MPD: JaxKOMP-EAP genotype: E130311K13Rik<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: E130311K13Rik^em1(IMPC)J -/- Gene E130311K13Rik

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	0.66366	1.3888	-0.069204	0.892	0.640
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	2.0833	2.6526	0.49167	0.826	0.444
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-1.0642	1.9996	-0.42502	0.862	0.602
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	1.0707	4.2167	0.051394	0.930	0.803
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	3.1250	3.7795	0.46326	0.745	0.421
body composition	body length	0.034939	0.037068	0.69227	0.638	0.351
body composition	body weight (at time of DXA)	-0.47170	0.59343	-0.27001	0.645	0.431
body composition	bone area, whole body scan, head excluded	0.083132	0.13558	0.54614	0.766	0.543
body composition	bone mineral content of whole body scan, head excluded	0.0024506	0.010292	0.28364	0.920	0.813
body composition	bone mineral content to body weight ratio	0.00021151	0.00043092	0.45482	0.806	0.626
body composition	bone mineral density of whole body scan, head excluded	0.00012874	0.00045735	0.17228	0.898	0.780
body composition	fat tissue mass of whole body scan, head excluded	-0.13509	0.31063	-0.23422	0.832	0.666
body composition	fat tissue mass to body weight ratio	-0.0078271	0.010662	-0.31936	0.687	0.466
body composition	lean tissue mass of whole body scan, head excluded	0.099449	0.22408	0.050536	0.863	0.659
body composition	lean tissue mass to body weight ratio	0.0017753	0.0086600	0.034840	0.921	0.838
body composition	percent fat, whole body scan, head excluded	-0.68868	1.0173	-0.28790	0.717	0.502
body composition	ratio of soft-tissue attenuation coefficients	0.00037204	0.0011551	0.10417	0.887	0.749
body composition	tissue area	0.081333	0.16661	0.48589	0.856	0.628
body composition	total tissue mass, whole body scan, head excluded	0.0057427	0.21349	-0.19371	0.991	0.979
clinical blood chemistry	alanine transaminase (plasma ALT)	42.583	19.500	1.7828	0.324	0.0375
clinical blood chemistry	albumin (plasma Alb)	-0.40041	0.38371	-0.50228	0.619	0.306
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.2412	2.6657	0.041813	0.481	0.235
clinical blood chemistry	aspartate transaminase (plasma AST)	0.037879	26.965	0.0	0.999	0.999
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.42486	0.22789	-1.2364	0.419	0.0728
clinical blood chemistry	blood urea nitrogen (BUN)	0.51571	1.1894	0.18959	0.839	0.668
clinical blood chemistry	calcium (plasma Ca)	-0.14702	0.078533	-0.71201	0.233	0.0721
clinical blood chemistry	creatinine (plasma)	-0.045966	0.024415	-0.90566	0.254	0.0744
clinical blood chemistry	glucose (plasma GLU, no fast)	-7.8929	12.540	-0.0078556	0.721	0.534
clinical blood chemistry	HDL cholesterol (plasma HDL)	-1.8940	1.9637	-0.74047	0.637	0.343
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.00099758	0.0064414	-0.10052	0.969	0.878
clinical blood chemistry	phosphorus (plasma phosphate)	0.38475	0.27345	0.52228	0.434	0.170
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.00074298	0.0091138	-0.046857	0.982	0.936
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-2.4638	2.7092	-0.65630	0.672	0.371
clinical blood chemistry	total protein (plasma TP)	-0.64335	0.52514	-0.56380	0.511	0.231
clinical blood chemistry	triglyceride (plasma TG, no fast)	-2.1704	6.3271	0.10751	0.882	0.734
EKG	duration of PQ interval	0.11908	1.3958	0.25668	0.984	0.933
EKG	duration of PR interval	1.3290	1.5449	1.4188	0.878	0.398
EKG	duration of QRS interval	0.71725	0.42325	1.7969	0.885	0.104
EKG	duration of QT interval	0.16350	0.59591	0.31546	0.960	0.786
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.56053	0.52038	0.67702	0.835	0.293
EKG	duration of RR interval	-1.1696	2.4610	-0.36026	0.875	0.639
EKG	duration of ST interval	-0.38077	0.71964	-0.17007	0.903	0.602
EKG	heart rate coefficient of variation (signal intensity)	1.5734	2.2093	1.3356	0.878	0.484
EKG	heart rate variability, mean of differences between sequential beats; beats per min	8.9460	16.909	1.0773	0.931	0.602
EKG	heart rate, beats per min	12.561	24.248	0.50575	0.848	0.609
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.19240	0.14150	-1.5386	0.564	0.187
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.38431	0.17189	-2.1626	0.260	0.0349
EKG	number of signals	2.2801	5.4548	0.42778	0.930	0.680
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	14.887	5.2363	2.2266	0.662	0.00898
EKG	QT dispersion, measured as inter-lead variability of QT intervals	2.4752	6.6141	0.75515	0.968	0.712
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	1.5032	8.2492	0.41018	0.975	0.857
EKG	root mean square of successive differences of neighboring RR intervals	2.5253	3.5458	1.3020	0.897	0.483
glucose tolerance test	amount glucose injected	-2.1882	1.9733	-0.29360	0.647	0.273
glucose tolerance test	plasma glucose, 0min	-14.226	5.0226	-1.4128	0.0430	0.00669
glucose tolerance test	plasma glucose, 15min	-21.297	20.982	-0.46666	0.642	0.315
glucose tolerance test	plasma glucose, 30min	-3.8884	18.712	0.010982	0.935	0.836
glucose tolerance test	plasma glucose, 60min	5.9200	12.781	0.38251	0.865	0.645
glucose tolerance test	plasma glucose, 120min	16.837	7.4925	0.97696	0.220	0.0292
grip strength	body weight (at time of grip strength test)	-0.52938	0.58877	-0.27769	0.568	0.375
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-11.930	6.8986	-0.60585	0.246	0.0928
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.54332	0.30465	-0.61460	0.236	0.0834
grip strength	forelimb and hindlimb grip strength by trial, trial1	-1.8316	9.3942	0.098916	0.946	0.847
grip strength	forelimb and hindlimb grip strength by trial, trial2	-25.951	9.9540	-1.3900	0.0931	0.0133
grip strength	forelimb and hindlimb grip strength by trial, trial3	-10.876	11.642	-0.49431	0.627	0.357
grip strength	forelimb grip strength (mean of trials), average	-5.3840	4.8522	-0.40905	0.539	0.275
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.33172	0.22962	-0.60237	0.407	0.158
grip strength	forelimb grip strength by trial, trial1	-0.56175	5.6846	0.21662	0.972	0.922
grip strength	forelimb grip strength by trial, trial2	-3.2786	6.6143	-0.13254	0.855	0.623
grip strength	forelimb grip strength by trial, trial3	-13.725	8.0730	-1.1468	0.357	0.0980
heart weight	heart weight, normalized to body weight	-0.086701	0.12716	-0.78703	0.691	0.499
heart weight	heart weight, weight	-4.0347	3.7233	-0.91311	0.494	0.284
hematology	basophil differential (percent of total WBC)	-0.024113	0.090664	-0.34293	0.947	0.792
hematology	calculated hemoglobin (cHGB)	0.55522	0.70106	1.4162	0.698	0.435
hematology	eosinophil differential (percent of total WBC)	-0.37698	0.25188	-0.95332	0.532	0.146
hematology	hematocrit (HCT)	2.0962	2.4390	1.7043	0.658	0.398
hematology	hemoglobin concentration distribution width (HDW)	-0.021269	0.015413	-0.60098	0.480	0.179
hematology	large unstained cells (percent of total WBC)	0.021064	0.091791	0.14556	0.917	0.820
hematology	lymphocyte differential (percent of total WBC)	1.4540	1.2403	0.51377	0.505	0.251
hematology	mean corpuscular hemoglobin (CHr)	-0.11131	0.061136	-0.89112	0.247	0.0798
hematology	mean platelet volume (MPV)	0.11862	0.11361	0.58538	0.535	0.306
hematology	mean RBC corpuscular hemoglobin (MCH)	0.046256	0.58410	0.15301	0.975	0.937
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.21995	1.2562	0.51187	0.956	0.862
hematology	mean RBC corpuscular volume (MCV)	-0.094041	0.25193	-0.17307	0.861	0.712
hematology	measured hemoglobin (mHGB)	0.47819	0.91991	1.0132	0.810	0.607
hematology	monocyte differential (percent of total WBC)	0.10784	0.15168	0.58531	0.774	0.483
hematology	neutrophil differential (percent of total WBC)	-1.2704	1.0959	-0.57560	0.507	0.256
hematology	platelet count (PLT; units per volume x 10³)	48.637	80.778	0.70483	0.820	0.552
hematology	RBC corpuscular distribution width (RDW)	-0.27543	0.099199	-1.0373	0.0944	0.00986
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.15342	0.14927	-0.45376	0.580	0.314
hematology	red blood cell count (RBC; per volume x 10⁶)	0.50910	0.51886	1.7852	0.605	0.335
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-4.2433	19.663	-0.10527	0.949	0.831
hematology	reticulocyte differential (percent of total RBC)	-0.21363	0.078671	-0.72175	0.194	0.0114
hematology	white blood cell count (WBC; units per volume x 10³)	-0.14698	0.71619	0.076613	0.913	0.839
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.50717	0.62649	0.56256	0.799	0.425
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.33750	0.32763	-0.41228	0.782	0.311
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.46250	0.54002	-0.70068	0.830	0.399
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.96250	0.57468	1.0157	0.561	0.104
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.075000	0.48307	-0.012660	0.970	0.878
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.025000	0.29800	0.12685	0.994	0.934
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.25000	0.25783	-0.70830	0.852	0.340
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-1.1750	0.39242	-1.7945	0.247	0.00547
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.23223	0.39994	0.49784	0.905	0.566
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.38750	0.23676	-1.0909	0.711	0.112
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.72253	0.33169	-1.9064	0.582	0.0374
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.83441	0.54683	-1.2611	0.590	0.138
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.88528	0.85067	0.94258	0.718	0.307
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.050000	0.35876	-0.015182	0.982	0.890
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-1.0375	0.48924	-1.6087	0.448	0.0423
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.71005	0.93799	0.64825	0.800	0.455
holeboard	total number of hole pokes, 20 min test	-3.0427	3.8551	-0.31908	0.690	0.436
light / dark	fecal boli count, 20 min test	-0.036688	0.85072	-0.0060841	0.984	0.966
light / dark	latency to enter dark zone, 20 min test	183.88	69.284	2.4567	0.208	0.0107
light / dark	number of transitions between light and dark zones, 20 min test	2.8458	8.4892	0.35477	0.892	0.739
light / dark	percentage of total time in dark zone, 20 min test	-7.6457	4.9309	-1.2235	0.482	0.127
light / dark	percentage of total time in light zone, 20 min test	7.6457	4.9309	1.2206	0.481	0.127
light / dark	time mobile in dark zone, 20 min test	-25.466	14.562	-1.4749	0.324	0.0865
light / dark	time mobile in light zone, 20 min test	20.410	12.692	0.89848	0.334	0.114
light / dark	time spent in dark zone, 20 min test	-159.26	65.458	-1.8547	0.229	0.0187
light / dark	time spent in light zone, 20 min test	159.26	65.458	1.8547	0.229	0.0187
open field	average speed in center of arena, 20 min test	0.83123	0.48602	1.2929	0.386	0.0935
open field	average speed in periphery of arena, 20 min test	0.31326	0.15922	0.67744	0.174	0.0548
open field	distance traveled habituation ratio, 20 min test	1.9778	7.4780	0.20620	0.918	0.793
open field	distance traveled in center of arena, 20 min test	57.493	84.408	0.0046991	0.713	0.499
open field	distance traveled in periphery of arena, 20 min test	414.09	158.87	1.1131	0.0793	0.0121
open field	distance traveled slope, 20 min test	2.4727	7.3681	0.29910	0.906	0.739
open field	distance traveled, 20 min test, 1st 5min	86.886	80.362	0.35863	0.528	0.285
open field	distance traveled, 20 min test, 2nd 5min	114.20	61.266	0.74310	0.232	0.0683
open field	distance traveled, 20 min test, 3rd 5min	155.21	54.305	1.1566	0.0489	0.00624
open field	distance traveled, 20 min test, 4th 5min	106.40	55.220	0.67744	0.220	0.0598
open field	number of clockwise revolution episodes, 20 min test	1.0645	1.2686	0.21249	0.744	0.405
open field	number of counter-clockwise revolution episodes, 20 min test	2.5150	1.2842	0.89526	0.256	0.0560
open field	number of fecal boli, 20 min test	-2.0301	1.0568	-1.3129	0.301	0.0606
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-4.4407	2.4607	-1.3989	0.280	0.0773
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	2.9355	2.6600	0.41068	0.562	0.275
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	5.1886	2.4047	0.88528	0.186	0.0360
open field	number of rears in 5 min bins, 20 min test, 4th 5min	4.0642	3.3308	0.53847	0.499	0.228
open field	percentage of total time in center of arena, 20 min test	-3.5469	2.2961	-1.0934	0.429	0.129
open field	percentage of total time in center of arena, slope, 20 min test	0.11164	1.3264	0.17612	0.980	0.933
open field	percentage of total time in center, habituation ratio, 20 min test	-0.17215	1.3531	0.040961	0.973	0.899
open field	percentage of total time in corners of arena, 20 min test	5.8003	2.6675	1.3376	0.219	0.0346
open field	percentage of total time in corners, habituation ratio, 20 min test	1.4198	1.6498	0.34720	0.843	0.394
open field	percentage of total time in corners, slope, 20 min test	0.84677	1.5746	0.11505	0.911	0.593
open field	permanence time in center of arena, 20 min test	-42.578	27.553	-1.0958	0.430	0.129
open field	permanence time in corners of arena, 20 min test	69.598	32.008	1.3376	0.219	0.0346
open field	permanence time in periphery of arena, 20 min test	42.600	27.552	1.0934	0.429	0.129
open field	total distance traveled, 20 min test	512.97	209.02	0.93818	0.0820	0.0178
open field	total number of rears, 20 min test	8.3880	8.9484	0.24338	0.604	0.353
open field	whole arena average speed, 20 min test	0.42732	0.17450	0.93610	0.0827	0.0180
open field	whole arena resting time, 20 min test	-46.594	18.755	-0.73429	0.0765	0.0164
open field	whole arena time spent mobile, 20 min test	46.698	18.739	0.97208	0.0762	0.0161
open field	whole arena time spent vertical, 20 min test	10.724	10.351	0.72552	0.610	0.305
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.2000	1.6196	-0.31845	0.737	0.468
startle / PPI	average baseline movement during background noise	-0.21458	1.1939	-0.077841	0.986	0.858
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	2.4835	1.1714	2.9333	0.277	0.0390
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.12675	0.053807	1.1379	0.218	0.0225
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.0694	6.7270	0.80970	0.877	0.298
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	14.733	6.1720	1.4767	0.252	0.0208
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	13.229	5.7844	1.2500	0.175	0.0265
startle / PPI	average startle response to full pulse (120 dB)	21.140	27.473	0.66441	0.680	0.445
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	2.7860	27.164	0.25132	0.963	0.919
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-13.051	25.005	-0.087683	0.764	0.604
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-21.860	22.934	-0.34362	0.568	0.345
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.082441	0.91118	0.018916	0.987	0.928
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.14778	1.2842	0.12008	0.985	0.909
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.26399	1.3049	-0.045553	0.963	0.841
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.071863	0.070498	0.73420	0.869	0.313
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.16473	0.068578	1.3098	0.224	0.0201
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.13484	0.068837	0.84282	0.217	0.0557
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	21.463	27.578	0.66266	0.681	0.440
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	2.8597	26.890	0.25422	0.963	0.916
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-13.014	25.161	-0.089090	0.763	0.607
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-21.677	23.102	-0.32140	0.568	0.353
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.055869	0.075948	0.50632	0.909	0.465
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.18213	0.078233	1.3579	0.228	0.0240
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	7.1987	3.4602	3.0568	0.193	0.0426
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	91.788	106.02	0.70336	0.626	0.391
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	30.878	100.30	0.34362	0.885	0.759
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-52.557	97.857	-0.10176	0.756	0.594
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-84.776	86.811	-0.35255	0.546	0.333
startle / PPI	maximum baseline movement during background noise	-0.63750	2.4027	-0.089090	0.960	0.792
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.7013	7.3430	0.60949	0.901	0.441
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	16.934	7.3396	1.4809	0.262	0.0252
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	16.834	6.4961	1.4093	0.118	0.0125
startle / PPI	maximum startle response to full pulse (120 dB)	90.863	105.81	0.70875	0.629	0.395
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	29.966	100.89	0.34362	0.891	0.768
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-52.591	97.487	-0.10739	0.759	0.592
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-86.634	86.225	-0.36750	0.541	0.320
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-0.82292	1.8906	-0.14128	0.926	0.665
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	0.56611	2.6416	0.18530	0.974	0.831
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-0.94409	2.7984	-0.37801	0.904	0.737

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	20.0 %	0.0378
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	9.0 %	0.0569
eye morphology	cornea vascularization	females	12.0 %	0.189
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	6.0 %	0.234
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	11.0 %	0.220
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	5.0 %	0.292
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	11.0 %	0.316
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	5.0 %	0.467
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	12.0 %	0.178
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	6.0 %	0.247
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	15.0 %	0.202
eye morphology	retina	males	47.0 %	0.00434
eye morphology	retina	both	31.0 %	0.00545
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.00
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.00
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.00
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.0
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.00
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.00
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.00
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.0
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.0
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.0
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.00
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.0
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.0
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.00
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.0
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.0
SHIRPA	snout size	females	0.0 %	1.00
SHIRPA	snout size	males	1.0 %	1.00
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.0
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.0
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.0
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.00
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.0
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.0
SHIRPA	vibrissae presence	males	1.0 %	1.00
SHIRPA	vibrissae presence	both	2.0 %	1.00
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.00
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate E130311K13Rik^em1(IMPC)J -/- with genotype: