ITP survival analysis:   2-(2-Hydroxyphenyl)benzoxazole

Intervention:   2-(2-Hydroxyphenyl)benzoxazole     multi-site proton acceptor and proton donor
Trial code: HBX Dose: 1 ppm initiated at age: 15 mo Sex: both Cohort: C2012
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
HBX effect on survival, females, test site = All
Log-rank test chisq = 0.6171 p = 0.4321
Wang-Allison test odds ratio = 0.7747 p = 0.607
Quantiles HBX Control % difference
25% died before day: 749 770 -3 %
Median lifespan (days) 856 877 -2 %
75% died before day: 988 1006 -2 %
90% died before day: 1091 1100 -1 %
Max lifespan observed (days) 1372 1301
Number of mice at start 136 279
Animal censor events are denoted by + marks in the plot
All test sites combined – male
HBX effect on survival, males, test site = All
Log-rank test chisq = 0.6088 p = 0.4352
Wang-Allison test odds ratio = 1.3852 p = 0.3255
Quantiles HBX Control % difference
25% died before day: 625 620 +1 %
Median lifespan (days) 822 816 +1 %
75% died before day: 955 960 -1 %
90% died before day: 1069 1055 +1 %
Max lifespan observed (days) 1289 1260
Number of mice at start 155 284
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
HBX effect on survival, females, test site = TJL
Log-rank test chisq = 0.9082 p = 0.3406
Wang-Allison test odds ratio = 1.8693 p = 0.2594
Quantiles HBX Control % difference
25% died before day: 798 801 0 %
Median lifespan (days) 951 924 +3 %
75% died before day: 1054 1014 +4 %
90% died before day: 1133 1092 +4 %
Max lifespan observed (days) 1372 1301
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
HBX effect on survival, males, test site = TJL
Log-rank test chisq = 4.5513 p = 0.0329
Wang-Allison test odds ratio = 2.6671 p = 0.0933
Quantiles HBX Control % difference
25% died before day: 637 624 +2 %
Median lifespan (days) 842 844 0 %
75% died before day: 1019 960 +6 %
90% died before day: 1111 1006 +10 %
Max lifespan observed (days) 1289 1163
Number of mice at start 54 101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
HBX effect on survival, females, test site = UM
Log-rank test chisq = 1.4711 p = 0.2252
Wang-Allison test odds ratio = 0.5278 p = 0.5483
Quantiles HBX Control % difference
25% died before day: 742 745 0 %
Median lifespan (days) 812 843 -4 %
75% died before day: 888 988 -10 %
90% died before day: 1029 1084 -5 %
Max lifespan observed (days) 1211 1243
Number of mice at start 44 90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
HBX effect on survival, males, test site = UM
Log-rank test chisq = 0.0333 p = 0.8552
Wang-Allison test odds ratio = 0.9264 p = 1.0
Quantiles HBX Control % difference
25% died before day: 730 719 +2 %
Median lifespan (days) 913 872 +5 %
75% died before day: 964 1022 -6 %
90% died before day: 1113 1111 0 %
Max lifespan observed (days) 1228 1204
Number of mice at start 50 84
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
HBX effect on survival, females, test site = UT
Log-rank test chisq = 1.5894 p = 0.2074
Wang-Allison test odds ratio = 0.3236 p = 0.2253
Quantiles HBX Control % difference
25% died before day: 738 738 0 %
Median lifespan (days) 848 873 -3 %
75% died before day: 938 1008 -7 %
90% died before day: 1061 1116 -5 %
Max lifespan observed (days) 1226 1255
Number of mice at start 44 93
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
HBX effect on survival, males, test site = UT
Log-rank test chisq = 1.1599 p = 0.2815
Wang-Allison test odds ratio = 0.9676 p = 1.0
Quantiles HBX Control % difference
25% died before day: 541 577 -6 %
Median lifespan (days) 740 751 -1 %
75% died before day: 843 886 -5 %
90% died before day: 949 994 -5 %
Max lifespan observed (days) 1121 1260
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions