ITP survival analysis:   MitoQ

Intervention:   MitoQ     anti-oxidant, also known as Coenzyme Q10
Trial code: MitoQ Dose: 100 ppm initiated at age: 7 mo Sex: both Cohort: C2015
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
MitoQ effect on survival, females, test site = All
Log-rank test chisq = 0.1818 p = 0.6698
Wang-Allison test odds ratio = 1.0124 p = 1.0
Quantiles MitoQ Control % difference
25% died before day: 775 786 -1 %
Median lifespan (days) 890 904 -2 %
75% died before day: 1002 1016 -1 %
90% died before day: 1105 1095 +1 %
Max lifespan observed (days) 1293 1396
Number of mice at start 136 274
Animal censor events are denoted by + marks in the plot
All test sites combined – male
MitoQ effect on survival, males, test site = All
Log-rank test chisq = 0.0127 p = 0.9102
Wang-Allison test odds ratio = 1.135 p = 0.7349
Quantiles MitoQ Control % difference
25% died before day: 559 581 -4 %
Median lifespan (days) 784 772 +2 %
75% died before day: 926 918 +1 %
90% died before day: 1066 1049 +2 %
Max lifespan observed (days) 1366 1237
Number of mice at start 145 264
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
MitoQ effect on survival, females, test site = TJL
Log-rank test chisq = 0.5881 p = 0.4431
Wang-Allison test odds ratio = 1.8482 p = 0.2625
Quantiles MitoQ Control % difference
25% died before day: 788 785 0 %
Median lifespan (days) 968 928 +4 %
75% died before day: 1064 1043 +2 %
90% died before day: 1205 1156 +4 %
Max lifespan observed (days) 1293 1396
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
MitoQ effect on survival, males, test site = TJL
Log-rank test chisq = 0.2705 p = 0.603
Wang-Allison test odds ratio = 1.5589 p = 0.4132
Quantiles MitoQ Control % difference
25% died before day: 559 608 -8 %
Median lifespan (days) 800 818 -2 %
75% died before day: 960 942 +2 %
90% died before day: 1116 1061 +5 %
Max lifespan observed (days) 1366 1237
Number of mice at start 54 92
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
MitoQ effect on survival, females, test site = UM
Log-rank test chisq = 0.3484 p = 0.555
Wang-Allison test odds ratio = 0.3526 p = 0.2216
Quantiles MitoQ Control % difference
25% died before day: 776 791 -2 %
Median lifespan (days) 884 899 -2 %
75% died before day: 990 992 0 %
90% died before day: 1035 1079 -4 %
Max lifespan observed (days) 1220 1291
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
MitoQ effect on survival, males, test site = UM
Log-rank test chisq = 0.7987 p = 0.3715
Wang-Allison test odds ratio = 0.782 p = 0.7698
Quantiles MitoQ Control % difference
25% died before day: 472 601 -21 %
Median lifespan (days) 769 740 +4 %
75% died before day: 876 905 -3 %
90% died before day: 1021 1027 -1 %
Max lifespan observed (days) 1133 1231
Number of mice at start 45 81
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
MitoQ effect on survival, females, test site = UT
Log-rank test chisq = 1.0151 p = 0.3137
Wang-Allison test odds ratio = 1.1243 p = 1.0
Quantiles MitoQ Control % difference
25% died before day: 753 786 -4 %
Median lifespan (days) 870 892 -2 %
75% died before day: 948 1014 -7 %
90% died before day: 1068 1078 -1 %
Max lifespan observed (days) 1206 1280
Number of mice at start 44 88
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
MitoQ effect on survival, males, test site = UT
Log-rank test chisq = 0.2329 p = 0.6294
Wang-Allison test odds ratio = 1.1102 p = 1.0
Quantiles MitoQ Control % difference
25% died before day: 636 500 +27 %
Median lifespan (days) 784 786 0 %
75% died before day: 906 888 +2 %
90% died before day: 1066 1025 +4 %
Max lifespan observed (days) 1190 1220
Number of mice at start 46 91
Animal censor events are denoted by + marks in the plot


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Statistical definitions