ITP survival analysis:   curcumin

Intervention:   curcumin     dietary supplement
Trial code: Cur Dose: 2000 ppm initiated at age: 4 mo Sex: both Cohort: C2007
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Cur effect on survival, females, test site = All
Log-rank test chisq = 0.5851 p = 0.4443
Wang-Allison test odds ratio = 1.3315 p = 0.389
Quantiles Cur Control % difference
25% died before day: 749 753 -1 %
Median lifespan (days) 905 865 +5 %
75% died before day: 1029 994 +4 %
90% died before day: 1091 1088 0 %
Max lifespan observed (days) 1385 1359
Number of mice at start 131 275
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Cur effect on survival, males, test site = All
Log-rank test chisq = 0.0346 p = 0.8524
Wang-Allison test odds ratio = 1.0141 p = 1.0
Quantiles Cur Control % difference
25% died before day: 647 588 +10 %
Median lifespan (days) 804 784 +3 %
75% died before day: 942 954 -1 %
90% died before day: 1057 1074 -2 %
Max lifespan observed (days) 1337 1247
Number of mice at start 146 276
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Cur effect on survival, females, test site = TJL
Log-rank test chisq = 0.3902 p = 0.5322
Wang-Allison test odds ratio = 1.2116 p = 0.7666
Quantiles Cur Control % difference
25% died before day: 808 740 +9 %
Median lifespan (days) 948 860 +10 %
75% died before day: 1039 1016 +2 %
90% died before day: 1122 1111 +1 %
Max lifespan observed (days) 1246 1340
Number of mice at start 43 92
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Cur effect on survival, males, test site = TJL
Log-rank test chisq = 0.6249 p = 0.4292
Wang-Allison test odds ratio = 0.9424 p = 1.0
Quantiles Cur Control % difference
25% died before day: 648 569 +14 %
Median lifespan (days) 800 728 +10 %
75% died before day: 906 923 -2 %
90% died before day: 1020 1039 -2 %
Max lifespan observed (days) 1337 1200
Number of mice at start 51 87
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Cur effect on survival, females, test site = UM
Log-rank test chisq = 0.0194 p = 0.8892
Wang-Allison test odds ratio = 0.8113 p = 1.0
Quantiles Cur Control % difference
25% died before day: 789 767 +3 %
Median lifespan (days) 878 900 -2 %
75% died before day: 1037 999 +4 %
90% died before day: 1112 1114 0 %
Max lifespan observed (days) 1187 1359
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Cur effect on survival, males, test site = UM
Log-rank test chisq = 1.1816 p = 0.277
Wang-Allison test odds ratio = 2.2486 p = 0.2268
Quantiles Cur Control % difference
25% died before day: 657 659 0 %
Median lifespan (days) 838 793 +6 %
75% died before day: 976 953 +2 %
90% died before day: 1116 1076 +4 %
Max lifespan observed (days) 1237 1191
Number of mice at start 45 93
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Cur effect on survival, females, test site = UT
Log-rank test chisq = 0.3129 p = 0.5759
Wang-Allison test odds ratio = 2.2819 p = 0.1449
Quantiles Cur Control % difference
25% died before day: 686 756 -9 %
Median lifespan (days) 808 840 -4 %
75% died before day: 1012 962 +5 %
90% died before day: 1067 1045 +2 %
Max lifespan observed (days) 1385 1261
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Cur effect on survival, males, test site = UT
Log-rank test chisq = 2.6838 p = 0.1014
Wang-Allison test odds ratio = 0.449 p = 0.2641
Quantiles Cur Control % difference
25% died before day: 600 584 +3 %
Median lifespan (days) 758 810 -6 %
75% died before day: 941 1010 -7 %
90% died before day: 1040 1132 -8 %
Max lifespan observed (days) 1163 1247
Number of mice at start 50 96
Animal censor events are denoted by + marks in the plot


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Statistical definitions