MPD: JaxKOMP-EAP genotype: Lcn2<sup>tm1b(KOMP)Wtsi</sup> -/-

JaxKOMP-EAP effect sizes: Lcn2^{tm1b(KOMP)Wtsi} -/- Gene Lcn2

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-1.5001	1.8659	-0.72229	0.803	0.435
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	1.4062	1.8688	0.33564	0.827	0.464
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	12.152	2.3124	1.6141	0.00826	0.000122
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-1.7583	4.3372	-0.39344	0.884	0.692
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-8.3046	3.6459	-1.1682	0.300	0.0403
body composition	body length	-0.036471	0.036307	-0.22790	0.615	0.318
body composition	body weight (at time of DXA)	0.10406	0.62016	0.19013	0.946	0.867
body composition	bone area, whole body scan, head excluded	0.21858	0.11127	1.1385	0.222	0.0526
body composition	bone mineral content of whole body scan, head excluded	0.023326	0.0087546	1.4779	0.0786	0.00916
body composition	bone mineral content to body weight ratio	0.00078583	0.00038272	1.2293	0.187	0.0430
body composition	bone mineral density of whole body scan, head excluded	0.0013941	0.00046525	1.4536	0.0523	0.00354
body composition	fat tissue mass of whole body scan, head excluded	-1.0424	0.29149	-1.8209	0.0132	0.000567
body composition	fat tissue mass to body weight ratio	-0.037096	0.010376	-1.6990	0.0123	0.000568
body composition	lean tissue mass of whole body scan, head excluded	0.76276	0.25428	1.2803	0.0590	0.00350
body composition	lean tissue mass to body weight ratio	0.025876	0.0096912	1.2769	0.0861	0.00902
body composition	percent fat, whole body scan, head excluded	-3.4694	1.0023	-1.6385	0.0163	0.000827
body composition	ratio of soft-tissue attenuation coefficients	0.0038517	0.0011139	1.6480	0.0166	0.000837
body composition	tissue area	-0.32313	0.14135	-0.90940	0.163	0.0246
body composition	total tissue mass, whole body scan, head excluded	-0.27142	0.17801	-0.89171	0.346	0.131
clinical blood chemistry	alanine transaminase (plasma ALT)	-12.755	18.415	-1.0397	0.797	0.491
clinical blood chemistry	albumin (plasma Alb)	-1.1857	0.53180	-1.4718	0.208	0.0294
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-0.17753	3.8288	-0.55505	0.983	0.963
clinical blood chemistry	aspartate transaminase (plasma AST)	-13.566	17.266	-0.66032	0.729	0.435
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.077888	0.22075	-0.24222	0.917	0.725
clinical blood chemistry	blood urea nitrogen (BUN)	-1.2144	1.9167	-0.53876	0.748	0.529
clinical blood chemistry	calcium (plasma Ca)	-0.18585	0.082299	-1.0017	0.134	0.0275
clinical blood chemistry	carbon dioxide (plasma CO₂)	-0.55768	0.61994	-0.81194	0.643	0.372
clinical blood chemistry	chloride (plasma Cl)	0.29380	0.47455	0.20228	0.705	0.538
clinical blood chemistry	glucose (plasma GLU, no fast)	-113.39	18.415	-2.6530	0.0000191	6.70e-8
clinical blood chemistry	HDL cholesterol (plasma HDL)	-2.6120	3.1402	-0.88649	0.694	0.409
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.00076358	0.014895	-0.21443	0.993	0.959
clinical blood chemistry	iron (plasma Fe)	-0.096569	0.018677	-2.2134	0.000294	0.00000282
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	0.047064	0.061332	0.43813	0.680	0.446
clinical blood chemistry	phosphorus (plasma phosphate)	0.22765	0.36465	0.32408	0.774	0.535
clinical blood chemistry	potassium (plasma K)	0.024019	0.11553	-0.87614	0.869	0.836
clinical blood chemistry	sodium (plasma Na)	1.7439	0.46386	0.66404	0.00231	0.000384
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0029565	0.0064812	-0.23055	0.864	0.650
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-2.7785	5.2916	-0.72859	0.835	0.601
clinical blood chemistry	total protein (plasma TP)	5.9706	2.7176	2.2584	0.198	0.0318
clinical blood chemistry	triglyceride (plasma TG, no fast)	-12.544	6.4527	-0.47032	0.247	0.0567
EKG	duration of PQ interval	0.58417	0.76956	0.75783	0.889	0.450
EKG	duration of PR interval	0.71967	0.79208	0.84105	0.877	0.367
EKG	duration of QRS interval	-0.051304	0.37986	-0.28595	0.990	0.893
EKG	duration of QT interval	-0.53464	0.95609	-0.35382	0.898	0.578
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.059501	0.85796	-0.028213	0.999	0.945
EKG	duration of RR interval	-2.3112	1.3628	-0.92126	0.479	0.0944
EKG	duration of ST interval	-0.44183	0.78078	-0.23177	0.891	0.573
EKG	heart rate coefficient of variation (signal intensity)	-1.0118	1.1137	-0.76861	0.867	0.367
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-6.3658	7.9421	-0.66189	0.883	0.426
EKG	heart rate, beats per min	19.095	11.224	0.91764	0.460	0.0933
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.30959	0.081180	2.1626	0.0330	0.000292
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.40575	0.099597	2.0683	0.0136	0.000120
EKG	number of signals	10.654	4.6517	1.6464	0.409	0.0250
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-5.0482	4.9983	-0.91772	0.839	0.316
EKG	QT dispersion, measured as inter-lead variability of QT intervals	4.4534	3.5012	1.2089	0.870	0.208
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	5.5959	3.8861	1.2834	0.856	0.154
EKG	root mean square of successive differences of neighboring RR intervals	-1.3124	2.0885	-0.62472	0.901	0.532
electroretinography	a-wave amplitude of rod photoreceptors, left	10.446	11.011	0.024577	0.773	0.374
electroretinography	a-wave amplitude of rod photoreceptors, right	17.338	10.941	0.50058	0.559	0.152
electroretinography	b-wave amplitude of cone photoreceptors, left	2.5038	14.081	0.22988	0.995	0.863
electroretinography	b-wave amplitude of cone photoreceptors, right	-6.9175	10.502	-0.49872	0.928	0.529
electroretinography	b-wave amplitude of rod photoreceptors, left	-37.887	36.638	-0.31312	0.679	0.331
electroretinography	b-wave amplitude of rod photoreceptors, right	-36.900	24.608	-0.31312	0.517	0.172
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	1.3750	0.61661	1.1557	0.443	0.0563
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	2.3750	0.55120	1.8094	0.107	0.00258
electroretinography	rod a wave implicit time, left	-0.42917	1.1099	-0.88785	0.925	0.710
electroretinography	rod a wave implicit time, right	0.24038	0.94694	-0.17551	0.938	0.807
electroretinography	rod b wave implicit time, left	-0.53585	1.9466	-0.71822	0.977	0.791
electroretinography	rod b wave implicit time, right	-0.40539	1.6823	-0.50872	0.979	0.816
glucose tolerance test	amount glucose injected	-2.5659	2.2010	-0.38688	0.639	0.249
glucose tolerance test	plasma glucose, 0min	12.318	4.8461	0.99257	0.0718	0.0143
glucose tolerance test	plasma glucose, 15min	20.135	28.295	0.68921	0.770	0.480
glucose tolerance test	plasma glucose, 30min	5.2271	24.181	0.29526	0.930	0.830
glucose tolerance test	plasma glucose, 60min	15.917	13.993	0.74423	0.592	0.261
glucose tolerance test	plasma glucose, 120min	-4.0165	12.105	-0.41372	0.909	0.741
grip strength	body weight (at time of grip strength test)	1.2021	0.56045	1.2614	0.121	0.0384
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-1.7289	7.0116	0.12230	0.898	0.807
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.012482	0.36558	0.21662	0.984	0.973
grip strength	forelimb and hindlimb grip strength by trial, trial1	-11.369	9.7745	-0.54754	0.551	0.252
grip strength	forelimb and hindlimb grip strength by trial, trial2	7.9555	8.8680	0.76190	0.623	0.375
grip strength	forelimb and hindlimb grip strength by trial, trial3	-2.0938	9.7762	0.077047	0.932	0.832
grip strength	forelimb grip strength (mean of trials), average	4.1438	5.4639	0.80735	0.698	0.453
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.22736	0.25715	0.83173	0.650	0.382
grip strength	forelimb grip strength by trial, trial1	-4.5084	7.0601	-0.26446	0.802	0.527
grip strength	forelimb grip strength by trial, trial2	3.5786	6.5786	0.63579	0.839	0.590
grip strength	forelimb grip strength by trial, trial3	15.797	6.3956	1.7856	0.158	0.0181
heart weight	heart weight, normalized to body weight	0.70691	0.15421	1.5382	0.000811	0.0000171
heart weight	heart weight, weight	19.632	4.0940	1.8474	0.000609	0.00000777
hematology	basophil differential (percent of total WBC)	0.0047134	0.039491	0.10176	0.982	0.906
hematology	calculated hemoglobin (cHGB)	-0.025604	0.16720	-0.36797	0.952	0.879
hematology	eosinophil differential (percent of total WBC)	-0.21062	0.28122	-0.52111	0.802	0.460
hematology	hematocrit (HCT)	-0.74616	0.60574	-1.0297	0.525	0.228
hematology	hemoglobin concentration distribution width (HDW)	0.065310	0.029133	1.6322	0.224	0.0328
hematology	large unstained cells (percent of total WBC)	0.31200	0.10221	1.7405	0.111	0.00482
hematology	lymphocyte differential (percent of total WBC)	-4.6733	2.9850	-1.6539	0.368	0.128
hematology	mean corpuscular hemoglobin (CHr)	-0.040883	0.070857	-0.33304	0.773	0.569
hematology	mean platelet volume (MPV)	0.10825	0.077075	0.53087	0.370	0.171
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.067238	0.14114	-0.28332	0.849	0.637
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.52365	0.36596	1.0121	0.512	0.163
hematology	mean RBC corpuscular volume (MCV)	-0.61388	0.31291	-1.0532	0.191	0.0594
hematology	measured hemoglobin (mHGB)	-0.13478	0.22416	-0.57031	0.771	0.552
hematology	monocyte differential (percent of total WBC)	0.15220	0.15256	0.70834	0.671	0.327
hematology	neutrophil differential (percent of total WBC)	4.4423	2.9309	1.7281	0.374	0.140
hematology	platelet count (PLT; units per volume x 10³)	111.33	48.252	1.4226	0.252	0.0284
hematology	RBC corpuscular distribution width (RDW)	0.41579	0.19216	1.2720	0.190	0.0389
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.39982	0.20423	0.98141	0.214	0.0600
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.064541	0.11739	-0.61883	0.783	0.587
hematology	reticulocyte count (Retic; units per volume x 10⁹)	14.303	16.281	0.68531	0.745	0.387
hematology	reticulocyte differential (percent of total RBC)	0.18053	0.17335	0.91196	0.676	0.306
hematology	white blood cell count (WBC; units per volume x 10³)	1.1480	0.71035	0.92606	0.278	0.117
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.58146	0.62296	-0.52731	0.754	0.353
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.18988	0.35290	-0.16191	0.890	0.592
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.47500	0.35747	-0.72023	0.714	0.187
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.1956	0.64812	-1.1234	0.485	0.0684
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.39754	0.37730	-0.55270	0.769	0.295
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.43156	0.21432	-1.2104	0.554	0.0470
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.053339	0.26141	-0.17413	0.983	0.839
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.44758	0.37376	-0.64563	0.754	0.234
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.41250	0.33885	-0.63886	0.696	0.227
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.12975	0.25342	-0.29691	0.935	0.610
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.0099626	0.22918	0.035479	0.991	0.965
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.057411	0.39183	0.011808	0.971	0.884
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.9000	0.76887	-1.8208	0.353	0.0153
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.85387	0.31035	-1.2877	0.261	0.00719
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.069593	0.38355	0.19006	0.958	0.856
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.66555	0.56897	-0.53177	0.663	0.245
holeboard	total number of hole pokes, 20 min test	-8.0213	3.1377	-1.0744	0.121	0.0123
light / dark	fecal boli count, 20 min test	-0.73750	0.56557	-0.79402	0.598	0.196
light / dark	latency to enter dark zone, 20 min test	2.3239	29.424	-0.069007	0.978	0.937
light / dark	number of transitions between light and dark zones, 20 min test	5.5616	6.5682	0.60400	0.695	0.399
light / dark	percentage of total time in dark zone, 20 min test	-15.513	4.3114	-2.1966	0.0334	0.000524
light / dark	percentage of total time in light zone, 20 min test	15.513	4.3114	2.1818	0.0323	0.000524
light / dark	time mobile in dark zone, 20 min test	-10.336	10.316	-0.75748	0.612	0.319
light / dark	time mobile in light zone, 20 min test	29.146	9.0957	1.2675	0.0265	0.00187
light / dark	time spent in dark zone, 20 min test	-160.54	50.084	-1.8700	0.0832	0.00187
light / dark	time spent in light zone, 20 min test	160.54	50.084	1.8700	0.0832	0.00187
open field	average speed in center of arena, 20 min test	0.73290	0.36598	1.1257	0.298	0.0493
open field	average speed in periphery of arena, 20 min test	0.19277	0.14301	0.24614	0.386	0.182
open field	distance traveled habituation ratio, 20 min test	6.1988	8.0695	0.52455	0.732	0.445
open field	distance traveled in center of arena, 20 min test	72.434	78.060	0.12045	0.613	0.357
open field	distance traveled in periphery of arena, 20 min test	198.00	139.92	0.35148	0.373	0.162
open field	distance traveled slope, 20 min test	6.2599	7.7576	0.58087	0.712	0.423
open field	distance traveled, 20 min test, 1st 5min	6.9283	80.657	-0.28649	0.971	0.932
open field	distance traveled, 20 min test, 2nd 5min	90.412	52.474	0.51533	0.269	0.0895
open field	distance traveled, 20 min test, 3rd 5min	111.93	41.742	0.74842	0.0635	0.00922
open field	distance traveled, 20 min test, 4th 5min	64.348	42.414	0.25584	0.340	0.134
open field	number of clockwise revolution episodes, 20 min test	1.2720	1.0488	0.34240	0.586	0.229
open field	number of counter-clockwise revolution episodes, 20 min test	1.6457	1.0668	0.46387	0.389	0.128
open field	number of fecal boli, 20 min test	-0.019293	1.0030	0.26265	0.996	0.985
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-1.8806	2.8500	-0.70258	0.742	0.512
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	1.7654	2.2065	0.094795	0.696	0.426
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	0.93868	2.2947	-0.10694	0.843	0.684
open field	number of rears in 5 min bins, 20 min test, 4th 5min	1.7923	2.8837	0.062471	0.755	0.536
open field	percentage of total time in center of arena, 20 min test	0.99559	2.4177	0.034243	0.881	0.682
open field	percentage of total time in center of arena, slope, 20 min test	-3.2575	1.6599	-1.5328	0.445	0.0539
open field	percentage of total time in center, habituation ratio, 20 min test	-3.5297	1.7527	-1.5639	0.437	0.0481
open field	percentage of total time in corners of arena, 20 min test	1.1199	3.3540	0.50463	0.896	0.740
open field	percentage of total time in corners, habituation ratio, 20 min test	4.1977	2.1277	1.5156	0.460	0.0526
open field	percentage of total time in corners, slope, 20 min test	3.8602	2.0389	1.4396	0.499	0.0626
open field	permanence time in center of arena, 20 min test	11.947	29.013	0.035586	0.882	0.682
open field	permanence time in corners of arena, 20 min test	13.427	40.248	0.50463	0.897	0.740
open field	permanence time in periphery of arena, 20 min test	-11.995	29.009	-0.035586	0.881	0.681
open field	total distance traveled, 20 min test	292.36	184.55	0.35577	0.291	0.118
open field	total number of rears, 20 min test	1.6224	8.2382	-0.21856	0.933	0.844
open field	whole arena average speed, 20 min test	0.24173	0.15387	0.34863	0.295	0.121
open field	whole arena resting time, 20 min test	-26.297	18.559	-0.19935	0.340	0.161
open field	whole arena time spent mobile, 20 min test	26.263	18.536	0.44748	0.344	0.161
open field	whole arena time spent vertical, 20 min test	-6.2389	9.9623	-0.63252	0.786	0.533
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-13.098	8.6024	-0.84547	0.653	0.131
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-3.2928	2.6066	-0.63827	0.757	0.210
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	1.1925	6.9220	0.41109	0.961	0.864
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	2.0000	10.751	0.43073	0.952	0.853
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	3.8835	1.5561	1.7243	0.142	0.0159
sleep	differential wake percentages during light and dark phase	0.48200	0.23760	1.0347	0.409	0.0484
sleep	mean breath rate during-sleep	-0.11024	0.054606	-0.78766	0.213	0.0495
sleep	mean of sleep bout lengths	-4.0451	27.802	0.28929	0.972	0.885
sleep	mean of sleep bout lengths with lights off	-25.419	21.902	-0.68090	0.616	0.252
sleep	mean of sleep bout lengths with lights on	52.279	39.296	1.2956	0.575	0.190
sleep	mean percentage of time sleeping over 24 h periods	-0.59869	1.0779	-0.59350	0.904	0.581
sleep	mean percentage of time sleeping with lights on	-0.43868	1.2087	-0.12258	0.929	0.718
sleep	mean percentage of time spent sleeping with lights off	-0.88675	1.8730	-0.73324	0.920	0.638
sleep	peak wake with respect to dark onset median	-0.33950	0.95708	-0.39742	0.932	0.724
sleep	percentage of time awake one hour before and after light onset	1.8932	4.0710	0.73324	0.839	0.644
startle / PPI	average baseline movement during background noise	-0.20582	1.9114	-0.070816	0.995	0.915
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.10837	0.067022	0.88598	0.442	0.115
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.12880	0.061137	1.1514	0.291	0.0422
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	12.610	8.7486	1.5378	0.843	0.158
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	13.421	5.4991	1.3339	0.246	0.0197
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	9.9940	5.1166	0.90481	0.272	0.0584
startle / PPI	average startle response to full pulse (120 dB)	-8.6233	17.455	-0.00070057	0.822	0.624
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-28.022	19.375	-0.38404	0.369	0.157
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-27.218	14.971	-0.38555	0.231	0.0774
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-13.194	15.077	-0.13280	0.600	0.387
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.031152	0.95690	0.059583	0.994	0.974
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.19276	1.0662	0.14553	0.974	0.858
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.1006	1.5010	-0.74895	0.807	0.468
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.10626	0.099149	1.0325	0.869	0.291
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.15179	0.059617	1.1762	0.195	0.0153
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.12780	0.061559	0.79768	0.194	0.0451
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-8.4175	18.057	0.0021017	0.837	0.644
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-27.991	19.688	-0.37651	0.375	0.164
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-27.411	15.092	-0.37500	0.233	0.0777
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-12.094	15.491	-0.098941	0.645	0.440
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.053218	0.10766	0.48888	0.930	0.624
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.15113	0.067724	1.0912	0.255	0.0320
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.13473	0.062986	0.78617	0.184	0.0393
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-122.12	66.092	-0.44512	0.230	0.0726
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-147.98	67.897	-0.58770	0.139	0.0359
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-154.60	54.632	-0.63842	0.0497	0.00757
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-83.314	52.055	-0.33916	0.294	0.118
startle / PPI	maximum baseline movement during background noise	-2.2058	4.6378	-0.59939	0.918	0.637
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.6870	9.8026	0.60780	0.938	0.565
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	13.854	6.4971	1.1996	0.306	0.0399
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	10.837	5.6881	0.86542	0.273	0.0648
startle / PPI	maximum startle response to full pulse (120 dB)	-122.75	65.381	-0.44203	0.220	0.0684
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-144.68	67.949	-0.56783	0.149	0.0401
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-155.92	55.051	-0.65050	0.0488	0.00752
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-88.802	51.372	-0.38555	0.259	0.0922
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-0.97123	2.1825	-0.20387	0.925	0.659
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	0.22321	2.7293	0.089090	0.996	0.935
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-4.2208	3.0046	-1.0640	0.539	0.169
urinalysis	albumin-creatinine ratio (urine ACR)	5.3891	2.3930	1.0759	0.122	0.0277
urinalysis	creatinine (urine CREA)	0.43293	3.3036	0.67449	0.957	0.896
urinalysis	glucose (urine GLU)	3.4250	2.0005	0.89623	0.414	0.0903
urinalysis	magnesium level (urine Mg)	-0.026314	0.020136	-0.62890	0.521	0.195
urinalysis	microalbumin (urine MA), calculated	0.48168	0.11545	1.4601	0.00684	0.0000900

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	6.0 %	0.0613
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	5.0 %	0.344
eye morphology	cornea opacity	4.0 %	0.428
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	6.0 %	0.179
eye morphology	iris pigmentation	6.0 %	0.142
eye morphology	iris transillumination	6.0 %	0.116
eye morphology	irispupil	6.0 %	0.171
eye morphology	lacrimation	6.0 %	0.248
eye morphology	lens	22.0 %	0.0200
eye morphology	lens opacity	6.0 %	0.357
eye morphology	narrow eye opening	6.0 %	0.144
eye morphology	optic disc	5.0 %	0.241
eye morphology	persistence of hyaloid vascular system	9.0 %	0.163
eye morphology	pupil dilation	6.0 %	0.162
eye morphology	pupil light response	6.0 %	0.236
eye morphology	pupil position	6.0 %	0.186
eye morphology	pupil shape	6.0 %	0.185
eye morphology	retina	6.0 %	0.330
eye morphology	retinal blood vessels	5.0 %	0.196
eye morphology	retinal blood vessels pattern	5.0 %	0.279
eye morphology	retinal blood vessels structure	5.0 %	0.215
eye morphology	retinal pigmentation	7.0 %	0.387
eye morphology	retinal structure	5.0 %	0.223
eye morphology	synechia	5.0 %	0.200
eye morphology	vitreous	5.0 %	0.189
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	1.0 %	1.0
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Lcn2^{tm1b(KOMP)Wtsi} -/- with genotype: