ITP survival analysis:   rapamycin

Intervention:   rapamycin     mTOR complex repressor, anti-aging
Trial code: Rapa Dose: 14 ppm initiated at age: 20 mo Sex: both Cohort: C2005
This compound had a significant effect on survival:   both sexes p < 0.0001

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Rapa effect on survival, females, test site = All
Log-rank test chisq = 41.321 p < 0.0001
Wang-Allison test odds ratio = 5.4126 p < 0.0001
Quantiles Rapa Control % difference
25% died before day: 831 756 +10 %
Median lifespan (days) 1005 886 +13 %
75% died before day: 1125 983 +14 %
90% died before day: 1249 1094 +14 %
Max lifespan observed (days) 1360 1281
Number of mice at start 143 289
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Rapa effect on survival, males, test site = All
Log-rank test chisq = 34.3093 p < 0.0001
Wang-Allison test odds ratio = 4.1244 p < 0.0001
Quantiles Rapa Control % difference
25% died before day: 730 597 +22 %
Median lifespan (days) 949 794 +20 %
75% died before day: 1092 964 +13 %
90% died before day: 1176 1078 +9 %
Max lifespan observed (days) 1254 1303
Number of mice at start 168 357
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Rapa effect on survival, females, test site = TJL
Log-rank test chisq = 19.6086 p < 0.0001
Wang-Allison test odds ratio = 6.8437 p = 0.0009
Quantiles Rapa Control % difference
25% died before day: 823 748 +10 %
Median lifespan (days) 1011 881 +15 %
75% died before day: 1163 952 +22 %
90% died before day: 1282 1100 +17 %
Max lifespan observed (days) 1360 1229
Number of mice at start 47 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Rapa effect on survival, males, test site = TJL
Log-rank test chisq = 4.4511 p = 0.0349
Wang-Allison test odds ratio = 3.4994 p = 0.0159
Quantiles Rapa Control % difference
25% died before day: 639 575 +11 %
Median lifespan (days) 815 802 +2 %
75% died before day: 1044 937 +11 %
90% died before day: 1142 1035 +10 %
Max lifespan observed (days) 1196 1220
Number of mice at start 57 126
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Rapa effect on survival, females, test site = UM
Log-rank test chisq = 22.1401 p < 0.0001
Wang-Allison test odds ratio = 16.8954 p < 0.0001
Quantiles Rapa Control % difference
25% died before day: 856 731 +17 %
Median lifespan (days) 1030 878 +17 %
75% died before day: 1170 1016 +15 %
90% died before day: 1252 1094 +14 %
Max lifespan observed (days) 1274 1248
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Rapa effect on survival, males, test site = UM
Log-rank test chisq = 6.2559 p = 0.0124
Wang-Allison test odds ratio = 2.4372 p = 0.0948
Quantiles Rapa Control % difference
25% died before day: 852 676 +26 %
Median lifespan (days) 1053 895 +18 %
75% died before day: 1114 1042 +7 %
90% died before day: 1186 1141 +4 %
Max lifespan observed (days) 1254 1303
Number of mice at start 51 112
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Rapa effect on survival, females, test site = UT
Log-rank test chisq = 4.4344 p = 0.0352
Wang-Allison test odds ratio = 1.9327 p = 0.2513
Quantiles Rapa Control % difference
25% died before day: 816 776 +5 %
Median lifespan (days) 958 896 +7 %
75% died before day: 1069 984 +9 %
90% died before day: 1179 1089 +8 %
Max lifespan observed (days) 1272 1281
Number of mice at start 48 99
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Rapa effect on survival, males, test site = UT
Log-rank test chisq = 30.7045 p < 0.0001
Wang-Allison test odds ratio = 8.6306 p < 0.0001
Quantiles Rapa Control % difference
25% died before day: 751 527 +43 %
Median lifespan (days) 969 722 +34 %
75% died before day: 1094 865 +26 %
90% died before day: 1186 1020 +16 %
Max lifespan observed (days) 1235 1176
Number of mice at start 60 119
Animal censor events are denoted by + marks in the plot


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Statistical definitions