MPD: JaxKOMP-EAP genotype: Rimklb<sup>tm1.1(KOMP)Vlcg</sup> -/-

JaxKOMP-EAP effect sizes: Rimklb^{tm1.1(KOMP)Vlcg} -/- Gene Rimklb

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.2500	2.1565	0.11550	0.884	0.621
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-0.93750	3.3205	-0.20042	0.949	0.804
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	4.6875	3.7170	0.74624	0.701	0.334
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	3.4056	3.9305	0.45037	0.780	0.478
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	4.7021	4.7082	0.71736	0.745	0.423
body composition	body length	0.17501	0.047538	1.9754	0.0127	0.000517
body composition	body weight (at time of DXA)	-0.92103	0.49800	-0.58019	0.208	0.0695
body composition	bone area, whole body scan, head excluded	0.56994	0.11545	2.3775	0.000668	0.00000728
body composition	bone mineral content of whole body scan, head excluded	0.045840	0.0083015	2.3135	0.000174	8.60e-7
body composition	bone mineral content to body weight ratio	0.0019863	0.00038106	2.4012	0.000340	0.00000259
body composition	bone mineral density of whole body scan, head excluded	0.0023816	0.00043813	2.2239	0.000197	0.00000118
body composition	fat tissue mass of whole body scan, head excluded	-1.0612	0.23159	-1.8428	0.00213	0.0000255
body composition	fat tissue mass to body weight ratio	-0.046467	0.0093214	-2.0854	0.000726	0.00000593
body composition	lean tissue mass of whole body scan, head excluded	1.0016	0.24551	1.6130	0.0115	0.000142
body composition	lean tissue mass to body weight ratio	0.040008	0.0088787	1.8206	0.00314	0.0000325
body composition	percent fat, whole body scan, head excluded	-4.4689	0.89698	-2.1100	0.000733	0.00000599
body composition	ratio of soft-tissue attenuation coefficients	0.0050202	0.00099858	2.1091	0.000665	0.00000509
body composition	tissue area	-0.30990	0.18921	-0.86285	0.362	0.107
body composition	total tissue mass, whole body scan, head excluded	-0.074242	0.17647	-0.39357	0.832	0.676
clinical blood chemistry	alanine transaminase (plasma ALT)	-4.2041	9.2367	-0.40855	0.895	0.651
clinical blood chemistry	albumin (plasma Alb)	-0.21176	0.39939	-0.26249	0.842	0.598
clinical blood chemistry	alkaline phosphatase (plasma ALP)	0.62061	2.8009	-0.41935	0.920	0.825
clinical blood chemistry	aspartate transaminase (plasma AST)	-26.344	19.570	-1.1586	0.507	0.183
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.23556	0.25816	-0.74292	0.755	0.365
clinical blood chemistry	blood urea nitrogen (BUN)	0.90955	0.99241	0.32600	0.636	0.364
clinical blood chemistry	calcium (plasma Ca)	-0.057990	0.082579	-0.064737	0.700	0.485
clinical blood chemistry	carbon dioxide (plasma CO₂)	0.22191	0.61676	-0.064748	0.868	0.720
clinical blood chemistry	chloride (plasma Cl)	0.24200	0.49324	0.13917	0.777	0.626
clinical blood chemistry	glucose (plasma GLU, no fast)	-44.776	11.210	-1.2237	0.00335	0.000209
clinical blood chemistry	HDL cholesterol (plasma HDL)	-1.3794	2.0760	-0.65549	0.769	0.509
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.015996	0.012749	0.75963	0.552	0.215
clinical blood chemistry	iron (plasma Fe)	-0.0057018	0.0056018	-0.38195	0.571	0.313
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.076189	0.060852	-0.60624	0.484	0.216
clinical blood chemistry	phosphorus (plasma phosphate)	0.15972	0.30940	0.21760	0.816	0.608
clinical blood chemistry	potassium (plasma K)	0.082364	0.16977	-0.65810	0.736	0.629
clinical blood chemistry	sodium (plasma Na)	1.8391	0.57887	0.76258	0.00912	0.00238
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.015540	0.0096941	-1.0937	0.404	0.114
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-2.9919	2.5003	-0.75859	0.552	0.236
clinical blood chemistry	total protein (plasma TP)	0.28474	0.70324	0.15334	0.847	0.687
clinical blood chemistry	triglyceride (plasma TG, no fast)	-30.953	9.4731	-1.2725	0.0416	0.00186
ECT	applied stimulus (current), by day, day 2	0.28090	0.31721	0.43719	0.669	0.381
ECT	applied stimulus (current), by day, day 3	0.20481	0.23622	0.31353	0.726	0.391
ECT	behavior following applied stimulus (current), by day, day 1	-0.60241	0.39625	-1.1094	0.418	0.136
ECT	behavior following applied stimulus (current), by day, day 3	-0.37657	0.25920	-1.1075	0.724	0.153
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.24458	0.19539	0.41360	0.507	0.217
EKG	duration of PQ interval	-0.55622	0.83588	-0.47013	0.900	0.508
EKG	duration of PR interval	-0.72394	0.95114	-0.62963	0.887	0.450
EKG	duration of QRS interval	-0.44748	0.38048	-1.3505	0.885	0.244
EKG	duration of QT interval	-0.71545	0.87895	-0.53879	0.858	0.419
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.77604	0.78955	-0.73388	0.856	0.330
EKG	duration of RR interval	0.37714	1.4398	0.42999	0.931	0.794
EKG	duration of ST interval	-0.21567	0.76650	-0.018136	0.958	0.779
EKG	heart rate coefficient of variation (signal intensity)	0.88182	0.63873	0.80709	0.841	0.173
EKG	heart rate variability, mean of differences between sequential beats; beats per min	6.7275	4.4659	0.85839	0.846	0.137
EKG	heart rate, beats per min	-1.6206	12.293	-0.36164	0.969	0.896
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.25017	0.092231	-1.9474	0.161	0.00882
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.31267	0.11716	-1.7966	0.166	0.00990
EKG	number of signals	4.3126	2.0700	0.82112	0.472	0.0416
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	2.3576	2.7721	0.51648	0.848	0.399
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-0.78481	2.3042	-0.19877	0.968	0.735
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-0.47625	2.5835	-0.11916	0.975	0.854
EKG	root mean square of successive differences of neighboring RR intervals	0.12800	0.81096	0.17007	0.969	0.875
electroretinography	a-wave amplitude of rod photoreceptors, left	6.6723	27.997	-0.17288	0.939	0.812
electroretinography	a-wave amplitude of rod photoreceptors, right	10.533	22.056	0.048759	0.851	0.635
electroretinography	b-wave amplitude of cone photoreceptors, left	-14.385	14.037	-0.99820	0.809	0.309
electroretinography	b-wave amplitude of cone photoreceptors, right	-21.782	11.906	-1.3953	0.459	0.0719
electroretinography	b-wave amplitude of rod photoreceptors, left	-11.492	49.048	0.12637	0.916	0.816
electroretinography	b-wave amplitude of rod photoreceptors, right	-86.167	34.506	-1.2322	0.243	0.0151
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	-0.95078	0.72377	-1.1851	0.569	0.194
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	-0.70695	0.67887	-0.82291	0.707	0.302
electroretinography	rod a wave implicit time, right	-1.0312	0.54305	-1.4445	0.364	0.0621
electroretinography	rod b wave implicit time, left	-11.377	2.7849	-2.3805	0.0142	0.000123
electroretinography	rod b wave implicit time, right	-6.9288	2.0320	-1.8173	0.0559	0.00113
glucose tolerance test	amount glucose injected	-0.11707	1.5867	0.35887	0.977	0.942
glucose tolerance test	plasma glucose, 0min	3.3420	3.7906	0.11971	0.610	0.383
glucose tolerance test	plasma glucose, 15min	14.357	28.592	0.53040	0.856	0.618
glucose tolerance test	plasma glucose, 30min	29.280	22.940	0.98809	0.551	0.209
glucose tolerance test	plasma glucose, 60min	10.909	13.786	0.57194	0.738	0.433
glucose tolerance test	plasma glucose, 120min	-0.58223	8.0254	-0.15158	0.971	0.943
grip strength	body weight (at time of grip strength test)	0.010249	0.46655	0.22231	0.989	0.983
grip strength	forelimb and hindlimb grip strength (mean of trials), average	12.438	8.5356	1.1638	0.336	0.155
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.29124	0.44787	0.62163	0.704	0.520
grip strength	forelimb and hindlimb grip strength by trial, trial1	32.662	9.1919	2.1389	0.0236	0.00121
grip strength	forelimb and hindlimb grip strength by trial, trial2	0.090120	9.0234	0.22555	0.996	0.992
grip strength	forelimb and hindlimb grip strength by trial, trial3	22.801	7.7109	1.6190	0.0578	0.00579
grip strength	forelimb grip strength (mean of trials), average	13.428	4.4688	1.8875	0.0511	0.00513
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.52413	0.23007	1.5104	0.150	0.0293
grip strength	forelimb grip strength by trial, trial1	16.384	5.9546	1.9325	0.124	0.00969
grip strength	forelimb grip strength by trial, trial2	13.943	6.7115	1.6754	0.261	0.0459
grip strength	forelimb grip strength by trial, trial3	6.1516	7.9242	0.87777	0.740	0.443
heart weight	heart weight, normalized to body weight	0.98820	0.14751	2.0777	0.00000373	1.01e-8
heart weight	heart weight, weight	22.081	3.4461	2.0662	0.00000948	3.07e-8
hematology	basophil differential (percent of total WBC)	-0.041696	0.040091	-0.62115	0.720	0.303
hematology	calculated hemoglobin (cHGB)	0.56801	0.21130	1.4501	0.0998	0.00963
hematology	eosinophil differential (percent of total WBC)	-0.26062	0.22757	-0.63258	0.647	0.257
hematology	hematocrit (HCT)	1.6981	0.61923	1.4114	0.0944	0.00835
hematology	hemoglobin concentration distribution width (HDW)	0.025941	0.022415	0.70203	0.561	0.252
hematology	large unstained cells (percent of total WBC)	-0.028095	0.066970	-0.17724	0.873	0.677
hematology	lymphocyte differential (percent of total WBC)	-3.1418	0.97676	-1.2766	0.0400	0.00223
hematology	mean corpuscular hemoglobin (CHr)	0.27998	0.059136	1.7872	0.000410	0.0000179
hematology	mean platelet volume (MPV)	-0.18955	0.068684	-1.1675	0.0469	0.00801
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.92415	0.54323	-1.5509	0.401	0.0950
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-2.4377	1.2106	-1.8266	0.311	0.0493
hematology	mean RBC corpuscular volume (MCV)	0.71571	0.26400	1.2143	0.0550	0.00912
hematology	measured hemoglobin (mHGB)	-0.46229	0.58975	-1.1297	0.696	0.437
hematology	monocyte differential (percent of total WBC)	-0.26812	0.13722	-0.66168	0.349	0.0561
hematology	neutrophil differential (percent of total WBC)	3.6789	0.76687	1.5783	0.00134	0.0000139
hematology	platelet count (PLT; units per volume x 10³)	-27.384	41.877	-0.32548	0.797	0.516
hematology	RBC corpuscular distribution width (RDW)	0.20194	0.10885	0.72215	0.265	0.0693
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.12249	0.18370	0.31498	0.740	0.508
hematology	red blood cell count (RBC; per volume x 10⁶)	0.24077	0.15514	0.70223	0.369	0.127
hematology	reticulocyte count (Retic; units per volume x 10⁹)	4.4664	16.013	0.29901	0.941	0.781
hematology	white blood cell count (WBC; units per volume x 10³)	-1.8277	0.62258	-1.0676	0.0357	0.00495
insulin blood level	insulin (plasma)	-218.21	275.21	-0.48491	0.719	0.430
light / dark	fecal boli count, 20 min test	-0.15904	0.48705	-0.13221	0.927	0.745
light / dark	latency to enter dark zone, 20 min test	63.487	49.806	1.0229	0.633	0.207
light / dark	number of transitions between light and dark zones, 20 min test	31.173	7.2084	2.3811	0.00432	0.0000597
light / dark	percentage of total time in dark zone, 20 min test	-6.8820	3.4972	-1.0914	0.347	0.0538
light / dark	percentage of total time in light zone, 20 min test	6.8820	3.4972	1.0865	0.345	0.0538
light / dark	time mobile in dark zone, 20 min test	30.540	13.399	1.3370	0.163	0.0263
light / dark	time mobile in light zone, 20 min test	53.764	10.354	2.1015	0.000238	0.00000269
light / dark	time spent in dark zone, 20 min test	-98.773	50.503	-1.1709	0.389	0.0552
light / dark	time spent in light zone, 20 min test	98.773	50.503	1.1709	0.389	0.0552
open field	average speed in center of arena, 20 min test	1.8865	0.41600	2.3004	0.00250	0.0000294
open field	average speed in periphery of arena, 20 min test	1.0947	0.16013	2.1562	3.67e-7	5.12e-9
open field	distance traveled habituation ratio, 20 min test	-36.172	7.9009	-2.3613	0.00184	0.0000247
open field	distance traveled in center of arena, 20 min test	499.89	80.197	2.0047	0.00000548	5.29e-8
open field	distance traveled in periphery of arena, 20 min test	941.85	169.67	2.0804	0.0000427	7.09e-7
open field	distance traveled slope, 20 min test	-35.906	7.3517	-2.3400	0.000815	0.00000829
open field	distance traveled, 20 min test, 1st 5min	630.22	76.504	2.5186	4.05e-9	2.17e-11
open field	distance traveled, 20 min test, 2nd 5min	339.16	56.498	2.0148	0.00000864	1.28e-7
open field	distance traveled, 20 min test, 3rd 5min	227.91	54.940	1.7012	0.00278	0.000109
open field	distance traveled, 20 min test, 4th 5min	304.12	57.688	2.0047	0.0000987	0.00000201
open field	number of clockwise revolution episodes, 20 min test	6.1217	1.2491	2.1166	0.000662	0.00000780
open field	number of counter-clockwise revolution episodes, 20 min test	5.5850	1.0973	2.0148	0.000458	0.00000392
open field	number of fecal boli, 20 min test	-0.056095	0.72962	0.22683	0.980	0.939
open field	number of rears in 5 min bins, 20 min test, 1st 5min	2.9750	2.4532	0.60928	0.496	0.230
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-0.43116	2.4762	-0.46686	0.945	0.862
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-1.4440	2.4817	-0.62597	0.771	0.563
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-1.0034	2.3658	-0.56978	0.833	0.673
open field	percentage of total time in center of arena, 20 min test	4.6719	2.7437	0.84814	0.375	0.0940
open field	percentage of total time in center of arena, slope, 20 min test	1.7508	1.6902	1.0861	0.765	0.304
open field	percentage of total time in center, habituation ratio, 20 min test	1.3480	1.8293	0.86364	0.845	0.464
open field	percentage of total time in corners of arena, 20 min test	-11.985	4.0149	-1.8074	0.0715	0.00415
open field	percentage of total time in corners, habituation ratio, 20 min test	3.4956	2.0641	1.2247	0.554	0.0956
open field	percentage of total time in corners, slope, 20 min test	3.0868	1.9365	1.1081	0.608	0.116
open field	permanence time in center of arena, 20 min test	56.064	32.924	0.84814	0.375	0.0940
open field	permanence time in corners of arena, 20 min test	-143.83	48.180	-1.8143	0.0715	0.00414
open field	permanence time in periphery of arena, 20 min test	-56.074	32.925	-0.85007	0.375	0.0939
open field	total distance traveled, 20 min test	1498.3	205.76	2.1562	8.41e-8	9.01e-10
open field	total number of rears, 20 min test	-1.1227	8.0511	-0.41946	0.950	0.890
open field	whole arena average speed, 20 min test	1.2483	0.17147	2.1562	8.48e-8	9.09e-10
open field	whole arena resting time, 20 min test	-136.17	17.843	-2.1168	2.87e-8	2.30e-10
open field	whole arena time spent mobile, 20 min test	136.25	17.837	2.1845	2.78e-8	2.24e-10
open field	whole arena time spent vertical, 20 min test	-13.282	8.1124	-1.1358	0.371	0.107
plasma chemistry analysis	free fatty acids (plasma)	-0.19364	0.11045	-0.43882	0.182	0.0861
plasma chemistry analysis	plasma cholesterol	-10.733	3.8838	-1.5781	0.0681	0.00814
plasma chemistry analysis	plasma glucose (4h fast)	-10.548	6.3451	-0.30849	0.277	0.103
plasma chemistry analysis	plasma HDL	-3.7325	3.4317	-0.60338	0.495	0.282
plasma chemistry analysis	plasma triglycerides (4h fast)	7.8405	4.6442	1.5364	0.235	0.0980
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-13.892	17.189	-0.91837	0.852	0.424
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-5.9207	5.0884	-1.2594	0.787	0.251
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-18.010	13.748	-1.2112	0.543	0.198
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	-20.138	16.370	-0.94612	0.788	0.226
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	3.7016	1.6484	1.6338	0.207	0.0320
startle / PPI	average baseline movement during background noise	-0.46710	0.76878	-0.27744	0.901	0.546
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.20556	0.042910	1.6751	0.00677	0.0000158
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.17229	0.042181	1.5653	0.0165	0.000163
startle / PPI	average of maximum percent pre-pulse inhibition for each pre-pulse tested	14.924	4.3464	1.4150	0.0723	0.00142
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	14.628	6.7805	1.7478	0.765	0.0360
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	13.434	4.7303	1.3374	0.157	0.00655
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	17.669	4.3347	1.7288	0.00997	0.000167
startle / PPI	average startle response to full pulse (120 dB)	3.4988	17.235	0.29496	0.941	0.840
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.69017	15.895	0.16965	0.984	0.966
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-12.876	16.256	-0.084870	0.633	0.432
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-22.323	14.661	-0.35404	0.330	0.134
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.43716	1.0054	-0.26001	0.935	0.666
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.49886	0.86480	0.36151	0.912	0.567
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	2.1778	1.2180	0.76388	0.480	0.0801
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.15224	0.072801	1.5066	0.744	0.0418
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.15403	0.054026	1.2105	0.131	0.00636
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.19918	0.051927	1.3235	0.0123	0.000358
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	3.9370	17.307	0.29935	0.931	0.821
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-0.26776	16.066	0.16538	0.994	0.987
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-13.266	16.343	-0.091903	0.623	0.421
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-24.610	14.717	-0.38706	0.273	0.101
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.19598	0.081329	1.6695	0.611	0.0198
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.18700	0.051287	1.3867	0.0588	0.000644
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.21004	0.053075	1.3268	0.00934	0.000244
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	7.7051	70.716	0.24699	0.970	0.914
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-18.703	62.162	0.082058	0.888	0.765
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-76.452	61.331	-0.24843	0.433	0.218
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-111.73	55.925	-0.49679	0.179	0.0513
startle / PPI	maximum baseline movement during background noise	-0.43011	1.6412	-0.013311	0.960	0.794
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	18.335	7.5618	1.8947	0.615	0.0191
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	17.580	4.6883	1.5706	0.0502	0.000468
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	20.010	4.7039	1.7609	0.00702	0.0000942
startle / PPI	maximum startle response to full pulse (120 dB)	7.3034	70.549	0.23833	0.967	0.918
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-18.568	61.574	0.082058	0.888	0.764
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-75.193	61.072	-0.24410	0.442	0.224
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-104.51	55.728	-0.47315	0.212	0.0667
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.8046	2.5840	-0.47628	0.849	0.488
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	1.3149	1.8499	0.41744	0.849	0.481
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	5.7684	2.8699	0.79424	0.360	0.0500
tail suspension	duration of immobility, 5 min test	-10.803	12.448	-1.2746	0.618	0.390
tail suspension	latency to immobility, 5 min test	2.3597	1.9579	1.2407	0.725	0.234

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.0
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	1.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	5.0 %	0.415
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	24.0 %	0.0170
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.00
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	9.0 %	1.00
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	5.0 %	0.440
eye morphology	pupil shape	6.0 %	0.324
eye morphology	retina	13.0 %	1.0
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.0
eye morphology	retinal pigmentation	13.0 %	1.0
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	7.0 %	0.624
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	touch escape	14.0 %	0.253
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	4.0 %	0.268
tail suspension	climbing, 5 min test (yes, no)	22.0 %	0.0520

GENOTYPE CORRELATION PLOT

Correlate Rimklb^{tm1.1(KOMP)Vlcg} -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.