<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Ssx2ip^em1(IMPC)J -/- Gene Ssx2ip

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-3.2695	4.4120	-1.1434	0.817	0.476
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	2.1918	4.1288	0.53369	0.886	0.606
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-4.0523	1.7496	-1.0118	0.293	0.0409
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	7.7083	3.3800	1.1016	0.288	0.0435
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-1.6667	3.2581	-0.30760	0.847	0.619
body composition	body length	-0.030119	0.048316	-0.16209	0.780	0.536
body composition	body weight (at time of DXA)	-2.3190	0.61373	-1.3727	0.00567	0.000436
body composition	bone area, whole body scan, head excluded	-0.50656	0.14127	-1.6030	0.0153	0.000785
body composition	bone mineral content of whole body scan, head excluded	-0.020829	0.012512	-0.96524	0.326	0.103
body composition	bone mineral content to body weight ratio	-0.00089721	0.00056539	-0.93522	0.341	0.119
body composition	bone mineral density of whole body scan, head excluded	-0.00020616	0.00054211	-0.18755	0.866	0.705
body composition	fat tissue mass of whole body scan, head excluded	0.51404	0.31369	0.78685	0.317	0.108
body composition	fat tissue mass to body weight ratio	0.016278	0.011335	0.76106	0.375	0.158
body composition	lean tissue mass of whole body scan, head excluded	0.026676	0.29267	-0.095715	0.979	0.928
body composition	lean tissue mass to body weight ratio	-0.0069810	0.012443	-0.43173	0.789	0.577
body composition	percent fat, whole body scan, head excluded	1.6588	1.0784	0.83039	0.335	0.131
body composition	ratio of soft-tissue attenuation coefficients	-0.0016997	0.0012224	-0.79271	0.398	0.171
body composition	tissue area	0.28602	0.25271	1.0580	0.566	0.263
body composition	total tissue mass, whole body scan, head excluded	0.51037	0.28620	0.84201	0.259	0.0810
clinical blood chemistry	alanine transaminase (plasma ALT)	26.228	16.020	1.3772	0.469	0.111
clinical blood chemistry	albumin (plasma Alb)	-0.082183	0.47710	-0.067065	0.952	0.864
clinical blood chemistry	alkaline phosphatase (plasma ALP)	6.0495	2.5239	0.56168	0.118	0.0222
clinical blood chemistry	aspartate transaminase (plasma AST)	12.563	15.480	0.52994	0.722	0.423
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.49978	0.29208	-1.4255	0.474	0.0962
clinical blood chemistry	blood urea nitrogen (BUN)	-1.3859	1.3434	-0.59088	0.581	0.310
clinical blood chemistry	calcium (plasma Ca)	0.015437	0.086837	0.45372	0.927	0.860
clinical blood chemistry	creatinine (plasma)	-0.025246	0.018771	-0.47830	0.423	0.188
clinical blood chemistry	glucose (plasma GLU, no fast)	-27.896	9.2434	-0.70484	0.0316	0.00480
clinical blood chemistry	HDL cholesterol (plasma HDL)	3.0811	3.6051	0.41472	0.686	0.399
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.0026322	0.012616	-0.31621	0.960	0.836
clinical blood chemistry	phosphorus (plasma phosphate)	0.41292	0.24087	0.55357	0.314	0.0956
clinical blood chemistry	total bilirubin (plasma TBIL)	0.017581	0.011511	1.0759	0.440	0.136
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	4.6063	4.6930	0.58561	0.641	0.333
clinical blood chemistry	total protein (plasma TP)	-0.76133	0.67580	-0.67449	0.547	0.268
clinical blood chemistry	triglyceride (plasma TG, no fast)	12.947	8.0166	0.89887	0.371	0.116
EKG	duration of PQ interval	1.2335	1.3528	1.4079	0.870	0.373
EKG	duration of PR interval	0.56986	1.2667	0.66944	0.938	0.658
EKG	duration of QRS interval	0.40845	0.40679	1.0454	0.885	0.328
EKG	duration of QT interval	1.9151	1.0935	1.7969	0.628	0.0969
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	2.8161	1.1312	2.5347	0.547	0.0222
EKG	duration of RR interval	-1.8348	1.8077	-0.70517	0.734	0.324
EKG	duration of ST interval	1.3472	0.91965	1.5591	0.670	0.160
EKG	heart rate coefficient of variation (signal intensity)	-0.81399	0.64256	-0.55752	0.841	0.221
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-5.6895	4.4199	-0.58122	0.853	0.213
EKG	heart rate, beats per min	14.565	15.583	0.62652	0.738	0.362
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.40338	0.15104	2.4069	0.206	0.0151
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.34872	0.19280	1.7966	0.394	0.0864
EKG	number of signals	4.9994	5.6689	0.95569	0.832	0.389
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-5.0256	2.6486	-0.91154	0.758	0.0731
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-7.6847	3.1611	-2.0198	0.765	0.0251
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-8.2798	3.3663	-1.8728	0.654	0.0237
EKG	root mean square of successive differences of neighboring RR intervals	-0.041109	0.28232	0.086753	0.970	0.886
glucose tolerance test	amount glucose injected	-1.4790	6.4942	-0.087424	0.943	0.821
glucose tolerance test	plasma glucose, 0min	18.130	9.1732	1.4550	0.177	0.0563
glucose tolerance test	plasma glucose, 15min	28.508	26.936	0.92940	0.627	0.297
glucose tolerance test	plasma glucose, 30min	14.933	27.959	0.56066	0.826	0.597
glucose tolerance test	plasma glucose, 60min	38.575	21.543	1.5528	0.334	0.0823
glucose tolerance test	plasma glucose, 120min	16.001	11.832	0.93789	0.494	0.185
grip strength	body weight (at time of grip strength test)	-1.9480	0.41561	-1.4178	0.00107	0.0000605
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-39.055	5.8200	-2.2166	0.0000451	2.32e-7
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.3720	0.33386	-1.6522	0.00607	0.000313
grip strength	forelimb and hindlimb grip strength by trial, trial1	-41.904	6.9983	-2.2166	0.000711	0.00000165
grip strength	forelimb and hindlimb grip strength by trial, trial2	-29.506	7.8265	-1.6299	0.0189	0.000776
grip strength	forelimb and hindlimb grip strength by trial, trial3	-36.542	6.7121	-1.9419	0.00116	0.00000738
grip strength	forelimb grip strength (mean of trials), average	-28.862	4.0537	-2.6474	0.0000381	7.79e-8
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-1.5057	0.25618	-2.2705	0.000439	0.00000254
grip strength	forelimb grip strength by trial, trial1	-29.459	4.6657	-2.6019	0.000291	6.76e-7
grip strength	forelimb grip strength by trial, trial2	-27.224	5.1170	-2.3785	0.00203	0.0000104
grip strength	forelimb grip strength by trial, trial3	-29.936	4.3002	-2.4908	0.0000681	1.18e-7
heart weight	heart weight, normalized to body weight	-0.094486	0.12452	-0.80745	0.655	0.453
heart weight	heart weight, weight	-2.3325	3.3024	-0.68770	0.680	0.484
hematology	basophil differential (percent of total WBC)	0.011864	0.048616	0.21862	0.950	0.809
hematology	calculated hemoglobin (cHGB)	0.30270	0.19004	0.66254	0.370	0.120
hematology	eosinophil differential (percent of total WBC)	-0.10086	0.20350	-0.21008	0.881	0.623
hematology	hematocrit (HCT)	0.48126	0.53732	0.16060	0.640	0.377
hematology	hemoglobin concentration distribution width (HDW)	-0.041435	0.019322	-1.1378	0.247	0.0395
hematology	large unstained cells (percent of total WBC)	-0.12739	0.090034	-0.83570	0.515	0.166
hematology	lymphocyte differential (percent of total WBC)	4.4232	2.1261	1.4417	0.207	0.0451
hematology	mean corpuscular hemoglobin (CHr)	0.026048	0.068048	0.26078	0.855	0.704
hematology	mean platelet volume (MPV)	0.062654	0.13363	0.22905	0.814	0.642
hematology	mean RBC corpuscular hemoglobin (MCH)	0.25279	0.16890	0.93143	0.480	0.144
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.49674	0.38359	0.97400	0.573	0.204
hematology	mean RBC corpuscular volume (MCV)	0.082105	0.33675	0.19253	0.917	0.809
hematology	measured hemoglobin (mHGB)	0.39218	0.24180	0.81961	0.386	0.114
hematology	monocyte differential (percent of total WBC)	-0.078231	0.13222	-0.041014	0.820	0.558
hematology	neutrophil differential (percent of total WBC)	-4.1412	2.0361	-1.5237	0.213	0.0498
hematology	platelet count (PLT; units per volume x 10³)	-54.283	50.369	-0.66168	0.646	0.289
hematology	RBC corpuscular distribution width (RDW)	-0.17888	0.12843	-0.66634	0.423	0.173
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.12345	0.23499	0.31681	0.803	0.603
hematology	red blood cell count (RBC; per volume x 10⁶)	0.18632	0.13029	0.46654	0.418	0.162
hematology	reticulocyte count (Retic; units per volume x 10⁹)	26.574	11.095	1.1480	0.260	0.0223
hematology	reticulocyte differential (percent of total RBC)	0.20156	0.10908	0.99938	0.393	0.0734
hematology	white blood cell count (WBC; units per volume x 10³)	0.74312	0.67176	0.68223	0.482	0.276
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.59621	0.53759	0.64771	0.728	0.273
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.25534	0.39760	0.51570	0.878	0.524
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.15874	0.34152	-0.18418	0.926	0.644
holeboard	number of hole pokes by individual hole number, 20 min test, 4	1.4716	0.58217	1.4607	0.304	0.0148
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.059042	0.34547	0.20827	0.970	0.865
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.13525	0.31313	0.40374	0.945	0.668
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.25363	0.32195	0.67396	0.902	0.435
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.47287	0.35427	0.93688	0.729	0.188
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.099029	0.32329	0.28241	0.958	0.761
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.31553	0.26455	0.86942	0.788	0.239
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.12718	0.21363	0.36250	0.899	0.554
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.13521	0.35915	-0.12685	0.942	0.708
holeboard	number of hole pokes by individual hole number, 20 min test, 13	1.4890	0.76560	1.4045	0.413	0.0577
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.54838	0.51910	0.89625	0.718	0.296
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.53505	0.42183	0.91660	0.669	0.211
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.72974	0.74087	0.66499	0.730	0.329
holeboard	total number of hole pokes, 20 min test	7.5685	3.5108	1.0744	0.214	0.0361
light / dark	fecal boli count, 20 min test	-0.32500	0.67626	-0.33040	0.876	0.633
light / dark	latency to enter dark zone, 20 min test	-1.7074	39.883	-0.13835	0.989	0.966
light / dark	number of transitions between light and dark zones, 20 min test	9.3000	6.2419	0.95668	0.441	0.143
light / dark	percentage of total time in dark zone, 20 min test	-2.8753	4.5633	-0.38517	0.802	0.531
light / dark	percentage of total time in light zone, 20 min test	2.8753	4.5633	0.38081	0.800	0.531
light / dark	time mobile in dark zone, 20 min test	26.446	13.420	1.1982	0.250	0.0543
light / dark	time mobile in light zone, 20 min test	32.405	10.741	1.3883	0.0448	0.00401
light / dark	time spent in dark zone, 20 min test	37.148	65.566	0.79402	0.861	0.574
light / dark	time spent in light zone, 20 min test	-37.148	65.566	-0.79402	0.861	0.574
open field	average speed in center of arena, 20 min test	0.23349	0.34819	0.33439	0.793	0.506
open field	average speed in periphery of arena, 20 min test	0.51802	0.11130	1.2837	0.000665	0.0000242
open field	distance traveled habituation ratio, 20 min test	-2.2758	7.7390	-0.13534	0.905	0.770
open field	distance traveled in center of arena, 20 min test	38.474	80.456	-0.14891	0.795	0.635
open field	distance traveled in periphery of arena, 20 min test	545.84	111.43	1.5030	0.000364	0.0000105
open field	distance traveled slope, 20 min test	-2.8376	7.7461	-0.19250	0.895	0.716
open field	distance traveled, 20 min test, 1st 5min	128.84	60.482	0.65565	0.163	0.0381
open field	distance traveled, 20 min test, 2nd 5min	146.04	47.913	1.0909	0.0354	0.00368
open field	distance traveled, 20 min test, 3rd 5min	137.95	36.231	0.98726	0.00747	0.000384
open field	distance traveled, 20 min test, 4th 5min	171.76	31.855	1.2806	0.0000958	0.00000190
open field	number of clockwise revolution episodes, 20 min test	4.2500	1.2429	1.6159	0.0276	0.00126
open field	number of counter-clockwise revolution episodes, 20 min test	-1.4833	1.3597	-1.2304	0.561	0.281
open field	number of fecal boli, 20 min test	-0.13499	0.92126	0.17052	0.953	0.884
open field	number of rears in 5 min bins, 20 min test, 1st 5min	6.5924	2.6934	1.5637	0.123	0.0180
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	4.3550	2.2413	0.80469	0.253	0.0578
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	2.2224	3.0147	0.21031	0.713	0.465
open field	number of rears in 5 min bins, 20 min test, 4th 5min	1.9500	2.6552	0.096144	0.712	0.466
open field	percentage of total time in center of arena, 20 min test	-0.38222	2.7229	-0.29069	0.962	0.889
open field	percentage of total time in center of arena, slope, 20 min test	-1.8578	1.3115	-0.87146	0.628	0.163
open field	percentage of total time in center, habituation ratio, 20 min test	-2.0808	1.4232	-0.92574	0.619	0.150
open field	percentage of total time in corners of arena, 20 min test	-1.6894	3.0089	-0.0073843	0.818	0.577
open field	percentage of total time in corners, habituation ratio, 20 min test	1.4296	1.4571	0.35434	0.798	0.331
open field	percentage of total time in corners, slope, 20 min test	0.90912	1.4230	0.14483	0.891	0.526
open field	permanence time in center of arena, 20 min test	-4.5927	32.675	-0.28929	0.961	0.889
open field	permanence time in corners of arena, 20 min test	-20.266	36.109	-0.0073843	0.818	0.577
open field	permanence time in periphery of arena, 20 min test	4.5775	32.679	0.29069	0.961	0.889
open field	total distance traveled, 20 min test	583.85	141.50	1.1007	0.00250	0.000139
open field	total number of rears, 20 min test	7.0375	8.1173	0.14348	0.641	0.390
open field	whole arena average speed, 20 min test	0.48713	0.11804	1.1007	0.00252	0.000139
open field	whole arena resting time, 20 min test	-58.005	14.985	-0.97639	0.00392	0.000315
open field	whole arena time spent mobile, 20 min test	58.129	14.972	1.1832	0.00411	0.000304
open field	whole arena time spent vertical, 20 min test	10.875	9.9805	0.74134	0.593	0.281
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.42244	1.3077	0.0051577	0.915	0.749
startle / PPI	average baseline movement during background noise	-3.1398	2.2850	-2.0288	0.720	0.180
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.030211	0.097336	-0.36300	0.900	0.758
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.039101	0.091638	-0.45964	0.871	0.673
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-13.522	10.027	-1.3906	0.850	0.188
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-4.7867	9.1363	-0.49996	0.847	0.604
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	1.6309	11.721	0.060987	0.956	0.890
startle / PPI	average startle response to full pulse (120 dB)	7.5782	44.342	0.39462	0.951	0.866
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	29.465	42.801	0.76013	0.715	0.497
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	8.6085	39.746	0.36600	0.901	0.830
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-14.044	28.831	-0.15403	0.780	0.630
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	4.2195	2.0937	1.9969	0.524	0.0536
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.58679	1.1821	-0.39008	0.927	0.623
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.0649	2.1841	0.32879	0.899	0.630
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.10675	0.11626	-0.97679	0.874	0.366
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.025673	0.099091	-0.32178	0.937	0.797
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.0071882	0.11854	-0.11945	0.981	0.952
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	9.8863	44.184	0.45287	0.933	0.825
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	25.235	43.204	0.69977	0.757	0.564
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	8.0625	39.418	0.35702	0.907	0.839
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-14.872	29.115	-0.16680	0.769	0.613
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.10355	0.12653	-0.88806	0.887	0.420
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.0087082	0.10387	-0.032250	0.973	0.934
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.0039117	0.12086	-0.22478	0.991	0.974
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	19.929	157.37	0.31698	0.965	0.900
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	65.511	158.42	0.52231	0.840	0.682
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-19.950	143.88	0.077841	0.935	0.891
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-59.833	105.24	-0.18530	0.739	0.574
startle / PPI	maximum baseline movement during background noise	-2.9124	5.9301	-0.80388	0.909	0.627
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-15.687	9.9582	-1.4324	0.809	0.126
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-1.3399	9.0228	-0.19529	0.960	0.883
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-3.8480	9.7688	-0.48100	0.862	0.697
startle / PPI	maximum startle response to full pulse (120 dB)	17.017	157.57	0.30375	0.966	0.915
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	82.956	155.42	0.60949	0.785	0.598
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-22.158	144.13	0.069412	0.930	0.879
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-59.491	103.88	-0.18816	0.733	0.571
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	17.366	8.8749	2.5370	0.522	0.0604
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-2.5193	2.5144	-0.69977	0.777	0.325
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	0.82665	5.1564	-0.011910	0.965	0.874

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	30.0 %	0.154
eye morphology	cornea opacity	both	31.0 %	0.0997
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.00
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.00
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	30.0 %	0.247
eye morphology	lens opacity	both	31.0 %	0.204
eye morphology	narrow eye opening	females	33.0 %	0.0681
eye morphology	narrow eye opening	both	33.0 %	0.0283
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.00
eye morphology	retina	both	13.0 %	1.00
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.00
eye morphology	retinal pigmentation	both	13.0 %	1.00
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	12.0 %	0.126
SHIRPA	activity body position	both	6.0 %	0.193
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	1.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	12.0 %	0.0235
SHIRPA	startle response	both	6.0 %	0.0349
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	12.0 %	0.0740
SHIRPA	tail elevation	males	11.0 %	0.142
SHIRPA	tail elevation	both	11.0 %	0.0329
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	12.0 %	0.128
SHIRPA	transfer arousal	both	6.0 %	0.202
SHIRPA	tremor	females	12.0 %	0.0175
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	6.0 %	0.0262
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Ssx2ip^em1(IMPC)J -/- with genotype: