MPD: JaxKOMP-EAP genotype: Srcin1<sup>tm1.1(KOMP)Vlcg</sup> -/+

JaxKOMP-EAP effect sizes: Srcin1^{tm1.1(KOMP)Vlcg} -/+ Gene Srcin1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-2.1468	3.1764	-0.46625	0.844	0.511
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-7.7242	4.4385	-1.6353	0.455	0.105
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	0.45488	1.7568	-0.055622	0.929	0.799
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	8.1301	3.1254	1.2286	0.223	0.0220
body composition	body length	0.021397	0.037138	0.50013	0.794	0.566
body composition	body weight (at time of DXA)	0.57953	0.43313	0.56572	0.393	0.185
body composition	bone area, whole body scan, head excluded	0.31398	0.11676	1.5028	0.0733	0.00900
body composition	bone mineral content of whole body scan, head excluded	0.021646	0.0079321	1.3551	0.0728	0.00808
body composition	bone mineral content to body weight ratio	0.00088955	0.00035750	1.3055	0.101	0.0153
body composition	bone mineral density of whole body scan, head excluded	0.00069367	0.00034613	0.78831	0.229	0.0491
body composition	fat tissue mass of whole body scan, head excluded	-0.56855	0.21741	-1.0853	0.0897	0.0109
body composition	fat tissue mass to body weight ratio	-0.023532	0.0085860	-1.0515	0.0627	0.00783
body composition	lean tissue mass of whole body scan, head excluded	0.25431	0.21649	0.38179	0.542	0.244
body composition	lean tissue mass to body weight ratio	0.010965	0.0084087	0.52675	0.448	0.197
body composition	percent fat, whole body scan, head excluded	-2.1140	0.83340	-1.0234	0.0891	0.0135
body composition	ratio of soft-tissue attenuation coefficients	0.0023793	0.00092672	1.0454	0.0851	0.0124
body composition	tissue area	-0.54761	0.12667	-1.4897	0.00325	0.0000515
body composition	total tissue mass, whole body scan, head excluded	-0.34852	0.15154	-1.0977	0.130	0.0245
ECT	applied stimulus (current), by day, day 2	0.13720	0.13747	0.0	0.615	0.323
ECT	applied stimulus (current), by day, day 3	-0.052188	0.18326	-0.56502	0.944	0.777
ECT	behavior following applied stimulus (current), by day, day 1	-0.37053	0.23119	-0.66227	0.382	0.115
ECT	behavior following applied stimulus (current), by day, day 3	0.25284	0.24399	0.45820	0.807	0.306
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	-0.11410	0.13823	-0.72112	0.691	0.413
EKG	duration of PQ interval	0.44627	0.62945	0.61252	0.889	0.481
EKG	duration of PR interval	0.022436	0.69098	0.10295	0.993	0.974
EKG	duration of QRS interval	-0.43884	0.31419	-1.3210	0.885	0.167
EKG	duration of QT interval	-0.37694	0.71204	-0.18030	0.902	0.598
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.37177	0.60383	0.45891	0.925	0.540
EKG	duration of RR interval	-2.5890	1.2638	-1.1140	0.369	0.0443
EKG	duration of ST interval	0.0084052	0.62387	0.21730	0.997	0.989
EKG	heart rate coefficient of variation (signal intensity)	0.60065	1.1292	0.57170	0.924	0.596
EKG	heart rate variability, mean of differences between sequential beats; beats per min	6.6128	8.4552	0.84392	0.883	0.437
EKG	heart rate, beats per min	24.267	10.810	1.2426	0.295	0.0280
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.25735	0.082828	1.7767	0.0935	0.00274
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.35599	0.098839	1.8386	0.0463	0.000597
EKG	number of signals	2.9067	5.0600	0.53181	0.883	0.568
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-4.4614	3.8018	-0.78608	0.814	0.245
EKG	QT dispersion, measured as inter-lead variability of QT intervals	2.6910	4.1850	0.79875	0.955	0.522
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	3.1489	5.0817	0.82678	0.932	0.538
EKG	root mean square of successive differences of neighboring RR intervals	2.9553	2.2082	1.4470	0.843	0.185
electroretinography	a-wave amplitude of rod photoreceptors, left	5.6812	12.096	-0.21582	0.877	0.645
electroretinography	a-wave amplitude of rod photoreceptors, right	5.3511	7.1631	-0.28947	0.785	0.467
electroretinography	b-wave amplitude of cone photoreceptors, left	-8.7686	8.1602	-0.69248	0.809	0.301
electroretinography	b-wave amplitude of cone photoreceptors, right	-0.60062	5.6045	0.10581	0.981	0.916
electroretinography	b-wave amplitude of rod photoreceptors, left	-13.556	33.204	0.084120	0.877	0.689
electroretinography	b-wave amplitude of rod photoreceptors, right	1.0538	26.102	0.43329	0.984	0.968
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	0.97290	0.47612	0.76802	0.443	0.0603
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	1.0855	0.59470	1.0134	0.436	0.0894
electroretinography	rod a wave implicit time, left	0.56250	0.71083	0.35975	0.778	0.441
electroretinography	rod a wave implicit time, right	1.1250	0.64952	0.96536	0.439	0.104
electroretinography	rod b wave implicit time, left	1.3125	1.2269	0.40445	0.779	0.302
electroretinography	rod b wave implicit time, right	1.4375	1.2418	0.53354	0.758	0.265
FACS	spleen weight	0.0058059	0.023467	0.41698	0.937	0.846
glucose tolerance test	amount glucose injected	-4.9203	2.0836	-1.0119	0.214	0.0216
glucose tolerance test	plasma glucose, 0min	5.2198	4.0476	0.29382	0.408	0.202
glucose tolerance test	plasma glucose, 15min	2.9505	24.416	0.18919	0.964	0.904
glucose tolerance test	plasma glucose, 30min	-30.160	21.585	-0.82068	0.505	0.168
glucose tolerance test	plasma glucose, 60min	2.5525	12.660	0.23694	0.934	0.841
glucose tolerance test	plasma glucose, 120min	-8.5839	7.2079	-0.71911	0.551	0.239
grip strength	body weight (at time of grip strength test)	0.75515	0.72411	0.90886	0.493	0.303
grip strength	forelimb and hindlimb grip strength (mean of trials), average	12.852	7.2015	1.2018	0.228	0.0821
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.37037	0.39925	0.74263	0.566	0.359
grip strength	forelimb and hindlimb grip strength by trial, trial1	-4.3413	9.0124	-0.068310	0.846	0.633
grip strength	forelimb and hindlimb grip strength by trial, trial2	22.831	9.5963	1.6409	0.128	0.0223
grip strength	forelimb and hindlimb grip strength by trial, trial3	18.149	10.247	1.3313	0.292	0.0844
grip strength	forelimb grip strength (mean of trials), average	3.0745	4.0430	0.69191	0.697	0.452
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.022483	0.20816	0.30226	0.969	0.915
grip strength	forelimb grip strength by trial, trial1	3.1426	5.8558	0.61460	0.829	0.594
grip strength	forelimb grip strength by trial, trial2	6.0902	5.4387	0.91245	0.591	0.269
grip strength	forelimb grip strength by trial, trial3	6.4254	5.7327	0.89498	0.586	0.269
heart weight	heart weight, normalized to body weight	0.77706	0.13309	1.6924	0.0000215	1.62e-7
heart weight	heart weight, weight	19.068	3.3593	1.7582	0.0000596	3.21e-7
hematology	basophil differential (percent of total WBC)	0.082572	0.069816	1.1431	0.684	0.241
hematology	calculated hemoglobin (cHGB)	-0.19149	0.16459	-0.83766	0.531	0.249
hematology	eosinophil differential (percent of total WBC)	0.52363	0.43034	1.4299	0.618	0.228
hematology	hematocrit (HCT)	-0.75281	0.52843	-1.0320	0.440	0.159
hematology	hemoglobin concentration distribution width (HDW)	0.018663	0.021588	0.50377	0.691	0.390
hematology	large unstained cells (percent of total WBC)	0.40922	0.13394	1.9852	0.0798	0.00321
hematology	lymphocyte differential (percent of total WBC)	-7.3859	2.1274	-2.2751	0.0242	0.000903
hematology	mean corpuscular hemoglobin (CHr)	-0.00064904	0.062453	0.021432	0.997	0.992
hematology	mean platelet volume (MPV)	-0.20748	0.057195	-1.2471	0.00679	0.000554
hematology	mean RBC corpuscular hemoglobin (MCH)	0.047879	0.094637	0.15654	0.839	0.615
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.19946	0.16650	0.45946	0.602	0.235
hematology	mean RBC corpuscular volume (MCV)	-0.093197	0.32048	-0.17030	0.897	0.772
hematology	measured hemoglobin (mHGB)	-0.15655	0.18755	-0.62259	0.681	0.407
hematology	monocyte differential (percent of total WBC)	0.38844	0.22258	1.3376	0.405	0.0855
hematology	neutrophil differential (percent of total WBC)	6.1961	1.9515	1.9972	0.0397	0.00225
hematology	platelet count (PLT; units per volume x 10³)	-109.65	43.019	-1.2674	0.164	0.0131
hematology	RBC corpuscular distribution width (RDW)	0.15738	0.24145	0.51608	0.729	0.517
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.049303	0.13057	0.12215	0.860	0.707
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.14553	0.13647	-0.92741	0.561	0.290
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-11.357	13.081	-0.40574	0.745	0.388
hematology	reticulocyte differential (percent of total RBC)	-0.040988	0.13251	0.048655	0.905	0.758
hematology	white blood cell count (WBC; units per volume x 10³)	-1.1144	0.67203	-0.60160	0.256	0.102
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.056054	0.72394	0.10060	0.979	0.939
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.37138	0.51979	0.71151	0.868	0.477
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.13596	0.49750	0.32197	0.949	0.785
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.21903	0.64224	0.29365	0.917	0.734
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.077080	0.34259	-0.016036	0.965	0.823
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.61144	0.30125	1.3397	0.554	0.0462
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.75922	0.43441	1.6458	0.716	0.0849
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.44800	0.38325	0.89830	0.757	0.246
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.30426	0.39769	0.64509	0.859	0.447
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.35943	0.35312	0.94869	0.837	0.312
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.74719	0.60912	1.5839	0.789	0.224
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.080583	0.54858	0.24187	0.971	0.884
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.52520	0.60057	-0.42580	0.750	0.385
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.30391	0.38925	0.57901	0.814	0.438
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.059109	0.49321	0.0050605	0.973	0.905
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.68999	0.96550	0.62757	0.812	0.477
holeboard	total number of hole pokes, 20 min test	4.7379	4.5747	0.73173	0.592	0.304
light / dark	fecal boli count, 20 min test	-1.3805	0.62603	-1.4973	0.355	0.0307
light / dark	latency to enter dark zone, 20 min test	27.060	26.737	0.40711	0.716	0.315
light / dark	number of transitions between light and dark zones, 20 min test	-4.0925	6.0154	-0.31615	0.759	0.499
light / dark	percentage of total time in dark zone, 20 min test	0.20189	2.8787	0.16296	0.985	0.944
light / dark	percentage of total time in light zone, 20 min test	-0.20189	2.8787	-0.16981	0.985	0.944
light / dark	time mobile in dark zone, 20 min test	20.633	10.591	0.99366	0.253	0.0554
light / dark	time mobile in light zone, 20 min test	9.4952	9.8747	0.37065	0.606	0.340
light / dark	time spent in dark zone, 20 min test	-18.776	36.755	-0.074429	0.877	0.611
light / dark	time spent in light zone, 20 min test	18.776	36.755	0.074429	0.877	0.611
open field	average speed in center of arena, 20 min test	-0.098970	0.31864	-0.28229	0.914	0.757
open field	average speed in periphery of arena, 20 min test	0.036622	0.10948	-0.39031	0.857	0.739
open field	distance traveled habituation ratio, 20 min test	0.55360	8.3562	0.075930	0.975	0.947
open field	distance traveled in center of arena, 20 min test	91.452	75.509	0.24753	0.485	0.230
open field	distance traveled in periphery of arena, 20 min test	-23.918	104.80	-0.54469	0.913	0.820
open field	distance traveled slope, 20 min test	1.1347	8.0241	0.18977	0.975	0.888
open field	distance traveled, 20 min test, 1st 5min	30.123	67.328	-0.089402	0.842	0.656
open field	distance traveled, 20 min test, 2nd 5min	-15.600	44.628	-0.68591	0.860	0.728
open field	distance traveled, 20 min test, 3rd 5min	12.921	43.952	-0.26557	0.900	0.770
open field	distance traveled, 20 min test, 4th 5min	27.901	41.662	-0.12993	0.732	0.505
open field	number of clockwise revolution episodes, 20 min test	0.55668	1.0010	-0.068563	0.831	0.580
open field	number of counter-clockwise revolution episodes, 20 min test	-0.61333	1.0193	-0.74842	0.765	0.549
open field	number of fecal boli, 20 min test	-0.12025	0.89937	0.18298	0.961	0.894
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-1.1460	2.2914	-0.52409	0.817	0.619
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-2.7764	2.3938	-1.0343	0.546	0.250
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-2.6840	2.0644	-0.92781	0.473	0.198
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-4.6804	2.3848	-1.3310	0.248	0.0537
open field	percentage of total time in center of arena, 20 min test	2.5019	2.3084	0.36723	0.600	0.282
open field	percentage of total time in center of arena, slope, 20 min test	-0.32149	1.3438	-0.057091	0.957	0.812
open field	percentage of total time in center, habituation ratio, 20 min test	-0.28972	1.4175	-0.038273	0.960	0.839
open field	percentage of total time in corners of arena, 20 min test	2.5746	3.7625	0.76271	0.760	0.496
open field	percentage of total time in corners, habituation ratio, 20 min test	0.91747	1.8457	0.13805	0.921	0.621
open field	percentage of total time in corners, slope, 20 min test	1.3205	1.8273	0.33297	0.873	0.472
open field	permanence time in center of arena, 20 min test	30.037	27.700	0.36723	0.601	0.282
open field	permanence time in corners of arena, 20 min test	30.902	45.151	0.76451	0.760	0.496
open field	permanence time in periphery of arena, 20 min test	-30.032	27.704	-0.36580	0.600	0.282
open field	total distance traveled, 20 min test	67.535	144.96	-0.29349	0.803	0.643
open field	total number of rears, 20 min test	-10.459	7.4148	-1.0861	0.393	0.163
open field	whole arena average speed, 20 min test	0.055397	0.12103	-0.29629	0.807	0.649
open field	whole arena resting time, 20 min test	-5.3042	15.300	0.43122	0.840	0.730
open field	whole arena time spent mobile, 20 min test	5.2234	15.277	-0.30754	0.849	0.733
open field	whole arena time spent vertical, 20 min test	-14.472	7.7696	-1.2106	0.299	0.0667
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-17.353	10.038	-1.2019	0.632	0.0883
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-5.3862	3.1384	-1.2112	0.631	0.0906
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	8.8919	6.8641	1.0574	0.543	0.199
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	2.7944	11.692	0.47051	0.940	0.812
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	0.59028	1.9268	0.43234	0.919	0.761
startle / PPI	average baseline movement during background noise	0.94360	1.3467	0.67845	0.877	0.488
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.0068102	0.075803	-0.052567	0.968	0.929
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.021729	0.066379	-0.28652	0.900	0.745
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-9.3956	12.131	-0.98358	0.879	0.443
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.44647	6.4443	0.0049040	0.982	0.945
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	6.2157	4.4597	0.55634	0.457	0.171
startle / PPI	average startle response to full pulse (120 dB)	3.1296	15.122	0.28327	0.939	0.837
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.0752	16.559	0.35702	0.833	0.672
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-2.6198	13.734	0.12573	0.914	0.850
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-9.0058	9.9275	-0.030129	0.587	0.370
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.10045	0.86651	0.16396	0.982	0.908
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.55252	0.99096	0.39765	0.913	0.580
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.23331	1.2500	-0.065199	0.968	0.853
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.14284	0.15242	-1.2349	0.869	0.354
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.0087605	0.069225	-0.0077149	0.974	0.900
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.10372	0.063989	0.62088	0.327	0.113
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	1.2098	15.481	0.23833	0.971	0.938
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	6.4916	16.625	0.34065	0.856	0.698
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-3.9537	13.882	0.10317	0.871	0.777
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-9.7450	10.366	-0.031531	0.568	0.353
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.058742	0.18067	-0.51110	0.954	0.747
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.047484	0.077514	0.27541	0.790	0.544
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.10282	0.065962	0.57396	0.353	0.127
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	22.797	57.840	0.33471	0.863	0.696
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	27.248	61.344	0.32436	0.826	0.659
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-7.7112	50.414	0.14836	0.932	0.879
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-29.620	37.840	0.010509	0.636	0.438
startle / PPI	maximum baseline movement during background noise	3.6239	2.5251	1.0301	0.654	0.159
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-6.3435	14.996	-0.59939	0.950	0.675
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	3.4693	7.2317	0.21963	0.841	0.634
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	7.4937	5.0087	0.56948	0.407	0.143
startle / PPI	maximum startle response to full pulse (120 dB)	28.045	57.287	0.36300	0.825	0.627
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	28.862	61.316	0.33175	0.811	0.640
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-3.4751	50.174	0.15970	0.967	0.945
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-26.723	36.691	0.017515	0.665	0.471
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	0.48776	1.7546	0.27744	0.958	0.783
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	2.7963	2.1684	0.75453	0.708	0.205
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	1.7134	3.2610	0.14695	0.861	0.602
urinalysis	albumin-creatinine ratio (urine ACR)	2.7983	2.3382	0.26184	0.454	0.238
urinalysis	creatinine (urine CREA)	-7.5614	4.1400	-0.75867	0.240	0.0743
urinalysis	glucose (urine GLU)	-0.80296	2.4918	-0.32292	0.924	0.749
urinalysis	magnesium level (urine Mg)	0.042359	0.045201	0.82079	0.705	0.354
urinalysis	microalbumin (urine MA), calculated	-2.7808	4.2236	-2.7185	0.801	0.514

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.00
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.00
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	6.0 %	0.258
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	5.0 %	0.400
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	4.0 %	1.00
eye morphology	pupil shape	3.0 %	1.00
eye morphology	retina	13.0 %	1.0
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.00
eye morphology	retinal pigmentation	13.0 %	1.0
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	1.0 %	1.0
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Srcin1^{tm1.1(KOMP)Vlcg} -/+ with genotype: