MPD: JaxKOMP-EAP genotype: Moxd1<sup>tm2b(KOMP)Wtsi</sup> -/-

JaxKOMP-EAP effect sizes: Moxd1^{tm2b(KOMP)Wtsi} -/- Gene Moxd1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-2.6062	1.4841	-0.98834	0.606	0.177
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-2.0002	3.7856	-0.41781	0.894	0.634
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	1.4946	3.4560	0.16333	0.896	0.695
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-2.8415	6.9662	-0.56406	0.894	0.711
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-1.1206	8.2875	-0.20900	0.971	0.901
body composition	body length	-0.037903	0.028228	-0.23919	0.471	0.185
body composition	body weight (at time of DXA)	-0.88489	0.40239	-0.55614	0.125	0.0319
body composition	bone area, whole body scan, head excluded	-0.045656	0.085770	-0.0081917	0.804	0.597
body composition	bone mineral content of whole body scan, head excluded	-0.0054152	0.0062184	-0.18120	0.665	0.387
body composition	bone mineral content to body weight ratio	0.000026548	0.00031821	0.19232	0.977	0.934
body composition	bone mineral density of whole body scan, head excluded	-0.00029191	0.00040120	-0.27315	0.735	0.470
body composition	fat tissue mass of whole body scan, head excluded	-0.34992	0.16178	-0.64900	0.171	0.0348
body composition	fat tissue mass to body weight ratio	-0.016747	0.0072904	-0.74294	0.120	0.0252
body composition	lean tissue mass of whole body scan, head excluded	0.32206	0.17742	0.51939	0.314	0.0748
body composition	lean tissue mass to body weight ratio	0.027404	0.0077124	1.3313	0.0222	0.000764
body composition	percent fat, whole body scan, head excluded	-1.8006	0.68073	-0.85966	0.0773	0.0105
body composition	ratio of soft-tissue attenuation coefficients	0.0019923	0.00075744	0.85220	0.0796	0.0109
body composition	tissue area	-0.11135	0.11349	-0.20368	0.635	0.331
body composition	total tissue mass, whole body scan, head excluded	0.028991	0.14555	-0.15213	0.924	0.843
clinical blood chemistry	alanine transaminase (plasma ALT)	-0.59745	13.807	-0.067357	0.989	0.966
clinical blood chemistry	albumin (plasma Alb)	-0.050380	0.35607	-0.027094	0.967	0.888
clinical blood chemistry	alkaline phosphatase (plasma ALP)	5.7971	5.0479	0.52554	0.507	0.256
clinical blood chemistry	aspartate transaminase (plasma AST)	-5.6884	57.105	-0.28747	0.981	0.921
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.12242	0.49968	0.42088	0.939	0.807
clinical blood chemistry	blood urea nitrogen (BUN)	-2.0223	1.0579	-0.82701	0.234	0.0617
clinical blood chemistry	calcium (plasma Ca)	-0.034951	0.066528	0.097548	0.775	0.601
clinical blood chemistry	carbon dioxide (plasma CO₂)	-0.34551	0.49420	-0.62564	0.725	0.487
clinical blood chemistry	chloride (plasma Cl)	-0.59875	0.58415	-0.60406	0.496	0.310
clinical blood chemistry	glucose (plasma GLU, no fast)	-43.531	13.000	-1.1882	0.0135	0.00155
clinical blood chemistry	HDL cholesterol (plasma HDL)	1.2128	2.0750	-0.023382	0.802	0.561
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.031958	0.020909	1.5298	0.449	0.132
clinical blood chemistry	iron (plasma Fe)	-0.0028168	0.012465	-0.17652	0.913	0.822
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.059481	0.061594	-0.42150	0.612	0.339
clinical blood chemistry	phosphorus (plasma phosphate)	0.68728	0.26202	0.97465	0.101	0.0114
clinical blood chemistry	potassium (plasma K)	0.30889	0.19442	0.21898	0.252	0.118
clinical blood chemistry	sodium (plasma Na)	2.1033	0.57655	1.0508	0.00309	0.000588
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0094829	0.015954	-0.70966	0.808	0.555
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-2.3185	4.0339	-0.62834	0.821	0.568
clinical blood chemistry	total protein (plasma TP)	2.7689	1.4917	1.7201	0.294	0.0691
clinical blood chemistry	triglyceride (plasma TG, no fast)	-16.986	7.7070	-0.70535	0.182	0.0321
ECT	applied stimulus (current), by day, day 2	0.10890	0.097179	-0.076568	0.589	0.271
ECT	applied stimulus (current), by day, day 3	-0.31153	0.18752	-1.1875	0.364	0.108
ECT	behavior following applied stimulus (current), by day, day 1	-0.14248	0.096416	-0.18812	0.435	0.150
ECT	behavior following applied stimulus (current), by day, day 3	-0.53007	0.43039	-1.4137	0.724	0.229
ECT	behavior following applied stimulus (current), by day, day 4	0.17805	0.43515	0.18001	0.902	0.691
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.11001	0.16066	0.010444	0.742	0.498
EKG	duration of PQ interval	0.18018	0.54703	0.31546	0.939	0.743
EKG	duration of PR interval	0.23298	0.56844	0.31123	0.938	0.683
EKG	duration of QRS interval	0.20435	0.32875	0.40143	0.942	0.537
EKG	duration of QT interval	0.96667	0.74941	1.0882	0.693	0.202
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.4116	0.67114	1.4763	0.619	0.0396
EKG	duration of RR interval	-1.2872	1.2536	-0.40362	0.730	0.309
EKG	duration of ST interval	0.77472	0.69940	1.0214	0.754	0.272
EKG	heart rate coefficient of variation (signal intensity)	-0.67281	0.94306	-0.45443	0.878	0.478
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-4.8801	6.7034	-0.49959	0.887	0.469
EKG	heart rate, beats per min	12.681	9.9675	0.51494	0.600	0.208
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.17818	0.076891	1.2470	0.256	0.0239
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.25784	0.10159	1.4129	0.184	0.0138
EKG	number of signals	2.8375	2.5105	0.50874	0.764	0.263
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-0.10543	4.3730	0.050887	0.997	0.981
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-0.40987	2.3105	-0.076644	0.987	0.860
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-0.36768	2.6115	-0.094846	0.986	0.889
EKG	root mean square of successive differences of neighboring RR intervals	-0.36926	1.7651	-0.086753	0.962	0.835
electroretinography	a-wave amplitude of rod photoreceptors, left	9.0399	13.498	-0.059717	0.804	0.522
electroretinography	a-wave amplitude of rod photoreceptors, right	24.769	19.425	0.93459	0.676	0.234
electroretinography	b-wave amplitude of cone photoreceptors, left	-11.163	8.3879	-0.84569	0.744	0.216
electroretinography	b-wave amplitude of cone photoreceptors, right	-18.203	10.990	-1.2141	0.576	0.132
electroretinography	b-wave amplitude of rod photoreceptors, left	-44.394	33.351	-0.48779	0.638	0.216
electroretinography	b-wave amplitude of rod photoreceptors, right	-51.106	42.037	-0.66136	0.579	0.255
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	0.66494	0.80025	0.46341	0.790	0.428
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	0.76909	0.48909	0.64932	0.529	0.150
electroretinography	rod a wave implicit time, left	-0.039830	0.69241	-0.45020	0.988	0.956
electroretinography	rod a wave implicit time, right	0.63373	0.73174	0.40251	0.725	0.412
electroretinography	rod b wave implicit time, left	4.1417	3.6093	1.6547	0.771	0.284
electroretinography	rod b wave implicit time, right	3.8529	3.4578	1.7144	0.788	0.294
FACS	spleen weight	0.012160	0.0057219	1.0676	0.519	0.101
glucose tolerance test	amount glucose injected	-1.1307	1.5298	0.018564	0.784	0.464
glucose tolerance test	plasma glucose, 0min	2.7972	4.8539	0.063188	0.754	0.567
glucose tolerance test	plasma glucose, 15min	-5.7933	19.489	-0.054937	0.918	0.768
glucose tolerance test	plasma glucose, 30min	-5.8145	19.419	-0.042568	0.907	0.766
glucose tolerance test	plasma glucose, 60min	-0.10346	14.802	0.12525	0.997	0.994
glucose tolerance test	plasma glucose, 120min	8.5441	9.0356	0.44533	0.640	0.349
grip strength	body weight (at time of grip strength test)	-1.9063	0.64213	-1.3868	0.0337	0.00669
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-18.461	11.489	-0.99722	0.290	0.122
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.4550	0.63408	-1.7715	0.122	0.0308
grip strength	forelimb and hindlimb grip strength by trial, trial1	-21.932	14.109	-1.2078	0.381	0.134
grip strength	forelimb and hindlimb grip strength by trial, trial2	-7.1801	10.167	-0.21662	0.720	0.487
grip strength	forelimb and hindlimb grip strength by trial, trial3	-16.608	14.502	-0.86292	0.529	0.264
grip strength	forelimb grip strength (mean of trials), average	7.1180	5.4409	1.2018	0.456	0.204
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.48255	0.31586	1.3862	0.387	0.140
grip strength	forelimb grip strength by trial, trial1	12.827	6.7835	1.6031	0.327	0.0713
grip strength	forelimb grip strength by trial, trial2	-2.2514	6.9802	-0.021786	0.913	0.750
grip strength	forelimb grip strength by trial, trial3	5.7370	8.4603	0.84618	0.770	0.504
heart weight	heart weight, normalized to body weight	0.71779	0.18074	1.5653	0.00472	0.000203
heart weight	heart weight, weight	16.402	3.9643	1.5427	0.00401	0.000119
hematology	basophil differential (percent of total WBC)	-0.21947	0.17852	-2.0159	0.663	0.226
hematology	calculated hemoglobin (cHGB)	0.51424	0.48156	1.3105	0.576	0.292
hematology	eosinophil differential (percent of total WBC)	0.37204	0.25022	1.1118	0.532	0.144
hematology	hematocrit (HCT)	1.9808	1.6331	1.6175	0.526	0.232
hematology	hemoglobin concentration distribution width (HDW)	-0.014459	0.036823	-0.36983	0.864	0.697
hematology	large unstained cells (percent of total WBC)	-0.25182	0.32476	-1.4968	0.751	0.442
hematology	lymphocyte differential (percent of total WBC)	-1.9856	0.77793	-0.89095	0.113	0.0143
hematology	mean corpuscular hemoglobin (CHr)	-0.054558	0.051637	-0.41611	0.535	0.297
hematology	mean platelet volume (MPV)	-0.14139	0.34347	-1.0042	0.838	0.683
hematology	mean RBC corpuscular hemoglobin (MCH)	0.057431	0.36812	0.18482	0.957	0.877
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.15687	0.82182	0.37575	0.950	0.850
hematology	mean RBC corpuscular volume (MCV)	-0.17838	0.36382	-0.33558	0.800	0.626
hematology	measured hemoglobin (mHGB)	0.51090	0.61047	1.1067	0.681	0.407
hematology	monocyte differential (percent of total WBC)	0.25536	0.15062	1.0158	0.429	0.0972
hematology	neutrophil differential (percent of total WBC)	1.6321	0.59621	0.83347	0.0847	0.00897
hematology	platelet count (PLT; units per volume x 10³)	25.087	71.347	0.37929	0.897	0.727
hematology	RBC corpuscular distribution width (RDW)	-0.039024	0.40625	-0.12297	0.967	0.924
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.084545	0.21429	0.20509	0.856	0.695
hematology	red blood cell count (RBC; per volume x 10⁶)	0.42234	0.37279	1.4647	0.537	0.264
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-35.062	27.780	-1.3118	0.614	0.214
hematology	reticulocyte differential (percent of total RBC)	-0.52310	0.33507	-1.7236	0.466	0.126
hematology	white blood cell count (WBC; units per volume x 10³)	-3.1675	4.0521	-1.8133	0.631	0.439
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.74775	1.7119	0.76471	0.907	0.670
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.094541	0.76516	0.29894	0.988	0.904
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.98261	0.56365	-1.5497	0.633	0.105
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.29130	1.0343	0.35954	0.933	0.783
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.33478	1.0037	0.64771	0.951	0.744
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.0049480	0.67395	0.025305	1.00	0.994
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.32609	0.33500	0.83107	0.858	0.348
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.99565	0.74466	1.6023	0.735	0.204
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.29130	0.47636	-0.45432	0.903	0.551
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.44783	0.44038	1.1002	0.843	0.328
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.40870	0.36921	-1.0766	0.807	0.288
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.68261	0.73125	1.1334	0.786	0.368
holeboard	number of hole pokes by individual hole number, 20 min test, 13	2.3929	1.4278	2.0499	0.507	0.120
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.68696	0.53050	1.0865	0.665	0.218
holeboard	number of hole pokes by individual hole number, 20 min test, 15	2.0435	1.3751	2.4714	0.637	0.161
holeboard	number of hole pokes by individual hole number, 20 min test, 16	2.9565	1.7036	2.3486	0.542	0.106
holeboard	total number of hole pokes, 20 min test	10.917	6.3614	1.4136	0.361	0.110
insulin blood level	insulin (plasma)	-6.6353	202.85	0.52650	0.999	0.974
light / dark	fecal boli count, 20 min test	-0.70389	0.55354	-0.73693	0.614	0.209
light / dark	latency to enter dark zone, 20 min test	62.763	29.649	1.0026	0.390	0.0392
light / dark	number of transitions between light and dark zones, 20 min test	-20.047	5.8934	-1.8042	0.0392	0.00131
light / dark	percentage of total time in dark zone, 20 min test	6.6761	3.4822	1.3673	0.366	0.0608
light / dark	percentage of total time in light zone, 20 min test	-6.6761	3.4822	-1.3708	0.363	0.0608
light / dark	time mobile in dark zone, 20 min test	-33.296	10.613	-1.7708	0.0395	0.00283
light / dark	time mobile in light zone, 20 min test	-34.594	9.1782	-2.2614	0.00958	0.000427
light / dark	time spent in dark zone, 20 min test	14.306	45.594	0.43518	0.924	0.755
light / dark	time spent in light zone, 20 min test	-14.306	45.594	-0.43518	0.924	0.755
open field	average speed in center of arena, 20 min test	0.49532	0.50012	0.76992	0.662	0.328
open field	average speed in periphery of arena, 20 min test	-0.27081	0.14149	-1.4866	0.191	0.0628
open field	distance traveled habituation ratio, 20 min test	3.2162	7.3875	0.31035	0.868	0.666
open field	distance traveled in center of arena, 20 min test	-55.988	66.311	-0.72902	0.649	0.403
open field	distance traveled in periphery of arena, 20 min test	-348.71	136.72	-1.8503	0.0886	0.0147
open field	distance traveled slope, 20 min test	1.5465	6.8864	0.22681	0.944	0.823
open field	distance traveled, 20 min test, 1st 5min	-67.723	71.061	-0.86754	0.591	0.346
open field	distance traveled, 20 min test, 2nd 5min	-79.406	43.501	-1.4247	0.246	0.0754
open field	distance traveled, 20 min test, 3rd 5min	-123.10	47.779	-1.6788	0.0824	0.0137
open field	distance traveled, 20 min test, 4th 5min	-34.052	54.677	-0.84239	0.748	0.537
open field	number of clockwise revolution episodes, 20 min test	-2.2208	0.96976	-1.7183	0.198	0.0272
open field	number of counter-clockwise revolution episodes, 20 min test	0.29154	1.1198	-0.27392	0.910	0.796
open field	number of fecal boli, 20 min test	-1.1015	0.66620	-0.62276	0.391	0.106
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-3.4230	2.4218	-1.1381	0.417	0.165
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-1.3787	2.0485	-0.69785	0.739	0.505
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-1.8092	2.4170	-0.70128	0.710	0.458
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-2.5887	2.1705	-0.88727	0.513	0.240
open field	percentage of total time in center of arena, 20 min test	-2.0097	2.2121	-0.69614	0.682	0.369
open field	percentage of total time in center of arena, slope, 20 min test	-1.8891	1.6532	-0.87934	0.720	0.260
open field	percentage of total time in center, habituation ratio, 20 min test	-1.7632	1.7634	-0.79914	0.786	0.323
open field	percentage of total time in corners of arena, 20 min test	5.2291	3.8296	1.2537	0.488	0.180
open field	percentage of total time in corners, habituation ratio, 20 min test	4.1775	1.7496	1.5030	0.336	0.0217
open field	percentage of total time in corners, slope, 20 min test	3.5827	1.7175	1.3245	0.453	0.0432
open field	permanence time in center of arena, 20 min test	-24.114	26.544	-0.69272	0.682	0.369
open field	permanence time in corners of arena, 20 min test	62.759	45.954	1.2537	0.489	0.179
open field	permanence time in periphery of arena, 20 min test	24.102	26.550	0.69443	0.682	0.369
open field	total distance traveled, 20 min test	-325.54	178.09	-1.3885	0.215	0.0750
open field	total number of rears, 20 min test	-9.9204	7.0611	-1.0458	0.402	0.168
open field	whole arena average speed, 20 min test	-0.27281	0.14842	-1.3956	0.214	0.0735
open field	whole arena resting time, 20 min test	35.670	17.922	1.5594	0.172	0.0534
open field	whole arena time spent mobile, 20 min test	-35.641	17.929	-1.8006	0.171	0.0537
open field	whole arena time spent vertical, 20 min test	-9.4087	7.5928	-0.84239	0.531	0.222
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-8.7465	8.6439	-0.46049	0.816	0.316
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-3.1970	2.6915	-0.55244	0.785	0.240
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-5.0573	7.0385	-0.18980	0.800	0.475
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	-9.0691	11.934	-0.20354	0.838	0.450
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-4.4972	1.9991	-1.6567	0.210	0.0335
sleep	differential wake percentages during light and dark phase	-1.0528	0.83555	-1.2498	0.698	0.239
sleep	mean breath rate during-sleep	-0.093235	0.11935	-0.66811	0.709	0.455
sleep	mean of sleep bout lengths	-113.34	51.609	-2.2509	0.284	0.0557
sleep	mean of sleep bout lengths with lights off	-87.289	26.450	-2.2509	0.134	0.00923
sleep	mean of sleep bout lengths with lights on	-43.479	71.733	-0.65542	0.798	0.559
sleep	mean percentage of time sleeping over 24 h periods	0.72000	1.6486	0.29993	0.904	0.673
sleep	mean percentage of time sleeping with lights on	0.41000	2.3049	0.33207	0.958	0.863
sleep	mean percentage of time spent sleeping with lights off	3.8538	5.3065	1.2498	0.862	0.488
sleep	peak wake with respect to dark onset median	0.00098039	0.78582	0.071387	1.00	0.999
sleep	percentage of time awake one hour before and after light onset	-4.8689	6.5495	-0.28929	0.758	0.476
startle / PPI	average baseline movement during background noise	0.17850	1.0210	0.22969	0.987	0.862
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.014977	0.068929	0.030129	0.933	0.829
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.026626	0.063868	0.19408	0.874	0.680
startle / PPI	average of maximum percent pre-pulse inhibition for each pre-pulse tested	2.4235	7.3450	0.26556	0.905	0.744
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.55398	6.9113	0.12714	0.995	0.937
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	6.5834	6.5172	0.61286	0.673	0.320
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	5.2555	6.3761	0.46376	0.704	0.416
startle / PPI	average startle response to full pulse (120 dB)	-0.96424	18.692	0.18816	0.985	0.959
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-10.826	18.972	-0.041345	0.765	0.572
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-8.1650	17.597	0.0049040	0.793	0.646
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.28523	15.027	0.20101	0.995	0.985
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-1.1288	1.0996	-0.76388	0.793	0.313
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.45497	1.8248	0.33175	0.961	0.805
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-2.0729	3.9053	-1.2319	0.889	0.599
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.010360	0.075431	-0.065199	0.987	0.892
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.076874	0.072285	0.56689	0.632	0.296
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.067762	0.083608	0.37147	0.684	0.424
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-1.2884	18.620	0.18245	0.974	0.945
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-9.6972	18.995	-0.011910	0.796	0.613
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-8.6200	17.553	0.0077063	0.774	0.627
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	0.10315	17.064	0.19958	0.997	0.995
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.014955	0.083541	-0.089090	0.975	0.859
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.059348	0.078119	0.37899	0.745	0.453
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.062512	0.080600	0.28124	0.687	0.444
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	6.9001	85.431	0.23977	0.975	0.936
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-39.236	88.792	-0.055373	0.828	0.662
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-27.103	83.958	0.044150	0.851	0.749
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	23.166	71.686	0.33916	0.853	0.749
startle / PPI	maximum baseline movement during background noise	0.94589	2.1411	0.39462	0.926	0.662
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.013200	7.8933	0.034335	1.00	0.999
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	5.4313	7.4350	0.41133	0.766	0.471
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	5.6109	6.6241	0.39159	0.682	0.403
startle / PPI	maximum startle response to full pulse (120 dB)	8.1719	85.634	0.24699	0.970	0.925
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-44.367	88.628	-0.087683	0.799	0.620
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-26.813	84.127	0.031531	0.856	0.752
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	26.484	78.916	0.36151	0.851	0.739
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-4.6500	2.8862	-1.2319	0.603	0.118
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	0.28920	4.1515	0.11162	0.996	0.945
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-10.431	14.061	-2.0870	0.803	0.464
tail suspension	duration of immobility, 5 min test	19.706	9.4659	0.90004	0.217	0.0447
tail suspension	latency to immobility, 5 min test	1.3973	1.8984	0.90004	0.800	0.467
urinalysis	albumin-creatinine ratio (urine ACR)	-3.9110	5.2689	-1.8413	0.658	0.465
urinalysis	creatinine (urine CREA)	-0.71044	5.2922	0.45466	0.957	0.894
urinalysis	glucose (urine GLU)	1.0496	4.9374	0.22154	0.951	0.834
urinalysis	magnesium level (urine Mg)	0.066860	0.043820	1.2928	0.417	0.141

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	4.0 %	0.428
eye morphology	cornea vascularization	6.0 %	0.234
eye morphology	corneal deposits	6.0 %	0.136
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	5.0 %	0.292
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	6.0 %	0.179
eye morphology	iris pigmentation	11.0 %	0.0103
eye morphology	iris transillumination	6.0 %	0.116
eye morphology	irispupil	6.0 %	0.171
eye morphology	lacrimation	6.0 %	0.248
eye morphology	lens	6.0 %	0.317
eye morphology	lens opacity	6.0 %	0.357
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	5.0 %	0.241
eye morphology	persistence of hyaloid vascular system	6.0 %	0.357
eye morphology	pupil dilation	6.0 %	0.162
eye morphology	pupil light response	6.0 %	0.236
eye morphology	pupil position	6.0 %	0.186
eye morphology	pupil shape	6.0 %	0.185
eye morphology	retina	7.0 %	0.356
eye morphology	retinal blood vessels	5.0 %	0.196
eye morphology	retinal blood vessels pattern	5.0 %	0.279
eye morphology	retinal blood vessels structure	5.0 %	0.215
eye morphology	retinal pigmentation	8.0 %	0.197
eye morphology	retinal structure	5.0 %	0.223
eye morphology	synechia	5.0 %	0.200
eye morphology	vitreous	5.0 %	0.189
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.0
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.00
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.00
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.0
SHIRPA	coat hair distribution back	0.0 %	1.00
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	0.279
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.0
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.00
SHIRPA	forelimb digit size	0.0 %	1.00
SHIRPA	forelimb footpads	0.0 %	1.00
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.00
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.00
SHIRPA	genitalia size	0.0 %	1.00
SHIRPA	head bobbing	0.0 %	1.00
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.0
SHIRPA	hindlimb digit position	0.0 %	1.00
SHIRPA	hindlimb digit shape	5.0 %	0.0413
SHIRPA	hindlimb digit size	0.0 %	1.0
SHIRPA	hindlimb nail length	0.0 %	1.0
SHIRPA	hindlimb nail number	0.0 %	1.0
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.00
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.00
SHIRPA	hindpaw shape	0.0 %	1.00
SHIRPA	hindpaw size	0.0 %	1.00
SHIRPA	limb grasp	7.0 %	0.394
SHIRPA	lower lip morphology	0.0 %	1.00
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.0
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.00
SHIRPA	skin color whole body	0.0 %	1.00
SHIRPA	skin texture back paw	0.0 %	1.00
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.00
SHIRPA	startle response	0.0 %	1.0
SHIRPA	tail curvature	0.0 %	1.00
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	touch escape	14.0 %	0.383
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.0
tail suspension	climbing, 5 min test (yes, no)	24.0 %	0.0725

GENOTYPE CORRELATION PLOT

Correlate Moxd1^{tm2b(KOMP)Wtsi} -/- with genotype: