ITP survival analysis:   b-guanidinopropionic acid

Intervention:   b-guanidinopropionic acid     dietary supplement
Trial code: bGPA Dose: 3300 ppm initiated at age: 6 mo Sex: both Cohort: C2015
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
bGPA effect on survival, females, test site = All
Log-rank test chisq = 0.0134 p = 0.9079
Wang-Allison test odds ratio = 1.2191 p = 0.6082
Quantiles bGPA Control % difference
25% died before day: 758 786 -4 %
Median lifespan (days) 892 904 -1 %
75% died before day: 1016 1016 0 %
90% died before day: 1114 1095 +2 %
Max lifespan observed (days) 1272 1396
Number of mice at start 136 274
Animal censor events are denoted by + marks in the plot
All test sites combined – male
bGPA effect on survival, males, test site = All
Log-rank test chisq = 0.1153 p = 0.7342
Wang-Allison test odds ratio = 0.979 p = 1.0
Quantiles bGPA Control % difference
25% died before day: 538 581 -7 %
Median lifespan (days) 764 772 -1 %
75% died before day: 916 918 0 %
90% died before day: 1054 1049 0 %
Max lifespan observed (days) 1283 1237
Number of mice at start 140 264
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
bGPA effect on survival, females, test site = TJL
Log-rank test chisq = 0.5896 p = 0.4426
Wang-Allison test odds ratio = 0.4633 p = 0.3862
Quantiles bGPA Control % difference
25% died before day: 750 785 -4 %
Median lifespan (days) 954 928 +3 %
75% died before day: 1028 1043 -1 %
90% died before day: 1086 1156 -6 %
Max lifespan observed (days) 1239 1396
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
bGPA effect on survival, males, test site = TJL
Log-rank test chisq = 0.1783 p = 0.6729
Wang-Allison test odds ratio = 0.8378 p = 1.0
Quantiles bGPA Control % difference
25% died before day: 598 608 -2 %
Median lifespan (days) 766 818 -6 %
75% died before day: 953 942 +1 %
90% died before day: 1057 1061 0 %
Max lifespan observed (days) 1283 1237
Number of mice at start 54 92
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
bGPA effect on survival, females, test site = UM
Log-rank test chisq = 0.009 p = 0.9243
Wang-Allison test odds ratio = 1.1667 p = 0.7712
Quantiles bGPA Control % difference
25% died before day: 786 791 -1 %
Median lifespan (days) 868 899 -3 %
75% died before day: 998 992 +1 %
90% died before day: 1081 1079 0 %
Max lifespan observed (days) 1246 1291
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
bGPA effect on survival, males, test site = UM
Log-rank test chisq = 0.2198 p = 0.6392
Wang-Allison test odds ratio = 1.2648 p = 0.7595
Quantiles bGPA Control % difference
25% died before day: 500 601 -17 %
Median lifespan (days) 749 740 +1 %
75% died before day: 832 905 -8 %
90% died before day: 1046 1027 +2 %
Max lifespan observed (days) 1197 1231
Number of mice at start 41 81
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
bGPA effect on survival, females, test site = UT
Log-rank test chisq = 0.4483 p = 0.5031
Wang-Allison test odds ratio = 3.0087 p = 0.0693
Quantiles bGPA Control % difference
25% died before day: 755 786 -4 %
Median lifespan (days) 868 892 -3 %
75% died before day: 1043 1014 +3 %
90% died before day: 1120 1078 +4 %
Max lifespan observed (days) 1272 1280
Number of mice at start 44 88
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
bGPA effect on survival, males, test site = UT
Log-rank test chisq = 0.084 p = 0.772
Wang-Allison test odds ratio = 0.9007 p = 1.0
Quantiles bGPA Control % difference
25% died before day: 648 500 +30 %
Median lifespan (days) 818 786 +4 %
75% died before day: 883 888 -1 %
90% died before day: 1025 1025 0 %
Max lifespan observed (days) 1192 1220
Number of mice at start 45 91
Animal censor events are denoted by + marks in the plot


See our ITP data portal page for more information on National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.

Statistical definitions