ITP survival analysis:   medium-chain triglyceride oil

Intervention:   medium-chain triglyceride oil    
Trial code: MCTO Dose: 60,000 ppm initiated at age: 4 mo Sex: both Cohort: C2007
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
MCTO effect on survival, females, test site = All
Log-rank test chisq = 2.0662 p = 0.1506
Wang-Allison test odds ratio = 1.4897 p = 0.2281
Quantiles MCTO Control % difference
25% died before day: 766 753 +2 %
Median lifespan (days) 882 865 +2 %
75% died before day: 1022 994 +3 %
90% died before day: 1116 1088 +3 %
Max lifespan observed (days) 1322 1359
Number of mice at start 131 275
Animal censor events are denoted by + marks in the plot
All test sites combined – male
MCTO effect on survival, males, test site = All
Log-rank test chisq = 0.6601 p = 0.4165
Wang-Allison test odds ratio = 1.3577 p = 0.4007
Quantiles MCTO Control % difference
25% died before day: 572 588 -3 %
Median lifespan (days) 777 784 -1 %
75% died before day: 974 954 +2 %
90% died before day: 1100 1074 +2 %
Max lifespan observed (days) 1303 1247
Number of mice at start 153 276
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
MCTO effect on survival, females, test site = TJL
Log-rank test chisq = 0.1134 p = 0.7363
Wang-Allison test odds ratio = 0.8421 p = 1.0
Quantiles MCTO Control % difference
25% died before day: 801 740 +8 %
Median lifespan (days) 899 860 +5 %
75% died before day: 1036 1016 +2 %
90% died before day: 1109 1111 0 %
Max lifespan observed (days) 1322 1340
Number of mice at start 43 92
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
MCTO effect on survival, males, test site = TJL
Log-rank test chisq = 0.0045 p = 0.9465
Wang-Allison test odds ratio = 0.9424 p = 1.0
Quantiles MCTO Control % difference
25% died before day: 531 569 -7 %
Median lifespan (days) 738 728 +1 %
75% died before day: 895 923 -3 %
90% died before day: 1025 1039 -1 %
Max lifespan observed (days) 1203 1200
Number of mice at start 51 87
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
MCTO effect on survival, females, test site = UM
Log-rank test chisq = 0.9145 p = 0.3389
Wang-Allison test odds ratio = 1.6318 p = 0.3835
Quantiles MCTO Control % difference
25% died before day: 812 767 +6 %
Median lifespan (days) 904 900 0 %
75% died before day: 1047 999 +5 %
90% died before day: 1140 1114 +2 %
Max lifespan observed (days) 1249 1359
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
MCTO effect on survival, males, test site = UM
Log-rank test chisq = 4.3054 p = 0.038
Wang-Allison test odds ratio = 3.0806 p = 0.0466
Quantiles MCTO Control % difference
25% died before day: 666 659 +1 %
Median lifespan (days) 860 793 +8 %
75% died before day: 1040 953 +9 %
90% died before day: 1150 1076 +7 %
Max lifespan observed (days) 1270 1191
Number of mice at start 51 93
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
MCTO effect on survival, females, test site = UT
Log-rank test chisq = 1.4125 p = 0.2346
Wang-Allison test odds ratio = 2.2819 p = 0.1449
Quantiles MCTO Control % difference
25% died before day: 731 756 -3 %
Median lifespan (days) 859 840 +2 %
75% died before day: 1014 962 +5 %
90% died before day: 1097 1045 +5 %
Max lifespan observed (days) 1266 1261
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
MCTO effect on survival, males, test site = UT
Log-rank test chisq = 0.6032 p = 0.4374
Wang-Allison test odds ratio = 0.7658 p = 0.7731
Quantiles MCTO Control % difference
25% died before day: 552 584 -5 %
Median lifespan (days) 766 810 -5 %
75% died before day: 996 1010 -1 %
90% died before day: 1092 1132 -4 %
Max lifespan observed (days) 1303 1247
Number of mice at start 51 96
Animal censor events are denoted by + marks in the plot


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Statistical definitions