ITP survival analysis:   17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride

Intervention:   17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride     heat shock protein 90 inhibitor
Trial code: DMAG Dose: 30 ppm initiated at age: 6 mo Sex: both Cohort: C2015
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
DMAG effect on survival, females, test site = All
Log-rank test chisq = 2.3995 p = 0.1214
Wang-Allison test odds ratio = 0.7132 p = 0.39
Quantiles DMAG Control % difference
25% died before day: 732 786 -7 %
Median lifespan (days) 866 904 -4 %
75% died before day: 992 1016 -2 %
90% died before day: 1074 1095 -2 %
Max lifespan observed (days) 1219 1396
Number of mice at start 132 274
Animal censor events are denoted by + marks in the plot
All test sites combined – male
DMAG effect on survival, males, test site = All
Log-rank test chisq = 2.4526 p = 0.1173
Wang-Allison test odds ratio = 1.1523 p = 0.7385
Quantiles DMAG Control % difference
25% died before day: 642 581 +10 %
Median lifespan (days) 844 772 +9 %
75% died before day: 988 918 +8 %
90% died before day: 1090 1049 +4 %
Max lifespan observed (days) 1221 1237
Number of mice at start 152 264
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
DMAG effect on survival, females, test site = TJL
Log-rank test chisq = 1.0435 p = 0.307
Wang-Allison test odds ratio = 0.5476 p = 0.5482
Quantiles DMAG Control % difference
25% died before day: 731 785 -7 %
Median lifespan (days) 903 928 -3 %
75% died before day: 1035 1043 -1 %
90% died before day: 1091 1156 -6 %
Max lifespan observed (days) 1199 1396
Number of mice at start 45 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
DMAG effect on survival, males, test site = TJL
Log-rank test chisq = 0.6841 p = 0.4082
Wang-Allison test odds ratio = 1.5925 p = 0.4076
Quantiles DMAG Control % difference
25% died before day: 631 608 +4 %
Median lifespan (days) 833 818 +2 %
75% died before day: 1029 942 +9 %
90% died before day: 1102 1061 +4 %
Max lifespan observed (days) 1221 1237
Number of mice at start 53 92
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
DMAG effect on survival, females, test site = UM
Log-rank test chisq = 3.3961 p = 0.0653
Wang-Allison test odds ratio = 0.3234 p = 0.2246
Quantiles DMAG Control % difference
25% died before day: 708 791 -10 %
Median lifespan (days) 854 899 -5 %
75% died before day: 969 992 -2 %
90% died before day: 1002 1079 -7 %
Max lifespan observed (days) 1160 1291
Number of mice at start 43 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
DMAG effect on survival, males, test site = UM
Log-rank test chisq = 0.0091 p = 0.9241
Wang-Allison test odds ratio = 0.4758 p = 0.3692
Quantiles DMAG Control % difference
25% died before day: 644 601 +7 %
Median lifespan (days) 841 740 +14 %
75% died before day: 918 905 +1 %
90% died before day: 1005 1027 -2 %
Max lifespan observed (days) 1096 1231
Number of mice at start 48 81
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
DMAG effect on survival, females, test site = UT
Log-rank test chisq = 0.0109 p = 0.9168
Wang-Allison test odds ratio = 1.5732 p = 0.5496
Quantiles DMAG Control % difference
25% died before day: 762 786 -3 %
Median lifespan (days) 866 892 -3 %
75% died before day: 1014 1014 0 %
90% died before day: 1085 1078 +1 %
Max lifespan observed (days) 1219 1280
Number of mice at start 44 88
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
DMAG effect on survival, males, test site = UT
Log-rank test chisq = 3.0031 p = 0.0831
Wang-Allison test odds ratio = 1.6445 p = 0.4002
Quantiles DMAG Control % difference
25% died before day: 677 500 +35 %
Median lifespan (days) 856 786 +9 %
75% died before day: 1007 888 +13 %
90% died before day: 1106 1025 +8 %
Max lifespan observed (days) 1215 1220
Number of mice at start 51 91
Animal censor events are denoted by + marks in the plot


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Statistical definitions