MPD: JaxKOMP-EAP genotype: Wscd2<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Wscd2^em1(IMPC)J -/- Gene Wscd2

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	6.6403	4.3556	1.4176	0.661	0.225
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	4.8212	7.0756	0.99455	0.862	0.545
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	5.4330	5.7791	0.84365	0.755	0.417
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	6.8247	12.058	0.96480	0.847	0.611
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	6.4811	6.0805	0.99235	0.702	0.365
body composition	body length	-0.14305	0.037807	-1.2738	0.0110	0.000421
body composition	body weight (at time of DXA)	-0.013711	0.55133	0.088126	0.989	0.980
body composition	bone area, whole body scan, head excluded	-0.040605	0.11932	0.0081917	0.881	0.735
body composition	bone mineral content of whole body scan, head excluded	-0.0069584	0.0089496	-0.26804	0.702	0.441
body composition	bone mineral content to body weight ratio	-0.000069413	0.00036551	0.054638	0.939	0.850
body composition	bone mineral density of whole body scan, head excluded	-0.00058634	0.00048817	-0.64016	0.533	0.235
body composition	fat tissue mass of whole body scan, head excluded	-0.032111	0.26236	-0.050536	0.959	0.903
body composition	fat tissue mass to body weight ratio	0.00058586	0.0088917	0.099830	0.981	0.948
body composition	lean tissue mass of whole body scan, head excluded	0.073514	0.22743	-0.0040958	0.898	0.748
body composition	lean tissue mass to body weight ratio	0.013247	0.0081771	0.66381	0.327	0.112
body composition	percent fat, whole body scan, head excluded	-0.21888	0.85913	-0.047803	0.911	0.800
body composition	ratio of soft-tissue attenuation coefficients	0.00024408	0.00095497	0.049277	0.916	0.799
body composition	tissue area	-0.25135	0.18018	-0.65998	0.452	0.169
body composition	total tissue mass, whole body scan, head excluded	0.026513	0.18487	-0.16042	0.949	0.887
clinical blood chemistry	alanine transaminase (plasma ALT)	-4.3524	4.5655	-0.42090	0.704	0.352
clinical blood chemistry	albumin (plasma Alb)	-0.093912	0.44223	-0.084224	0.941	0.834
clinical blood chemistry	alkaline phosphatase (plasma ALP)	8.8941	3.2887	0.96931	0.0857	0.0141
clinical blood chemistry	aspartate transaminase (plasma AST)	-27.891	17.925	-1.2071	0.443	0.135
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.28431	0.29590	-0.88741	0.745	0.348
clinical blood chemistry	blood urea nitrogen (BUN)	-4.1382	1.3066	-1.4608	0.0545	0.00485
clinical blood chemistry	calcium (plasma Ca)	0.34574	0.074936	2.2083	0.00519	0.000168
clinical blood chemistry	creatinine (plasma)	-0.14342	0.021776	-2.1174	0.000463	0.00000265
clinical blood chemistry	glucose (plasma GLU, no fast)	16.741	14.418	0.94152	0.464	0.260
clinical blood chemistry	HDL cholesterol (plasma HDL)	1.9750	1.6970	0.14289	0.562	0.259
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.022067	0.011161	1.0766	0.329	0.0620
clinical blood chemistry	phosphorus (plasma phosphate)	0.091492	0.15977	0.10493	0.796	0.573
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.022317	0.0075367	-1.4535	0.102	0.00772
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	0.11821	2.4850	-0.22001	0.991	0.963
clinical blood chemistry	total protein (plasma TP)	0.13095	0.60131	0.035694	0.924	0.830
clinical blood chemistry	triglyceride (plasma TG, no fast)	-14.822	10.180	-0.59742	0.445	0.162
EKG	duration of PQ interval	0.075491	0.74450	0.21112	0.982	0.920
EKG	duration of PR interval	-0.097528	0.73856	0.0	0.980	0.896
EKG	duration of QRS interval	0.022999	0.28787	-0.086753	0.991	0.937
EKG	duration of QT interval	-0.46736	0.71569	-0.27965	0.898	0.517
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.14250	0.75622	-0.11105	0.986	0.851
EKG	duration of RR interval	-1.0925	1.0766	-0.32819	0.731	0.316
EKG	duration of ST interval	-0.30875	0.72318	-0.096870	0.928	0.672
EKG	heart rate coefficient of variation (signal intensity)	-0.22200	0.94960	-0.084730	0.968	0.816
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-1.1122	6.6614	-0.022167	0.972	0.868
EKG	heart rate, beats per min	8.6195	8.2696	0.26628	0.704	0.304
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.039000	0.083704	-0.43146	0.884	0.644
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.071083	0.11852	-0.51264	0.814	0.552
EKG	number of signals	-2.0042	2.9857	-0.45891	0.877	0.506
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-2.7695	3.6197	-0.44341	0.858	0.449
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-0.037587	3.0196	0.024182	0.999	0.990
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	0.10760	3.3035	0.028213	0.993	0.974
EKG	root mean square of successive differences of neighboring RR intervals	-0.012029	1.7624	0.096870	0.998	0.995
glucose tolerance test	amount glucose injected	-0.31952	2.0190	0.29935	0.958	0.875
glucose tolerance test	plasma glucose, 0min	2.9025	3.7617	0.071443	0.663	0.446
glucose tolerance test	plasma glucose, 15min	56.587	26.962	1.5528	0.251	0.0444
glucose tolerance test	plasma glucose, 30min	-0.57036	17.104	0.11971	0.990	0.974
glucose tolerance test	plasma glucose, 60min	2.6070	12.012	0.24117	0.930	0.830
glucose tolerance test	plasma glucose, 120min	-6.1002	5.6905	-0.57194	0.599	0.293
grip strength	body weight (at time of grip strength test)	-0.63529	0.47102	-0.35704	0.367	0.188
grip strength	forelimb and hindlimb grip strength (mean of trials), average	8.1047	8.9037	0.84204	0.585	0.370
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.43618	0.38286	0.83584	0.475	0.264
grip strength	forelimb and hindlimb grip strength by trial, trial1	8.5718	10.217	0.83173	0.693	0.408
grip strength	forelimb and hindlimb grip strength by trial, trial2	11.587	9.9488	0.96665	0.509	0.253
grip strength	forelimb and hindlimb grip strength by trial, trial3	6.0558	9.1677	0.60063	0.750	0.514
grip strength	forelimb grip strength (mean of trials), average	7.0525	6.1809	1.1988	0.528	0.263
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.42405	0.28937	1.2385	0.401	0.153
grip strength	forelimb grip strength by trial, trial1	9.7461	7.6847	1.3456	0.564	0.215
grip strength	forelimb grip strength by trial, trial2	4.3364	6.9501	0.71610	0.811	0.538
grip strength	forelimb grip strength by trial, trial3	7.1172	5.5584	0.97362	0.519	0.210
heart weight	heart weight, normalized to body weight	0.17700	0.15419	0.18139	0.480	0.262
heart weight	heart weight, weight	3.2435	4.2008	0.065584	0.651	0.447
hematology	basophil differential (percent of total WBC)	-0.022619	0.054112	-0.32840	0.908	0.680
hematology	calculated hemoglobin (cHGB)	0.24643	0.19186	0.48218	0.498	0.214
hematology	eosinophil differential (percent of total WBC)	-0.18452	0.21554	-0.45335	0.770	0.402
hematology	hematocrit (HCT)	0.44881	0.58396	0.12607	0.698	0.451
hematology	hemoglobin concentration distribution width (HDW)	-0.010430	0.014042	-0.26017	0.729	0.466
hematology	large unstained cells (percent of total WBC)	-0.031509	0.090968	-0.20377	0.890	0.733
hematology	lymphocyte differential (percent of total WBC)	1.7798	1.1703	0.65150	0.390	0.144
hematology	mean corpuscular hemoglobin (CHr)	-0.079139	0.069577	-0.64399	0.502	0.269
hematology	mean platelet volume (MPV)	0.26857	0.19178	1.2382	0.379	0.178
hematology	mean RBC corpuscular hemoglobin (MCH)	0.80119	0.96509	1.9597	0.750	0.416
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	2.1286	2.1167	2.1347	0.682	0.327
hematology	mean RBC corpuscular volume (MCV)	-0.38073	0.33341	-0.70133	0.499	0.268
hematology	measured hemoglobin (mHGB)	1.0262	0.98869	2.0612	0.615	0.312
hematology	monocyte differential (percent of total WBC)	-0.57143	0.16583	-1.2057	0.0953	0.00256
hematology	neutrophil differential (percent of total WBC)	-0.78896	0.97999	-0.36318	0.646	0.431
hematology	platelet count (PLT; units per volume x 10³)	11.655	43.490	0.19949	0.925	0.791
hematology	RBC corpuscular distribution width (RDW)	-0.12951	0.080045	-0.45137	0.357	0.121
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.21283	0.26816	0.53040	0.687	0.437
hematology	red blood cell count (RBC; per volume x 10⁶)	0.18393	0.12970	0.46197	0.434	0.172
hematology	reticulocyte count (Retic; units per volume x 10⁹)	16.844	17.178	0.77683	0.715	0.339
hematology	reticulocyte differential (percent of total RBC)	0.10440	0.16159	0.65165	0.799	0.526
hematology	white blood cell count (WBC; units per volume x 10³)	1.2047	0.60016	0.97545	0.183	0.0592
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.3053	0.55317	-1.2459	0.381	0.0223
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.40078	0.38332	-0.51378	0.777	0.301
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.73792	0.33522	-1.1757	0.493	0.0326
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.0259	0.50535	-0.98509	0.434	0.0479
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.13750	0.42455	0.33801	0.951	0.747
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.10656	0.22112	-0.28378	0.937	0.632
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.16250	0.24216	-0.48200	0.919	0.505
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.35000	0.34884	-0.47373	0.799	0.321
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.68750	0.37333	-1.0979	0.492	0.0716
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.55011	0.25752	-1.5487	0.582	0.0378
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.10691	0.20979	-0.25788	0.918	0.613
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.22795	0.37475	-0.30138	0.894	0.546
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.2530	0.72870	-1.1398	0.484	0.0918
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.27500	0.43293	-0.33867	0.848	0.528
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.55000	0.44159	-0.77201	0.671	0.219
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.72500	0.80706	-0.60716	0.739	0.373
holeboard	total number of hole pokes, 20 min test	-8.4125	3.5035	-1.1175	0.157	0.0202
light / dark	fecal boli count, 20 min test	-1.1498	0.62947	-1.2660	0.437	0.0737
light / dark	latency to enter dark zone, 20 min test	0.31368	57.174	-0.11109	0.997	0.996
light / dark	number of transitions between light and dark zones, 20 min test	16.840	7.1440	1.5163	0.176	0.0224
light / dark	percentage of total time in dark zone, 20 min test	-11.443	5.7231	-1.7517	0.341	0.0511
light / dark	percentage of total time in light zone, 20 min test	11.443	5.7231	1.7517	0.338	0.0511
light / dark	time mobile in dark zone, 20 min test	7.0649	14.575	0.37210	0.841	0.630
light / dark	time mobile in light zone, 20 min test	43.229	12.269	1.7839	0.0151	0.000920
light / dark	time spent in dark zone, 20 min test	-117.57	65.708	-1.4474	0.442	0.0797
light / dark	time spent in light zone, 20 min test	117.57	65.708	1.4474	0.442	0.0797
open field	average speed in center of arena, 20 min test	0.045284	0.36325	-0.010070	0.968	0.901
open field	average speed in periphery of arena, 20 min test	0.53800	0.15675	1.3677	0.0130	0.00121
open field	distance traveled habituation ratio, 20 min test	-4.2428	6.3653	-0.32164	0.763	0.508
open field	distance traveled in center of arena, 20 min test	176.61	80.894	0.75376	0.155	0.0337
open field	distance traveled in periphery of arena, 20 min test	425.71	153.33	1.1592	0.0593	0.00776
open field	distance traveled slope, 20 min test	-2.4796	5.7179	-0.15162	0.867	0.666
open field	distance traveled, 20 min test, 1st 5min	173.98	62.896	0.99825	0.0556	0.00793
open field	distance traveled, 20 min test, 2nd 5min	124.00	58.471	0.85586	0.165	0.0389
open field	distance traveled, 20 min test, 3rd 5min	171.30	50.816	1.3117	0.0196	0.00147
open field	distance traveled, 20 min test, 4th 5min	135.84	48.425	1.0094	0.0548	0.00719
open field	number of clockwise revolution episodes, 20 min test	2.0250	1.4878	0.76411	0.529	0.180
open field	number of counter-clockwise revolution episodes, 20 min test	3.3791	1.0747	1.3086	0.0511	0.00280
open field	number of fecal boli, 20 min test	-3.0244	0.80577	-1.8902	0.0253	0.000455
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-0.62888	1.9077	-0.39271	0.881	0.743
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-2.1875	2.2544	-0.88528	0.621	0.337
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-2.1500	2.5308	-0.78444	0.670	0.400
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-0.61250	2.8749	-0.46836	0.920	0.832
open field	percentage of total time in center of arena, 20 min test	3.2480	2.9427	0.52301	0.594	0.275
open field	percentage of total time in center of arena, slope, 20 min test	0.88006	1.5604	0.61458	0.879	0.575
open field	percentage of total time in center, habituation ratio, 20 min test	0.93754	1.6231	0.62597	0.880	0.566
open field	percentage of total time in corners of arena, 20 min test	-6.1016	3.8576	-0.85586	0.416	0.120
open field	percentage of total time in corners, habituation ratio, 20 min test	-1.8853	1.5440	-1.1539	0.731	0.228
open field	percentage of total time in corners, slope, 20 min test	-2.0026	1.5513	-1.2304	0.684	0.203
open field	permanence time in center of arena, 20 min test	38.968	35.310	0.52455	0.595	0.275
open field	permanence time in corners of arena, 20 min test	-73.221	46.294	-0.85586	0.417	0.120
open field	permanence time in periphery of arena, 20 min test	-38.991	35.312	-0.52610	0.594	0.275
open field	total distance traveled, 20 min test	600.02	192.08	1.1257	0.0243	0.00300
open field	total number of rears, 20 min test	-5.6750	8.0404	-0.73429	0.711	0.484
open field	whole arena average speed, 20 min test	0.49982	0.15981	1.1257	0.0240	0.00296
open field	whole arena resting time, 20 min test	-53.893	18.803	-0.88528	0.0377	0.00606
open field	whole arena time spent mobile, 20 min test	53.905	18.798	1.1007	0.0395	0.00604
open field	whole arena time spent vertical, 20 min test	-12.399	8.0590	-1.0598	0.403	0.130
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.6897	1.8935	0.90240	0.677	0.379
startle / PPI	average baseline movement during background noise	1.1294	1.5692	0.76575	0.877	0.477
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.070165	0.075905	0.55144	0.700	0.362
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.099453	0.070675	0.89144	0.515	0.169
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	8.1357	9.2754	0.93910	0.879	0.387
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	8.2445	7.9339	0.78277	0.664	0.307
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	4.9650	6.8105	0.43124	0.743	0.471
startle / PPI	average startle response to full pulse (120 dB)	-13.222	30.613	-0.086277	0.850	0.669
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-18.893	34.440	-0.19815	0.775	0.587
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-15.673	27.674	-0.15403	0.744	0.575
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-10.902	21.175	-0.079247	0.767	0.610
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.49616	1.8898	0.42203	0.971	0.795
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.57885	2.2303	-0.38253	0.961	0.797
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	5.2005	1.6649	1.6809	0.132	0.00378
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.076335	0.10072	0.76575	0.900	0.454
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.10210	0.091099	0.79150	0.609	0.271
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.10745	0.074823	0.65873	0.396	0.161
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-14.565	30.494	-0.11162	0.832	0.636
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-19.685	34.261	-0.20673	0.762	0.570
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-15.491	27.517	-0.13987	0.749	0.577
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-16.183	21.044	-0.19386	0.648	0.448
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.032594	0.11314	0.30815	0.960	0.775
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.092234	0.091610	0.64659	0.658	0.322
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.10341	0.075273	0.58058	0.434	0.179
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-38.661	113.67	-0.044150	0.887	0.736
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-69.363	129.20	-0.21533	0.785	0.595
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-50.459	100.78	-0.086277	0.768	0.620
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-60.498	74.244	-0.18816	0.627	0.421
startle / PPI	maximum baseline movement during background noise	2.1766	3.4706	0.68730	0.866	0.535
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	6.3014	10.545	0.67669	0.936	0.554
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	7.8634	8.9075	0.64359	0.715	0.384
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	5.1720	7.1875	0.34808	0.745	0.477
startle / PPI	maximum startle response to full pulse (120 dB)	-36.581	114.03	-0.027326	0.896	0.750
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-67.842	129.39	-0.20816	0.789	0.604
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-49.562	100.68	-0.094718	0.778	0.626
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-46.201	74.038	-0.10176	0.711	0.537
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	0.90227	4.1706	0.41286	0.961	0.830
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.36372	4.5616	-0.090496	0.996	0.937
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	14.015	4.2804	1.7543	0.0911	0.00255

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	17.0 %	0.243
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	7.0 %	0.319
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.00
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.00
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	19.0 %	0.182
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	8.0 %	0.325
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.00
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	14.0 %	0.291
eye morphology	lens opacity	both	6.0 %	0.566
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.00
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	46.0 %	0.0113
eye morphology	persistence of hyaloid vascular system	males	16.0 %	0.0965
eye morphology	persistence of hyaloid vascular system	both	27.0 %	0.00801
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	18.0 %	0.201
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	8.0 %	0.346
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.00
eye morphology	retina	males	28.0 %	0.132
eye morphology	retina	both	14.0 %	0.319
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	28.0 %	0.119
eye morphology	retinal pigmentation	males	13.0 %	0.423
eye morphology	retinal pigmentation	both	14.0 %	0.215
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	12.0 %	0.00594
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	6.0 %	0.00891
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	12.0 %	0.0146
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	6.0 %	0.0349
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	12.0 %	0.0740
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	5.0 %	0.202
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	12.0 %	0.0876
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	6.0 %	0.202
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Wscd2^em1(IMPC)J -/- with genotype: