MPD: JaxKOMP-EAP genotype: Ipp<sup>tm1.1(KOMP)Vlcg</sup> -/-

JaxKOMP-EAP effect sizes: Ipp^{tm1.1(KOMP)Vlcg} -/- Gene Ipp

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.3239	2.6471	0.13292	0.896	0.651
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	0.27010	3.1595	0.071618	0.976	0.937
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-1.5000	3.7771	-0.51384	0.902	0.718
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	2.6250	3.1157	0.31402	0.770	0.461
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-4.5270	3.7894	-0.71012	0.678	0.318
body composition	body length	-0.0053492	0.034807	0.11771	0.958	0.878
body composition	body weight (at time of DXA)	-0.14303	0.47531	-0.018422	0.881	0.764
body composition	bone area, whole body scan, head excluded	0.080391	0.085145	0.52879	0.608	0.347
body composition	bone mineral content of whole body scan, head excluded	0.0011170	0.0058127	0.20067	0.939	0.848
body composition	bone mineral content to body weight ratio	0.000087721	0.00030427	0.28080	0.900	0.774
body composition	bone mineral density of whole body scan, head excluded	-0.00055509	0.00038701	-0.60042	0.432	0.154
body composition	fat tissue mass of whole body scan, head excluded	-0.26738	0.17523	-0.50693	0.347	0.130
body composition	fat tissue mass to body weight ratio	-0.013967	0.0071867	-0.61235	0.197	0.0543
body composition	lean tissue mass of whole body scan, head excluded	0.11188	0.16526	0.083378	0.759	0.500
body composition	lean tissue mass to body weight ratio	0.011948	0.0070449	0.58576	0.295	0.0925
body composition	percent fat, whole body scan, head excluded	-1.3642	0.68059	-0.62558	0.183	0.0473
body composition	ratio of soft-tissue attenuation coefficients	0.0015158	0.00075659	0.63382	0.185	0.0474
body composition	tissue area	-0.080128	0.11280	-0.094446	0.761	0.479
body composition	total tissue mass, whole body scan, head excluded	-0.11721	0.14797	-0.50383	0.675	0.430
clinical blood chemistry	alanine transaminase (plasma ALT)	30.351	11.911	1.4964	0.206	0.0130
clinical blood chemistry	albumin (plasma Alb)	1.0935	0.50924	1.5716	0.229	0.0351
clinical blood chemistry	alkaline phosphatase (plasma ALP)	26.320	7.9394	2.4397	0.0208	0.00145
clinical blood chemistry	aspartate transaminase (plasma AST)	68.548	34.501	1.8729	0.296	0.0507
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.30876	0.42280	-0.95242	0.810	0.468
clinical blood chemistry	carbon dioxide (plasma CO₂)	-0.36136	0.78206	-0.64323	0.841	0.645
clinical blood chemistry	chloride (plasma Cl)	-2.0280	0.50845	-1.7498	0.00245	0.000160
clinical blood chemistry	HDL cholesterol (plasma HDL)	7.1718	2.0411	1.2877	0.0228	0.000773
clinical blood chemistry	potassium (plasma K)	0.45207	0.25549	0.73103	0.198	0.0811
clinical blood chemistry	sodium (plasma Na)	-0.78833	0.59239	-1.5468	0.294	0.187
clinical blood chemistry	total bilirubin (plasma TBIL)	0.030870	0.012439	1.6576	0.151	0.0154
ECT	applied stimulus (current), by day, day 2	0.16004	0.24714	0.041200	0.773	0.520
ECT	applied stimulus (current), by day, day 3	0.064398	0.24243	-0.15344	0.944	0.791
ECT	applied stimulus (current), by day, day 4	-1.5812	0.73376	-1.3779	0.348	0.0681
ECT	behavior following applied stimulus (current), by day, day 1	0.14068	0.26985	0.60093	0.846	0.604
ECT	behavior following applied stimulus (current), by day, day 3	0.56693	0.31649	1.3580	0.655	0.0782
ECT	behavior following applied stimulus (current), by day, day 4	-0.55102	0.56827	-0.80460	0.674	0.361
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	-0.019035	0.22260	-0.42500	0.971	0.932
EKG	duration of PQ interval	-0.43494	0.60328	-0.32394	0.889	0.472
EKG	duration of PR interval	0.25895	0.64898	0.33458	0.938	0.691
EKG	duration of QRS interval	0.15445	0.28466	0.29015	0.949	0.588
EKG	duration of QT interval	1.6828	0.82046	1.6310	0.508	0.0425
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.1694	0.70224	1.2563	0.687	0.0986
EKG	duration of RR interval	2.7222	1.6296	1.5940	0.480	0.0975
EKG	duration of ST interval	1.4747	0.76169	1.6868	0.513	0.0553
EKG	heart rate coefficient of variation (signal intensity)	0.45612	0.97934	0.45443	0.927	0.642
EKG	heart rate variability, mean of differences between sequential beats; beats per min	2.3785	6.7305	0.34739	0.950	0.724
EKG	heart rate, beats per min	-22.412	12.002	-1.6008	0.384	0.0644
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.16477	0.085269	-1.4020	0.331	0.0557
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.18100	0.11438	-1.1248	0.458	0.116
EKG	number of signals	-5.5821	3.7955	-1.0666	0.667	0.144
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	4.5785	5.0370	0.91462	0.846	0.365
EKG	QT dispersion, measured as inter-lead variability of QT intervals	3.3458	4.1153	0.94619	0.939	0.418
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	3.7965	4.4830	0.99790	0.914	0.399
EKG	root mean square of successive differences of neighboring RR intervals	3.0616	2.4190	1.5069	0.843	0.208
electroretinography	a-wave amplitude of rod photoreceptors, left	-15.616	12.936	-1.3259	0.682	0.253
electroretinography	a-wave amplitude of rod photoreceptors, right	5.6464	9.7255	-0.26775	0.837	0.573
electroretinography	b-wave amplitude of cone photoreceptors, left	-0.72590	4.8461	-0.064134	0.995	0.884
electroretinography	b-wave amplitude of cone photoreceptors, right	-9.2228	5.0981	-0.64820	0.485	0.0978
electroretinography	b-wave amplitude of rod photoreceptors, left	14.968	37.392	0.59316	0.880	0.697
electroretinography	b-wave amplitude of rod photoreceptors, right	-43.616	31.221	-0.49569	0.538	0.190
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	1.0278	0.70400	0.82904	0.536	0.172
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	0.55948	0.88740	0.42804	0.839	0.541
electroretinography	rod a wave implicit time, left	0.29268	0.74420	-0.026508	0.924	0.702
electroretinography	rod a wave implicit time, right	0.75610	0.76716	0.60543	0.725	0.346
electroretinography	rod b wave implicit time, left	1.2927	1.4654	0.38882	0.846	0.397
electroretinography	rod b wave implicit time, right	0.85366	1.5586	0.20735	0.897	0.595
glucose tolerance test	amount glucose injected	-2.5272	2.0522	-0.37800	0.606	0.222
glucose tolerance test	plasma glucose, 0min	1.0293	4.0692	-0.12801	0.904	0.801
glucose tolerance test	plasma glucose, 15min	56.677	22.069	1.5620	0.122	0.0120
glucose tolerance test	plasma glucose, 30min	39.072	23.806	1.2710	0.405	0.105
glucose tolerance test	plasma glucose, 60min	27.510	14.245	1.2060	0.279	0.0569
glucose tolerance test	plasma glucose, 120min	15.750	10.988	0.92307	0.464	0.155
grip strength	body weight (at time of grip strength test)	0.13511	0.54223	0.32475	0.889	0.804
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-9.0487	4.7337	-0.40589	0.182	0.0606
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.29176	0.30069	-0.21959	0.548	0.336
grip strength	forelimb and hindlimb grip strength by trial, trial1	-16.663	8.1018	-0.85035	0.211	0.0439
grip strength	forelimb and hindlimb grip strength by trial, trial2	-10.832	6.7334	-0.44244	0.318	0.113
grip strength	forelimb and hindlimb grip strength by trial, trial3	1.3755	7.3264	0.30074	0.936	0.852
grip strength	forelimb grip strength (mean of trials), average	0.20995	3.5003	0.30378	0.986	0.952
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.15087	0.21481	0.63047	0.742	0.485
grip strength	forelimb grip strength by trial, trial1	-1.6408	5.1292	0.090163	0.904	0.750
grip strength	forelimb grip strength by trial, trial2	3.5559	4.8461	0.62870	0.768	0.466
grip strength	forelimb grip strength by trial, trial3	-2.5714	4.2888	-0.018881	0.790	0.551
heart weight	heart weight, normalized to body weight	0.65575	0.18551	1.4633	0.00922	0.000587
heart weight	heart weight, weight	16.099	4.2946	1.5081	0.00596	0.000280
hematology	basophil differential (percent of total WBC)	-0.10156	0.030428	-1.2929	0.0967	0.00132
hematology	calculated hemoglobin (cHGB)	-0.0032752	0.21207	-0.28543	0.993	0.988
hematology	eosinophil differential (percent of total WBC)	-0.17276	0.24228	-0.42174	0.814	0.478
hematology	hematocrit (HCT)	0.99940	0.65878	0.78418	0.408	0.134
hematology	hemoglobin concentration distribution width (HDW)	-0.042656	0.015165	-1.1682	0.0828	0.00628
hematology	large unstained cells (percent of total WBC)	-0.060746	0.066327	-0.40231	0.689	0.363
hematology	lymphocyte differential (percent of total WBC)	0.18341	0.82677	0.034176	0.925	0.825
hematology	mean corpuscular hemoglobin (CHr)	-0.033612	0.052301	-0.26507	0.744	0.522
hematology	mean platelet volume (MPV)	-0.11380	0.061788	-0.87816	0.207	0.0696
hematology	mean RBC corpuscular hemoglobin (MCH)	0.34440	0.49210	1.2388	0.783	0.486
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.25187	1.1065	0.55770	0.945	0.821
hematology	mean RBC corpuscular volume (MCV)	0.73708	0.24705	1.2404	0.0286	0.00387
hematology	measured hemoglobin (mHGB)	0.37266	0.52275	0.76715	0.723	0.478
hematology	monocyte differential (percent of total WBC)	-0.22886	0.16151	-0.55795	0.521	0.161
hematology	neutrophil differential (percent of total WBC)	0.40634	0.69518	0.24010	0.753	0.561
hematology	platelet count (PLT; units per volume x 10³)	47.213	35.050	0.68223	0.559	0.182
hematology	RBC corpuscular distribution width (RDW)	-0.19804	0.11602	-0.73825	0.310	0.0921
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.56896	0.18119	-1.4346	0.0282	0.00243
hematology	red blood cell count (RBC; per volume x 10⁶)	0.051719	0.16284	-0.11243	0.887	0.752
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-6.5031	14.643	-0.19839	0.887	0.658
hematology	reticulocyte differential (percent of total RBC)	-0.056886	0.13916	-0.018707	0.874	0.684
hematology	white blood cell count (WBC; units per volume x 10³)	-2.2632	0.68260	-1.3146	0.0158	0.00143
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.33283	0.54830	-0.27432	0.853	0.545
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.00032578	0.40191	0.13460	0.999	0.999
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.13182	0.41394	-0.12268	0.948	0.751
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.95731	0.65744	-0.90337	0.629	0.148
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.16054	0.37104	-0.16020	0.935	0.666
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.0086244	0.20790	0.010121	0.999	0.967
holeboard	number of hole pokes by individual hole number, 20 min test, 7	1.0979	0.27441	2.1235	0.0546	0.000110
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.85288	0.40274	1.4461	0.471	0.0363
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.16742	0.44132	-0.22311	0.941	0.705
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.51748	0.23297	1.2266	0.582	0.0282
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.15027	0.23203	-0.38241	0.885	0.518
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.13611	0.36767	-0.12855	0.943	0.712
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.28476	0.55913	0.36920	0.879	0.612
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.77813	0.35319	1.2210	0.356	0.0295
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.44472	0.39493	0.76521	0.718	0.262
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.39952	0.65717	-0.32797	0.853	0.544
holeboard	total number of hole pokes, 20 min test	1.0246	3.7392	0.24013	0.900	0.785
insulin blood level	insulin (plasma)	370.94	223.67	1.5684	0.534	0.101
light / dark	fecal boli count, 20 min test	-0.98864	0.56656	-1.1176	0.451	0.0836
light / dark	latency to enter dark zone, 20 min test	33.607	30.479	0.51697	0.684	0.272
light / dark	number of transitions between light and dark zones, 20 min test	-1.3801	6.1201	-0.0067601	0.926	0.822
light / dark	percentage of total time in dark zone, 20 min test	-3.8057	3.5623	-0.56233	0.649	0.288
light / dark	percentage of total time in light zone, 20 min test	3.8057	3.5623	0.56074	0.648	0.288
light / dark	time mobile in dark zone, 20 min test	-1.7133	10.141	-0.20836	0.947	0.866
light / dark	time mobile in light zone, 20 min test	14.807	9.6383	0.62687	0.353	0.127
light / dark	time spent in dark zone, 20 min test	-59.319	43.209	-0.66518	0.599	0.172
light / dark	time spent in light zone, 20 min test	59.319	43.209	0.66518	0.599	0.172
open field	average speed in center of arena, 20 min test	-0.99566	0.84325	-1.9304	0.589	0.240
open field	average speed in periphery of arena, 20 min test	-0.32809	0.93198	-1.6955	0.852	0.725
open field	distance traveled habituation ratio, 20 min test	6.6313	21.995	0.56033	0.901	0.764
open field	distance traveled in center of arena, 20 min test	-221.77	806.01	-1.7185	0.890	0.784
open field	distance traveled in periphery of arena, 20 min test	-162.82	237.69	-1.0836	0.715	0.495
open field	distance traveled slope, 20 min test	4.9269	19.067	0.47586	0.934	0.797
open field	distance traveled, 20 min test, 1st 5min	-139.73	353.40	-1.4100	0.854	0.693
open field	distance traveled, 20 min test, 2nd 5min	-63.480	238.30	-1.2478	0.902	0.790
open field	distance traveled, 20 min test, 3rd 5min	-95.134	266.08	-1.4511	0.874	0.721
open field	distance traveled, 20 min test, 4th 5min	-80.377	165.61	-1.3575	0.805	0.628
open field	number of clockwise revolution episodes, 20 min test	-3.3636	4.6152	-2.2304	0.771	0.468
open field	number of counter-clockwise revolution episodes, 20 min test	0.95758	2.0073	0.10019	0.816	0.634
open field	number of fecal boli, 20 min test	-1.5358	0.74879	-0.97507	0.255	0.0425
open field	number of rears in 5 min bins, 20 min test, 1st 5min	0.38478	2.4179	-0.10632	0.944	0.874
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	4.2406	1.8824	0.77353	0.154	0.0261
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	1.1942	1.9233	-0.034243	0.756	0.536
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-1.9595	1.9742	-0.75555	0.603	0.323
open field	percentage of total time in center of arena, 20 min test	3.2261	3.0570	0.51687	0.609	0.293
open field	percentage of total time in center of arena, slope, 20 min test	0.95501	1.3744	0.65565	0.855	0.489
open field	percentage of total time in center, habituation ratio, 20 min test	0.58040	1.3903	0.42680	0.905	0.677
open field	percentage of total time in corners of arena, 20 min test	-2.2318	3.7346	-0.10829	0.801	0.551
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.54549	1.5882	-0.53692	0.947	0.732
open field	percentage of total time in corners, slope, 20 min test	-1.1720	1.5721	-0.85780	0.864	0.457
open field	permanence time in center of arena, 20 min test	38.708	36.683	0.51840	0.609	0.293
open field	permanence time in corners of arena, 20 min test	-26.777	44.815	-0.10829	0.801	0.551
open field	permanence time in periphery of arena, 20 min test	-38.702	36.681	-0.51840	0.609	0.294
open field	total distance traveled, 20 min test	-378.21	1016.5	-1.5199	0.848	0.710
open field	total number of rears, 20 min test	3.4707	6.4432	-0.10019	0.783	0.591
open field	whole arena average speed, 20 min test	-0.31456	0.84704	-1.5241	0.849	0.711
open field	whole arena resting time, 20 min test	-2.4926	19.344	0.50463	0.944	0.898
open field	whole arena time spent mobile, 20 min test	2.4022	19.339	-0.41800	0.947	0.901
open field	whole arena time spent vertical, 20 min test	-6.7360	27.942	-0.66902	0.921	0.810
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	1.3801	9.5813	0.30567	0.963	0.886
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	1.1315	2.9664	0.53163	0.923	0.704
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	0.49198	7.5626	0.36268	0.989	0.948
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	6.0242	12.726	0.64932	0.890	0.637
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-5.7639	1.8129	-2.0663	0.0656	0.00258
sleep	differential wake percentages during light and dark phase	0.70459	0.41523	1.3443	0.501	0.0981
sleep	mean breath rate during-sleep	-0.025340	0.051903	-0.081607	0.828	0.628
sleep	mean of sleep bout lengths	26.148	31.889	1.1260	0.710	0.418
sleep	mean of sleep bout lengths with lights off	-27.559	26.147	-0.74663	0.658	0.299
sleep	mean of sleep bout lengths with lights on	150.73	53.320	2.1380	0.154	0.00754
sleep	mean percentage of time sleeping over 24 h periods	-1.0688	1.1257	-0.87401	0.843	0.349
sleep	mean percentage of time sleeping with lights on	2.3408	1.5204	1.1070	0.483	0.132
sleep	mean percentage of time spent sleeping with lights off	-4.3663	1.4010	-1.7918	0.108	0.00353
sleep	peak wake with respect to dark onset median	-0.031876	0.61028	0.040769	0.975	0.959
sleep	percentage of time awake one hour before and after light onset	-2.4313	4.0086	0.10207	0.790	0.548
startle / PPI	average baseline movement during background noise	-0.036364	1.0320	0.053970	0.997	0.972
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.10588	0.066254	0.86135	0.444	0.116
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.086624	0.066051	0.78194	0.548	0.195
startle / PPI	average of maximum percent pre-pulse inhibition for each pre-pulse tested	13.359	7.3279	1.2845	0.372	0.0762
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	20.641	10.503	2.3917	0.798	0.0546
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	4.0227	5.1948	0.34510	0.741	0.442
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-1.4091	4.6155	-0.24554	0.907	0.761
startle / PPI	average startle response to full pulse (120 dB)	28.488	17.236	0.77518	0.290	0.104
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	6.1917	15.117	0.33916	0.841	0.684
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	15.579	12.458	0.52714	0.433	0.217
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	11.806	8.9786	0.48257	0.405	0.194
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.85282	1.0408	0.63157	0.832	0.416
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.61048	0.98532	0.42970	0.896	0.538
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.0518	1.1561	0.31993	0.752	0.367
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.26189	0.14421	2.3240	0.772	0.0750
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.035788	0.056703	0.22419	0.787	0.531
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.035326	0.054549	-0.46482	0.752	0.520
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	28.524	17.227	0.78277	0.285	0.104
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	5.3389	15.213	0.31256	0.870	0.727
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	14.967	12.581	0.51910	0.457	0.240
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	10.748	9.0180	0.46220	0.454	0.239
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.28566	0.14973	2.0995	0.720	0.0618
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.040171	0.057914	0.20900	0.767	0.491
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.0059187	0.054527	-0.23630	0.968	0.914
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	103.42	63.931	0.75267	0.301	0.112
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	13.611	57.538	0.25711	0.916	0.814
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	55.206	47.275	0.50155	0.461	0.248
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	30.023	34.072	0.38404	0.589	0.382
startle / PPI	maximum baseline movement during background noise	-0.29988	1.7738	0.042748	0.969	0.866
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	25.035	12.597	2.6142	0.778	0.0521
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	5.1393	5.4401	0.38404	0.695	0.349
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	1.0522	4.8763	-0.051164	0.926	0.830
startle / PPI	maximum startle response to full pulse (120 dB)	103.12	63.769	0.76013	0.300	0.112
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	15.183	57.220	0.25856	0.901	0.792
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	55.952	46.598	0.51110	0.451	0.235
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	32.885	33.796	0.40068	0.552	0.335
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	1.5722	1.8619	0.56948	0.797	0.402
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	0.74357	2.2940	0.23977	0.950	0.747
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	2.6609	2.4469	0.32140	0.670	0.282
urinalysis	albumin-creatinine ratio (urine ACR)	3.4832	1.5359	0.49167	0.115	0.0253
urinalysis	creatinine (urine CREA)	-5.7548	3.4333	-0.40115	0.277	0.0965
urinalysis	glucose (urine GLU)	-1.3707	1.8197	-0.50952	0.732	0.453
urinalysis	magnesium level (urine Mg)	-0.0049618	0.021822	-0.15627	0.941	0.821
urinalysis	microalbumin (urine MA), calculated	0.14544	0.12788	0.35671	0.548	0.258

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.00
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	6.0 %	0.0385
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	5.0 %	0.435
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	10.0 %	0.275
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	9.0 %	1.00
eye morphology	pupil dilation	6.0 %	0.0353
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	5.0 %	0.461
eye morphology	pupil shape	5.0 %	0.342
eye morphology	retina	18.0 %	0.0991
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.00
eye morphology	retinal pigmentation	13.0 %	1.0
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	6.0 %	0.0234
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	6.0 %	0.0796
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	11.0 %	0.0618
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	26.0 %	0.00240
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	5.0 %	0.327
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	4.0 %	0.268

GENOTYPE CORRELATION PLOT

Correlate Ipp^{tm1.1(KOMP)Vlcg} -/- with genotype: