ITP survival analysis:   ursodeoxycholic acid

Intervention:   ursodeoxycholic acid     involved in regulation of lipid, glucose and energy metabolism
Trial code: UDCA Dose: 5000 ppm initiated at age: 5 mo Sex: both Cohort: C2011
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
UDCA effect on survival, females, test site = All
Log-rank test chisq = 0.1267 p = 0.7219
Wang-Allison test odds ratio = 1.2856 p = 0.4912
Quantiles UDCA Control % difference
25% died before day: 710 771 -8 %
Median lifespan (days) 882 873 +1 %
75% died before day: 1009 985 +2 %
90% died before day: 1107 1089 +2 %
Max lifespan observed (days) 1225 1456
Number of mice at start 133 281
Animal censor events are denoted by + marks in the plot
All test sites combined – male
UDCA effect on survival, males, test site = All
Log-rank test chisq = 0.5766 p = 0.4477
Wang-Allison test odds ratio = 1.0991 p = 0.8679
Quantiles UDCA Control % difference
25% died before day: 650 595 +9 %
Median lifespan (days) 839 783 +7 %
75% died before day: 945 921 +3 %
90% died before day: 1064 1057 +1 %
Max lifespan observed (days) 1153 1258
Number of mice at start 149 294
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
UDCA effect on survival, females, test site = TJL
Log-rank test chisq = 0.1544 p = 0.6944
Wang-Allison test odds ratio = 1.0118 p = 1.0
Quantiles UDCA Control % difference
25% died before day: 805 788 +2 %
Median lifespan (days) 913 892 +2 %
75% died before day: 1045 1015 +3 %
90% died before day: 1107 1106 0 %
Max lifespan observed (days) 1208 1267
Number of mice at start 47 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
UDCA effect on survival, males, test site = TJL
Log-rank test chisq = 0.2809 p = 0.5961
Wang-Allison test odds ratio = 1.1365 p = 0.7888
Quantiles UDCA Control % difference
25% died before day: 648 587 +10 %
Median lifespan (days) 864 763 +13 %
75% died before day: 951 886 +7 %
90% died before day: 1067 1057 +1 %
Max lifespan observed (days) 1128 1258
Number of mice at start 54 101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
UDCA effect on survival, females, test site = UM
Log-rank test chisq = 0.5949 p = 0.4405
Wang-Allison test odds ratio = 1.2888 p = 0.7611
Quantiles UDCA Control % difference
25% died before day: 710 750 -5 %
Median lifespan (days) 819 872 -6 %
75% died before day: 932 979 -5 %
90% died before day: 1110 1081 +3 %
Max lifespan observed (days) 1225 1456
Number of mice at start 42 95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
UDCA effect on survival, males, test site = UM
Log-rank test chisq = 0.5482 p = 0.459
Wang-Allison test odds ratio = 0.5543 p = 0.5478
Quantiles UDCA Control % difference
25% died before day: 622 712 -13 %
Median lifespan (days) 844 860 -2 %
75% died before day: 1000 983 +2 %
90% died before day: 1088 1121 -3 %
Max lifespan observed (days) 1153 1251
Number of mice at start 44 94
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
UDCA effect on survival, females, test site = UT
Log-rank test chisq = 0.0795 p = 0.778
Wang-Allison test odds ratio = 1.6318 p = 0.3835
Quantiles UDCA Control % difference
25% died before day: 668 754 -11 %
Median lifespan (days) 862 857 +1 %
75% died before day: 1004 977 +3 %
90% died before day: 1097 1089 +1 %
Max lifespan observed (days) 1141 1301
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
UDCA effect on survival, males, test site = UT
Log-rank test chisq = 1.9325 p = 0.1645
Wang-Allison test odds ratio = 1.8021 p = 0.3887
Quantiles UDCA Control % difference
25% died before day: 663 542 +22 %
Median lifespan (days) 789 715 +10 %
75% died before day: 921 857 +7 %
90% died before day: 1034 1013 +2 %
Max lifespan observed (days) 1126 1186
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions