ITP survival analysis:   3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-one

Intervention:   3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-one     proinflammatory cytokine antagonist
Trial code: MIF098 Dose: 240 ppm initiated at age: 8 mo Sex: both Cohort: C2016
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
MIF098 effect on survival, females, test site = All
Log-rank test chisq = 3.3125 p = 0.0688
Wang-Allison test odds ratio = 0.7152 p = 0.3954
Quantiles MIF098 Control % difference
25% died before day: 750 790 -5 %
Median lifespan (days) 862 875 -1 %
75% died before day: 957 975 -2 %
90% died before day: 1026 1055 -3 %
Max lifespan observed (days) 1222 1339
Number of mice at start 136 303
Animal censor events are denoted by + marks in the plot
All test sites combined – male
MIF098 effect on survival, males, test site = All
Log-rank test chisq = 0.2126 p = 0.6447
Wang-Allison test odds ratio = 1.0101 p = 1.0
Quantiles MIF098 Control % difference
25% died before day: 658 608 +8 %
Median lifespan (days) 822 782 +5 %
75% died before day: 964 935 +3 %
90% died before day: 1058 1055 0 %
Max lifespan observed (days) 1167 1264
Number of mice at start 146 275
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
MIF098 effect on survival, females, test site = TJL
Log-rank test chisq = 0.0673 p = 0.7953
Wang-Allison test odds ratio = 0.9885 p = 1.0
Quantiles MIF098 Control % difference
25% died before day: 758 816 -7 %
Median lifespan (days) 886 883 0 %
75% died before day: 962 971 -1 %
90% died before day: 1062 1057 0 %
Max lifespan observed (days) 1222 1230
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
MIF098 effect on survival, males, test site = TJL
Log-rank test chisq = 0.7507 p = 0.3862
Wang-Allison test odds ratio = 1.2855 p = 0.7755
Quantiles MIF098 Control % difference
25% died before day: 622 608 +2 %
Median lifespan (days) 829 749 +11 %
75% died before day: 964 891 +8 %
90% died before day: 1045 1005 +4 %
Max lifespan observed (days) 1140 1262
Number of mice at start 50 94
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
MIF098 effect on survival, females, test site = UM
Log-rank test chisq = 2.9893 p = 0.0838
Wang-Allison test odds ratio = 0.3197 p = 0.2256
Quantiles MIF098 Control % difference
25% died before day: 720 788 -9 %
Median lifespan (days) 836 858 -3 %
75% died before day: 928 961 -3 %
90% died before day: 986 1034 -5 %
Max lifespan observed (days) 1042 1189
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
MIF098 effect on survival, males, test site = UM
Log-rank test chisq = 0.2361 p = 0.627
Wang-Allison test odds ratio = 0.5167 p = 0.3787
Quantiles MIF098 Control % difference
25% died before day: 686 534 +28 %
Median lifespan (days) 807 814 -1 %
75% died before day: 968 996 -3 %
90% died before day: 1039 1071 -3 %
Max lifespan observed (days) 1167 1258
Number of mice at start 45 82
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
MIF098 effect on survival, females, test site = UT
Log-rank test chisq = 1.5445 p = 0.2139
Wang-Allison test odds ratio = 0.9367 p = 1.0
Quantiles MIF098 Control % difference
25% died before day: 720 774 -7 %
Median lifespan (days) 866 882 -2 %
75% died before day: 956 984 -3 %
90% died before day: 1036 1058 -2 %
Max lifespan observed (days) 1117 1339
Number of mice at start 44 116
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
MIF098 effect on survival, males, test site = UT
Log-rank test chisq = 0.1247 p = 0.724
Wang-Allison test odds ratio = 1.3306 p = 0.5807
Quantiles MIF098 Control % difference
25% died before day: 667 640 +4 %
Median lifespan (days) 826 799 +3 %
75% died before day: 955 936 +2 %
90% died before day: 1080 1064 +2 %
Max lifespan observed (days) 1161 1264
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions