MPD: JaxKOMP-EAP genotype: Cldn13<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Cldn13^em1(IMPC)J -/- Gene Cldn13

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.6468	1.0629	0.23850	0.567	0.145
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	3.0030	2.3248	0.67138	0.708	0.219
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	2.7763	1.8531	0.40644	0.519	0.160
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	2.2993	2.7839	0.25975	0.751	0.424
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	0.82131	6.0369	0.095475	0.969	0.894
body composition	body length	0.017204	0.040647	0.43425	0.849	0.674
body composition	body weight (at time of DXA)	0.48692	0.52172	0.50276	0.573	0.354
body composition	bone area, whole body scan, head excluded	0.19640	0.11931	1.0211	0.331	0.105
body composition	bone mineral content of whole body scan, head excluded	0.011014	0.0082039	0.78499	0.461	0.185
body composition	bone mineral content to body weight ratio	0.00059579	0.00036957	0.96960	0.333	0.112
body composition	bone mineral density of whole body scan, head excluded	0.00019716	0.00035649	0.24208	0.793	0.582
body composition	fat tissue mass of whole body scan, head excluded	-0.15904	0.24587	-0.29075	0.745	0.520
body composition	fat tissue mass to body weight ratio	-0.0095025	0.0097046	-0.39062	0.577	0.331
body composition	lean tissue mass of whole body scan, head excluded	-0.12418	0.21903	-0.43823	0.809	0.573
body composition	lean tissue mass to body weight ratio	0.0016753	0.0077276	0.032107	0.917	0.829
body composition	percent fat, whole body scan, head excluded	-0.79101	0.91675	-0.33809	0.636	0.392
body composition	ratio of soft-tissue attenuation coefficients	0.00081826	0.0010220	0.30284	0.656	0.427
body composition	tissue area	-0.011372	0.14218	0.14953	0.983	0.937
body composition	total tissue mass, whole body scan, head excluded	-0.28322	0.17589	-0.92052	0.318	0.113
clinical blood chemistry	alanine transaminase (plasma ALT)	-13.828	11.110	-1.0897	0.596	0.223
clinical blood chemistry	albumin (plasma Alb)	0.098958	0.42799	0.19951	0.936	0.819
clinical blood chemistry	alkaline phosphatase (plasma ALP)	7.0431	3.5044	0.71462	0.206	0.0538
clinical blood chemistry	aspartate transaminase (plasma AST)	-7.3773	17.016	-0.37435	0.880	0.668
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.14595	0.24632	0.49338	0.852	0.558
clinical blood chemistry	blood urea nitrogen (BUN)	-0.033120	1.2915	-0.048030	0.989	0.980
clinical blood chemistry	calcium (plasma Ca)	0.0071210	0.086703	0.40230	0.966	0.935
clinical blood chemistry	carbon dioxide (plasma CO₂)	2.4572	0.91493	1.9624	0.122	0.0156
clinical blood chemistry	chloride (plasma Cl)	-3.0788	0.65160	-2.3439	0.00276	0.000196
clinical blood chemistry	creatinine (plasma)	-0.011667	0.026367	-0.19219	0.823	0.667
clinical blood chemistry	glucose (plasma GLU, no fast)	6.5039	11.722	0.54831	0.755	0.583
clinical blood chemistry	HDL cholesterol (plasma HDL)	3.3408	2.6714	0.47574	0.525	0.221
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0021710	0.010840	-0.017794	0.960	0.843
clinical blood chemistry	iron (plasma Fe)	-0.014069	0.012799	-0.89925	0.549	0.287
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	0.12302	0.20612	1.1027	0.759	0.560
clinical blood chemistry	phosphorus (plasma phosphate)	-0.47044	0.33488	-0.81114	0.434	0.171
clinical blood chemistry	potassium (plasma K)	0.47856	0.16520	0.82138	0.0524	0.0100
clinical blood chemistry	sodium (plasma Na)	-1.4085	1.0293	-2.0345	0.295	0.189
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0043377	0.010781	-0.33398	0.881	0.690
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	3.3464	3.2618	0.35797	0.617	0.313
clinical blood chemistry	total protein (plasma TP)	0.43427	0.68704	0.24804	0.749	0.532
clinical blood chemistry	triglyceride (plasma TG, no fast)	-2.5414	8.9987	0.090258	0.903	0.780
EKG	duration of PQ interval	1.4587	0.73707	1.6703	0.535	0.0567
EKG	duration of PR interval	1.8675	0.80763	1.8846	0.469	0.0276
EKG	duration of QRS interval	0.52875	0.29117	1.3760	0.885	0.0791
EKG	duration of QT interval	0.91875	0.75298	1.0385	0.725	0.232
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.29500	0.78043	0.38836	0.956	0.708
EKG	duration of RR interval	2.5113	1.1128	1.4823	0.350	0.0312
EKG	duration of ST interval	0.39250	0.73701	0.61495	0.901	0.598
EKG	heart rate coefficient of variation (signal intensity)	1.0801	1.1273	0.96528	0.867	0.345
EKG	heart rate variability, mean of differences between sequential beats; beats per min	6.5948	8.3062	0.83818	0.883	0.433
EKG	heart rate, beats per min	-24.290	9.6723	-1.6948	0.251	0.0176
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.093856	0.064773	-0.89634	0.521	0.157
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.15858	0.079214	-0.99737	0.316	0.0541
EKG	number of signals	-3.0697	3.4078	-0.67956	0.832	0.375
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	9.5380	4.3604	1.6992	0.758	0.0364
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-2.8843	4.1101	-0.82678	0.945	0.488
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-4.0749	4.6672	-1.0955	0.914	0.389
EKG	root mean square of successive differences of neighboring RR intervals	-2.2293	2.2723	-1.1641	0.860	0.334
glucose tolerance test	amount glucose injected	-2.3737	1.6571	-0.33405	0.517	0.158
glucose tolerance test	plasma glucose, 0min	-16.908	7.6652	-1.6411	0.123	0.0321
glucose tolerance test	plasma glucose, 15min	4.0427	22.916	0.23553	0.954	0.861
glucose tolerance test	plasma glucose, 30min	-7.6848	20.739	-0.10314	0.885	0.713
glucose tolerance test	plasma glucose, 60min	-6.3137	15.843	-0.14742	0.884	0.692
glucose tolerance test	plasma glucose, 120min	7.3729	6.4644	0.35752	0.571	0.259
grip strength	body weight (at time of grip strength test)	1.2516	0.52616	1.3077	0.0845	0.0228
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-22.694	7.8611	-1.3243	0.0419	0.00663
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.3031	0.36379	-1.6136	0.0128	0.00100
grip strength	forelimb and hindlimb grip strength by trial, trial1	-39.864	9.5978	-2.1534	0.00907	0.000200
grip strength	forelimb and hindlimb grip strength by trial, trial2	-28.356	9.8892	-1.5575	0.0631	0.00688
grip strength	forelimb and hindlimb grip strength by trial, trial3	-0.25871	11.552	0.18402	0.993	0.982
grip strength	forelimb grip strength (mean of trials), average	-11.947	5.2547	-1.1581	0.151	0.0290
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.56210	0.27386	-1.1440	0.207	0.0477
grip strength	forelimb grip strength by trial, trial1	-11.997	7.0893	-1.0690	0.373	0.0992
grip strength	forelimb grip strength by trial, trial2	-14.302	7.7036	-1.2479	0.318	0.0716
grip strength	forelimb grip strength by trial, trial3	-11.455	6.9403	-0.95742	0.375	0.108
heart weight	heart weight, normalized to body weight	0.27829	0.15119	0.50973	0.217	0.0709
heart weight	heart weight, weight	6.5059	3.7223	0.48070	0.246	0.0859
hematology	basophil differential (percent of total WBC)	0.078104	0.079768	1.1018	0.741	0.339
hematology	calculated hemoglobin (cHGB)	0.28569	0.21051	0.61773	0.466	0.189
hematology	eosinophil differential (percent of total WBC)	-0.49493	0.40962	-1.2490	0.630	0.241
hematology	hematocrit (HCT)	0.54744	0.67473	0.24151	0.682	0.426
hematology	hemoglobin concentration distribution width (HDW)	-0.025335	0.025137	-0.71319	0.626	0.326
hematology	large unstained cells (percent of total WBC)	0.20026	0.099127	1.2594	0.326	0.0570
hematology	lymphocyte differential (percent of total WBC)	5.8834	6.2420	1.7724	0.605	0.357
hematology	mean corpuscular hemoglobin (CHr)	-0.039587	0.074661	-0.32137	0.801	0.602
hematology	mean platelet volume (MPV)	-0.024199	0.083788	-0.37125	0.890	0.776
hematology	mean RBC corpuscular hemoglobin (MCH)	0.20475	0.26064	0.77826	0.765	0.441
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.31359	0.60029	0.67535	0.842	0.607
hematology	mean RBC corpuscular volume (MCV)	-0.41329	0.45246	-0.74392	0.598	0.371
hematology	measured hemoglobin (mHGB)	0.60188	0.29337	1.2950	0.270	0.0529
hematology	monocyte differential (percent of total WBC)	-4.3210	5.0422	-3.2661	0.724	0.401
hematology	neutrophil differential (percent of total WBC)	-1.5696	1.3913	-0.69610	0.520	0.273
hematology	platelet count (PLT; units per volume x 10³)	59.140	45.796	0.82384	0.580	0.211
hematology	RBC corpuscular distribution width (RDW)	0.071425	0.14443	0.25137	0.803	0.626
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.091497	0.23371	-0.27679	0.856	0.700
hematology	red blood cell count (RBC; per volume x 10⁶)	0.24330	0.13996	0.71278	0.331	0.0968
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-25.729	18.016	-0.98996	0.554	0.168
hematology	reticulocyte differential (percent of total RBC)	-0.40703	0.17875	-1.3931	0.296	0.0339
hematology	white blood cell count (WBC; units per volume x 10³)	0.45522	0.69665	0.48897	0.698	0.521
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.37593	0.83537	-0.30778	0.898	0.654
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.037601	0.46302	0.061650	0.989	0.936
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.091030	0.39291	-0.034610	0.952	0.818
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.60535	0.83379	-0.55663	0.834	0.471
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.040512	0.48753	0.046436	0.985	0.934
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.69820	0.24117	-1.9391	0.384	0.00528
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.10833	0.29598	0.29936	0.971	0.716
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.33500	0.40645	-0.43443	0.841	0.413
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.24829	0.40895	-0.37153	0.899	0.546
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.30750	0.30133	0.85227	0.837	0.312
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.077500	0.25445	0.23698	0.955	0.762
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.38540	0.42545	-0.57105	0.786	0.369
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.83483	0.63650	0.89373	0.614	0.195
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.0078035	0.37490	0.060763	0.994	0.983
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.28733	0.42814	-0.37824	0.852	0.505
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.95000	0.68368	-0.81359	0.588	0.170
holeboard	total number of hole pokes, 20 min test	-4.1091	4.2844	-0.49711	0.627	0.341
light / dark	fecal boli count, 20 min test	0.078572	0.92867	0.093424	0.969	0.933
light / dark	latency to enter dark zone, 20 min test	6.5493	33.265	0.031101	0.965	0.845
light / dark	number of transitions between light and dark zones, 20 min test	15.306	6.3641	1.4359	0.161	0.0193
light / dark	percentage of total time in dark zone, 20 min test	-1.4806	2.9513	-0.15064	0.861	0.618
light / dark	percentage of total time in light zone, 20 min test	1.4805	2.9514	0.14654	0.861	0.618
light / dark	time mobile in dark zone, 20 min test	11.499	11.191	0.58946	0.607	0.308
light / dark	time mobile in light zone, 20 min test	-6.3331	12.090	-0.72545	0.808	0.602
light / dark	time spent in dark zone, 20 min test	-5.7180	40.054	0.12743	0.964	0.887
light / dark	time spent in light zone, 20 min test	5.7180	40.054	-0.12743	0.964	0.887
open field	average speed in center of arena, 20 min test	-0.75489	0.45551	-1.5328	0.414	0.106
open field	average speed in periphery of arena, 20 min test	0.039526	0.17752	-0.37875	0.909	0.825
open field	distance traveled habituation ratio, 20 min test	-1.1696	9.6899	-0.046336	0.955	0.905
open field	distance traveled in center of arena, 20 min test	-96.599	110.02	-1.0049	0.636	0.386
open field	distance traveled in periphery of arena, 20 min test	33.715	182.73	-0.30050	0.935	0.855
open field	distance traveled slope, 20 min test	-0.88955	8.9816	-0.035586	0.987	0.922
open field	distance traveled, 20 min test, 1st 5min	-24.061	80.286	-0.54469	0.899	0.766
open field	distance traveled, 20 min test, 2nd 5min	-19.407	60.794	-0.72727	0.875	0.751
open field	distance traveled, 20 min test, 3rd 5min	32.173	65.395	-0.074583	0.808	0.626
open field	distance traveled, 20 min test, 4th 5min	-4.1519	78.679	-0.50768	0.981	0.958
open field	number of clockwise revolution episodes, 20 min test	1.1867	1.6489	0.28595	0.775	0.476
open field	number of counter-clockwise revolution episodes, 20 min test	-1.0955	2.0360	-1.0206	0.791	0.594
open field	number of fecal boli, 20 min test	-1.1648	1.4116	-0.68092	0.708	0.415
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-3.5784	3.0413	-1.1856	0.511	0.247
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	1.3942	3.1140	-0.0087270	0.835	0.657
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	2.7481	3.5845	0.34577	0.705	0.448
open field	number of rears in 5 min bins, 20 min test, 4th 5min	2.8583	4.1757	0.30191	0.731	0.498
open field	percentage of total time in center of arena, 20 min test	1.1139	2.0766	0.058436	0.844	0.595
open field	percentage of total time in center of arena, slope, 20 min test	1.0766	1.5106	0.73957	0.852	0.480
open field	percentage of total time in center, habituation ratio, 20 min test	1.4129	1.6045	0.89326	0.825	0.384
open field	percentage of total time in corners of arena, 20 min test	-5.5278	4.0033	-0.72902	0.485	0.176
open field	percentage of total time in corners, habituation ratio, 20 min test	-1.5794	2.2195	-1.0161	0.874	0.481
open field	percentage of total time in corners, slope, 20 min test	-1.6949	2.1274	-1.0788	0.855	0.431
open field	permanence time in center of arena, 20 min test	13.363	24.918	0.061126	0.844	0.595
open field	permanence time in corners of arena, 20 min test	-66.321	48.042	-0.72902	0.485	0.176
open field	permanence time in periphery of arena, 20 min test	-13.339	24.914	-0.061126	0.846	0.596
open field	total distance traveled, 20 min test	-62.884	240.58	-0.68931	0.898	0.795
open field	total number of rears, 20 min test	4.4042	11.578	-0.040961	0.857	0.706
open field	whole arena average speed, 20 min test	-0.051067	0.20040	-0.67744	0.900	0.800
open field	whole arena resting time, 20 min test	7.0505	25.227	0.76271	0.875	0.781
open field	whole arena time spent mobile, 20 min test	-7.1571	25.227	-0.87539	0.876	0.778
open field	whole arena time spent vertical, 20 min test	10.738	12.550	0.72902	0.691	0.398
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.84179	1.3230	-0.16954	0.774	0.529
startle / PPI	average baseline movement during background noise	-0.71157	1.5453	-0.46689	0.922	0.647
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.085092	0.061789	-0.89222	0.531	0.174
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.089981	0.058993	-0.96035	0.465	0.133
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-8.8787	7.9107	-0.91328	0.877	0.267
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-9.8838	5.7438	-0.99962	0.424	0.0914
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-9.3623	6.5812	-0.98358	0.443	0.161
startle / PPI	average startle response to full pulse (120 dB)	62.699	56.402	1.2781	0.513	0.271
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	119.67	58.816	1.8237	0.168	0.0471
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	66.214	57.025	1.3137	0.470	0.251
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	82.549	54.454	1.6365	0.332	0.136
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.36216	1.9729	-0.21676	0.973	0.855
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	4.3381	2.0580	1.9118	0.465	0.0400
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	3.6513	2.3597	1.2229	0.554	0.128
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.081477	0.082320	-0.74156	0.869	0.327
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.089231	0.062240	-0.81279	0.497	0.158
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.083155	0.071532	-0.80541	0.513	0.251
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	63.326	56.127	1.2876	0.505	0.264
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	119.90	58.675	1.8237	0.167	0.0462
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	61.578	57.061	1.2686	0.501	0.286
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	78.336	54.639	1.6103	0.353	0.158
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.078356	0.085895	-0.68552	0.860	0.366
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.090347	0.064759	-0.77856	0.509	0.169
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.10214	0.073363	-0.93437	0.422	0.170
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	91.783	84.770	0.70156	0.528	0.284
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	176.49	87.357	1.0493	0.169	0.0486
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	119.33	82.526	0.83525	0.359	0.154
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	90.273	77.461	0.77329	0.465	0.249
startle / PPI	maximum baseline movement during background noise	-2.5985	3.1755	-0.71778	0.832	0.417
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-8.0045	8.3783	-0.75639	0.890	0.344
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-9.5141	6.0626	-0.91754	0.457	0.123
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-10.720	6.8069	-1.0640	0.381	0.121
startle / PPI	maximum startle response to full pulse (120 dB)	89.281	84.671	0.69441	0.544	0.297
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	178.02	87.298	1.0469	0.164	0.0466
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	123.27	81.929	0.84322	0.334	0.139
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	96.564	77.257	0.81555	0.429	0.217
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	0.087321	2.3190	0.14695	0.995	0.970
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	4.1375	2.5406	0.99501	0.598	0.110
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	7.6875	2.9460	1.0301	0.195	0.0119
urinalysis	albumin-creatinine ratio (urine ACR)	0.50945	3.8360	-0.56733	0.948	0.895
urinalysis	creatinine (urine CREA)	-1.6701	5.3471	0.33151	0.873	0.756
urinalysis	glucose (urine GLU)	1.5088	3.1240	0.36611	0.869	0.632
urinalysis	magnesium level (urine Mg)	0.032600	0.036913	0.64900	0.724	0.382
urinalysis	microalbumin (urine MA), calculated	0.017110	0.20188	-0.23641	0.975	0.933

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value

eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	6.0 %	0.128
eye morphology	corneal mineralization	1.0 %	1.0
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	1.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.0
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	9.0 %	1.0
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.00
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	44.0 %	0.0000563
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	3.0 %	1.0
eye morphology	retina	9.0 %	0.277
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.0
eye morphology	retinal pigmentation	11.0 %	0.189
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	18.0 %	0.0254
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Cldn13^em1(IMPC)J -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.