MPD: JaxKOMP-EAP genotype: Epb41l4a<sup>tm1b(KOMP)Mbp</sup>/2J -/-

JaxKOMP-EAP effect sizes: Epb41l4a^{tm1b(KOMP)Mbp}/2J -/- Gene Epb41l4a

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-1.1893	1.6829	-0.62643	0.825	0.494
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-1.1364	2.0876	-0.23816	0.885	0.596
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-2.2727	1.5868	-0.68209	0.537	0.178
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-10.746	4.5506	-1.6845	0.257	0.0360
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-19.684	5.4768	-2.0626	0.0813	0.00369
body composition	body length	-0.069252	0.044024	-0.60084	0.378	0.121
body composition	body weight (at time of DXA)	0.70261	0.53498	0.68007	0.406	0.194
body composition	bone area, whole body scan, head excluded	-0.0067755	0.10858	0.13558	0.988	0.950
body composition	bone mineral content of whole body scan, head excluded	-0.0020040	0.0076169	0.020480	0.917	0.793
body composition	bone mineral content to body weight ratio	-0.00013184	0.00032643	-0.016384	0.845	0.688
body composition	bone mineral density of whole body scan, head excluded	-0.00015917	0.00044857	-0.14048	0.872	0.724
body composition	fat tissue mass of whole body scan, head excluded	-0.63874	0.20301	-1.1924	0.0368	0.00263
body composition	fat tissue mass to body weight ratio	-0.022837	0.0078792	-1.0374	0.0490	0.00529
body composition	lean tissue mass of whole body scan, head excluded	0.38556	0.19788	0.65237	0.266	0.0563
body composition	lean tissue mass to body weight ratio	0.016513	0.0076791	0.81467	0.171	0.0357
body composition	percent fat, whole body scan, head excluded	-2.1332	0.73292	-1.0350	0.0491	0.00511
body composition	ratio of soft-tissue attenuation coefficients	0.0023747	0.00081478	1.0407	0.0479	0.00505
body composition	tissue area	-0.40737	0.15791	-1.1223	0.110	0.0125
body composition	total tissue mass, whole body scan, head excluded	-0.29406	0.18130	-0.94798	0.313	0.110
clinical blood chemistry	alanine transaminase (plasma ALT)	-2.1612	18.738	-0.23524	0.972	0.909
clinical blood chemistry	albumin (plasma Alb)	-0.36964	0.38150	-0.47337	0.644	0.337
clinical blood chemistry	alkaline phosphatase (plasma ALP)	5.1554	3.3278	0.43643	0.340	0.127
clinical blood chemistry	aspartate transaminase (plasma AST)	-6.8639	16.858	-0.34862	0.890	0.685
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.057361	0.26130	0.20004	0.945	0.827
clinical blood chemistry	blood urea nitrogen (BUN)	-0.86806	1.2612	-0.39019	0.724	0.494
clinical blood chemistry	calcium (plasma Ca)	0.035390	0.067319	0.57551	0.775	0.601
clinical blood chemistry	carbon dioxide (plasma CO₂)	1.1446	0.50545	0.78557	0.161	0.0274
clinical blood chemistry	chloride (plasma Cl)	-0.24000	0.43940	-0.31612	0.749	0.587
clinical blood chemistry	glucose (plasma GLU, no fast)	-7.4741	11.991	0.0092839	0.721	0.536
clinical blood chemistry	HDL cholesterol (plasma HDL)	-1.9692	2.6159	-0.75735	0.736	0.455
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0066415	0.013345	0.23633	0.864	0.621
clinical blood chemistry	iron (plasma Fe)	0.0042226	0.0059398	0.37162	0.712	0.480
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.036427	0.057244	-0.26589	0.737	0.527
clinical blood chemistry	phosphorus (plasma phosphate)	-0.22629	0.22994	-0.42969	0.619	0.329
clinical blood chemistry	potassium (plasma K)	0.10911	0.16453	-0.54367	0.653	0.510
clinical blood chemistry	sodium (plasma Na)	1.3669	0.50896	0.37378	0.0272	0.00946
clinical blood chemistry	total bilirubin (plasma TBIL)	0.00039230	0.010790	0.034072	0.992	0.971
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-3.5138	2.7952	-0.82472	0.526	0.214
clinical blood chemistry	total protein (plasma TP)	0.0085504	0.58494	-0.045695	0.993	0.988
clinical blood chemistry	triglyceride (plasma TG, no fast)	-26.067	9.1725	-1.1284	0.0706	0.00625
ECT	applied stimulus (current), by day, day 2	0.10254	0.30356	-0.10020	0.882	0.737
ECT	applied stimulus (current), by day, day 3	-0.21849	0.20840	-0.94258	0.631	0.300
ECT	behavior following applied stimulus (current), by day, day 1	-0.45277	0.32090	-0.83211	0.464	0.165
ECT	behavior following applied stimulus (current), by day, day 3	0.38088	0.30018	0.84925	0.724	0.211
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	-0.26928	0.23710	-1.2243	0.568	0.262
EKG	duration of PQ interval	0.82914	0.93222	1.0282	0.870	0.380
EKG	duration of PR interval	1.7802	0.95285	1.7969	0.620	0.0706
EKG	duration of QRS interval	0.84241	0.27421	2.0198	0.470	0.00417
EKG	duration of QT interval	-0.53116	0.89577	-0.34739	0.898	0.557
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.23989	0.67705	-0.20082	0.960	0.725
EKG	duration of RR interval	-1.3717	1.7968	-0.45220	0.803	0.450
EKG	duration of ST interval	-1.3555	0.81471	-1.1028	0.603	0.105
EKG	heart rate coefficient of variation (signal intensity)	-2.3224	1.5871	-1.8390	0.841	0.153
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-13.762	11.736	-1.6785	0.853	0.249
EKG	heart rate, beats per min	8.7579	14.531	0.27884	0.821	0.551
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.020012	0.051902	0.049427	0.903	0.702
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.057945	0.076277	0.23714	0.760	0.453
EKG	number of signals	4.6550	2.8636	0.89089	0.605	0.113
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-0.99514	6.3856	-0.13058	0.990	0.877
EKG	QT dispersion, measured as inter-lead variability of QT intervals	3.3287	2.5354	0.93990	0.865	0.198
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	3.3890	2.6708	0.89089	0.860	0.213
EKG	root mean square of successive differences of neighboring RR intervals	-1.4235	1.4740	-0.67956	0.860	0.341
glucose tolerance test	amount glucose injected	2.4973	1.5271	1.0470	0.438	0.109
glucose tolerance test	plasma glucose, 0min	11.739	3.9860	0.94860	0.0356	0.00509
glucose tolerance test	plasma glucose, 15min	27.058	20.377	0.88791	0.507	0.191
glucose tolerance test	plasma glucose, 30min	29.938	18.390	1.0016	0.420	0.110
glucose tolerance test	plasma glucose, 60min	26.898	15.975	1.1671	0.366	0.0990
glucose tolerance test	plasma glucose, 120min	8.4715	6.8916	0.44230	0.535	0.225
grip strength	body weight (at time of grip strength test)	0.82346	0.56713	0.97439	0.326	0.157
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-14.879	9.5265	-0.77949	0.298	0.129
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.96606	0.48877	-1.1811	0.184	0.0577
grip strength	forelimb and hindlimb grip strength by trial, trial1	-12.939	10.957	-0.62340	0.544	0.247
grip strength	forelimb and hindlimb grip strength by trial, trial2	-17.102	12.187	-0.84204	0.407	0.171
grip strength	forelimb and hindlimb grip strength by trial, trial3	-11.745	10.545	-0.54754	0.542	0.274
grip strength	forelimb grip strength (mean of trials), average	-8.9623	4.4907	-0.81542	0.219	0.0551
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.53960	0.23886	-1.1004	0.158	0.0316
grip strength	forelimb grip strength by trial, trial1	-8.7807	6.7689	-0.75223	0.552	0.204
grip strength	forelimb grip strength by trial, trial2	-9.9247	6.1939	-0.85452	0.411	0.120
grip strength	forelimb grip strength by trial, trial3	-8.1497	7.1054	-0.64113	0.580	0.260
heart weight	heart weight, normalized to body weight	1.0282	0.36474	2.1676	0.0453	0.00672
heart weight	heart weight, weight	25.804	8.5772	2.2616	0.0364	0.00398
hematology	basophil differential (percent of total WBC)	0.016927	0.033988	0.29526	0.884	0.621
hematology	calculated hemoglobin (cHGB)	-0.16723	0.18484	-0.77041	0.644	0.371
hematology	eosinophil differential (percent of total WBC)	0.60839	0.29542	1.6122	0.331	0.0464
hematology	hematocrit (HCT)	-0.12052	0.62236	-0.48589	0.928	0.847
hematology	hemoglobin concentration distribution width (HDW)	-0.019259	0.019753	-0.53159	0.636	0.336
hematology	large unstained cells (percent of total WBC)	0.087407	0.068654	0.56246	0.562	0.211
hematology	lymphocyte differential (percent of total WBC)	-2.2622	1.9253	-0.97545	0.501	0.247
hematology	mean corpuscular hemoglobin (CHr)	0.084725	0.054890	0.71363	0.331	0.131
hematology	mean platelet volume (MPV)	0.048137	0.11352	0.15219	0.832	0.674
hematology	mean RBC corpuscular hemoglobin (MCH)	0.062161	0.14761	0.19724	0.860	0.676
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.18811	0.33245	-0.42322	0.826	0.575
hematology	mean RBC corpuscular volume (MCV)	0.51053	0.21265	0.87882	0.100	0.0214
hematology	measured hemoglobin (mHGB)	-0.14009	0.23540	-0.58485	0.773	0.555
hematology	monocyte differential (percent of total WBC)	-0.25499	0.24812	-0.62470	0.659	0.311
hematology	neutrophil differential (percent of total WBC)	1.8519	1.6710	0.94298	0.522	0.275
hematology	platelet count (PLT; units per volume x 10³)	10.446	44.755	0.18974	0.937	0.817
hematology	RBC corpuscular distribution width (RDW)	0.25795	0.14447	0.90339	0.294	0.0822
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.24802	0.16089	-0.68766	0.347	0.131
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.15198	0.14665	-0.95728	0.574	0.307
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-10.446	12.186	-0.37757	0.753	0.397
hematology	white blood cell count (WBC; units per volume x 10³)	0.57985	0.64683	0.57238	0.584	0.376
insulin blood level	insulin (plasma)	-534.18	304.21	-1.9306	0.524	0.0829
light / dark	fecal boli count, 20 min test	-0.80196	0.76102	-0.86261	0.701	0.296
light / dark	latency to enter dark zone, 20 min test	83.242	33.034	1.2921	0.233	0.0140
light / dark	number of transitions between light and dark zones, 20 min test	-3.5418	4.7479	-0.25698	0.731	0.458
light / dark	percentage of total time in dark zone, 20 min test	-5.5898	2.4885	-0.86261	0.268	0.0278
light / dark	percentage of total time in light zone, 20 min test	5.5898	2.4885	0.86065	0.265	0.0278
light / dark	time mobile in dark zone, 20 min test	-15.469	10.572	-1.0161	0.435	0.148
light / dark	time mobile in light zone, 20 min test	9.0035	7.1644	0.33898	0.469	0.213
light / dark	time spent in dark zone, 20 min test	-127.38	32.682	-1.5469	0.0270	0.000216
light / dark	time spent in light zone, 20 min test	127.38	32.682	1.5469	0.0270	0.000216
open field	average speed in center of arena, 20 min test	0.22318	0.43580	0.30754	0.840	0.610
open field	average speed in periphery of arena, 20 min test	0.065110	0.14336	-0.25307	0.808	0.651
open field	distance traveled habituation ratio, 20 min test	-3.3564	8.1718	-0.23509	0.875	0.682
open field	distance traveled in center of arena, 20 min test	110.06	65.505	0.38308	0.292	0.0970
open field	distance traveled in periphery of arena, 20 min test	20.393	151.53	-0.36006	0.951	0.893
open field	distance traveled slope, 20 min test	-3.3384	7.9177	-0.23233	0.872	0.674
open field	distance traveled, 20 min test, 1st 5min	51.554	76.033	0.071891	0.726	0.500
open field	distance traveled, 20 min test, 2nd 5min	29.882	53.982	-0.15298	0.782	0.582
open field	distance traveled, 20 min test, 3rd 5min	27.873	55.681	-0.12586	0.804	0.618
open field	distance traveled, 20 min test, 4th 5min	30.882	47.653	-0.093446	0.741	0.519
open field	number of clockwise revolution episodes, 20 min test	1.7015	1.0881	0.57408	0.450	0.122
open field	number of counter-clockwise revolution episodes, 20 min test	0.086399	0.95745	-0.38453	0.968	0.928
open field	number of fecal boli, 20 min test	-0.89684	0.72589	-0.45252	0.556	0.220
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-0.98318	1.8920	-0.47990	0.807	0.605
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	0.74938	2.1019	-0.16113	0.869	0.722
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	2.6027	2.1548	0.31882	0.506	0.231
open field	number of rears in 5 min bins, 20 min test, 4th 5min	5.6126	1.9131	0.87146	0.0639	0.00442
open field	percentage of total time in center of arena, 20 min test	2.8891	2.0331	0.42975	0.467	0.159
open field	percentage of total time in center of arena, slope, 20 min test	-0.71295	1.4822	-0.27113	0.914	0.632
open field	percentage of total time in center, habituation ratio, 20 min test	-1.0318	1.6203	-0.44304	0.862	0.526
open field	percentage of total time in corners of arena, 20 min test	-3.9284	2.8919	-0.40048	0.488	0.178
open field	percentage of total time in corners, habituation ratio, 20 min test	0.42266	2.0675	-0.085358	0.969	0.839
open field	percentage of total time in corners, slope, 20 min test	0.25055	1.9493	-0.16658	0.969	0.898
open field	permanence time in center of arena, 20 min test	34.666	24.398	0.43122	0.468	0.159
open field	permanence time in corners of arena, 20 min test	-47.129	34.704	-0.40048	0.488	0.178
open field	permanence time in periphery of arena, 20 min test	-34.661	24.402	-0.43122	0.467	0.160
open field	total distance traveled, 20 min test	138.59	191.40	-0.071891	0.682	0.471
open field	total number of rears, 20 min test	8.1186	6.4894	0.22131	0.458	0.215
open field	whole arena average speed, 20 min test	0.11578	0.15953	-0.070545	0.679	0.470
open field	whole arena resting time, 20 min test	-18.926	19.348	-0.0087270	0.534	0.331
open field	whole arena time spent mobile, 20 min test	18.878	19.348	0.25862	0.545	0.332
open field	whole arena time spent vertical, 20 min test	-1.1983	7.7962	-0.21031	0.951	0.878
plasma chemistry analysis	free fatty acids (plasma)	-0.076718	0.083755	0.29693	0.500	0.363
plasma chemistry analysis	plasma cholesterol	-1.7455	2.8313	0.0055212	0.705	0.540
plasma chemistry analysis	plasma glucose (4h fast)	-27.799	6.8452	-1.6177	0.00416	0.000129
plasma chemistry analysis	plasma HDL	-1.6647	2.6881	-0.27393	0.735	0.538
plasma chemistry analysis	plasma triglycerides (4h fast)	-4.8350	5.1261	0.039002	0.563	0.349
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-0.71773	11.785	0.16243	0.979	0.952
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-0.096439	3.5790	0.22192	0.991	0.979
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	16.469	9.2511	1.7574	0.383	0.0812
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	16.604	14.635	1.4376	0.788	0.262
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-2.1747	1.6226	-0.74706	0.512	0.191
startle / PPI	average baseline movement during background noise	-0.54094	0.25466	-0.33619	0.519	0.0463
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.22198	0.084608	-1.9296	0.185	0.0163
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.21842	0.070540	-2.1387	0.122	0.00569
startle / PPI	average of maximum percent pre-pulse inhibition for each pre-pulse tested	-19.947	8.9219	-1.6224	0.293	0.0369
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-17.580	8.2550	-1.7879	0.771	0.0458
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-18.971	8.8391	-1.8237	0.320	0.0443
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-24.772	6.9784	-2.1124	0.0527	0.00201
startle / PPI	average startle response to full pulse (120 dB)	4.0546	10.358	0.30522	0.864	0.700
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.9348	11.431	0.37651	0.714	0.496
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	8.4952	11.432	0.36300	0.662	0.466
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	16.878	8.7616	0.59772	0.225	0.0684
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.11306	0.31521	-0.0049040	0.951	0.724
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.67446	0.39156	-0.45287	0.591	0.100
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.3694	0.46907	-0.92182	0.196	0.00848
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.19342	0.078607	-1.6207	0.678	0.0231
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.20061	0.093798	-1.7159	0.296	0.0450
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.27782	0.076876	-2.0396	0.0295	0.00173
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	4.5955	10.422	0.31404	0.847	0.664
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	8.5058	11.427	0.37050	0.686	0.465
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	8.7459	11.463	0.36900	0.655	0.454
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	18.431	8.9110	0.63328	0.185	0.0518
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.22137	0.098993	-1.6809	0.700	0.0369
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.19923	0.10659	-1.6050	0.362	0.0763
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.27076	0.080964	-1.9293	0.0458	0.00323
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	14.834	47.614	0.29935	0.900	0.759
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	24.192	46.851	0.29642	0.792	0.611
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	27.003	51.454	0.32879	0.762	0.605
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	77.168	39.773	0.66791	0.210	0.0666
startle / PPI	maximum baseline movement during background noise	-1.6540	0.65808	-0.44977	0.380	0.0206
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-20.750	9.9097	-1.8387	0.778	0.0492
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-19.040	10.193	-1.7478	0.393	0.0765
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-24.782	7.5451	-2.0288	0.0603	0.00371
startle / PPI	maximum startle response to full pulse (120 dB)	13.180	47.598	0.28035	0.910	0.785
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	22.242	46.813	0.29496	0.811	0.640
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	26.422	51.632	0.31698	0.769	0.614
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	72.412	39.499	0.62815	0.243	0.0817
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-0.79027	0.91041	-0.13138	0.792	0.396
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-1.4854	1.1679	-0.38555	0.715	0.218
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-3.8924	1.5820	-0.99731	0.252	0.0236
tail suspension	duration of immobility, 5 min test	11.580	10.874	0.20912	0.526	0.291
tail suspension	latency to immobility, 5 min test	0.73233	1.4454	0.64108	0.895	0.614

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value

eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	6.0 %	0.140
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.0
eye morphology	corneal scleralization	6.0 %	0.277
eye morphology	corneal ulcer	1.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	5.0 %	0.415
eye morphology	lacrimation	6.0 %	0.234
eye morphology	lens	11.0 %	0.121
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.00
eye morphology	optic disc	6.0 %	0.227
eye morphology	persistence of hyaloid vascular system	11.0 %	0.0643
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	5.0 %	0.440
eye morphology	pupil shape	6.0 %	0.324
eye morphology	retina	14.0 %	0.0655
eye morphology	retinal blood vessels	6.0 %	0.184
eye morphology	retinal blood vessels pattern	6.0 %	0.263
eye morphology	retinal blood vessels structure	6.0 %	0.202
eye morphology	retinal pigmentation	7.0 %	0.0314
eye morphology	retinal structure	6.0 %	0.209
eye morphology	synechia	6.0 %	0.188
eye morphology	vitreous	6.0 %	0.177
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.0
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.00
SHIRPA	coat color back	0.0 %	1.0
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.0
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.0
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.0
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.00
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.00
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	7.0 %	0.0530
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.0
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	7.0 %	0.272
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.0
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	7.0 %	0.0230
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.0
SHIRPA	tail curvature	0.0 %	1.00
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	0.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	touch escape	14.0 %	0.246
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00
tail suspension	climbing, 5 min test (yes, no)	22.0 %	0.219

GENOTYPE CORRELATION PLOT

Correlate Epb41l4a^{tm1b(KOMP)Mbp}/2J -/- with genotype: