MPD: JaxKOMP-EAP genotype: Pla2g2d<sup>tm1.1(KOMP)Vlcg</sup> -/-

JaxKOMP-EAP effect sizes: Pla2g2d^{tm1.1(KOMP)Vlcg} -/- Gene Pla2g2d

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.8199	1.5591	0.31637	0.683	0.258
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	0.20331	2.0877	0.050324	0.975	0.923
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-0.68315	1.0402	-0.34697	0.810	0.520
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	0.59904	3.4525	-0.034489	0.949	0.864
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	3.0750	3.7703	0.45547	0.745	0.425
body composition	body length	0.036102	0.042317	0.71160	0.685	0.398
body composition	body weight (at time of DXA)	0.67965	0.63547	0.65788	0.512	0.290
body composition	bone area, whole body scan, head excluded	0.19253	0.12632	1.0052	0.387	0.134
body composition	bone mineral content of whole body scan, head excluded	0.010723	0.0094398	0.76106	0.548	0.261
body composition	bone mineral content to body weight ratio	0.00024579	0.00038640	0.48685	0.749	0.528
body composition	bone mineral density of whole body scan, head excluded	0.00021986	0.00048809	0.26182	0.834	0.654
body composition	fat tissue mass of whole body scan, head excluded	-0.55501	0.31355	-1.0731	0.272	0.0828
body composition	fat tissue mass to body weight ratio	-0.021817	0.011321	-0.99392	0.207	0.0595
body composition	lean tissue mass of whole body scan, head excluded	0.30426	0.26083	0.49301	0.546	0.249
body composition	lean tissue mass to body weight ratio	0.0054027	0.0089052	0.23927	0.770	0.547
body composition	percent fat, whole body scan, head excluded	-1.8976	1.0690	-0.91844	0.256	0.0819
body composition	ratio of soft-tissue attenuation coefficients	0.0021078	0.0011885	0.91695	0.257	0.0821
body composition	tissue area	-0.22472	0.14196	-0.56916	0.382	0.120
body composition	total tissue mass, whole body scan, head excluded	-0.24922	0.20431	-0.81507	0.470	0.228
clinical blood chemistry	alanine transaminase (plasma ALT)	-30.164	29.707	-1.9431	0.681	0.321
clinical blood chemistry	albumin (plasma Alb)	0.77778	0.53231	1.1524	0.474	0.158
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-2.1895	2.2574	-0.91412	0.590	0.342
clinical blood chemistry	aspartate transaminase (plasma AST)	-26.820	24.216	-1.1754	0.600	0.280
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.063902	0.18350	0.22036	0.917	0.731
clinical blood chemistry	blood urea nitrogen (BUN)	3.4379	1.1994	1.3213	0.0782	0.00873
clinical blood chemistry	calcium (plasma Ca)	-0.30392	0.081367	-1.7157	0.0169	0.00108
clinical blood chemistry	carbon dioxide (plasma CO₂)	1.7575	0.58783	1.4563	0.0923	0.00654
clinical blood chemistry	chloride (plasma Cl)	-1.5611	0.47524	-1.4170	0.0216	0.00338
clinical blood chemistry	glucose (plasma GLU, no fast)	-51.003	11.645	-1.3765	0.00364	0.000239
clinical blood chemistry	HDL cholesterol (plasma HDL)	6.6778	2.7254	1.1929	0.167	0.0227
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.030444	0.0092999	-1.7670	0.0683	0.00334
clinical blood chemistry	iron (plasma Fe)	-0.0039869	0.0073415	-0.29029	0.798	0.592
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.073856	0.048325	-0.58212	0.398	0.140
clinical blood chemistry	phosphorus (plasma phosphate)	-0.91046	0.51129	-1.4002	0.300	0.0882
clinical blood chemistry	potassium (plasma K)	-0.12889	0.17598	-1.2980	0.635	0.471
clinical blood chemistry	sodium (plasma Na)	-0.60915	0.46727	-1.3676	0.314	0.205
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.00078013	0.0081461	-0.051120	0.981	0.925
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	12.293	3.5687	1.6240	0.0429	0.00231
clinical blood chemistry	total protein (plasma TP)	0.94771	0.71842	0.66200	0.482	0.200
clinical blood chemistry	triglyceride (plasma TG, no fast)	28.882	8.8221	1.5699	0.0540	0.00333
ECT	applied stimulus (current), by day, day 2	0.21940	0.23515	0.23153	0.641	0.356
ECT	applied stimulus (current), by day, day 3	0.39683	0.31335	0.78136	0.537	0.213
ECT	behavior following applied stimulus (current), by day, day 1	-1.0113	0.30473	-1.7244	0.0522	0.00177
ECT	behavior following applied stimulus (current), by day, day 3	0.29362	0.42853	0.56774	0.884	0.497
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.23651	0.19448	0.37970	0.524	0.230
EKG	duration of PQ interval	-0.87375	0.86150	-0.75783	0.829	0.318
EKG	duration of PR interval	-0.29875	0.92214	-0.20906	0.938	0.748
EKG	duration of QRS interval	1.1312	0.47117	2.4876	0.695	0.0223
EKG	duration of QT interval	2.2024	1.2002	1.9613	0.573	0.0758
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	2.4009	0.98790	2.2304	0.547	0.0209
EKG	duration of RR interval	0.077240	1.9446	0.27337	0.984	0.969
EKG	duration of ST interval	0.86588	1.1105	1.1140	0.854	0.441
EKG	heart rate coefficient of variation (signal intensity)	0.57580	1.8733	0.53646	0.968	0.761
EKG	heart rate variability, mean of differences between sequential beats; beats per min	3.7525	13.076	0.51104	0.965	0.776
EKG	heart rate, beats per min	1.5729	15.403	-0.15693	0.979	0.919
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.085199	0.12312	-0.82904	0.794	0.494
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.23849	0.13720	-1.4581	0.408	0.0921
EKG	number of signals	-6.5375	4.3897	-1.2475	0.667	0.146
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-5.5593	8.9004	-0.98490	0.884	0.537
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-2.7654	5.2411	-0.79598	0.964	0.601
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-5.2615	5.4408	-1.3356	0.895	0.341
EKG	root mean square of successive differences of neighboring RR intervals	2.4356	3.5517	1.2880	0.899	0.498
electroretinography	a-wave amplitude of rod photoreceptors, left	-0.89900	24.129	-0.50915	0.993	0.971
electroretinography	a-wave amplitude of rod photoreceptors, right	22.412	12.658	0.81222	0.526	0.107
electroretinography	b-wave amplitude of cone photoreceptors, left	-14.823	19.979	-1.0219	0.892	0.475
electroretinography	b-wave amplitude of cone photoreceptors, right	-7.0286	6.6983	-0.51473	0.725	0.319
electroretinography	b-wave amplitude of rod photoreceptors, left	-3.2900	60.949	0.29113	0.986	0.958
electroretinography	b-wave amplitude of rod photoreceptors, right	-49.659	25.935	-0.62690	0.431	0.0845
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	0.89919	1.3040	0.66293	0.827	0.506
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	0.55879	0.71169	0.42000	0.794	0.451
electroretinography	rod a wave implicit time, left	-0.0099816	1.6517	-0.41692	1.0	0.995
electroretinography	rod a wave implicit time, right	0.74487	0.83741	0.53243	0.725	0.395
electroretinography	rod b wave implicit time, left	0.70937	2.1061	0.075922	0.977	0.743
electroretinography	rod b wave implicit time, right	-0.70916	1.7502	-0.65422	0.943	0.694
glucose tolerance test	amount glucose injected	-1.1443	1.7585	0.014438	0.816	0.520
glucose tolerance test	plasma glucose, 0min	4.9983	5.1436	0.27381	0.566	0.339
glucose tolerance test	plasma glucose, 15min	6.2875	24.553	0.29239	0.935	0.800
glucose tolerance test	plasma glucose, 30min	18.200	21.650	0.66162	0.716	0.407
glucose tolerance test	plasma glucose, 60min	5.9025	18.749	0.38104	0.913	0.755
glucose tolerance test	plasma glucose, 120min	6.6375	11.409	0.30819	0.807	0.565
heart weight	heart weight, normalized to body weight	0.43165	0.15045	0.92963	0.0428	0.00606
heart weight	heart weight, weight	11.299	3.9071	1.0772	0.0471	0.00574
hematology	basophil differential (percent of total WBC)	-0.033791	0.044148	-0.50216	0.802	0.450
hematology	calculated hemoglobin (cHGB)	0.13421	0.11658	0.13250	0.540	0.259
hematology	eosinophil differential (percent of total WBC)	0.26815	0.23860	0.81388	0.651	0.270
hematology	hematocrit (HCT)	1.4541	0.44087	1.2287	0.0493	0.00251
hematology	hemoglobin concentration distribution width (HDW)	-0.017775	0.019521	-0.48608	0.675	0.370
hematology	large unstained cells (percent of total WBC)	-0.25724	0.095385	-1.5352	0.173	0.0114
hematology	lymphocyte differential (percent of total WBC)	-2.3106	0.61933	-0.99320	0.0233	0.000827
hematology	mean corpuscular hemoglobin (CHr)	-0.098061	0.054268	-0.78880	0.248	0.0808
hematology	mean platelet volume (MPV)	0.0036075	0.063922	-0.17026	0.978	0.955
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.035829	0.097926	-0.17066	0.879	0.717
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.30478	0.19010	-0.60803	0.447	0.119
hematology	mean RBC corpuscular volume (MCV)	0.44356	0.25514	0.78047	0.249	0.0924
hematology	measured hemoglobin (mHGB)	0.23512	0.14491	0.36851	0.387	0.115
hematology	monocyte differential (percent of total WBC)	0.17136	0.11929	0.76390	0.522	0.162
hematology	neutrophil differential (percent of total WBC)	2.1573	0.57304	1.0628	0.0213	0.000755
hematology	platelet count (PLT; units per volume x 10³)	-83.010	54.324	-1.0022	0.504	0.137
hematology	RBC corpuscular distribution width (RDW)	-0.18291	0.14913	-0.67492	0.494	0.230
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.51136	0.15295	-1.3139	0.0268	0.00223
hematology	red blood cell count (RBC; per volume x 10⁶)	0.23092	0.091359	0.65402	0.128	0.0170
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-22.362	12.832	-0.87336	0.436	0.0916
hematology	reticulocyte differential (percent of total RBC)	-0.27949	0.12352	-0.96543	0.284	0.0310
hematology	white blood cell count (WBC; units per volume x 10³)	-3.2673	0.62274	-1.8652	0.000560	0.0000116
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.18750	0.62362	0.24116	0.942	0.765
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.31250	0.48401	-0.36404	0.878	0.521
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.025000	0.42251	0.054886	0.978	0.953
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.5375	0.82302	-0.47751	0.857	0.517
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.40000	0.49815	0.74451	0.842	0.426
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.28750	0.35633	-0.78113	0.884	0.423
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.2	0.30756	0.54762	0.924	0.518
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.26250	0.36619	-0.33087	0.871	0.477
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.625	0.33111	1.1455	0.477	0.0647
holeboard	number of hole pokes by individual hole number, 20 min test, 10	7.7182e-17	0.28552	0.082973	1.0	1.0
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.27084	0.22265	-0.72850	0.797	0.229
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.40156	0.38889	0.74280	0.744	0.307
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.83750	0.79650	-0.73836	0.715	0.298
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.69622	0.38763	-1.0218	0.486	0.0784
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.425	0.36693	-0.58700	0.708	0.252
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.76250	0.72371	-0.63995	0.704	0.297
holeboard	total number of hole pokes, 20 min test	-2.375	3.2948	-0.22800	0.715	0.474
light / dark	fecal boli count, 20 min test	0.29442	0.74929	0.35189	0.914	0.696
light / dark	latency to enter dark zone, 20 min test	-11.585	28.952	-0.32754	0.908	0.691
light / dark	number of transitions between light and dark zones, 20 min test	13.438	6.9425	1.2983	0.296	0.0584
light / dark	percentage of total time in dark zone, 20 min test	-7.9674	4.3438	-1.3078	0.385	0.0723
light / dark	percentage of total time in light zone, 20 min test	7.9674	4.3438	1.3046	0.382	0.0723
light / dark	time mobile in dark zone, 20 min test	18.721	10.823	0.91069	0.327	0.0896
light / dark	time mobile in light zone, 20 min test	39.699	11.273	1.6754	0.0149	0.000902
light / dark	time spent in dark zone, 20 min test	-76.309	50.441	-0.92304	0.555	0.136
light / dark	time spent in light zone, 20 min test	76.309	50.441	0.92304	0.555	0.136
open field	average speed in center of arena, 20 min test	0.65773	0.44693	1.0116	0.480	0.154
open field	average speed in periphery of arena, 20 min test	0.31333	0.13308	0.67913	0.111	0.0271
open field	distance traveled habituation ratio, 20 min test	27.041	10.957	1.9218	0.174	0.0208
open field	distance traveled in center of arena, 20 min test	-49.009	77.648	-0.68421	0.738	0.534
open field	distance traveled in periphery of arena, 20 min test	455.16	148.02	1.2304	0.0445	0.00519
open field	distance traveled slope, 20 min test	22.200	10.642	1.7740	0.268	0.0478
open field	distance traveled, 20 min test, 1st 5min	-62.536	61.317	-0.83285	0.560	0.318
open field	distance traveled, 20 min test, 2nd 5min	163.60	50.300	1.2191	0.0333	0.00327
open field	distance traveled, 20 min test, 3rd 5min	156.22	56.369	1.1671	0.0687	0.0106
open field	distance traveled, 20 min test, 4th 5min	153.11	71.907	1.1487	0.180	0.0437
open field	number of clockwise revolution episodes, 20 min test	-0.35909	1.1864	-0.62390	0.917	0.765
open field	number of counter-clockwise revolution episodes, 20 min test	2.9844	1.2290	1.1282	0.169	0.0230
open field	number of fecal boli, 20 min test	0.59397	1.2213	0.68609	0.838	0.631
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-3.2455	3.7155	-1.0809	0.646	0.391
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	4.0864	2.5735	0.72378	0.380	0.125
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	1.9727	2.9574	0.15570	0.745	0.511
open field	number of rears in 5 min bins, 20 min test, 4th 5min	6.4928	3.8709	1.0958	0.345	0.106
open field	percentage of total time in center of arena, 20 min test	-5.9182	3.3146	-1.6572	0.365	0.0863
open field	percentage of total time in center of arena, slope, 20 min test	-0.51441	2.4678	-0.18157	0.958	0.837
open field	percentage of total time in center, habituation ratio, 20 min test	0.15255	2.5798	0.19798	0.985	0.953
open field	percentage of total time in corners of arena, 20 min test	6.2627	5.0095	1.4100	0.538	0.223
open field	percentage of total time in corners, habituation ratio, 20 min test	-3.8781	2.7349	-1.9756	0.650	0.169
open field	percentage of total time in corners, slope, 20 min test	-4.1939	2.7670	-2.1296	0.629	0.143
open field	permanence time in center of arena, 20 min test	-71.02	39.779	-1.6572	0.365	0.0863
open field	permanence time in corners of arena, 20 min test	75.121	60.112	1.4100	0.538	0.223
open field	permanence time in periphery of arena, 20 min test	70.968	39.779	1.6572	0.364	0.0866
open field	total distance traveled, 20 min test	397.04	159.45	0.62271	0.0893	0.0201
open field	total number of rears, 20 min test	10.8	10.183	0.39031	0.553	0.299
open field	whole arena average speed, 20 min test	0.32958	0.13276	0.61458	0.0908	0.0204
open field	whole arena resting time, 20 min test	-42.504	17.685	-0.62434	0.0988	0.0243
open field	whole arena time spent mobile, 20 min test	42.422	17.657	0.86950	0.100	0.0244
open field	whole arena time spent vertical, 20 min test	26.259	10.644	1.7244	0.168	0.0208
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	3.8625	8.3052	0.50593	0.918	0.644
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	0.8925	2.5810	0.46049	0.940	0.731
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	3.3625	8.6203	0.58946	0.900	0.698
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	7.95	12.572	0.79516	0.861	0.530
sleep	differential wake percentages during light and dark phase	-0.092049	0.37397	0.25756	0.937	0.806
sleep	mean breath rate during-sleep	-0.0028724	0.056338	0.15344	0.987	0.959
sleep	mean of sleep bout lengths	-30.785	18.903	-0.47590	0.419	0.108
sleep	mean of sleep bout lengths with lights off	6.4176	14.533	0.58139	0.865	0.660
sleep	mean of sleep bout lengths with lights on	-40.416	27.039	-0.60570	0.517	0.139
sleep	mean percentage of time sleeping over 24 h periods	-0.47596	0.92244	-0.49885	0.904	0.607
sleep	mean percentage of time sleeping with lights on	-2.4518	1.1688	-1.0523	0.334	0.0395
sleep	mean percentage of time spent sleeping with lights off	2.2373	1.3052	0.65542	0.445	0.0909
sleep	peak wake with respect to dark onset median	0.20429	0.51890	0.33207	0.932	0.695
sleep	percentage of time awake one hour before and after light onset	0.85445	3.6945	0.64284	0.941	0.818
sleep	sleep data confidence level (<0.6=questionable; 1=good quality)	0.014059	0.012769	1.3754	0.845	0.275
startle / PPI	average baseline movement during background noise	3.7556	1.0093	1.8863	0.188	0.000883
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.13023	0.074427	-1.2624	0.402	0.0911
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.15630	0.080771	-1.6047	0.339	0.0631
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-17.663	9.3947	-1.7949	0.798	0.0705
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-6.4105	7.6221	-0.65396	0.729	0.407
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-13.689	7.7227	-1.3980	0.327	0.0876
startle / PPI	average startle response to full pulse (120 dB)	-50.987	29.806	-0.70515	0.280	0.0986
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-38.853	27.416	-0.54818	0.384	0.168
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-36.943	27.834	-0.55634	0.408	0.196
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-10.591	19.615	-0.068007	0.755	0.594
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	4.3067	1.1647	2.0179	0.187	0.000939
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	1.8707	1.2178	0.99731	0.630	0.136
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	3.1524	1.0908	1.0967	0.186	0.00736
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.20611	0.10822	-1.7043	0.764	0.0672
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.083122	0.091346	-0.76492	0.688	0.371
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.11956	0.092596	-1.0989	0.463	0.208
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-56.677	30.285	-0.79809	0.222	0.0722
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-42.561	27.185	-0.59604	0.329	0.129
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-39.312	27.537	-0.60443	0.369	0.165
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-13.809	19.782	-0.13987	0.684	0.491
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.16058	0.10572	-1.2686	0.804	0.140
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.070549	0.094692	-0.61072	0.751	0.462
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.10169	0.085045	-0.92144	0.506	0.242
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-251.01	109.96	-1.0089	0.135	0.0305
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-158.60	80.247	-0.63328	0.195	0.0584
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-157.32	76.086	-0.65050	0.172	0.0484
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-43.144	53.074	-0.076436	0.628	0.423
startle / PPI	maximum baseline movement during background noise	13.574	3.1362	2.3454	0.0846	0.000185
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-15.479	9.9882	-1.4055	0.828	0.132
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-5.8113	8.6530	-0.58603	0.784	0.507
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-11.865	7.5229	-1.1439	0.389	0.126
startle / PPI	maximum startle response to full pulse (120 dB)	-234.64	110.56	-0.94346	0.167	0.0431
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-147.82	82.295	-0.58271	0.252	0.0837
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-148.60	80.070	-0.60780	0.226	0.0744
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-28.245	55.796	0.013311	0.763	0.617
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	7.7301	3.1324	1.6925	0.430	0.0202
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	4.5453	2.6098	1.0916	0.582	0.0926
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	9.9711	2.2283	1.3071	0.0149	0.000116
urinalysis	albumin-creatinine ratio (urine ACR)	-1.0708	1.2574	-1.0053	0.603	0.398
urinalysis	creatinine (urine CREA)	-10.459	4.2559	-1.3973	0.127	0.0174
urinalysis	glucose (urine GLU)	-6.6092	2.2429	-1.8924	0.114	0.00483
urinalysis	magnesium level (urine Mg)	-0.079000	0.023291	-1.3517	0.0291	0.00133
urinalysis	microalbumin (urine MA), calculated	-0.19035	0.10964	-1.0907	0.350	0.0887

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	6.0 %	0.326
eye morphology	cornea opacity	3.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.0
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	1.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	12.0 %	0.0975
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	24.0 %	0.0197
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.00
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	16.0 %	0.210
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	12.0 %	0.109
eye morphology	pupil shape	12.0 %	0.0459
eye morphology	retina	5.0 %	0.442
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.0
eye morphology	retinal pigmentation	20.0 %	0.0367
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	11.0 %	0.106
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Pla2g2d^{tm1.1(KOMP)Vlcg} -/- with genotype: