MPD: JaxKOMP-EAP genotype: Esrra<sup>tm1.1(KOMP)Vlcg</sup> -/-

JaxKOMP-EAP effect sizes: Esrra^{tm1.1(KOMP)Vlcg} -/- Gene Esrra

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-2.1661	1.9870	-0.47257	0.751	0.325
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-2.2175	1.3266	-0.67494	0.512	0.155
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-8.6521	3.2073	-1.3919	0.287	0.0429
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-16.156	3.1215	-1.8617	0.0800	0.00354
body composition	body length	-0.13245	0.066992	-1.1832	0.235	0.0524
body composition	body weight (at time of DXA)	-4.7229	0.53219	-2.4533	3.44e-10	9.38e-13
body composition	bone area, whole body scan, head excluded	0.13125	0.19213	0.75378	0.735	0.497
body composition	bone mineral content of whole body scan, head excluded	0.013491	0.014193	0.92261	0.635	0.346
body composition	bone mineral content to body weight ratio	0.0017867	0.00040196	2.2755	0.00224	0.0000357
body composition	bone mineral density of whole body scan, head excluded	0.00070000	0.00068593	0.79954	0.612	0.311
body composition	fat tissue mass of whole body scan, head excluded	-0.56887	0.44434	-1.0878	0.446	0.205
body composition	fat tissue mass to body weight ratio	-0.037636	0.011073	-1.7166	0.0197	0.00117
body composition	lean tissue mass of whole body scan, head excluded	-0.091374	0.42851	-0.34968	0.932	0.832
body composition	lean tissue mass to body weight ratio	0.024904	0.010003	1.2319	0.114	0.0154
body composition	percent fat, whole body scan, head excluded	-3.5303	1.0570	-1.6544	0.0236	0.00140
body composition	ratio of soft-tissue attenuation coefficients	0.0039344	0.0011839	1.6922	0.0243	0.00147
body composition	tissue area	-1.2004	0.20270	-2.5823	0.0000563	1.44e-7
body composition	total tissue mass, whole body scan, head excluded	-0.46653	0.27388	-1.3830	0.282	0.0934
clinical blood chemistry	alanine transaminase (plasma ALT)	1.9885	20.871	0.19897	0.974	0.925
clinical blood chemistry	albumin (plasma Alb)	-2.3078	0.78200	-2.4106	0.0967	0.00717
clinical blood chemistry	alkaline phosphatase (plasma ALP)	12.993	6.9209	1.4544	0.244	0.0732
clinical blood chemistry	aspartate transaminase (plasma AST)	-24.732	39.994	-1.0945	0.810	0.542
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.40322	0.19200	-1.1977	0.354	0.0464
clinical blood chemistry	blood urea nitrogen (BUN)	6.0958	2.0356	2.1737	0.0675	0.00668
clinical blood chemistry	calcium (plasma Ca)	-0.13000	0.077351	-0.58392	0.293	0.106
clinical blood chemistry	creatinine (plasma)	0.039748	0.057906	1.1017	0.763	0.563
clinical blood chemistry	glucose (plasma GLU, no fast)	-92.523	33.313	-2.3847	0.0533	0.0105
clinical blood chemistry	HDL cholesterol (plasma HDL)	-1.0785	2.3185	-0.59687	0.861	0.646
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.023373	0.016894	1.1155	0.510	0.179
clinical blood chemistry	phosphorus (plasma phosphate)	0.42896	0.39700	0.58710	0.581	0.291
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.036654	0.019143	-2.0575	0.308	0.0680
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-1.5077	2.8547	-0.49992	0.835	0.602
clinical blood chemistry	total protein (plasma TP)	-2.0149	1.1516	-1.4755	0.350	0.0935
clinical blood chemistry	triglyceride (plasma TG, no fast)	-7.2793	10.769	-0.17690	0.747	0.506
ECT	applied stimulus (current), by day, day 2	0.29448	0.42262	0.46980	0.770	0.491
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	-0.17242	0.29535	-0.91061	0.774	0.564
EKG	duration of PQ interval	-3.2747	0.80649	-2.6504	0.0348	0.000140
EKG	duration of PR interval	-2.9999	0.83431	-2.3098	0.0997	0.000642
EKG	duration of QRS interval	1.0340	0.25813	2.3098	0.105	0.000168
EKG	duration of QT interval	0.37409	0.60712	0.52718	0.898	0.540
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.92705	0.60101	1.0248	0.702	0.128
EKG	duration of RR interval	-1.8484	1.1117	-0.70775	0.496	0.101
EKG	duration of ST interval	-0.65841	0.59318	-0.44551	0.754	0.271
EKG	heart rate coefficient of variation (signal intensity)	-0.30216	1.0671	-0.14763	0.968	0.778
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-1.7606	7.8908	-0.098895	0.971	0.824
EKG	heart rate, beats per min	16.026	9.2994	0.70972	0.450	0.0898
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.042718	0.075764	-0.46267	0.845	0.575
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.14441	0.099410	-0.90846	0.513	0.151
EKG	number of signals	2.2636	4.1212	0.42557	0.883	0.585
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	0.84930	4.4836	0.25923	0.983	0.850
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-4.2795	3.1593	-1.2131	0.865	0.180
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-3.1364	3.6489	-0.85258	0.914	0.393
EKG	root mean square of successive differences of neighboring RR intervals	-2.2001	1.8627	-1.1406	0.843	0.242
glucose tolerance test	amount glucose injected	-5.8012	2.7994	-1.2223	0.300	0.0443
glucose tolerance test	plasma glucose, 0min	20.801	6.5607	1.6464	0.0236	0.00277
glucose tolerance test	plasma glucose, 15min	-30.174	49.711	-0.71911	0.816	0.547
glucose tolerance test	plasma glucose, 30min	18.290	27.514	0.66504	0.776	0.510
glucose tolerance test	plasma glucose, 60min	-6.3058	20.654	-0.14603	0.913	0.762
glucose tolerance test	plasma glucose, 120min	12.055	12.013	0.70321	0.618	0.321
grip strength	body weight (at time of grip strength test)	-3.6408	0.46788	-2.2170	4.76e-7	3.86e-9
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-13.530	13.296	-0.70117	0.530	0.316
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.87530	0.45734	1.4622	0.197	0.0638
grip strength	forelimb and hindlimb grip strength by trial, trial1	-10.962	18.331	-0.51576	0.790	0.554
grip strength	forelimb and hindlimb grip strength by trial, trial2	-14.484	11.080	-0.68088	0.447	0.200
grip strength	forelimb and hindlimb grip strength by trial, trial3	8.4740	19.006	0.77360	0.837	0.659
grip strength	forelimb grip strength (mean of trials), average	4.6109	7.4559	0.87990	0.764	0.540
grip strength	forelimb grip strength (mean of trials), average normalized to bw	1.0544	0.24120	2.4039	0.00566	0.000105
grip strength	forelimb grip strength by trial, trial1	2.4561	5.9151	0.53577	0.869	0.681
grip strength	forelimb grip strength by trial, trial2	20.082	10.600	2.3106	0.308	0.0667
grip strength	forelimb grip strength by trial, trial3	-8.9437	7.3065	-0.71610	0.548	0.229
heart weight	heart weight, normalized to body weight	0.43345	0.12147	0.94220	0.0101	0.000687
heart weight	heart weight, weight	8.2887	4.5317	0.70318	0.226	0.0721
hematology	basophil differential (percent of total WBC)	0.10927	0.075115	1.3944	0.594	0.153
hematology	calculated hemoglobin (cHGB)	-0.19452	0.32409	-0.85007	0.776	0.551
hematology	eosinophil differential (percent of total WBC)	0.031600	0.21118	0.16276	0.967	0.882
hematology	hematocrit (HCT)	-1.4309	0.99465	-1.5325	0.440	0.157
hematology	hemoglobin concentration distribution width (HDW)	-0.024173	0.019933	-0.68874	0.542	0.231
hematology	large unstained cells (percent of total WBC)	-0.23707	0.12313	-1.4357	0.334	0.0604
hematology	lymphocyte differential (percent of total WBC)	-0.017335	1.3392	-0.054697	0.993	0.990
hematology	mean corpuscular hemoglobin (CHr)	0.030527	0.059927	0.28662	0.805	0.613
hematology	mean platelet volume (MPV)	0.39458	0.086319	1.5045	0.000831	0.0000378
hematology	mean RBC corpuscular hemoglobin (MCH)	0.027681	0.14755	0.086332	0.947	0.852
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.23961	0.35748	0.53543	0.805	0.506
hematology	mean RBC corpuscular volume (MCV)	-0.66106	0.30701	-1.0945	0.142	0.0366
hematology	measured hemoglobin (mHGB)	-0.23457	0.31482	-0.78192	0.709	0.460
hematology	monocyte differential (percent of total WBC)	-0.33273	0.21614	-0.83154	0.484	0.131
hematology	neutrophil differential (percent of total WBC)	0.15233	1.1963	0.087584	0.951	0.899
hematology	platelet count (PLT; units per volume x 10³)	75.534	48.608	1.0227	0.491	0.127
hematology	RBC corpuscular distribution width (RDW)	0.37244	0.21474	1.1736	0.307	0.0897
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.55414	0.19478	1.2895	0.0537	0.00661
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.24016	0.24908	-1.2546	0.609	0.340
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-28.931	17.037	-1.1167	0.448	0.0962
hematology	reticulocyte differential (percent of total RBC)	-0.36071	0.16582	-1.2697	0.300	0.0348
hematology	white blood cell count (WBC; units per volume x 10³)	-1.6519	0.69432	-0.95801	0.0941	0.0216
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.13864	0.70166	0.19793	0.953	0.844
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.15114	0.55685	-0.11079	0.961	0.787
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.94942	0.65593	-1.5063	0.683	0.155
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.18633	0.76593	-0.085346	0.944	0.809
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.34659	0.44254	0.66446	0.846	0.438
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.24830	0.32680	0.70336	0.894	0.451
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.23000	0.47539	-0.65709	0.958	0.631
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.58540	0.49286	-0.86592	0.757	0.241
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.26761	0.52361	0.57390	0.924	0.612
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.26875	0.35231	0.74299	0.878	0.450
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.52932	0.32251	-1.3728	0.680	0.108
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.32251	0.54082	-0.45741	0.897	0.554
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.99830	0.79967	1.0448	0.647	0.218
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.20485	0.46275	0.42764	0.893	0.660
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.55024	0.68043	-0.78342	0.822	0.423
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-1.8453	0.83793	-1.6026	0.368	0.0328
holeboard	total number of hole pokes, 20 min test	-1.8611	5.5927	-0.15923	0.881	0.741
light / dark	fecal boli count, 20 min test	-0.77596	1.1943	-0.83356	0.831	0.518
light / dark	latency to enter dark zone, 20 min test	-5.1084	29.248	-0.20974	0.967	0.862
light / dark	number of transitions between light and dark zones, 20 min test	-3.0509	6.9499	-0.19869	0.851	0.662
light / dark	percentage of total time in dark zone, 20 min test	-5.3025	4.2253	-0.82403	0.590	0.214
light / dark	percentage of total time in light zone, 20 min test	5.3025	4.2253	0.82213	0.590	0.214
light / dark	time mobile in dark zone, 20 min test	36.799	11.006	1.5743	0.0241	0.00139
light / dark	time mobile in light zone, 20 min test	23.000	13.530	1.0183	0.297	0.0941
light / dark	time spent in dark zone, 20 min test	-95.236	54.371	-1.1341	0.444	0.0847
light / dark	time spent in light zone, 20 min test	95.236	54.371	1.1341	0.444	0.0847
open field	average speed in center of arena, 20 min test	0.13139	0.44983	0.14755	0.918	0.771
open field	average speed in periphery of arena, 20 min test	0.20303	0.17646	0.28369	0.476	0.255
open field	distance traveled habituation ratio, 20 min test	6.6066	9.0472	0.55876	0.739	0.469
open field	distance traveled in center of arena, 20 min test	58.899	104.14	0.018126	0.764	0.574
open field	distance traveled in periphery of arena, 20 min test	237.56	164.44	0.48189	0.363	0.155
open field	distance traveled slope, 20 min test	3.5895	8.8048	0.38019	0.878	0.685
open field	distance traveled, 20 min test, 1st 5min	-62.815	94.360	-0.83666	0.736	0.509
open field	distance traveled, 20 min test, 2nd 5min	203.39	61.807	1.5241	0.0219	0.00180
open field	distance traveled, 20 min test, 3rd 5min	139.47	57.964	1.0027	0.102	0.0197
open field	distance traveled, 20 min test, 4th 5min	21.613	57.269	-0.21581	0.861	0.707
open field	number of clockwise revolution episodes, 20 min test	1.2132	1.6208	0.30559	0.768	0.457
open field	number of counter-clockwise revolution episodes, 20 min test	0.93018	1.4853	0.081317	0.757	0.534
open field	number of fecal boli, 20 min test	1.2489	1.0935	1.1714	0.590	0.259
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-12.151	2.2101	-2.8562	0.000220	0.00000118
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-3.6664	2.6455	-1.2420	0.456	0.172
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-4.0197	2.6833	-1.2449	0.395	0.140
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-4.2088	3.0931	-1.2449	0.450	0.179
open field	percentage of total time in center of arena, 20 min test	-1.1746	3.2670	-0.49702	0.891	0.721
open field	percentage of total time in center of arena, slope, 20 min test	-0.37217	1.4296	-0.088054	0.955	0.796
open field	percentage of total time in center, habituation ratio, 20 min test	-1.0449	1.4865	-0.45492	0.845	0.485
open field	percentage of total time in corners of arena, 20 min test	9.2950	6.5952	1.8731	0.474	0.165
open field	percentage of total time in corners, habituation ratio, 20 min test	0.92144	1.6608	0.14076	0.908	0.581
open field	percentage of total time in corners, slope, 20 min test	-0.42315	1.5984	-0.46686	0.954	0.792
open field	permanence time in center of arena, 20 min test	-14.124	39.203	-0.49702	0.892	0.720
open field	permanence time in corners of arena, 20 min test	111.52	79.144	1.8731	0.474	0.165
open field	permanence time in periphery of arena, 20 min test	14.051	39.203	0.49550	0.892	0.721
open field	total distance traveled, 20 min test	284.58	233.47	0.32872	0.438	0.228
open field	total number of rears, 20 min test	-24.090	9.3226	-1.9304	0.0859	0.0126
open field	whole arena average speed, 20 min test	0.23770	0.19463	0.32872	0.436	0.227
open field	whole arena resting time, 20 min test	-53.162	22.001	-0.87146	0.0834	0.0192
open field	whole arena time spent mobile, 20 min test	53.242	21.980	1.0861	0.0830	0.0189
open field	whole arena time spent vertical, 20 min test	-33.517	8.6816	-2.2306	0.0103	0.000314
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-17.238	19.827	-1.1746	0.846	0.390
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-3.8217	6.2369	-0.81378	0.907	0.544
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-28.414	18.212	-1.7168	0.478	0.128
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	-11.050	27.330	-0.35788	0.891	0.688
sleep	differential wake percentages during light and dark phase	-1.0455	0.61027	-1.2278	0.500	0.0958
sleep	mean breath rate during-sleep	-0.14565	0.080398	-1.0174	0.268	0.0789
sleep	mean of sleep bout lengths	-96.919	24.895	-1.6984	0.0179	0.000440
sleep	mean of sleep bout lengths with lights off	-28.777	24.267	-0.77384	0.616	0.244
sleep	mean of sleep bout lengths with lights on	-112.31	43.250	-1.7918	0.199	0.0138
sleep	mean percentage of time sleeping over 24 h periods	2.5063	1.1494	1.6568	0.544	0.0362
sleep	mean percentage of time sleeping with lights on	-2.0567	2.4168	-0.83006	0.792	0.401
sleep	mean percentage of time spent sleeping with lights off	3.8387	1.8908	1.2278	0.406	0.0502
sleep	peak wake with respect to dark onset median	-0.58742	0.83623	-0.78766	0.860	0.487
sleep	percentage of time awake one hour before and after light onset	-11.548	4.7451	-1.3964	0.237	0.0204
startle / PPI	average baseline movement during background noise	-0.82050	1.2960	-0.56948	0.895	0.531
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-1.6941	1.1301	-3.0570	0.483	0.143
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.085398	0.093854	-0.92320	0.703	0.369
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	13.509	11.102	1.5902	0.859	0.232
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-4.1056	6.5489	-0.44048	0.805	0.535
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-13.329	5.6319	-1.3477	0.162	0.0236
startle / PPI	average startle response to full pulse (120 dB)	73.530	24.823	1.3833	0.0436	0.00546
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	75.811	24.950	1.3653	0.0348	0.00447
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	61.530	24.500	1.2812	0.0860	0.0168
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	66.162	19.268	1.4169	0.0182	0.00155
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.18117	1.4037	-0.056776	0.981	0.898
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.97192	1.3647	-0.68552	0.883	0.481
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.73146	1.6192	0.18103	0.907	0.654
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.14942	0.11854	1.4644	0.852	0.216
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.056009	0.074942	-0.54235	0.743	0.460
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.18691	0.079904	-1.5899	0.142	0.0252
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	73.933	24.971	1.3870	0.0432	0.00548
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	75.820	25.279	1.3477	0.0375	0.00496
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	62.415	23.975	1.2844	0.0740	0.0135
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	65.108	19.321	1.4324	0.0204	0.00184
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.11831	0.12091	1.0542	0.860	0.335
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.053566	0.080755	-0.48838	0.776	0.511
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-5.0459	3.3314	-3.2589	0.370	0.139
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	282.54	92.987	1.3943	0.0370	0.00448
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	296.93	92.039	1.4522	0.0256	0.00272
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	237.12	90.768	1.3038	0.0729	0.0132
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	246.41	74.179	1.4767	0.0216	0.00210
startle / PPI	maximum baseline movement during background noise	-2.1153	2.6114	-0.56454	0.835	0.423
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	11.374	11.636	1.1825	0.890	0.335
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-4.1681	7.4178	-0.43740	0.828	0.578
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-12.609	6.2109	-1.2229	0.244	0.0500
startle / PPI	maximum startle response to full pulse (120 dB)	281.28	92.635	1.3943	0.0359	0.00450
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	296.03	91.256	1.4522	0.0255	0.00259
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	233.88	91.745	1.3038	0.0790	0.0153
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	249.61	73.983	1.4851	0.0200	0.00182
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.2637	2.9798	-0.30815	0.928	0.674
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-3.4280	2.9351	-0.95004	0.748	0.251
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	11.074	5.9013	1.4285	0.415	0.0692
urinalysis	albumin-creatinine ratio (urine ACR)	9.1881	1.6733	1.6860	0.000329	0.00000433
urinalysis	creatinine (urine CREA)	-14.567	5.2240	-1.8924	0.0924	0.00872
urinalysis	glucose (urine GLU)	-3.5910	3.2819	-1.1907	0.642	0.282
urinalysis	magnesium level (urine Mg)	0.012906	0.034242	0.21462	0.924	0.709
urinalysis	microalbumin (urine MA), calculated	0.36194	0.13632	1.1210	0.113	0.0121

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	4.0 %	0.428
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.00
eye morphology	lacrimation	22.0 %	0.00324
eye morphology	lens	4.0 %	0.645
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	9.0 %	0.261
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	4.0 %	1.00
eye morphology	pupil shape	3.0 %	1.00
eye morphology	retina	7.0 %	0.888
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.00
eye morphology	retinal pigmentation	31.0 %	0.00692
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.00
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.0
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.00
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.0
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.0
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.00
SHIRPA	forelimb digit size	0.0 %	1.00
SHIRPA	forelimb footpads	0.0 %	1.00
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.00
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.00
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.00
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.00
SHIRPA	head morphology	0.0 %	1.00
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.0
SHIRPA	hindlimb digit position	0.0 %	1.00
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.0
SHIRPA	hindlimb nail length	0.0 %	1.0
SHIRPA	hindlimb nail number	0.0 %	1.0
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.00
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.00
SHIRPA	hindpaw shape	0.0 %	1.00
SHIRPA	hindpaw size	0.0 %	1.00
SHIRPA	limb grasp	7.0 %	1.0
SHIRPA	lower lip morphology	0.0 %	1.00
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.0
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.00
SHIRPA	skin color whole body	0.0 %	1.00
SHIRPA	skin texture back paw	0.0 %	1.00
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.0
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.0
XRay	alive (yes, no)	8.0 %	1.00
XRay	brachydactyly	0.0 %	1.0
XRay	clavicle	0.0 %	1.0
XRay	digit integrity	0.0 %	1.0
XRay	femur	0.0 %	1.0
XRay	fibula	0.0 %	1.0
XRay	fusion of ribs	0.0 %	1.0
XRay	fusion of vertebrae	0.0 %	1.0
XRay	humerus	0.0 %	1.0
XRay	joints	13.0 %	1.0
XRay	kyphosis	0.0 %	1.0
XRay	lordosis	0.0 %	1.0
XRay	mandibles	0.0 %	1.0
XRay	maxilla	0.0 %	1.0
XRay	pelvis	4.0 %	1.00
XRay	processes on vertebrae	0.0 %	1.0
XRay	radius	0.0 %	1.0
XRay	scapulae	0.0 %	1.0
XRay	scoliosis	0.0 %	1.0
XRay	shape of ribs	0.0 %	1.0
XRay	shape of spine	0.0 %	1.0
XRay	shape of vertebrae	1.0 %	1.0
XRay	skull shape	0.0 %	1.0
XRay	syndactylism	0.0 %	1.0
XRay	teeth	0.0 %	1.0
XRay	tibia	0.0 %	1.0
XRay	ulna	0.0 %	1.0
XRay	zygomatic bone	0.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Esrra^{tm1.1(KOMP)Vlcg} -/- with genotype: