ITP survival analysis:   nitroflurbiprofen

Intervention:   nitroflurbiprofen     nonsteroidal anti-inflammatory drug
Trial code: NFP Dose: 200 ppm initiated at age: 4 mo Sex: both Cohort: C2004
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
NFP effect on survival, females, test site = All
Log-rank test chisq = 0.5038 p = 0.4778
Wang-Allison test odds ratio = 0.8786 p = 0.8631
Quantiles NFP Control % difference
25% died before day: 769 739 +4 %
Median lifespan (days) 884 888 0 %
75% died before day: 970 988 -2 %
90% died before day: 1052 1072 -2 %
Max lifespan observed (days) 1217 1212
Number of mice at start 136 271
Animal censor events are denoted by + marks in the plot
All test sites combined – male
NFP effect on survival, males, test site = All
Log-rank test chisq = 0.7045 p = 0.4013
Wang-Allison test odds ratio = 0.9279 p = 0.8792
Quantiles NFP Control % difference
25% died before day: 642 612 +5 %
Median lifespan (days) 812 784 +4 %
75% died before day: 951 912 +4 %
90% died before day: 1025 1048 -2 %
Max lifespan observed (days) 1203 1305
Number of mice at start 172 350
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
NFP effect on survival, females, test site = TJL
Log-rank test chisq = 0.0279 p = 0.8673
Wang-Allison test odds ratio = 1.0718 p = 1.0
Quantiles NFP Control % difference
25% died before day: 776 738 +5 %
Median lifespan (days) 898 858 +5 %
75% died before day: 990 969 +2 %
90% died before day: 1077 1050 +3 %
Max lifespan observed (days) 1144 1212
Number of mice at start 48 93
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
NFP effect on survival, males, test site = TJL
Log-rank test chisq = 3.8581 p = 0.0495
Wang-Allison test odds ratio = 2.021 p = 0.1944
Quantiles NFP Control % difference
25% died before day: 632 553 +14 %
Median lifespan (days) 792 757 +5 %
75% died before day: 962 875 +10 %
90% died before day: 1068 967 +10 %
Max lifespan observed (days) 1203 1216
Number of mice at start 60 125
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
NFP effect on survival, females, test site = UM
Log-rank test chisq = 0.3859 p = 0.5345
Wang-Allison test odds ratio = 0.5862 p = 0.5426
Quantiles NFP Control % difference
25% died before day: 784 772 +2 %
Median lifespan (days) 894 916 -2 %
75% died before day: 955 1005 -5 %
90% died before day: 1043 1111 -6 %
Max lifespan observed (days) 1210 1210
Number of mice at start 40 82
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
NFP effect on survival, males, test site = UM
Log-rank test chisq = 2.2469 p = 0.1339
Wang-Allison test odds ratio = 0.367 p = 0.1777
Quantiles NFP Control % difference
25% died before day: 728 727 0 %
Median lifespan (days) 831 864 -4 %
75% died before day: 969 995 -3 %
90% died before day: 1028 1121 -8 %
Max lifespan observed (days) 1190 1305
Number of mice at start 57 106
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
NFP effect on survival, females, test site = UT
Log-rank test chisq = 0.6581 p = 0.4172
Wang-Allison test odds ratio = 1.0 p = 1.0
Quantiles NFP Control % difference
25% died before day: 690 744 -7 %
Median lifespan (days) 834 880 -5 %
75% died before day: 960 994 -3 %
90% died before day: 1086 1076 +1 %
Max lifespan observed (days) 1217 1188
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
NFP effect on survival, males, test site = UT
Log-rank test chisq = 0.5795 p = 0.4465
Wang-Allison test odds ratio = 0.8163 p = 0.7952
Quantiles NFP Control % difference
25% died before day: 559 592 -6 %
Median lifespan (days) 764 739 +3 %
75% died before day: 907 877 +3 %
90% died before day: 981 988 -1 %
Max lifespan observed (days) 1145 1132
Number of mice at start 55 119
Animal censor events are denoted by + marks in the plot


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Statistical definitions