MPD: JaxKOMP-EAP genotype: Slc8b1<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Slc8b1^em1(IMPC)J -/- Gene Slc8b1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-3.9884	1.6074	-1.2848	0.277	0.0232
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-0.63878	3.1979	-0.13002	0.956	0.844
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-3.5390	3.1799	-0.90612	0.636	0.280
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	3.0000	3.8173	0.37677	0.757	0.442
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	1.6249e-14	2.2093	-0.030847	1.00	1.00
body composition	body length	0.032502	0.033965	0.66290	0.635	0.342
body composition	body weight (at time of DXA)	-0.44936	0.42612	-0.25307	0.517	0.295
body composition	bone area, whole body scan, head excluded	0.12099	0.089842	0.70217	0.447	0.183
body composition	bone mineral content of whole body scan, head excluded	0.0021122	0.0056862	0.25673	0.869	0.711
body composition	bone mineral content to body weight ratio	-0.000019931	0.00029511	0.12043	0.978	0.946
body composition	bone mineral density of whole body scan, head excluded	-0.00027839	0.00038354	-0.26465	0.735	0.470
body composition	fat tissue mass of whole body scan, head excluded	-0.24957	0.14848	-0.46697	0.299	0.0974
body composition	fat tissue mass to body weight ratio	-0.013554	0.0067464	-0.59108	0.183	0.0485
body composition	lean tissue mass of whole body scan, head excluded	0.18078	0.16950	0.21741	0.591	0.290
body composition	lean tissue mass to body weight ratio	0.0039443	0.0067417	0.15843	0.779	0.560
body composition	percent fat, whole body scan, head excluded	-1.1956	0.64902	-0.55249	0.233	0.0697
body composition	ratio of soft-tissue attenuation coefficients	0.0012369	0.00073434	0.50659	0.280	0.0966
body composition	tissue area	0.26898	0.11864	1.0022	0.169	0.0266
body composition	total tissue mass, whole body scan, head excluded	-0.10476	0.14758	-0.46849	0.704	0.480
clinical blood chemistry	alanine transaminase (plasma ALT)	-8.2266	25.504	-0.70914	0.926	0.751
clinical blood chemistry	albumin (plasma Alb)	-0.097749	0.50251	-0.087086	0.949	0.848
clinical blood chemistry	alkaline phosphatase (plasma ALP)	6.1555	4.5026	0.57835	0.433	0.188
clinical blood chemistry	aspartate transaminase (plasma AST)	22.816	40.947	0.87565	0.828	0.584
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.038182	0.47446	0.13812	0.981	0.937
clinical blood chemistry	calcium (plasma Ca)	-0.22827	0.062052	-1.2729	0.0219	0.00172
clinical blood chemistry	carbon dioxide (plasma CO₂)	-3.4601	0.76852	-2.8923	0.0177	0.000276
clinical blood chemistry	chloride (plasma Cl)	0.055653	0.53493	-0.033492	0.951	0.918
clinical blood chemistry	glucose (plasma GLU, no fast)	-41.891	19.169	-1.1268	0.139	0.0416
clinical blood chemistry	HDL cholesterol (plasma HDL)	0.20263	2.7910	-0.27624	0.982	0.943
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.011694	0.013941	0.49088	0.718	0.412
clinical blood chemistry	iron (plasma Fe)	-0.11415	0.026511	-2.3417	0.0119	0.000479
clinical blood chemistry	phosphorus (plasma phosphate)	0.23067	0.35974	0.32708	0.774	0.529
clinical blood chemistry	potassium (plasma K)	0.30620	0.30635	0.20433	0.506	0.330
clinical blood chemistry	sodium (plasma Na)	0.29221	0.82261	-0.59990	0.812	0.726
clinical blood chemistry	total bilirubin (plasma TBIL)	0.030920	0.017112	1.6632	0.353	0.0875
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-1.6671	3.1205	-0.52750	0.835	0.599
clinical blood chemistry	total protein (plasma TP)	-3.0934	4.1230	-1.9494	0.703	0.463
clinical blood chemistry	triglyceride (plasma TG, no fast)	-3.5090	9.8257	0.024325	0.875	0.725
ECT	applied stimulus (current), by day, day 1	0.11589	0.14195	0.0	0.441	0.418
ECT	applied stimulus (current), by day, day 2	0.26239	0.16634	0.36072	0.408	0.122
ECT	applied stimulus (current), by day, day 3	0.13707	0.15236	0.11978	0.709	0.373
ECT	behavior following applied stimulus (current), by day, day 1	0.017685	0.13154	0.28577	0.977	0.894
ECT	behavior following applied stimulus (current), by day, day 3	-0.14109	0.25642	-0.56148	0.910	0.585
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.15360	0.14617	0.18380	0.597	0.299
EKG	duration of PQ interval	0.80125	0.54117	1.0046	0.713	0.143
EKG	duration of PR interval	0.89398	0.63843	1.0737	0.726	0.166
EKG	duration of QRS interval	0.077507	0.27547	0.080686	0.976	0.779
EKG	duration of QT interval	0.88088	0.86209	1.0012	0.778	0.310
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.1586	0.79224	1.2344	0.725	0.148
EKG	duration of RR interval	-0.61854	1.4271	-0.038294	0.879	0.666
EKG	duration of ST interval	0.75958	0.77107	0.98800	0.775	0.328
EKG	heart rate coefficient of variation (signal intensity)	0.70783	1.0913	0.66944	0.891	0.519
EKG	heart rate variability, mean of differences between sequential beats; beats per min	6.1317	7.7848	0.77949	0.883	0.434
EKG	heart rate, beats per min	4.7084	11.543	0.0070581	0.877	0.685
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.080802	0.082717	0.51724	0.694	0.332
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.10171	0.11307	0.49660	0.702	0.371
EKG	number of signals	5.7500	3.8497	1.0489	0.656	0.140
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-0.051291	5.4946	0.071271	0.997	0.993
EKG	QT dispersion, measured as inter-lead variability of QT intervals	4.4875	4.2692	1.2131	0.893	0.297
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	5.7217	4.6522	1.3406	0.863	0.223
EKG	root mean square of successive differences of neighboring RR intervals	2.6787	2.2773	1.3760	0.843	0.244
electroretinography	a-wave amplitude of rod photoreceptors, left	-0.83067	9.8381	-0.50118	0.987	0.934
electroretinography	a-wave amplitude of rod photoreceptors, right	8.7857	11.590	-0.055732	0.785	0.468
electroretinography	b-wave amplitude of cone photoreceptors, left	9.1506	10.537	0.71070	0.831	0.406
electroretinography	b-wave amplitude of cone photoreceptors, right	24.562	13.524	2.0608	0.485	0.0994
electroretinography	b-wave amplitude of rod photoreceptors, left	16.018	24.399	0.60994	0.795	0.526
electroretinography	b-wave amplitude of rod photoreceptors, right	44.187	48.229	1.3107	0.691	0.381
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	0.41461	0.82861	0.22747	0.899	0.628
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	0.89262	0.76719	0.79236	0.692	0.272
electroretinography	rod a wave implicit time, left	1.4001	0.49205	1.2331	0.236	0.0174
electroretinography	rod a wave implicit time, right	1.4139	0.49304	1.1868	0.234	0.0167
electroretinography	rod b wave implicit time, left	4.0833	1.1860	1.6270	0.155	0.00630
electroretinography	rod b wave implicit time, right	3.2500	1.1733	1.3448	0.301	0.0198
FACS	spleen weight	-0.0074000	0.0025733	-0.75354	0.519	0.103
glucose tolerance test	amount glucose injected	-1.2830	2.4813	-0.024065	0.867	0.607
glucose tolerance test	plasma glucose, 0min	10.618	4.2698	0.84397	0.0786	0.0162
glucose tolerance test	plasma glucose, 15min	-68.517	25.334	-1.7022	0.108	0.00927
glucose tolerance test	plasma glucose, 30min	-26.132	27.149	-0.68747	0.659	0.340
glucose tolerance test	plasma glucose, 60min	-27.108	14.503	-1.0222	0.306	0.0673
glucose tolerance test	plasma glucose, 120min	-22.196	8.5670	-1.5809	0.142	0.0125
grip strength	body weight (at time of grip strength test)	-0.011469	0.47387	0.20598	0.989	0.981
grip strength	forelimb and hindlimb grip strength (mean of trials), average	7.4436	7.3322	0.78739	0.532	0.317
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.26477	0.43096	0.57302	0.721	0.543
grip strength	forelimb and hindlimb grip strength by trial, trial1	8.1052	9.7754	0.79135	0.694	0.413
grip strength	forelimb and hindlimb grip strength by trial, trial2	-3.0741	8.3021	0.037768	0.864	0.713
grip strength	forelimb and hindlimb grip strength by trial, trial3	16.061	9.2280	1.2139	0.304	0.0908
grip strength	forelimb grip strength (mean of trials), average	-2.5110	3.9584	-0.056669	0.759	0.530
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.18181	0.21760	-0.23300	0.672	0.409
grip strength	forelimb grip strength by trial, trial1	-2.1354	5.7058	0.017428	0.880	0.711
grip strength	forelimb grip strength by trial, trial2	-1.4564	5.5588	0.063944	0.929	0.795
grip strength	forelimb grip strength by trial, trial3	-4.6125	5.6892	-0.25395	0.728	0.423
heart weight	heart weight, normalized to body weight	0.40883	0.17144	0.86496	0.0962	0.0199
heart weight	heart weight, weight	7.6104	3.6656	0.62238	0.171	0.0418
hematology	basophil differential (percent of total WBC)	-0.016703	0.027780	-0.24400	0.846	0.550
hematology	calculated hemoglobin (cHGB)	0.081876	0.22610	-0.041731	0.866	0.718
hematology	eosinophil differential (percent of total WBC)	0.82418	0.32576	1.8728	0.214	0.0139
hematology	hematocrit (HCT)	0.20363	0.75136	-0.15783	0.893	0.787
hematology	hemoglobin concentration distribution width (HDW)	0.017675	0.015433	0.47633	0.566	0.256
hematology	large unstained cells (percent of total WBC)	-0.024022	0.071825	-0.14380	0.890	0.739
hematology	lymphocyte differential (percent of total WBC)	-2.4657	0.96759	-1.0508	0.108	0.0132
hematology	mean corpuscular hemoglobin (CHr)	0.047017	0.060314	0.40108	0.675	0.439
hematology	mean platelet volume (MPV)	-0.10447	0.087800	-0.83850	0.458	0.238
hematology	mean RBC corpuscular hemoglobin (MCH)	0.011703	0.24931	0.016549	0.983	0.963
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.043260	0.54692	-0.093278	0.976	0.937
hematology	mean RBC corpuscular volume (MCV)	0.0083143	0.23500	0.028706	0.988	0.972
hematology	measured hemoglobin (mHGB)	0.10100	0.33074	0.0075213	0.891	0.761
hematology	monocyte differential (percent of total WBC)	0.072759	0.18930	0.45535	0.895	0.702
hematology	neutrophil differential (percent of total WBC)	1.6157	0.79372	0.82192	0.200	0.0459
hematology	platelet count (PLT; units per volume x 10³)	-42.305	36.984	-0.52471	0.626	0.257
hematology	RBC corpuscular distribution width (RDW)	-0.063824	0.096473	-0.22598	0.726	0.511
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.073465	0.18459	0.17319	0.854	0.692
hematology	red blood cell count (RBC; per volume x 10⁶)	0.043689	0.16775	-0.15800	0.907	0.795
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-8.1857	12.578	-0.27040	0.818	0.518
hematology	reticulocyte differential (percent of total RBC)	-0.11316	0.12252	-0.27194	0.705	0.359
hematology	white blood cell count (WBC; units per volume x 10³)	-1.3269	0.68329	-0.73494	0.179	0.0565
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.4367	0.60126	-1.3775	0.376	0.0211
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.15054	0.41794	-0.10909	0.944	0.720
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.61003	0.46513	-0.95005	0.718	0.196
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.13816	0.78070	-0.046436	0.958	0.860
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.56053	0.48872	-0.80141	0.764	0.257
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.017715	0.21824	0.10308	0.994	0.936
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.0026316	0.27442	-0.034657	1.00	0.992
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.12408	0.41191	-0.11758	0.960	0.765
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.33947	0.31031	-0.53061	0.758	0.280
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.076316	0.20474	0.27401	0.951	0.711
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.43370	0.34142	1.0382	0.767	0.210
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.11455	0.43105	0.31554	0.953	0.792
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.94161	0.59608	-0.84210	0.509	0.121
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.11572	0.38164	0.27150	0.931	0.763
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.59724	0.59513	0.99934	0.760	0.321
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-1.2024	0.86766	-1.0162	0.588	0.172
holeboard	total number of hole pokes, 20 min test	-4.3371	3.7916	-0.54151	0.555	0.259
insulin blood level	insulin (plasma)	-330.17	163.02	-1.0973	0.524	0.0447
light / dark	fecal boli count, 20 min test	1.2123	0.57406	1.2890	0.379	0.0383
light / dark	latency to enter dark zone, 20 min test	121.29	39.393	1.8182	0.129	0.00298
light / dark	number of transitions between light and dark zones, 20 min test	-14.184	5.6764	-1.3239	0.141	0.0148
light / dark	percentage of total time in dark zone, 20 min test	6.0615	2.9150	1.2496	0.315	0.0413
light / dark	percentage of total time in light zone, 20 min test	-6.0615	2.9150	-1.2556	0.311	0.0413
light / dark	time mobile in dark zone, 20 min test	-12.778	10.135	-0.88040	0.509	0.212
light / dark	time mobile in light zone, 20 min test	-13.704	8.0835	-1.2292	0.298	0.0945
light / dark	time spent in dark zone, 20 min test	-31.305	42.442	-0.25838	0.810	0.463
light / dark	time spent in light zone, 20 min test	31.305	42.442	0.25838	0.810	0.463
open field	average speed in center of arena, 20 min test	-0.21567	0.27442	-0.45790	0.749	0.435
open field	average speed in periphery of arena, 20 min test	-0.10029	0.11578	-0.91345	0.609	0.389
open field	distance traveled habituation ratio, 20 min test	-7.8735	7.1167	-0.68591	0.600	0.272
open field	distance traveled in center of arena, 20 min test	60.355	60.284	0.036930	0.579	0.320
open field	distance traveled in periphery of arena, 20 min test	-149.65	115.76	-1.0343	0.428	0.200
open field	distance traveled slope, 20 min test	-8.6817	6.8117	-0.76092	0.528	0.207
open field	distance traveled, 20 min test, 1st 5min	19.371	57.787	-0.17612	0.880	0.738
open field	distance traveled, 20 min test, 2nd 5min	-0.75976	41.140	-0.50616	0.993	0.985
open field	distance traveled, 20 min test, 3rd 5min	-48.204	39.833	-0.99604	0.468	0.230
open field	distance traveled, 20 min test, 4th 5min	-51.438	48.486	-1.0528	0.540	0.292
open field	number of clockwise revolution episodes, 20 min test	-0.10833	0.90665	-0.47539	0.971	0.905
open field	number of counter-clockwise revolution episodes, 20 min test	-0.33333	1.0993	-0.60327	0.889	0.763
open field	number of fecal boli, 20 min test	-0.15833	0.73468	0.15602	0.926	0.830
open field	number of rears in 5 min bins, 20 min test, 1st 5min	0.34047	2.0083	-0.12526	0.943	0.866
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	1.8716	1.6751	0.12451	0.558	0.268
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	0.66901	1.7553	-0.16794	0.853	0.704
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-0.25137	1.8454	-0.40776	0.947	0.892
open field	percentage of total time in center of arena, 20 min test	1.6911	2.1742	0.19935	0.734	0.439
open field	percentage of total time in center of arena, slope, 20 min test	-0.74069	0.99464	-0.28789	0.840	0.459
open field	percentage of total time in center, habituation ratio, 20 min test	-0.40877	1.0191	-0.10154	0.911	0.690
open field	percentage of total time in corners of arena, 20 min test	-2.6387	3.7238	-0.16658	0.750	0.481
open field	percentage of total time in corners, habituation ratio, 20 min test	1.3085	1.4721	0.30191	0.839	0.377
open field	percentage of total time in corners, slope, 20 min test	1.9446	1.3962	0.61620	0.647	0.168
open field	permanence time in center of arena, 20 min test	20.294	26.092	0.19935	0.734	0.439
open field	permanence time in corners of arena, 20 min test	-31.656	44.685	-0.16658	0.750	0.481
open field	permanence time in periphery of arena, 20 min test	-20.251	26.089	-0.19661	0.734	0.440
open field	total distance traveled, 20 min test	-80.670	144.97	-0.73253	0.764	0.580
open field	total number of rears, 20 min test	2.5109	5.4592	-0.15570	0.819	0.647
open field	whole arena average speed, 20 min test	-0.067917	0.12091	-0.73077	0.760	0.576
open field	whole arena resting time, 20 min test	12.268	15.007	0.89326	0.616	0.416
open field	whole arena time spent mobile, 20 min test	-12.288	15.002	-1.0788	0.625	0.416
open field	whole arena time spent vertical, 20 min test	5.7621	6.1284	0.34863	0.656	0.350
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	5.1114	9.7487	0.68297	0.918	0.602
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-0.21718	3.0388	0.17610	0.985	0.943
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	12.422	8.0643	1.3432	0.478	0.128
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	4.5985	12.393	0.56294	0.900	0.712
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	0.83424	1.4987	0.53338	0.816	0.582
sleep	differential wake percentages during light and dark phase	1.0646	0.56754	1.6984	0.468	0.0704
sleep	mean breath rate during-sleep	-0.042363	0.067926	-0.25756	0.775	0.538
sleep	mean of sleep bout lengths	13.410	30.443	0.80163	0.886	0.663
sleep	mean of sleep bout lengths with lights off	-16.532	17.510	-0.29993	0.691	0.353
sleep	mean of sleep bout lengths with lights on	95.189	58.057	1.7918	0.497	0.112
sleep	mean percentage of time sleeping over 24 h periods	0.97594	1.8220	0.58139	0.904	0.596
sleep	mean percentage of time sleeping with lights on	3.6624	1.5036	1.7918	0.234	0.0210
sleep	mean percentage of time spent sleeping with lights off	-1.7528	2.8189	-0.98382	0.875	0.539
sleep	peak wake with respect to dark onset median	0.21408	0.62367	0.35368	0.932	0.734
sleep	percentage of time awake one hour before and after light onset	0.057166	5.9451	0.48734	0.999	0.992
startle / PPI	average baseline movement during background noise	-1.3288	1.0847	-0.90270	0.745	0.229
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.078950	0.10424	0.62986	0.763	0.454
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.067231	0.094063	0.59680	0.784	0.480
startle / PPI	average of maximum percent pre-pulse inhibition for each pre-pulse tested	7.4926	9.7179	0.79936	0.794	0.446
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	2.5022	10.638	0.32140	0.982	0.815
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	7.0804	8.4762	0.66092	0.731	0.409
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	10.559	9.6275	0.95004	0.579	0.280
startle / PPI	average startle response to full pulse (120 dB)	42.868	24.312	1.0206	0.261	0.0868
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	44.761	25.189	1.0066	0.251	0.0845
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	26.069	20.113	0.74340	0.417	0.204
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	17.519	21.215	0.61117	0.619	0.415
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.90971	1.4209	0.67317	0.890	0.526
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.2887	1.1837	-0.89640	0.803	0.284
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.25902	1.3275	-0.046955	0.965	0.846
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.049509	0.11659	0.51430	0.929	0.674
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.066865	0.092999	0.47686	0.753	0.477
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.10246	0.10456	0.61241	0.599	0.334
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	44.026	24.157	1.0445	0.233	0.0772
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	43.278	25.007	0.98131	0.268	0.0926
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	26.888	19.925	0.75639	0.394	0.186
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	16.980	20.992	0.60949	0.629	0.424
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.064577	0.13133	0.59939	0.930	0.626
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.069449	0.094354	0.46482	0.752	0.467
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.11967	0.12282	0.69398	0.601	0.337
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	178.59	89.776	1.0916	0.190	0.0548
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	192.60	96.243	1.0941	0.182	0.0534
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	115.32	77.140	0.82143	0.344	0.144
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	80.881	85.565	0.70336	0.562	0.351
startle / PPI	maximum baseline movement during background noise	-2.6451	1.8638	-0.72323	0.668	0.165
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	4.2877	12.130	0.45287	0.958	0.726
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	7.2565	8.9129	0.56618	0.740	0.421
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	12.039	11.367	0.96333	0.585	0.297
startle / PPI	maximum startle response to full pulse (120 dB)	176.05	90.094	1.0690	0.201	0.0590
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	195.74	96.476	1.1070	0.173	0.0504
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	114.35	77.257	0.80582	0.346	0.148
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	82.967	85.884	0.70875	0.557	0.341
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	1.7423	2.3986	0.60443	0.841	0.473
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-2.3329	2.1863	-0.65744	0.765	0.293
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	1.9198	2.5711	0.18673	0.799	0.461
urinalysis	albumin-creatinine ratio (urine ACR)	-0.16348	2.4479	-0.69789	0.962	0.947
urinalysis	creatinine (urine CREA)	1.2653	3.1352	0.82549	0.824	0.688
urinalysis	glucose (urine GLU)	1.8259	2.0585	0.46371	0.713	0.378
urinalysis	magnesium level (urine Mg)	0.073915	0.021896	1.3724	0.0291	0.00125
urinalysis	microalbumin (urine MA), calculated	0.022548	0.15973	-0.18598	0.964	0.888

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.00
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	5.0 %	0.292
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	5.0 %	0.435
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	6.0 %	0.258
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	3.0 %	0.790
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	5.0 %	0.461
eye morphology	pupil shape	5.0 %	0.342
eye morphology	retina	7.0 %	0.801
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.00
eye morphology	retinal pigmentation	13.0 %	1.0
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	6.0 %	0.0959
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	23.0 %	0.000326
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	70.0 %	1.27e-12
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	1.0 %	1.0
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	5.0 %	0.202
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Slc8b1^em1(IMPC)J -/- with genotype: