MPD: JaxKOMP-EAP genotype: Pip4k2c<sup>tm1b(KOMP)Wtsi</sup>/2J -/-

JaxKOMP-EAP effect sizes: Pip4k2c^{tm1b(KOMP)Wtsi}/2J -/- Gene Pip4k2c

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	2.4242	1.5526	0.47381	0.560	0.141
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-6.5147	2.6680	-1.2466	0.349	0.0285
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	0.78495	3.1837	-0.00070371	0.931	0.809
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-15.908	5.0910	-1.8309	0.125	0.00746
body composition	body length	-0.14600	0.058916	-1.3021	0.121	0.0166
body composition	body weight (at time of DXA)	-2.0239	0.55758	-1.2095	0.00750	0.000657
body composition	bone area, whole body scan, head excluded	-0.29366	0.14468	-0.94158	0.209	0.0477
body composition	bone mineral content of whole body scan, head excluded	-0.020669	0.010758	-0.95442	0.246	0.0604
body composition	bone mineral content to body weight ratio	-0.00038782	0.00044434	-0.32079	0.643	0.387
body composition	bone mineral density of whole body scan, head excluded	-0.00071027	0.00060480	-0.76613	0.546	0.246
body composition	fat tissue mass of whole body scan, head excluded	0.64627	0.29378	0.96090	0.164	0.0325
body composition	fat tissue mass to body weight ratio	0.024580	0.011775	1.0491	0.166	0.0420
body composition	lean tissue mass of whole body scan, head excluded	-0.67943	0.25785	-1.4194	0.120	0.0112
body composition	lean tissue mass to body weight ratio	-0.018627	0.0086077	-1.0139	0.171	0.0352
body composition	percent fat, whole body scan, head excluded	2.3949	1.1195	1.1103	0.155	0.0373
body composition	ratio of soft-tissue attenuation coefficients	-0.0018219	0.0011291	-0.83462	0.307	0.113
body composition	tissue area	-0.19468	0.14712	-0.46752	0.475	0.192
body composition	total tissue mass, whole body scan, head excluded	0.047747	0.19914	-0.11219	0.908	0.811
clinical blood chemistry	alanine transaminase (plasma ALT)	21.778	13.314	1.2313	0.469	0.113
clinical blood chemistry	albumin (plasma Alb)	-0.77246	0.50904	-0.95835	0.449	0.140
clinical blood chemistry	alkaline phosphatase (plasma ALP)	7.8834	3.7695	0.82717	0.185	0.0457
clinical blood chemistry	aspartate transaminase (plasma AST)	1.6555	33.200	0.086592	0.986	0.961
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.12754	0.31160	-0.40235	0.906	0.685
clinical blood chemistry	blood urea nitrogen (BUN)	-1.9532	1.5586	-0.80303	0.485	0.222
clinical blood chemistry	calcium (plasma Ca)	-0.21174	0.10407	-1.1851	0.193	0.0518
clinical blood chemistry	carbon dioxide (plasma CO₂)	0.78167	0.86981	0.48035	0.645	0.376
clinical blood chemistry	chloride (plasma Cl)	-0.43246	0.52125	-0.44477	0.596	0.414
clinical blood chemistry	glucose (plasma GLU, no fast)	22.842	13.122	1.1767	0.243	0.0936
clinical blood chemistry	HDL cholesterol (plasma HDL)	0.16012	2.1047	-0.28213	0.982	0.940
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.010225	0.012172	-0.70018	0.715	0.408
clinical blood chemistry	iron (plasma Fe)	0.0045516	0.0079116	0.39233	0.782	0.570
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.18107	0.11331	-1.3363	0.381	0.123
clinical blood chemistry	phosphorus (plasma phosphate)	0.53672	0.57214	0.75120	0.647	0.357
clinical blood chemistry	potassium (plasma K)	0.20610	0.20722	-0.15097	0.506	0.328
clinical blood chemistry	sodium (plasma Na)	-1.5475	0.47751	-2.0738	0.0111	0.00307
clinical blood chemistry	total bilirubin (plasma TBIL)	0.00019372	0.012430	0.022712	0.999	0.988
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	2.1961	3.3274	0.16496	0.784	0.515
clinical blood chemistry	total protein (plasma TP)	0.60095	3.4055	0.38778	0.937	0.861
clinical blood chemistry	triglyceride (plasma TG, no fast)	-10.315	11.976	-0.35651	0.673	0.398
EKG	duration of PQ interval	-1.5162	0.72493	-1.3259	0.507	0.0427
EKG	duration of PR interval	-1.5837	0.80544	-1.3865	0.576	0.0561
EKG	duration of QRS interval	-0.080932	0.35291	-0.36888	0.988	0.820
EKG	duration of QT interval	-0.71242	0.84934	-0.52718	0.858	0.406
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.41192	0.79669	-0.38836	0.935	0.608
EKG	duration of RR interval	-1.3575	1.3614	-0.44329	0.735	0.325
EKG	duration of ST interval	-0.66167	0.69083	-0.44774	0.792	0.344
EKG	heart rate coefficient of variation (signal intensity)	1.0100	1.1751	0.91206	0.867	0.395
EKG	heart rate variability, mean of differences between sequential beats; beats per min	7.7892	8.3595	0.97172	0.853	0.357
EKG	heart rate, beats per min	15.563	10.893	0.68147	0.549	0.161
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.026053	0.099402	-0.33379	0.928	0.795
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.026458	0.12129	-0.23299	0.936	0.828
EKG	number of signals	-2.8701	5.0065	-0.63455	0.883	0.570
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-5.3025	4.4406	-0.94599	0.814	0.239
EKG	QT dispersion, measured as inter-lead variability of QT intervals	1.1208	3.1036	0.35812	0.968	0.720
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	4.7167	3.7588	1.1641	0.860	0.217
EKG	root mean square of successive differences of neighboring RR intervals	3.0359	2.2155	1.4884	0.843	0.178
electroretinography	a-wave amplitude of rod photoreceptors, left	41.758	14.194	1.6408	0.399	0.0259
electroretinography	a-wave amplitude of rod photoreceptors, right	-1.2667	14.577	-0.65711	0.980	0.934
electroretinography	b-wave amplitude of cone photoreceptors, left	42.608	6.6971	2.3857	0.0830	0.00142
electroretinography	b-wave amplitude of cone photoreceptors, right	29.252	10.489	2.2823	0.431	0.0316
electroretinography	b-wave amplitude of rod photoreceptors, left	-104.80	31.663	-1.6158	0.292	0.0162
electroretinography	b-wave amplitude of rod photoreceptors, right	33.025	49.239	1.0818	0.793	0.527
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	-0.25000	0.70076	-0.58214	0.940	0.733
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	-2.2583	0.57489	-1.5918	0.211	0.0111
electroretinography	rod a wave implicit time, left	1.8333	0.87060	1.5265	0.413	0.0798
electroretinography	rod a wave implicit time, right	1.0000	0.59761	0.83721	0.492	0.145
electroretinography	rod b wave implicit time, left	4.2500	2.1304	1.7144	0.539	0.0931
electroretinography	rod b wave implicit time, right	4.1667	1.4379	1.8173	0.318	0.0274
glucose tolerance test	amount glucose injected	3.3038	1.6899	1.2458	0.348	0.0578
glucose tolerance test	plasma glucose, 0min	13.913	4.8772	1.1326	0.0434	0.00683
glucose tolerance test	plasma glucose, 15min	15.275	19.529	0.55265	0.739	0.439
glucose tolerance test	plasma glucose, 30min	31.668	23.801	1.0552	0.538	0.191
glucose tolerance test	plasma glucose, 60min	-8.7687	12.814	-0.24825	0.778	0.498
glucose tolerance test	plasma glucose, 120min	-5.0368	10.571	-0.49439	0.852	0.636
grip strength	body weight (at time of grip strength test)	-1.7604	0.58184	-1.2875	0.0262	0.00463
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-11.282	9.3109	-0.55769	0.441	0.234
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.40410	0.42455	-0.39017	0.556	0.348
grip strength	forelimb and hindlimb grip strength by trial, trial1	-19.117	10.837	-1.0068	0.304	0.0864
grip strength	forelimb and hindlimb grip strength by trial, trial2	-16.710	11.496	-0.81745	0.387	0.155
grip strength	forelimb and hindlimb grip strength by trial, trial3	4.1801	12.838	0.49431	0.891	0.747
grip strength	forelimb grip strength (mean of trials), average	1.9714	5.9699	0.54923	0.886	0.743
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.33169	0.28769	1.0716	0.533	0.257
grip strength	forelimb grip strength by trial, trial1	-1.2209	6.7309	0.14281	0.949	0.857
grip strength	forelimb grip strength by trial, trial2	-1.9703	8.1233	0.0058091	0.933	0.810
grip strength	forelimb grip strength by trial, trial3	7.3094	8.0290	0.99009	0.696	0.369
heart weight	heart weight, normalized to body weight	-0.039030	0.15990	-0.60931	0.899	0.808
heart weight	heart weight, weight	-2.6656	4.2466	-0.73645	0.715	0.533
hematology	basophil differential (percent of total WBC)	0.16202	0.071677	1.7703	0.356	0.0345
hematology	calculated hemoglobin (cHGB)	0.35351	0.24453	0.85007	0.433	0.162
hematology	eosinophil differential (percent of total WBC)	-0.042406	0.26110	-0.038984	0.962	0.872
hematology	hematocrit (HCT)	0.096678	0.58477	-0.27969	0.939	0.870
hematology	hemoglobin concentration distribution width (HDW)	0.0049292	0.035235	0.11673	0.950	0.890
hematology	large unstained cells (percent of total WBC)	-0.025159	0.10560	-0.15786	0.916	0.814
hematology	lymphocyte differential (percent of total WBC)	0.38753	1.3916	0.12883	0.903	0.783
hematology	mean corpuscular hemoglobin (CHr)	0.066667	0.067895	0.55947	0.579	0.337
hematology	mean platelet volume (MPV)	0.15901	0.11686	0.79258	0.396	0.188
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.53545	0.79917	-1.1950	0.795	0.510
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.96709	2.0549	-1.2570	0.866	0.643
hematology	mean RBC corpuscular volume (MCV)	0.24212	0.52038	0.46447	0.814	0.647
hematology	measured hemoglobin (mHGB)	-0.58542	0.79974	-1.2982	0.719	0.472
hematology	monocyte differential (percent of total WBC)	-0.38542	0.17062	-0.92396	0.277	0.0341
hematology	neutrophil differential (percent of total WBC)	-0.30699	1.1806	-0.12883	0.892	0.797
hematology	platelet count (PLT; units per volume x 10³)	-95.274	74.840	-1.1327	0.586	0.217
hematology	RBC corpuscular distribution width (RDW)	0.18958	0.12532	0.67664	0.385	0.145
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.33669	0.37093	0.83914	0.637	0.374
hematology	red blood cell count (RBC; per volume x 10⁶)	0.022500	0.15775	-0.26297	0.949	0.888
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-26.373	29.998	-1.0172	0.745	0.389
hematology	reticulocyte differential (percent of total RBC)	-0.34424	0.33951	-1.2116	0.679	0.322
hematology	white blood cell count (WBC; units per volume x 10³)	1.3135	0.62491	1.0508	0.159	0.0472
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.11989	0.64074	-0.053196	0.953	0.852
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.51619	0.55588	-0.68566	0.807	0.357
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.18100	0.51760	-0.22209	0.938	0.728
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.25515	0.67974	0.32553	0.914	0.709
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.36709	0.50613	-0.50417	0.859	0.472
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.074463	0.20057	0.25230	0.957	0.712
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.10553	0.27365	0.29406	0.971	0.701
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.91761	0.40736	-1.3863	0.466	0.0286
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-1.0526	0.66142	-1.6332	0.573	0.118
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.31250	0.22775	-0.82820	0.746	0.176
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.39754	0.27308	0.93381	0.723	0.152
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.53509	0.43414	0.95050	0.669	0.223
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.95146	0.86781	-0.84934	0.697	0.278
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.36666	0.36569	-0.52208	0.730	0.321
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.39247	0.41953	-0.52595	0.787	0.354
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.0125	0.67938	0.89625	0.572	0.142
holeboard	total number of hole pokes, 20 min test	-1.6353	4.2289	-0.12005	0.857	0.701
light / dark	fecal boli count, 20 min test	0.36579	0.64158	0.44188	0.857	0.571
light / dark	latency to enter dark zone, 20 min test	34.377	31.306	0.52626	0.687	0.278
light / dark	number of transitions between light and dark zones, 20 min test	-2.1455	7.6162	-0.092067	0.906	0.779
light / dark	percentage of total time in dark zone, 20 min test	-3.2056	4.8317	-0.45309	0.788	0.510
light / dark	percentage of total time in light zone, 20 min test	3.2056	4.8317	0.45009	0.787	0.510
light / dark	time mobile in dark zone, 20 min test	11.912	10.280	0.60400	0.555	0.253
light / dark	time mobile in light zone, 20 min test	14.570	13.632	0.61539	0.555	0.291
light / dark	time spent in dark zone, 20 min test	-55.140	57.285	-0.60400	0.722	0.341
light / dark	time spent in light zone, 20 min test	55.140	57.285	0.60400	0.722	0.341
open field	average speed in center of arena, 20 min test	0.14398	0.45785	0.16658	0.914	0.754
open field	average speed in periphery of arena, 20 min test	0.36852	0.16716	0.86559	0.125	0.0322
open field	distance traveled habituation ratio, 20 min test	0.51000	9.2093	0.071891	0.978	0.956
open field	distance traveled in center of arena, 20 min test	177.84	98.653	0.76092	0.256	0.0775
open field	distance traveled in periphery of arena, 20 min test	337.74	166.52	0.85200	0.187	0.0480
open field	distance traveled slope, 20 min test	-0.43950	8.9267	0.0060417	0.992	0.961
open field	distance traveled, 20 min test, 1st 5min	172.67	81.657	0.98073	0.167	0.0395
open field	distance traveled, 20 min test, 2nd 5min	125.57	56.427	0.87736	0.143	0.0307
open field	distance traveled, 20 min test, 3rd 5min	120.63	67.193	0.84430	0.253	0.0788
open field	distance traveled, 20 min test, 4th 5min	160.24	59.199	1.2191	0.0645	0.00932
open field	number of clockwise revolution episodes, 20 min test	1.8524	1.4063	0.69060	0.550	0.194
open field	number of counter-clockwise revolution episodes, 20 min test	2.3204	1.3369	0.78444	0.329	0.0889
open field	number of fecal boli, 20 min test	1.3885	0.87404	1.2890	0.408	0.118
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-2.7945	2.0004	-0.96101	0.421	0.169
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-0.98223	2.3347	-0.59043	0.842	0.676
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-1.7806	2.5417	-0.69272	0.728	0.487
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-1.2442	2.8567	-0.60811	0.831	0.665
open field	percentage of total time in center of arena, 20 min test	-0.029375	2.5005	-0.19935	0.998	0.991
open field	percentage of total time in center of arena, slope, 20 min test	-0.75825	1.1755	-0.30191	0.867	0.522
open field	percentage of total time in center, habituation ratio, 20 min test	-0.84362	1.1851	-0.30332	0.845	0.480
open field	percentage of total time in corners of arena, 20 min test	-1.1974	4.0445	0.079970	0.910	0.768
open field	percentage of total time in corners, habituation ratio, 20 min test	2.4629	1.7051	0.81214	0.641	0.155
open field	percentage of total time in corners, slope, 20 min test	2.5357	1.6659	0.87342	0.629	0.134
open field	permanence time in center of arena, 20 min test	-0.35250	30.003	-0.19661	0.998	0.991
open field	permanence time in corners of arena, 20 min test	-14.370	48.533	0.079970	0.910	0.768
open field	permanence time in periphery of arena, 20 min test	0.30250	30.000	0.19387	0.998	0.992
open field	total distance traveled, 20 min test	526.06	220.42	0.96778	0.0918	0.0209
open field	total number of rears, 20 min test	-4.9339	8.1146	-0.66567	0.749	0.546
open field	whole arena average speed, 20 min test	0.43793	0.18353	0.96564	0.0921	0.0209
open field	whole arena resting time, 20 min test	-46.411	20.233	-0.72029	0.103	0.0261
open field	whole arena time spent mobile, 20 min test	46.360	20.216	0.95499	0.105	0.0262
open field	whole arena time spent vertical, 20 min test	-11.804	7.4848	-1.0116	0.386	0.121
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	18.834	14.703	1.6431	0.749	0.209
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	5.5654	4.3657	1.6094	0.757	0.211
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-2.4425	11.087	0.044937	0.953	0.827
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	2.9187	15.067	0.48057	0.949	0.847
sleep	differential wake percentages during light and dark phase	-0.17453	0.50756	0.15344	0.881	0.734
sleep	mean breath rate during-sleep	-0.028857	0.091329	-0.13285	0.891	0.755
sleep	mean of sleep bout lengths	-57.772	29.917	-1.1653	0.316	0.0671
sleep	mean of sleep bout lengths with lights off	-15.336	22.344	-0.21564	0.761	0.500
sleep	mean of sleep bout lengths with lights on	-38.134	25.250	-0.53378	0.517	0.145
sleep	mean percentage of time sleeping over 24 h periods	1.7409	1.5276	1.0347	0.827	0.267
sleep	mean percentage of time sleeping with lights on	1.7259	1.5394	0.85918	0.618	0.274
sleep	mean percentage of time spent sleeping with lights off	1.7012	2.4670	0.45320	0.865	0.498
sleep	peak wake with respect to dark onset median	0.65569	0.51172	0.90427	0.789	0.213
sleep	percentage of time awake one hour before and after light onset	2.8490	5.8883	0.85918	0.839	0.633
startle / PPI	average baseline movement during background noise	-0.82263	0.99598	-0.57112	0.867	0.414
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.028323	0.060900	-0.34659	0.845	0.644
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.030479	0.057228	-0.38751	0.838	0.597
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-7.6784	7.8759	-0.79232	0.879	0.335
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-5.9621	6.0139	-0.61625	0.680	0.327
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	1.9690	6.2277	0.10035	0.905	0.754
startle / PPI	average startle response to full pulse (120 dB)	76.466	20.642	1.3980	0.00891	0.000626
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	90.684	22.915	1.5424	0.00493	0.000294
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	77.256	19.818	1.4522	0.00630	0.000352
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	60.364	18.140	1.3547	0.0206	0.00186
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-2.6507	0.96627	-1.7043	0.382	0.00898
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.5996	0.87326	-1.0967	0.570	0.0743
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-0.37569	1.6360	-0.37952	0.959	0.820
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.090951	0.081734	-0.81947	0.855	0.272
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.074389	0.062002	-0.69712	0.581	0.237
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.024419	0.074919	-0.38502	0.892	0.746
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	77.070	20.798	1.4093	0.00851	0.000624
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	93.184	22.956	1.5658	0.00406	0.000216
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	78.775	19.677	1.4644	0.00487	0.000256
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	40.936	21.198	1.1070	0.201	0.0606
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.065989	0.087733	-0.55798	0.903	0.456
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.083934	0.067174	-0.73377	0.562	0.219
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.020420	0.076616	-0.35350	0.916	0.791
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	318.24	78.068	1.5066	0.00403	0.000205
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	364.37	83.684	1.6528	0.00216	0.0000870
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	317.39	75.736	1.5378	0.00304	0.000144
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	230.85	67.542	1.4285	0.0169	0.00144
startle / PPI	maximum baseline movement during background noise	-0.93659	2.2766	-0.20244	0.936	0.683
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-5.7379	8.6574	-0.54168	0.921	0.511
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-7.0451	6.6173	-0.67493	0.647	0.293
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	1.6647	6.7517	0.0091075	0.919	0.807
startle / PPI	maximum startle response to full pulse (120 dB)	316.68	77.691	1.5110	0.00394	0.000205
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	357.56	83.508	1.6365	0.00256	0.000109
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	313.26	76.147	1.5333	0.00363	0.000183
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	232.30	67.505	1.4285	0.0165	0.00134
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-4.7831	2.5922	-1.2655	0.537	0.0724
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-4.3506	1.9028	-1.1602	0.420	0.0275
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	1.4833	4.0509	0.10598	0.897	0.716
urinalysis	albumin-creatinine ratio (urine ACR)	4.7204	1.7003	0.85339	0.0583	0.00767
urinalysis	creatinine (urine CREA)	-4.2411	2.9874	-0.13058	0.385	0.162
urinalysis	glucose (urine GLU)	-0.89607	2.3754	-0.34012	0.905	0.708
urinalysis	magnesium level (urine Mg)	0.064661	0.023015	1.2381	0.0941	0.00702
urinalysis	microalbumin (urine MA), calculated	0.26015	0.12776	0.80699	0.228	0.0469

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	6.0 %	0.0613
eye morphology	bulging eye	6.0 %	0.0409
eye morphology	cornea	10.0 %	0.0269
eye morphology	cornea opacity	6.0 %	0.0690
eye morphology	cornea vascularization	11.0 %	0.0122
eye morphology	corneal deposits	6.0 %	0.105
eye morphology	corneal mineralization	6.0 %	0.0612
eye morphology	corneal scleralization	10.0 %	0.0262
eye morphology	corneal ulcer	6.0 %	0.0738
eye morphology	eye closure	6.0 %	0.0408
eye morphology	eye hemorrhage or blood presence	6.0 %	0.0885
eye morphology	eyelid morphology	6.0 %	0.0494
eye morphology	eyes (present, absent)	6.0 %	0.0493
eye morphology	fusion between cornea and lens	6.0 %	0.179
eye morphology	iris pigmentation	6.0 %	0.142
eye morphology	iris transillumination	6.0 %	0.116
eye morphology	irispupil	9.0 %	0.0663
eye morphology	lacrimation	6.0 %	0.248
eye morphology	lens	10.0 %	0.0549
eye morphology	lens opacity	6.0 %	0.357
eye morphology	narrow eye opening	11.0 %	0.00747
eye morphology	optic disc	5.0 %	0.241
eye morphology	persistence of hyaloid vascular system	9.0 %	0.127
eye morphology	pupil dilation	11.0 %	0.0141
eye morphology	pupil light response	6.0 %	0.236
eye morphology	pupil position	9.0 %	0.0764
eye morphology	pupil shape	10.0 %	0.0587
eye morphology	retina	6.0 %	0.330
eye morphology	retinal blood vessels	5.0 %	0.196
eye morphology	retinal blood vessels pattern	5.0 %	0.279
eye morphology	retinal blood vessels structure	5.0 %	0.215
eye morphology	retinal pigmentation	7.0 %	0.387
eye morphology	retinal structure	5.0 %	0.223
eye morphology	synechia	5.0 %	0.200
eye morphology	vitreous	5.0 %	0.189
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	6.0 %	0.0184
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	18.0 %	0.0254
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Pip4k2c^{tm1b(KOMP)Wtsi}/2J -/- with genotype: