MPD: JaxKOMP-EAP genotype: Arsk<sup>tm1b(KOMP)Wtsi</sup> -/-

JaxKOMP-EAP effect sizes: Arsk^{tm1b(KOMP)Wtsi} -/- Gene Arsk

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	6.8750	2.3065	1.4580	0.172	0.00839
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	5.7202	2.6510	1.1317	0.401	0.0465
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	7.9268	4.4305	1.1773	0.434	0.0925
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	1.0401	2.9599	0.045757	0.900	0.730
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-3.1529	5.5062	-0.51062	0.832	0.575
body composition	body length	-0.0037949	0.057726	0.15097	0.989	0.948
body composition	body weight (at time of DXA)	1.7538	0.55239	1.5512	0.0205	0.00240
body composition	bone area, whole body scan, head excluded	-0.21534	0.12513	-0.70043	0.305	0.0907
body composition	bone mineral content of whole body scan, head excluded	-0.020619	0.0085655	-0.95013	0.126	0.0193
body composition	bone mineral content to body weight ratio	-0.00067242	0.00036589	-0.69868	0.257	0.0712
body composition	bone mineral density of whole body scan, head excluded	-0.0011115	0.00044863	-1.1540	0.126	0.0162
body composition	fat tissue mass of whole body scan, head excluded	0.46286	0.22661	0.70918	0.199	0.0457
body composition	fat tissue mass to body weight ratio	0.016463	0.0078890	0.77205	0.166	0.0413
body composition	lean tissue mass of whole body scan, head excluded	-0.35586	0.24909	-0.90397	0.456	0.159
body composition	lean tissue mass to body weight ratio	-0.018367	0.0074975	-1.0071	0.121	0.0173
body composition	percent fat, whole body scan, head excluded	1.6625	0.76757	0.83619	0.150	0.0344
body composition	ratio of soft-tissue attenuation coefficients	-0.0018363	0.00085634	-0.84045	0.153	0.0362
body composition	tissue area	0.032656	0.14247	0.30537	0.945	0.820
body composition	total tissue mass, whole body scan, head excluded	0.086571	0.19498	-0.025943	0.823	0.659
clinical blood chemistry	alanine transaminase (plasma ALT)	20.121	14.175	1.1645	0.532	0.162
clinical blood chemistry	albumin (plasma Alb)	-0.91117	0.40796	-1.1469	0.210	0.0298
clinical blood chemistry	alkaline phosphatase (plasma ALP)	2.7123	3.7645	-0.064517	0.700	0.474
clinical blood chemistry	aspartate transaminase (plasma AST)	11.272	29.450	0.49438	0.899	0.703
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.32943	0.26621	-0.99343	0.619	0.221
clinical blood chemistry	blood urea nitrogen (BUN)	1.3844	1.1668	0.53380	0.507	0.241
clinical blood chemistry	calcium (plasma Ca)	-0.013222	0.093337	0.26835	0.943	0.888
clinical blood chemistry	carbon dioxide (plasma CO₂)	0.96798	0.45086	0.63148	0.182	0.0363
clinical blood chemistry	chloride (plasma Cl)	0.13262	0.56219	0.043066	0.899	0.814
clinical blood chemistry	glucose (plasma GLU, no fast)	-26.697	15.162	-0.67404	0.228	0.0849
clinical blood chemistry	HDL cholesterol (plasma HDL)	1.3830	3.1171	0.0092105	0.869	0.659
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.019415	0.012543	-1.1702	0.443	0.128
clinical blood chemistry	iron (plasma Fe)	-0.0061286	0.0082309	-0.40796	0.708	0.460
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	0.076893	0.055695	0.71306	0.436	0.174
clinical blood chemistry	phosphorus (plasma phosphate)	0.32618	0.23487	0.44379	0.434	0.171
clinical blood chemistry	potassium (plasma K)	0.20644	0.15736	-0.14614	0.364	0.195
clinical blood chemistry	sodium (plasma Na)	0.80263	0.53857	-0.13168	0.240	0.142
clinical blood chemistry	total bilirubin (plasma TBIL)	0.015985	0.0094166	1.0265	0.369	0.0954
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	2.3605	3.3769	0.18807	0.767	0.488
clinical blood chemistry	total protein (plasma TP)	-0.27304	0.85401	-0.27611	0.889	0.750
clinical blood chemistry	triglyceride (plasma TG, no fast)	-1.7941	9.8482	0.12912	0.935	0.856
ECT	applied stimulus (current), by day, day 2	0.56091	0.25614	1.2002	0.231	0.0343
ECT	applied stimulus (current), by day, day 3	0.19959	0.26670	0.27868	0.771	0.459
ECT	behavior following applied stimulus (current), by day, day 1	-0.54313	0.31642	-1.0114	0.349	0.0938
ECT	behavior following applied stimulus (current), by day, day 3	0.45391	0.30631	1.0977	0.724	0.147
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.081938	0.19446	-0.083652	0.847	0.676
EKG	duration of PQ interval	0.68306	0.73751	0.86423	0.867	0.358
EKG	duration of PR interval	0.90110	0.76922	1.0918	0.807	0.247
EKG	duration of QRS interval	0.24194	0.23802	0.52255	0.885	0.314
EKG	duration of QT interval	1.0298	0.72733	1.1523	0.670	0.163
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.0062	0.63708	1.0809	0.702	0.120
EKG	duration of RR interval	0.40213	1.1344	0.44774	0.907	0.724
EKG	duration of ST interval	0.77159	0.63760	1.0112	0.725	0.232
EKG	heart rate coefficient of variation (signal intensity)	0.83459	0.57038	0.77132	0.841	0.149
EKG	heart rate variability, mean of differences between sequential beats; beats per min	5.6386	3.8915	0.72075	0.853	0.153
EKG	heart rate, beats per min	-2.9200	9.3505	-0.43590	0.907	0.756
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.0055907	0.049776	-0.18148	0.972	0.911
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.017887	0.080612	-0.18353	0.936	0.825
EKG	number of signals	6.6224	3.9505	1.2006	0.605	0.0995
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	4.4250	3.1289	0.89017	0.809	0.163
EKG	QT dispersion, measured as inter-lead variability of QT intervals	0.52313	1.3896	0.20700	0.968	0.708
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-0.14971	1.4746	-0.040310	0.986	0.920
EKG	root mean square of successive differences of neighboring RR intervals	0.28947	0.37173	0.27128	0.884	0.440
glucose tolerance test	amount glucose injected	-0.34050	1.5784	0.28643	0.947	0.830
glucose tolerance test	plasma glucose, 0min	0.66733	3.8510	-0.16270	0.934	0.863
glucose tolerance test	plasma glucose, 15min	3.3575	16.975	0.20458	0.946	0.844
glucose tolerance test	plasma glucose, 30min	0.89399	17.701	0.16548	0.984	0.960
glucose tolerance test	plasma glucose, 60min	-12.348	11.963	-0.40327	0.638	0.309
glucose tolerance test	plasma glucose, 120min	2.2103	5.9636	0.021966	0.893	0.713
grip strength	body weight (at time of grip strength test)	1.2494	0.53313	1.3043	0.103	0.0301
grip strength	forelimb and hindlimb grip strength (mean of trials), average	18.176	20.040	1.5014	0.588	0.376
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	1.1444	1.1687	1.7119	0.551	0.340
grip strength	forelimb and hindlimb grip strength by trial, trial1	18.874	17.987	1.4455	0.610	0.307
grip strength	forelimb and hindlimb grip strength by trial, trial2	36.613	26.603	2.2901	0.426	0.185
grip strength	forelimb and hindlimb grip strength by trial, trial3	-8.1651	24.688	-0.32361	0.891	0.744
grip strength	forelimb grip strength (mean of trials), average	-8.5364	7.5863	-0.78343	0.539	0.275
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.18888	0.42050	-0.24346	0.846	0.658
grip strength	forelimb grip strength by trial, trial1	-2.4991	8.4811	-0.017428	0.915	0.772
grip strength	forelimb grip strength by trial, trial2	-12.577	9.9243	-1.1058	0.549	0.221
grip strength	forelimb grip strength by trial, trial3	15.807	15.565	1.7928	0.647	0.323
heart weight	heart weight, normalized to body weight	-0.20123	0.37155	-1.2353	0.760	0.591
heart weight	heart weight, weight	-5.4111	8.5817	-1.1066	0.715	0.532
hematology	basophil differential (percent of total WBC)	-0.011739	0.028397	-0.16827	0.909	0.681
hematology	calculated hemoglobin (cHGB)	-0.21062	0.15399	-0.88040	0.450	0.178
hematology	eosinophil differential (percent of total WBC)	0.27777	0.20593	0.84474	0.578	0.184
hematology	hematocrit (HCT)	-0.57108	0.50150	-0.90527	0.561	0.261
hematology	hemoglobin concentration distribution width (HDW)	0.024596	0.022026	0.67122	0.577	0.270
hematology	large unstained cells (percent of total WBC)	0.15222	0.11453	0.97718	0.541	0.190
hematology	lymphocyte differential (percent of total WBC)	-2.9418	1.1193	-1.2287	0.102	0.0116
hematology	mean corpuscular hemoglobin (CHr)	-0.16696	0.049735	-1.2920	0.0143	0.00155
hematology	mean platelet volume (MPV)	0.064672	0.13608	0.25165	0.810	0.637
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.20080	0.079600	-0.71834	0.163	0.0150
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.18574	0.18389	-0.41276	0.677	0.318
hematology	mean RBC corpuscular volume (MCV)	-0.35425	0.22583	-0.64981	0.297	0.123
hematology	measured hemoglobin (mHGB)	-0.27965	0.14874	-0.85062	0.301	0.0663
hematology	monocyte differential (percent of total WBC)	0.20855	0.16016	0.87280	0.557	0.199
hematology	neutrophil differential (percent of total WBC)	2.4811	0.93816	1.1725	0.0963	0.0111
hematology	platelet count (PLT; units per volume x 10³)	-13.048	33.657	-0.12057	0.886	0.700
hematology	RBC corpuscular distribution width (RDW)	0.36553	0.16249	1.1547	0.171	0.0291
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.14269	0.16787	-0.42882	0.660	0.400
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.011199	0.12229	-0.39891	0.964	0.927
hematology	reticulocyte count (Retic; units per volume x 10⁹)	0.29274	12.214	0.10112	0.993	0.981
hematology	white blood cell count (WBC; units per volume x 10³)	0.086461	0.48040	0.24292	0.923	0.858
insulin blood level	insulin (plasma)	-149.02	225.69	-0.17470	0.760	0.510
light / dark	fecal boli count, 20 min test	0.36683	0.55079	0.44636	0.829	0.508
light / dark	latency to enter dark zone, 20 min test	-65.632	54.309	-1.3370	0.655	0.232
light / dark	number of transitions between light and dark zones, 20 min test	6.9661	6.9093	0.73604	0.636	0.318
light / dark	percentage of total time in dark zone, 20 min test	-6.3057	4.0706	-0.97827	0.482	0.127
light / dark	percentage of total time in light zone, 20 min test	6.3057	4.0706	0.97392	0.481	0.127
light / dark	time mobile in dark zone, 20 min test	5.7844	15.548	0.29631	0.883	0.711
light / dark	time mobile in light zone, 20 min test	19.442	9.4833	0.84316	0.201	0.0449
light / dark	time spent in dark zone, 20 min test	-12.579	53.846	0.037865	0.948	0.816
light / dark	time spent in light zone, 20 min test	12.579	53.846	-0.037865	0.948	0.816
open field	average speed in center of arena, 20 min test	0.53065	0.39292	0.82906	0.517	0.182
open field	average speed in periphery of arena, 20 min test	0.10948	0.11579	-0.057091	0.573	0.348
open field	distance traveled habituation ratio, 20 min test	-2.9267	7.5185	-0.20209	0.879	0.699
open field	distance traveled in center of arena, 20 min test	69.045	56.464	0.096144	0.481	0.226
open field	distance traveled in periphery of arena, 20 min test	180.10	132.49	0.26279	0.400	0.179
open field	distance traveled slope, 20 min test	-3.0041	7.0459	-0.20894	0.871	0.671
open field	distance traveled, 20 min test, 1st 5min	103.94	67.545	0.49550	0.338	0.129
open field	distance traveled, 20 min test, 2nd 5min	40.091	42.459	-0.047680	0.594	0.349
open field	distance traveled, 20 min test, 3rd 5min	20.344	40.146	-0.19524	0.801	0.614
open field	distance traveled, 20 min test, 4th 5min	77.061	44.741	0.38164	0.272	0.0903
open field	number of clockwise revolution episodes, 20 min test	0.59296	0.94879	-0.051068	0.804	0.534
open field	number of counter-clockwise revolution episodes, 20 min test	1.7277	1.0262	0.51994	0.348	0.0976
open field	number of fecal boli, 20 min test	-0.19770	0.79804	0.12504	0.920	0.805
open field	number of rears in 5 min bins, 20 min test, 1st 5min	2.8048	1.9288	0.56617	0.399	0.151
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	6.0257	2.0314	1.1724	0.0547	0.00437
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	5.3133	1.6876	0.91141	0.0383	0.00259
open field	number of rears in 5 min bins, 20 min test, 4th 5min	2.5189	2.7129	0.23233	0.631	0.357
open field	percentage of total time in center of arena, 20 min test	-1.6744	2.4758	-0.61620	0.775	0.502
open field	percentage of total time in center of arena, slope, 20 min test	1.3797	2.0329	0.89326	0.858	0.500
open field	percentage of total time in center, habituation ratio, 20 min test	1.4850	2.1817	0.92163	0.849	0.499
open field	percentage of total time in corners of arena, 20 min test	-3.1748	4.1191	-0.25584	0.723	0.444
open field	percentage of total time in corners, habituation ratio, 20 min test	-1.2879	2.1136	-0.88926	0.891	0.545
open field	percentage of total time in corners, slope, 20 min test	-1.3046	2.0900	-0.92368	0.895	0.535
open field	permanence time in center of arena, 20 min test	-20.086	29.711	-0.61620	0.776	0.502
open field	permanence time in corners of arena, 20 min test	-38.089	49.429	-0.25584	0.723	0.444
open field	permanence time in periphery of arena, 20 min test	20.068	29.713	0.61620	0.777	0.502
open field	total distance traveled, 20 min test	237.98	153.99	0.21031	0.305	0.128
open field	total number of rears, 20 min test	19.080	6.6245	0.96350	0.0516	0.00556
open field	whole arena average speed, 20 min test	0.19904	0.12837	0.21031	0.303	0.126
open field	whole arena resting time, 20 min test	-22.080	16.106	-0.086706	0.357	0.176
open field	whole arena time spent mobile, 20 min test	22.021	16.091	0.33439	0.361	0.176
open field	whole arena time spent vertical, 20 min test	13.054	7.0817	0.90938	0.309	0.0705
plasma chemistry analysis	free fatty acids (plasma)	-0.31281	0.086689	-1.2993	0.00605	0.000636
plasma chemistry analysis	plasma cholesterol	1.1211	3.3442	0.40262	0.828	0.739
plasma chemistry analysis	plasma glucose (4h fast)	6.5280	6.8910	1.2741	0.534	0.347
plasma chemistry analysis	plasma HDL	1.4246	3.1075	0.32009	0.823	0.648
plasma chemistry analysis	plasma triglycerides (4h fast)	-14.703	5.1815	-1.1108	0.0487	0.00622
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	4.5294	10.193	0.62184	0.918	0.658
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	0.66724	3.2685	0.40621	0.956	0.839
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-0.59548	8.6834	0.24501	0.989	0.946
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	-3.2583	14.873	0.15333	0.940	0.827
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	3.7668	3.0716	1.6684	0.551	0.236
startle / PPI	average baseline movement during background noise	-0.34993	0.28413	-0.17534	0.745	0.227
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.20954	0.069856	-1.8464	0.124	0.00520
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.18894	0.066478	-1.9113	0.139	0.00774
startle / PPI	average of maximum percent pre-pulse inhibition for each pre-pulse tested	-17.152	6.0759	-1.4707	0.163	0.00811
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-19.185	6.1602	-1.8700	0.433	0.00387
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-13.095	6.2276	-1.3271	0.320	0.0434
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-13.996	5.9241	-1.4207	0.163	0.0244
startle / PPI	average startle response to full pulse (120 dB)	26.425	12.284	0.74156	0.158	0.0391
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	29.328	11.350	0.75639	0.0790	0.0145
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	23.258	10.031	0.67493	0.116	0.0270
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	19.508	8.6175	0.65223	0.132	0.0305
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.14353	0.30496	-0.034335	0.932	0.641
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.85140	0.48880	-0.58437	0.587	0.0911
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.022069	0.52259	-0.17249	0.993	0.967
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.20148	0.066055	-1.6751	0.425	0.00457
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.17562	0.075894	-1.5373	0.250	0.0272
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.18710	0.077404	-1.6050	0.131	0.0215
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	26.775	12.308	0.73971	0.151	0.0371
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	29.234	11.371	0.76388	0.0801	0.0150
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	24.092	10.151	0.70336	0.106	0.0238
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	19.486	8.7358	0.65396	0.136	0.0328
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.23860	0.075852	-1.7743	0.391	0.00357
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.19576	0.077738	-1.5752	0.197	0.0170
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.19132	0.080410	-1.5421	0.138	0.0235
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	104.91	54.010	0.75826	0.204	0.0609
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	124.43	49.507	0.82536	0.0857	0.0172
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	104.27	45.736	0.75453	0.121	0.0294
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	80.570	37.705	0.69620	0.156	0.0404
startle / PPI	maximum baseline movement during background noise	-0.57574	0.71121	-0.063795	0.835	0.424
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-21.907	7.2524	-1.9479	0.489	0.00493
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-15.390	6.6039	-1.4324	0.265	0.0262
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-14.047	6.2948	-1.3724	0.193	0.0328
startle / PPI	maximum startle response to full pulse (120 dB)	104.33	54.010	0.76575	0.207	0.0623
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	124.87	49.471	0.82733	0.0844	0.0168
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	101.58	45.548	0.74156	0.132	0.0329
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	80.578	37.404	0.68730	0.153	0.0389
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	0.44121	0.71528	0.26726	0.868	0.542
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-2.7475	2.4062	-0.76388	0.751	0.262
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	0.0075918	1.4427	-0.16396	0.997	0.996
tail suspension	duration of immobility, 5 min test	23.905	10.396	1.1466	0.138	0.0251
tail suspension	latency to immobility, 5 min test	0.26906	0.90150	0.41951	0.959	0.766

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	4.0 %	0.428
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.0
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	1.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	5.0 %	0.435
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	10.0 %	0.275
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	8.0 %	0.504
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	5.0 %	0.461
eye morphology	pupil shape	5.0 %	0.342
eye morphology	retina	13.0 %	1.0
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	6.0 %	0.173
eye morphology	retinal blood vessels structure	6.0 %	0.0640
eye morphology	retinal pigmentation	56.0 %	1.89e-7
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	5.0 %	0.327
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	touch escape	14.0 %	0.161
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00
tail suspension	climbing, 5 min test (yes, no)	22.0 %	0.0307

GENOTYPE CORRELATION PLOT

Correlate Arsk^{tm1b(KOMP)Wtsi} -/- with genotype: