MPD: JaxKOMP-EAP genotype: Rasa3<sup>tm1b(KOMP)J</sup> -/+

JaxKOMP-EAP effect sizes: Rasa3^tm1b(KOMP)J -/+ Gene Rasa3

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	3.3333	1.5623	0.72229	0.486	0.0998
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	7.9167	2.4547	1.4382	0.362	0.0321
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-4.3750	1.4030	-1.0780	0.275	0.0356
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	8.7599	4.1642	1.2292	0.439	0.103
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	1.7419	5.1641	0.23919	0.898	0.753
body composition	body length	0.062952	0.043271	1.0195	0.432	0.153
body composition	body weight (at time of DXA)	1.0076	0.46689	0.91674	0.137	0.0367
body composition	bone area, whole body scan, head excluded	0.16850	0.11209	0.91636	0.393	0.140
body composition	bone mineral content of whole body scan, head excluded	0.016136	0.0069510	1.0563	0.144	0.0253
body composition	bone mineral content to body weight ratio	0.00049821	0.00030106	0.86163	0.322	0.105
body composition	bone mineral density of whole body scan, head excluded	0.0010053	0.00035372	1.1049	0.0810	0.00695
body composition	fat tissue mass of whole body scan, head excluded	-0.71185	0.23627	-1.3250	0.0524	0.00442
body composition	fat tissue mass to body weight ratio	-0.030603	0.0095593	-1.3585	0.0324	0.00264
body composition	lean tissue mass of whole body scan, head excluded	0.33231	0.23366	0.54614	0.459	0.163
body composition	lean tissue mass to body weight ratio	0.0093104	0.0088051	0.45282	0.555	0.297
body composition	percent fat, whole body scan, head excluded	-2.6956	0.92119	-1.2928	0.0518	0.00557
body composition	ratio of soft-tissue attenuation coefficients	0.0029940	0.0010236	1.2822	0.0514	0.00559
body composition	tissue area	-0.55419	0.10369	-1.4938	0.000562	0.00000368
body composition	total tissue mass, whole body scan, head excluded	-0.38773	0.16914	-1.1813	0.139	0.0271
clinical blood chemistry	alanine transaminase (plasma ALT)	-11.657	11.701	-0.96931	0.684	0.325
clinical blood chemistry	albumin (plasma Alb)	-0.63715	0.37105	-0.79890	0.380	0.0939
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-1.8647	2.3788	-0.85339	0.675	0.438
clinical blood chemistry	aspartate transaminase (plasma AST)	-18.635	18.784	-0.85095	0.646	0.327
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.010508	0.20646	0.055384	0.989	0.960
clinical blood chemistry	blood urea nitrogen (BUN)	0.42857	1.0312	0.13441	0.847	0.680
clinical blood chemistry	calcium (plasma Ca)	0.0080257	0.071331	0.40847	0.951	0.911
clinical blood chemistry	carbon dioxide (plasma CO₂)	0.79715	0.59513	0.49114	0.464	0.188
clinical blood chemistry	chloride (plasma Cl)	-0.96716	0.45082	-0.98540	0.114	0.0380
clinical blood chemistry	glucose (plasma GLU, no fast)	-52.381	16.557	-1.4143	0.0233	0.00327
clinical blood chemistry	HDL cholesterol (plasma HDL)	-2.7838	2.1732	-0.92059	0.511	0.208
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.016700	0.013693	-1.0199	0.567	0.230
clinical blood chemistry	iron (plasma Fe)	0.00092401	0.0072128	0.098790	0.947	0.899
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.030015	0.058884	-0.21387	0.791	0.613
clinical blood chemistry	phosphorus (plasma phosphate)	0.042914	0.26006	0.032069	0.947	0.870
clinical blood chemistry	potassium (plasma K)	-0.29213	0.17932	-1.9980	0.245	0.111
clinical blood chemistry	sodium (plasma Na)	0.097346	0.53513	-0.78838	0.909	0.857
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0012830	0.013130	-0.090966	0.979	0.923
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-1.4500	2.3799	-0.48547	0.808	0.546
clinical blood chemistry	total protein (plasma TP)	-0.23278	0.43755	-0.23775	0.792	0.598
clinical blood chemistry	triglyceride (plasma TG, no fast)	1.5000	7.5120	0.30512	0.925	0.843
ECT	applied stimulus (current), by day, day 2	0.074862	0.30649	-0.16551	0.911	0.809
ECT	applied stimulus (current), by day, day 3	0.15262	0.33704	0.13659	0.882	0.654
ECT	applied stimulus (current), by day, day 4	0.92807	0.65344	0.85505	0.549	0.181
ECT	behavior following applied stimulus (current), by day, day 1	0.019571	0.27719	0.29742	0.991	0.944
ECT	behavior following applied stimulus (current), by day, day 3	0.14903	0.35295	0.20952	0.939	0.676
ECT	behavior following applied stimulus (current), by day, day 4	0.020741	0.58318	-0.084913	0.980	0.972
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.35906	0.27189	0.79778	0.492	0.196
EKG	duration of PQ interval	0.25133	0.90720	0.38836	0.943	0.783
EKG	duration of PR interval	0.35740	0.98076	0.46339	0.938	0.717
EKG	duration of QRS interval	0.24427	0.26694	0.52718	0.885	0.365
EKG	duration of QT interval	-0.18375	0.84852	-0.020151	0.978	0.830
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.22083	0.73615	0.29856	0.979	0.766
EKG	duration of RR interval	-1.4908	1.3984	-0.51104	0.714	0.292
EKG	duration of ST interval	-0.43458	0.77830	-0.22143	0.894	0.580
EKG	heart rate coefficient of variation (signal intensity)	1.8955	0.99232	1.5869	0.774	0.0631
EKG	heart rate variability, mean of differences between sequential beats; beats per min	14.818	7.4161	1.6622	0.740	0.0524
EKG	heart rate, beats per min	14.075	11.270	0.59252	0.602	0.219
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.13383	0.090840	0.89936	0.512	0.148
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.17567	0.12869	0.96154	0.543	0.180
EKG	number of signals	-1.7686	0.79891	-0.41238	0.452	0.0323
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	4.1461	5.2245	0.85152	0.856	0.432
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-1.7167	1.5212	-0.47915	0.881	0.266
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-1.8062	1.5382	-0.47463	0.866	0.247
EKG	root mean square of successive differences of neighboring RR intervals	1.1890	0.83134	0.74447	0.843	0.160
electroretinography	a-wave amplitude of rod photoreceptors, left	-3.0896	28.191	-0.66789	0.979	0.913
electroretinography	a-wave amplitude of rod photoreceptors, right	-4.8632	22.448	-0.88200	0.945	0.829
electroretinography	b-wave amplitude of cone photoreceptors, left	0.41003	13.394	0.071271	0.995	0.976
electroretinography	b-wave amplitude of cone photoreceptors, right	31.953	12.433	2.3899	0.247	0.0125
electroretinography	b-wave amplitude of rod photoreceptors, left	-9.7546	45.947	0.16884	0.929	0.833
electroretinography	b-wave amplitude of rod photoreceptors, right	45.830	35.630	1.3275	0.546	0.203
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	-0.25502	0.70159	-0.59092	0.935	0.717
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	-0.87059	0.64920	-0.95382	0.566	0.185
electroretinography	rod a wave implicit time, left	0.36732	0.54649	0.094803	0.815	0.504
electroretinography	rod a wave implicit time, right	0.25790	0.49173	-0.12058	0.820	0.602
electroretinography	rod b wave implicit time, left	-0.064579	1.6076	-0.38104	1.00	0.968
electroretinography	rod b wave implicit time, right	0.63835	1.3110	0.090419	0.904	0.628
glucose tolerance test	amount glucose injected	-1.7258	1.9766	-0.15949	0.741	0.388
glucose tolerance test	plasma glucose, 0min	11.890	2.8644	0.96377	0.00334	0.000168
glucose tolerance test	plasma glucose, 15min	8.1429	22.288	0.34147	0.900	0.717
glucose tolerance test	plasma glucose, 30min	-0.84814	17.316	0.11280	0.984	0.961
glucose tolerance test	plasma glucose, 60min	-7.5292	11.773	-0.20739	0.796	0.526
glucose tolerance test	plasma glucose, 120min	-15.277	8.5780	-1.1863	0.354	0.0825
grip strength	body weight (at time of grip strength test)	2.0845	0.50768	2.0368	0.00558	0.000504
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-5.1573	11.722	-0.13841	0.815	0.665
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.31009	0.42504	-0.24047	0.671	0.474
grip strength	forelimb and hindlimb grip strength by trial, trial1	16.132	11.419	1.3174	0.443	0.172
grip strength	forelimb and hindlimb grip strength by trial, trial2	-6.3764	15.052	-0.16632	0.845	0.676
grip strength	forelimb and hindlimb grip strength by trial, trial3	-5.9146	11.125	-0.19437	0.803	0.601
grip strength	forelimb grip strength (mean of trials), average	-12.388	7.9741	-1.2230	0.362	0.136
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.69360	0.32135	-1.3786	0.197	0.0426
grip strength	forelimb grip strength by trial, trial1	-7.9658	8.8850	-0.66088	0.706	0.380
grip strength	forelimb grip strength by trial, trial2	-25.039	9.7221	-2.2166	0.148	0.0181
grip strength	forelimb grip strength by trial, trial3	9.6364	9.7949	1.2292	0.666	0.336
heart weight	heart weight, normalized to body weight	0.68476	0.40903	1.4997	0.266	0.102
heart weight	heart weight, weight	19.316	9.6230	1.8045	0.192	0.0513
hematology	basophil differential (percent of total WBC)	-0.057710	0.038394	-0.81876	0.577	0.141
hematology	calculated hemoglobin (cHGB)	-0.099802	0.13911	-0.58854	0.732	0.477
hematology	eosinophil differential (percent of total WBC)	-0.047504	0.27241	-0.058152	0.960	0.862
hematology	hematocrit (HCT)	-0.28584	0.41575	-0.63972	0.724	0.496
hematology	hemoglobin concentration distribution width (HDW)	0.040354	0.015067	1.0988	0.117	0.0106
hematology	large unstained cells (percent of total WBC)	-0.052739	0.10134	-0.34456	0.840	0.606
hematology	lymphocyte differential (percent of total WBC)	-3.3359	1.0623	-1.3309	0.0473	0.00313
hematology	mean corpuscular hemoglobin (CHr)	-0.044748	0.059473	-0.37425	0.689	0.456
hematology	mean platelet volume (MPV)	-0.022216	0.057869	-0.36391	0.848	0.703
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.36980	0.10622	-0.99229	0.0325	0.00122
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.87941	0.24056	-1.2016	0.0346	0.000738
hematology	mean RBC corpuscular volume (MCV)	0.043976	0.26288	0.10131	0.944	0.868
hematology	measured hemoglobin (mHGB)	-0.48097	0.15163	-1.1560	0.0577	0.00287
hematology	monocyte differential (percent of total WBC)	0.51316	0.15947	1.5688	0.0953	0.00252
hematology	neutrophil differential (percent of total WBC)	2.9127	0.83912	1.3211	0.0279	0.00123
hematology	platelet count (PLT; units per volume x 10³)	-6.9079	40.207	-0.035543	0.957	0.864
hematology	RBC corpuscular distribution width (RDW)	0.27255	0.16746	0.95186	0.340	0.111
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.068270	0.14193	-0.22290	0.823	0.633
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.068773	0.11149	-0.63549	0.755	0.541
hematology	reticulocyte count (Retic; units per volume x 10⁹)	28.447	23.561	1.2171	0.635	0.234
hematology	white blood cell count (WBC; units per volume x 10³)	-1.5396	0.58536	-0.85889	0.0635	0.0121
insulin blood level	insulin (plasma)	-280.58	423.39	-0.79223	0.760	0.512
light / dark	fecal boli count, 20 min test	-0.32749	0.55349	-0.33468	0.849	0.557
light / dark	latency to enter dark zone, 20 min test	30.004	27.800	0.47114	0.689	0.287
light / dark	number of transitions between light and dark zones, 20 min test	6.6992	7.2645	0.71319	0.665	0.362
light / dark	percentage of total time in dark zone, 20 min test	-0.11639	3.0222	0.10837	0.989	0.969
light / dark	percentage of total time in light zone, 20 min test	0.11639	3.0222	-0.11654	0.988	0.969
light / dark	time mobile in dark zone, 20 min test	0.33080	12.274	-0.073074	0.996	0.979
light / dark	time mobile in light zone, 20 min test	-4.4986	8.9956	-0.57345	0.814	0.620
light / dark	time spent in dark zone, 20 min test	-26.198	36.570	-0.19180	0.813	0.478
light / dark	time spent in light zone, 20 min test	26.198	36.570	0.19180	0.813	0.478
open field	average speed in center of arena, 20 min test	-0.98175	0.35316	-1.8888	0.112	0.00810
open field	average speed in periphery of arena, 20 min test	-0.38075	0.12901	-1.8284	0.0371	0.00516
open field	distance traveled habituation ratio, 20 min test	13.108	7.1849	1.0458	0.338	0.0752
open field	distance traveled in center of arena, 20 min test	-118.44	55.315	-1.1282	0.166	0.0381
open field	distance traveled in periphery of arena, 20 min test	-436.12	129.72	-2.0804	0.0204	0.00166
open field	distance traveled slope, 20 min test	10.460	6.6417	0.93194	0.414	0.123
open field	distance traveled, 20 min test, 1st 5min	-212.81	67.004	-1.8503	0.0273	0.00280
open field	distance traveled, 20 min test, 2nd 5min	-94.845	44.484	-1.5731	0.165	0.0389
open field	distance traveled, 20 min test, 3rd 5min	-144.15	46.466	-1.8654	0.0335	0.00343
open field	distance traveled, 20 min test, 4th 5min	-94.829	47.301	-1.5114	0.201	0.0515
open field	number of clockwise revolution episodes, 20 min test	-3.0879	1.0269	-2.0801	0.0702	0.00444
open field	number of counter-clockwise revolution episodes, 20 min test	-1.1458	0.98146	-1.0528	0.535	0.250
open field	number of fecal boli, 20 min test	1.0125	0.78281	1.0085	0.528	0.203
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-3.8417	1.7532	-1.2743	0.177	0.0340
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-4.8833	2.0086	-1.5072	0.128	0.0194
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-2.7042	1.9060	-0.93194	0.425	0.163
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-1.6042	2.4253	-0.69102	0.740	0.512
open field	percentage of total time in center of arena, 20 min test	2.1900	2.5157	0.30754	0.694	0.389
open field	percentage of total time in center of arena, slope, 20 min test	-2.9792	1.4117	-1.3746	0.433	0.0410
open field	percentage of total time in center, habituation ratio, 20 min test	-1.8293	1.3111	-0.83856	0.653	0.170
open field	percentage of total time in corners of arena, 20 min test	1.2818	3.7882	0.53382	0.896	0.737
open field	percentage of total time in corners, habituation ratio, 20 min test	1.1322	1.8396	0.22681	0.889	0.542
open field	percentage of total time in corners, slope, 20 min test	0.072082	1.7391	-0.22819	0.994	0.967
open field	permanence time in center of arena, 20 min test	26.290	30.185	0.30754	0.694	0.389
open field	permanence time in corners of arena, 20 min test	15.398	45.458	0.53382	0.897	0.737
open field	permanence time in periphery of arena, 20 min test	-26.265	30.193	-0.30754	0.695	0.389
open field	total distance traveled, 20 min test	-557.26	162.72	-1.9050	0.0149	0.00139
open field	total number of rears, 20 min test	-13.033	6.3306	-1.2449	0.194	0.0458
open field	whole arena average speed, 20 min test	-0.46487	0.13579	-1.9050	0.0150	0.00139
open field	whole arena resting time, 20 min test	55.933	15.759	1.9948	0.00989	0.000967
open field	whole arena time spent mobile, 20 min test	-56.019	15.761	-2.3004	0.0104	0.000953
open field	whole arena time spent vertical, 20 min test	-14.457	8.3006	-1.2051	0.340	0.0889
plasma chemistry analysis	free fatty acids (plasma)	-0.12240	0.10468	-0.071837	0.386	0.249
plasma chemistry analysis	plasma cholesterol	3.8471	4.7936	0.80139	0.614	0.427
plasma chemistry analysis	plasma glucose (4h fast)	3.9113	14.544	1.0565	0.912	0.789
plasma chemistry analysis	plasma HDL	-2.8877	3.3840	-0.45101	0.613	0.399
plasma chemistry analysis	plasma triglycerides (4h fast)	-4.8681	4.6218	0.027855	0.514	0.298
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	26.984	13.689	2.2400	0.594	0.0555
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	10.578	4.2719	2.5506	0.406	0.0175
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	14.742	9.3220	1.6431	0.467	0.121
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	39.452	17.369	2.2990	0.322	0.0284
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-5.3163	1.6972	-1.9755	0.0788	0.00394
startle / PPI	average baseline movement during background noise	-1.3893	0.64978	-0.92827	0.490	0.0388
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.15603	0.074852	1.2624	0.287	0.0435
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.20932	0.063822	1.8858	0.0727	0.00216
startle / PPI	average of maximum percent pre-pulse inhibition for each pre-pulse tested	13.923	7.4266	1.3151	0.363	0.0681
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	10.413	6.8689	1.1996	0.843	0.137
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	18.246	6.4673	1.9118	0.166	0.00741
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	20.589	5.9899	1.9767	0.0399	0.00138
startle / PPI	average startle response to full pulse (120 dB)	-23.660	10.273	-0.28181	0.127	0.0267
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-21.442	8.9614	-0.24988	0.101	0.0216
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-18.209	7.3280	-0.20816	0.0870	0.0172
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-25.826	7.0469	-0.44203	0.0119	0.000735
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-1.2847	0.62690	-0.87771	0.518	0.0472
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.15389	0.58022	-0.089090	0.961	0.792
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.015337	0.63566	-0.17534	0.995	0.981
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.12467	0.076596	1.2054	0.794	0.111
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.22101	0.071883	1.7737	0.109	0.00379
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.34809	0.085018	2.1390	0.00945	0.000206
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-22.271	10.314	-0.25566	0.151	0.0370
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-20.155	9.0219	-0.21533	0.129	0.0313
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-18.016	7.3021	-0.19815	0.0904	0.0180
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-25.899	7.0068	-0.41897	0.0108	0.000671
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.090638	0.088660	0.82733	0.859	0.313
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.16775	0.081723	1.2197	0.296	0.0467
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.20177	0.088760	1.2620	0.155	0.0285
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-103.96	44.850	-0.36450	0.120	0.0258
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-89.287	41.460	-0.32583	0.143	0.0375
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-77.552	33.375	-0.25277	0.111	0.0253
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-112.28	32.302	-0.50155	0.0160	0.00126
startle / PPI	maximum baseline movement during background noise	-2.7517	1.1783	-0.75639	0.395	0.0248
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.8009	7.9997	0.82536	0.890	0.335
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	13.925	7.4268	1.2083	0.374	0.0681
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	14.786	7.6890	1.2054	0.269	0.0616
startle / PPI	maximum startle response to full pulse (120 dB)	-106.71	44.859	-0.37651	0.109	0.0224
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-91.126	41.526	-0.33619	0.136	0.0342
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-77.247	33.329	-0.26001	0.111	0.0257
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-110.81	32.281	-0.50951	0.0169	0.00143
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.1858	1.0146	-0.27453	0.735	0.249
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	0.28636	0.99991	0.11021	0.961	0.776
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	1.0219	1.5350	0.027326	0.824	0.509
tail suspension	duration of immobility, 5 min test	-4.9382	9.4512	-0.94716	0.784	0.604
tail suspension	latency to immobility, 5 min test	0.51941	0.89671	0.56724	0.861	0.566

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.00
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.00
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	16.0 %	0.113
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	9.0 %	1.00
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	4.0 %	1.00
eye morphology	pupil shape	3.0 %	1.00
eye morphology	retina	13.0 %	1.0
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.00
eye morphology	retinal pigmentation	13.0 %	1.0
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	3.0 %	0.440
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	6.0 %	0.0959
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	6.0 %	0.0349
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	7.0 %	0.624
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	touch escape	14.0 %	0.161
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00
tail suspension	climbing, 5 min test (yes, no)	22.0 %	0.0307

GENOTYPE CORRELATION PLOT

Correlate Rasa3^tm1b(KOMP)J -/+ with genotype: