ITP survival analysis:   Protandim

Intervention:   Protandim    
Trial code: Prot Dose: 600 ppm then 1200 ppm initiated at age: 10 mo then 17 mo Sex: both Cohort: C2011
This compound had a significant effect on survival:   males p = 0.0095

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Prot effect on survival, females, test site = All
Log-rank test chisq = 1.1145 p = 0.2911
Wang-Allison test odds ratio = 1.6466 p = 0.1633
Quantiles Prot Control % difference
25% died before day: 778 771 +1 %
Median lifespan (days) 886 873 +1 %
75% died before day: 1013 985 +3 %
90% died before day: 1122 1089 +3 %
Max lifespan observed (days) 1291 1456
Number of mice at start 134 281
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Prot effect on survival, males, test site = All
Log-rank test chisq = 6.7287 p = 0.0095
Wang-Allison test odds ratio = 1.6843 p = 0.103
Quantiles Prot Control % difference
25% died before day: 650 595 +9 %
Median lifespan (days) 853 783 +9 %
75% died before day: 998 921 +8 %
90% died before day: 1106 1057 +5 %
Max lifespan observed (days) 1323 1258
Number of mice at start 155 294
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Prot effect on survival, females, test site = TJL
Log-rank test chisq = 1.5054 p = 0.2198
Wang-Allison test odds ratio = 1.8482 p = 0.2625
Quantiles Prot Control % difference
25% died before day: 746 788 -5 %
Median lifespan (days) 890 892 0 %
75% died before day: 1050 1015 +3 %
90% died before day: 1246 1106 +13 %
Max lifespan observed (days) 1291 1267
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Prot effect on survival, males, test site = TJL
Log-rank test chisq = 2.5085 p = 0.1132
Wang-Allison test odds ratio = 2.012 p = 0.2667
Quantiles Prot Control % difference
25% died before day: 609 587 +4 %
Median lifespan (days) 767 763 +1 %
75% died before day: 1005 886 +13 %
90% died before day: 1189 1057 +12 %
Max lifespan observed (days) 1323 1258
Number of mice at start 54 101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Prot effect on survival, females, test site = UM
Log-rank test chisq = 0.0177 p = 0.8941
Wang-Allison test odds ratio = 1.7556 p = 0.3657
Quantiles Prot Control % difference
25% died before day: 781 750 +4 %
Median lifespan (days) 872 872 0 %
75% died before day: 981 979 0 %
90% died before day: 1116 1081 +3 %
Max lifespan observed (days) 1171 1456
Number of mice at start 43 95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Prot effect on survival, males, test site = UM
Log-rank test chisq = 0.5995 p = 0.4388
Wang-Allison test odds ratio = 0.9338 p = 1.0
Quantiles Prot Control % difference
25% died before day: 803 712 +13 %
Median lifespan (days) 918 860 +7 %
75% died before day: 1014 983 +3 %
90% died before day: 1123 1121 0 %
Max lifespan observed (days) 1212 1251
Number of mice at start 50 94
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Prot effect on survival, females, test site = UT
Log-rank test chisq = 0.4917 p = 0.4832
Wang-Allison test odds ratio = 1.3293 p = 0.7565
Quantiles Prot Control % difference
25% died before day: 742 754 -2 %
Median lifespan (days) 926 857 +8 %
75% died before day: 1004 977 +3 %
90% died before day: 1099 1089 +1 %
Max lifespan observed (days) 1185 1301
Number of mice at start 43 91
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Prot effect on survival, males, test site = UT
Log-rank test chisq = 4.4797 p = 0.0343
Wang-Allison test odds ratio = 2.4293 p = 0.1481
Quantiles Prot Control % difference
25% died before day: 481 542 -11 %
Median lifespan (days) 816 715 +14 %
75% died before day: 979 857 +14 %
90% died before day: 1077 1013 +6 %
Max lifespan observed (days) 1217 1186
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions