MPD: JaxKOMP-EAP genotype: Polr2h<sup>tm1.1(KOMP)Wtsi</sup> -/+

JaxKOMP-EAP effect sizes: Polr2h^{tm1.1(KOMP)Wtsi} -/+ Gene Polr2h

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	2.7265	2.6185	0.56450	0.824	0.487
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-0.33194	7.6841	-0.050324	0.990	0.973
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-0.010747	6.9654	-0.17919	1.00	0.999
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-4.0897	7.8877	-0.73632	0.884	0.695
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-6.6250	2.9984	-0.98777	0.648	0.271
body composition	body length	0.077989	0.053004	1.2142	0.435	0.155
body composition	body weight (at time of DXA)	1.5079	0.64801	1.3319	0.117	0.0291
body composition	bone area, whole body scan, head excluded	0.22332	0.13427	1.1786	0.343	0.110
body composition	bone mineral content of whole body scan, head excluded	0.013730	0.0081753	0.94371	0.333	0.107
body composition	bone mineral content to body weight ratio	0.00047625	0.00032375	0.82846	0.403	0.155
body composition	bone mineral density of whole body scan, head excluded	0.00038528	0.00040503	0.43773	0.651	0.352
body composition	fat tissue mass of whole body scan, head excluded	-0.79651	0.25396	-1.4861	0.0542	0.00480
body composition	fat tissue mass to body weight ratio	-0.027297	0.0083287	-1.2178	0.0368	0.00330
body composition	lean tissue mass of whole body scan, head excluded	0.061281	0.22421	-0.021846	0.918	0.787
body composition	lean tissue mass to body weight ratio	0.00087351	0.0082264	0.00068301	0.958	0.916
body composition	percent fat, whole body scan, head excluded	-2.2605	0.81115	-1.0952	0.0773	0.0105
body composition	ratio of soft-tissue attenuation coefficients	0.0025125	0.00090145	1.0963	0.0770	0.0105
body composition	tissue area	-0.20040	0.15025	-0.49205	0.480	0.196
body composition	total tissue mass, whole body scan, head excluded	-0.73523	0.22717	-1.9498	0.0370	0.00379
clinical blood chemistry	alanine transaminase (plasma ALT)	10.55	16.703	0.76872	0.822	0.534
clinical blood chemistry	albumin (plasma Alb)	0.28096	0.34653	0.42604	0.723	0.426
clinical blood chemistry	alkaline phosphatase (plasma ALP)	2.3125	1.8475	-0.12716	0.477	0.223
clinical blood chemistry	aspartate transaminase (plasma AST)	30.1	32.617	1.0867	0.681	0.366
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.089200	0.28998	0.30560	0.931	0.761
clinical blood chemistry	blood urea nitrogen (BUN)	0.17500	1.4233	0.027951	0.949	0.903
clinical blood chemistry	calcium (plasma Ca)	-0.53750	0.19791	-2.5686	0.0816	0.0123
clinical blood chemistry	carbon dioxide (plasma CO₂)	-0.42875	0.68379	-0.72189	0.770	0.537
clinical blood chemistry	chloride (plasma Cl)	-2.0787	0.55034	-1.7724	0.00851	0.000977
clinical blood chemistry	glucose (plasma GLU, no fast)	-19.127	15.460	-0.44015	0.429	0.229
clinical blood chemistry	HDL cholesterol (plasma HDL)	-1.4323	2.3451	-0.66606	0.795	0.548
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.020187	0.015754	-1.2019	0.549	0.213
clinical blood chemistry	iron (plasma Fe)	-0.038125	0.014524	-1.4825	0.119	0.0151
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.209	0.087937	-1.5341	0.166	0.0262
clinical blood chemistry	phosphorus (plasma phosphate)	0.14500	0.24459	0.18270	0.790	0.559
clinical blood chemistry	potassium (plasma K)	0.54950	0.24716	1.0508	0.114	0.0363
clinical blood chemistry	sodium (plasma Na)	-2.3425	0.51546	-2.5293	0.00110	0.000145
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0185	0.0086922	1.1333	0.241	0.0442
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	0.41398	2.6158	-0.16064	0.953	0.876
clinical blood chemistry	total protein (plasma TP)	0.20000	0.75065	0.097221	0.905	0.792
clinical blood chemistry	triglyceride (plasma TG, no fast)	-8.7250	11.804	-0.27527	0.722	0.467
ECT	applied stimulus (current), by day, day 2	-0.43527	0.38084	-1.4387	0.584	0.267
ECT	applied stimulus (current), by day, day 3	-0.45949	0.41012	-1.3915	0.600	0.276
ECT	behavior following applied stimulus (current), by day, day 1	0.20089	0.26723	0.74819	0.770	0.461
ECT	behavior following applied stimulus (current), by day, day 3	-0.55000	0.34247	-1.5066	0.723	0.124
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	-0.32451	0.38475	-1.3306	0.690	0.409
EKG	duration of PQ interval	0.62411	1.2083	0.80430	0.924	0.611
EKG	duration of PR interval	1.1969	1.1277	1.3210	0.845	0.300
EKG	duration of QRS interval	0.60491	0.40119	1.4945	0.885	0.146
EKG	duration of QT interval	0.56027	0.94645	0.70258	0.898	0.560
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	2.1115	1.2568	2.0518	0.687	0.108
EKG	duration of RR interval	-2.5313	2.4910	-1.0809	0.731	0.321
EKG	duration of ST interval	-0.074554	0.99145	0.14152	0.984	0.941
EKG	heart rate coefficient of variation (signal intensity)	0.45527	0.58926	0.45220	0.877	0.448
EKG	heart rate variability, mean of differences between sequential beats; beats per min	3.6848	3.9591	0.49731	0.853	0.362
EKG	heart rate, beats per min	20.058	18.970	0.99076	0.704	0.302
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.13089	0.14038	0.86660	0.717	0.362
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.19722	0.19229	1.0696	0.664	0.317
EKG	number of signals	0.51339	1.7091	0.078665	0.948	0.767
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	2.5713	3.5754	0.54459	0.862	0.480
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-1.8237	2.5692	-0.51333	0.945	0.485
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-2.0772	2.6080	-0.57170	0.923	0.434
EKG	root mean square of successive differences of neighboring RR intervals	-0.21656	0.45954	0.0040300	0.933	0.642
electroretinography	a-wave amplitude of rod photoreceptors, left	-11.149	28.205	-1.0552	0.895	0.694
electroretinography	a-wave amplitude of rod photoreceptors, right	-10.188	22.209	-1.1639	0.855	0.648
electroretinography	b-wave amplitude of cone photoreceptors, left	22.549	14.294	1.6616	0.669	0.120
electroretinography	b-wave amplitude of cone photoreceptors, right	20.954	12.399	1.7586	0.485	0.0958
electroretinography	b-wave amplitude of rod photoreceptors, left	98.423	49.218	2.1258	0.392	0.0498
electroretinography	b-wave amplitude of rod photoreceptors, right	95.558	36.007	2.5372	0.223	0.00999
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	-0.080244	0.71930	-0.34305	0.972	0.912
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	-0.58801	0.65581	-0.71425	0.755	0.373
electroretinography	rod a wave implicit time, right	-0.036562	0.52764	-0.47951	0.991	0.945
electroretinography	rod b wave implicit time, left	-1.0207	1.6573	-0.98879	0.916	0.540
electroretinography	rod b wave implicit time, right	-0.023808	1.7005	-0.28932	0.998	0.989
glucose tolerance test	amount glucose injected	2.0137	2.9092	0.92405	0.805	0.496
glucose tolerance test	plasma glucose, 0min	16.433	3.6691	1.3487	0.00355	0.000187
glucose tolerance test	plasma glucose, 15min	21.988	26.251	0.74062	0.720	0.411
glucose tolerance test	plasma glucose, 30min	6.3252	26.363	0.32406	0.927	0.813
glucose tolerance test	plasma glucose, 60min	-29.988	18.196	-1.1404	0.393	0.114
glucose tolerance test	plasma glucose, 120min	-18.590	11.215	-1.3836	0.406	0.112
grip strength	body weight (at time of grip strength test)	1.9039	0.46743	1.7934	0.00574	0.000546
grip strength	forelimb and hindlimb grip strength (mean of trials), average	1.3756	10.941	0.33895	0.952	0.901
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.054091	0.40199	0.26596	0.948	0.894
grip strength	forelimb and hindlimb grip strength by trial, trial1	-12.460	12.074	-0.60237	0.616	0.314
grip strength	forelimb and hindlimb grip strength by trial, trial2	37.425	11.582	2.3106	0.0463	0.00400
grip strength	forelimb and hindlimb grip strength by trial, trial3	-11.062	14.476	-0.50583	0.703	0.454
grip strength	forelimb grip strength (mean of trials), average	21.980	5.5917	2.5613	0.0152	0.000766
grip strength	forelimb grip strength (mean of trials), average normalized to bw	1.1690	0.32095	2.6474	0.0280	0.00162
grip strength	forelimb grip strength by trial, trial1	18.025	7.3576	2.0849	0.195	0.0231
grip strength	forelimb grip strength by trial, trial2	19.726	9.7537	2.2705	0.285	0.0561
grip strength	forelimb grip strength by trial, trial3	23.555	9.3879	2.5245	0.168	0.0204
heart weight	heart weight, normalized to body weight	0.68271	0.38773	1.4956	0.250	0.0916
heart weight	heart weight, weight	18.223	10.010	1.6924	0.241	0.0823
insulin blood level	insulin (plasma)	345.01	235.44	1.4899	0.555	0.147
light / dark	fecal boli count, 20 min test	0.725	0.97411	0.83069	0.801	0.464
light / dark	latency to enter dark zone, 20 min test	-55.537	44.197	-1.1316	0.651	0.222
light / dark	number of transitions between light and dark zones, 20 min test	21.036	9.9848	1.8623	0.262	0.0468
light / dark	percentage of total time in dark zone, 20 min test	-8.9925	4.1899	-1.4789	0.316	0.0426
light / dark	percentage of total time in light zone, 20 min test	8.9925	4.1899	1.4789	0.313	0.0426
light / dark	time mobile in dark zone, 20 min test	18.819	16.649	0.91479	0.569	0.270
light / dark	time mobile in light zone, 20 min test	34.971	13.984	1.4994	0.123	0.0200
light / dark	time spent in dark zone, 20 min test	-60.275	51.726	-0.67874	0.669	0.256
light / dark	time spent in light zone, 20 min test	60.275	51.726	0.67874	0.669	0.256
open field	average speed in center of arena, 20 min test	0.69775	0.44679	1.0812	0.449	0.132
open field	average speed in periphery of arena, 20 min test	0.14576	0.19452	0.079970	0.687	0.461
open field	distance traveled habituation ratio, 20 min test	-15.140	8.8281	-1.2596	0.381	0.0998
open field	distance traveled in center of arena, 20 min test	192.73	101.50	0.83475	0.240	0.0702
open field	distance traveled in periphery of arena, 20 min test	93.833	184.33	-0.050369	0.791	0.616
open field	distance traveled slope, 20 min test	-11.930	7.8851	-1.0365	0.452	0.144
open field	distance traveled, 20 min test, 1st 5min	196.4	105.49	1.1282	0.244	0.0755
open field	distance traveled, 20 min test, 2nd 5min	-10.625	57.721	-0.62434	0.934	0.856
open field	distance traveled, 20 min test, 3rd 5min	40.313	67.459	0.014098	0.766	0.556
open field	distance traveled, 20 min test, 4th 5min	60.125	71.581	0.19935	0.643	0.410
open field	number of clockwise revolution episodes, 20 min test	0.050000	1.9787	-0.37680	0.992	0.980
open field	number of counter-clockwise revolution episodes, 20 min test	1.6125	1.3529	0.43860	0.532	0.245
open field	number of fecal boli, 20 min test	-1.1256	1.3738	-0.64778	0.716	0.421
open field	number of rears in 5 min bins, 20 min test, 1st 5min	9.025	3.0956	1.9946	0.0753	0.00779
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	7.75	3.0805	1.4866	0.128	0.0193
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	7.3625	3.1232	1.3310	0.158	0.0273
open field	number of rears in 5 min bins, 20 min test, 4th 5min	6.575	3.0529	1.1081	0.216	0.0420
open field	percentage of total time in center of arena, 20 min test	2.9094	2.2650	0.43564	0.526	0.212
open field	percentage of total time in center of arena, slope, 20 min test	2.3645	2.0035	1.4064	0.710	0.251
open field	percentage of total time in center, habituation ratio, 20 min test	2.1004	2.0564	1.2626	0.786	0.318
open field	percentage of total time in corners of arena, 20 min test	-8.0234	4.0893	-1.1724	0.309	0.0620
open field	percentage of total time in corners, habituation ratio, 20 min test	3.7739	2.0245	1.3376	0.519	0.0751
open field	percentage of total time in corners, slope, 20 min test	2.778	2.1069	0.99604	0.681	0.200
open field	permanence time in center of arena, 20 min test	34.874	27.182	0.43564	0.527	0.212
open field	permanence time in corners of arena, 20 min test	-96.276	49.071	-1.1724	0.309	0.0620
open field	permanence time in periphery of arena, 20 min test	-34.874	27.173	-0.43564	0.526	0.212
open field	total distance traveled, 20 min test	286.56	259.91	0.33439	0.503	0.282
open field	total number of rears, 20 min test	30.712	10.711	1.5967	0.0697	0.00871
open field	whole arena average speed, 20 min test	0.23950	0.21615	0.33581	0.500	0.279
open field	whole arena resting time, 20 min test	-16.502	24.765	0.063817	0.696	0.512
open field	whole arena time spent mobile, 20 min test	16.483	24.766	0.17748	0.699	0.512
open field	whole arena time spent vertical, 20 min test	37.961	11.366	2.1994	0.0431	0.00284
plasma chemistry analysis	free fatty acids (plasma)	0.54337	0.13258	2.2198	0.00453	0.000441
plasma chemistry analysis	plasma cholesterol	-7.0875	3.6162	-0.91302	0.223	0.0622
plasma chemistry analysis	plasma glucose (4h fast)	-14.725	7.5144	-0.65726	0.215	0.0623
plasma chemistry analysis	plasma HDL	-14.224	3.2609	-2.2198	0.00704	0.000249
plasma chemistry analysis	plasma triglycerides (4h fast)	1.0125	6.9556	0.74987	0.915	0.886
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-13.1	15.009	-0.85191	0.846	0.392
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-5.3488	4.5282	-1.1927	0.785	0.250
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-10.952	11.204	-0.62184	0.722	0.338
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	-27.575	17.710	-1.2495	0.656	0.133
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.0625	1.7517	-0.26157	0.793	0.551
startle / PPI	average baseline movement during background noise	-0.66250	0.66240	-0.43124	0.813	0.328
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.16560	0.093899	1.3512	0.402	0.0917
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.10272	0.098598	0.91251	0.657	0.309
startle / PPI	average of maximum percent pre-pulse inhibition for each pre-pulse tested	21.348	9.8934	2.2236	0.299	0.0421
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	11.443	9.3054	1.3339	0.859	0.232
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	17.031	9.0635	1.7351	0.397	0.0735
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	13.791	7.0132	1.3204	0.281	0.0620
startle / PPI	average startle response to full pulse (120 dB)	-9.0604	10.740	-0.0091075	0.654	0.408
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-16.777	10.420	-0.16965	0.321	0.122
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-20.006	9.6943	-0.23977	0.180	0.0510
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-15.904	8.1766	-0.20673	0.218	0.0647
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-1.7008	0.92796	-1.1466	0.566	0.0810
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.5563	0.91547	-1.0591	0.591	0.103
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.2500	1.0155	-0.84522	0.674	0.231
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.10612	0.10620	1.0301	0.869	0.329
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.14822	0.10920	1.1379	0.537	0.188
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.089037	0.10254	0.52826	0.657	0.395
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-8.3979	10.752	0.0035028	0.681	0.443
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-15.912	10.489	-0.15120	0.348	0.143
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-18.450	9.8555	-0.20244	0.227	0.0746
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-14.654	8.2398	-0.16254	0.255	0.0892
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.18522	0.091210	1.5952	0.705	0.0545
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.20030	0.11381	1.4806	0.386	0.0923
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.15306	0.091529	0.89392	0.324	0.109
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-42.508	47.968	-0.059583	0.621	0.385
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-74.658	45.887	-0.25132	0.312	0.118
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-87.014	44.392	-0.30375	0.204	0.0628
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-72.342	38.257	-0.26726	0.220	0.0719
startle / PPI	maximum baseline movement during background noise	-0.62083	1.3287	-0.076436	0.920	0.645
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	18.389	7.9741	1.9118	0.715	0.0309
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	21.343	9.8941	1.9296	0.309	0.0422
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	17.890	7.5020	1.5287	0.167	0.0261
startle / PPI	maximum startle response to full pulse (120 dB)	-43.129	47.815	-0.066603	0.614	0.377
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-75.875	45.680	-0.25711	0.300	0.111
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-89.908	44.099	-0.32436	0.184	0.0537
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-73.979	38.144	-0.29057	0.210	0.0654
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-3.3427	1.7199	-0.90692	0.530	0.0655
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-3.2063	1.6429	-0.88806	0.538	0.0638
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-1.6375	2.0860	-0.52714	0.789	0.441
tail suspension	duration of immobility, 5 min test	-26.291	9.4235	-1.8710	0.0839	0.0104
tail suspension	latency to immobility, 5 min test	-0.17500	1.5488	0.17778	0.979	0.911

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	9.0 %	0.0962
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	6.0 %	0.141
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	6.0 %	0.0208
eye morphology	iris pigmentation	6.0 %	0.0759
eye morphology	iris transillumination	6.0 %	0.0475
eye morphology	irispupil	9.0 %	0.0105
eye morphology	lacrimation	6.0 %	0.133
eye morphology	lens	16.0 %	0.00353
eye morphology	lens opacity	6.0 %	0.0349
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	6.0 %	0.167
eye morphology	persistence of hyaloid vascular system	9.0 %	0.0565
eye morphology	pupil dilation	11.0 %	0.00507
eye morphology	pupil light response	6.0 %	0.0908
eye morphology	pupil position	9.0 %	0.0133
eye morphology	pupil shape	10.0 %	0.00947
eye morphology	retina	9.0 %	0.0924
eye morphology	retinal blood vessels	6.0 %	0.118
eye morphology	retinal blood vessels pattern	6.0 %	0.173
eye morphology	retinal blood vessels structure	6.0 %	0.139
eye morphology	retinal pigmentation	6.0 %	0.0851
eye morphology	retinal structure	6.0 %	0.147
eye morphology	synechia	6.0 %	0.121
eye morphology	vitreous	6.0 %	0.110
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	9.0 %	0.110
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	12.0 %	0.00459
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	7.0 %	0.624
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	touch escape	14.0 %	0.161
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00
tail suspension	climbing, 5 min test (yes, no)	78.0 %	3.92e-11

GENOTYPE CORRELATION PLOT

Correlate Polr2h^{tm1.1(KOMP)Wtsi} -/+ with genotype: