ITP survival analysis:   caffeic acid phenethyl ester

Intervention:   caffeic acid phenethyl ester     anti-oxidant
Trial code: CAPE_lo Dose: 30 ppm initiated at age: 4 mo Sex: both Cohort: C2005
Trial code: CAPE_hi Dose: 300 ppm initiated at age: 4 mo Sex: both Cohort: C2005
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
CAPE_lo effect on survival, females, test site = All
Log-rank test chisq = 0.0392 p = 0.8431
Wang-Allison test odds ratio = 0.7534 p = 0.499
Quantiles CAPE_lo Control % difference
25% died before day: 768 756 +2 %
Median lifespan (days) 884 886 0 %
75% died before day: 982 983 0 %
90% died before day: 1088 1094 -1 %
Max lifespan observed (days) 1257 1281
Number of mice at start 140 289
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival, females, test site = All
Log-rank test chisq = 3.3667 p = 0.0665
Wang-Allison test odds ratio = 1.0795 p = 0.8651
Quantiles CAPE_hi Control % difference
25% died before day: 788 756 +4 %
Median lifespan (days) 926 886 +5 %
75% died before day: 1027 983 +4 %
90% died before day: 1104 1094 +1 %
Max lifespan observed (days) 1399 1281
Number of mice at start 147 289
Animal censor events are denoted by + marks in the plot
All test sites combined – male
CAPE_lo effect on survival, males, test site = All
Log-rank test chisq = 0.0197 p = 0.8883
Wang-Allison test odds ratio = 0.6171 p = 0.1698
Quantiles CAPE_lo Control % difference
25% died before day: 648 597 +9 %
Median lifespan (days) 817 794 +3 %
75% died before day: 965 964 0 %
90% died before day: 1044 1078 -3 %
Max lifespan observed (days) 1283 1303
Number of mice at start 175 357
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival, males, test site = All
Log-rank test chisq = 0.062 p = 0.8033
Wang-Allison test odds ratio = 0.8102 p = 0.5405
Quantiles CAPE_hi Control % difference
25% died before day: 624 597 +5 %
Median lifespan (days) 810 794 +2 %
75% died before day: 959 964 -1 %
90% died before day: 1063 1078 -1 %
Max lifespan observed (days) 1297 1303
Number of mice at start 171 357
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
CAPE_lo effect on survival, females, test site = TJL
Log-rank test chisq = 1.3333 p = 0.2482
Wang-Allison test odds ratio = 1.2232 p = 0.7659
Quantiles CAPE_lo Control % difference
25% died before day: 823 748 +10 %
Median lifespan (days) 915 881 +4 %
75% died before day: 976 952 +3 %
90% died before day: 1115 1100 +1 %
Max lifespan observed (days) 1231 1229
Number of mice at start 44 95
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival, females, test site = TJL
Log-rank test chisq = 6.8741 p = 0.0087
Wang-Allison test odds ratio = 1.5679 p = 0.5511
Quantiles CAPE_hi Control % difference
25% died before day: 850 748 +14 %
Median lifespan (days) 962 881 +9 %
75% died before day: 1043 952 +10 %
90% died before day: 1141 1100 +4 %
Max lifespan observed (days) 1263 1229
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
CAPE_lo effect on survival, males, test site = TJL
Log-rank test chisq = 0.0583 p = 0.8092
Wang-Allison test odds ratio = 0.5708 p = 0.4354
Quantiles CAPE_lo Control % difference
25% died before day: 642 575 +12 %
Median lifespan (days) 790 802 -1 %
75% died before day: 920 937 -2 %
90% died before day: 1010 1035 -2 %
Max lifespan observed (days) 1243 1220
Number of mice at start 56 126
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival, males, test site = TJL
Log-rank test chisq = 0.7513 p = 0.3861
Wang-Allison test odds ratio = 1.3209 p = 0.5869
Quantiles CAPE_hi Control % difference
25% died before day: 637 575 +11 %
Median lifespan (days) 838 802 +4 %
75% died before day: 970 937 +4 %
90% died before day: 1065 1035 +3 %
Max lifespan observed (days) 1297 1220
Number of mice at start 54 126
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
CAPE_lo effect on survival, females, test site = UM
Log-rank test chisq = 0.1373 p = 0.711
Wang-Allison test odds ratio = 0.6959 p = 0.7736
Quantiles CAPE_lo Control % difference
25% died before day: 790 731 +8 %
Median lifespan (days) 896 878 +2 %
75% died before day: 998 1016 -2 %
90% died before day: 1087 1094 -1 %
Max lifespan observed (days) 1257 1248
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival, females, test site = UM
Log-rank test chisq = 1.2335 p = 0.2667
Wang-Allison test odds ratio = 1.164 p = 0.7718
Quantiles CAPE_hi Control % difference
25% died before day: 788 731 +8 %
Median lifespan (days) 930 878 +6 %
75% died before day: 1047 1016 +3 %
90% died before day: 1133 1094 +4 %
Max lifespan observed (days) 1399 1248
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
CAPE_lo effect on survival, males, test site = UM
Log-rank test chisq = 1.6621 p = 0.1973
Wang-Allison test odds ratio = 0.373 p = 0.1787
Quantiles CAPE_lo Control % difference
25% died before day: 632 676 -7 %
Median lifespan (days) 881 895 -2 %
75% died before day: 987 1042 -5 %
90% died before day: 1086 1141 -5 %
Max lifespan observed (days) 1283 1303
Number of mice at start 59 112
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival, males, test site = UM
Log-rank test chisq = 2.1928 p = 0.1387
Wang-Allison test odds ratio = 0.4137 p = 0.2734
Quantiles CAPE_hi Control % difference
25% died before day: 680 676 +1 %
Median lifespan (days) 846 895 -5 %
75% died before day: 1027 1042 -1 %
90% died before day: 1087 1141 -5 %
Max lifespan observed (days) 1193 1303
Number of mice at start 54 112
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
CAPE_lo effect on survival, females, test site = UT
Log-rank test chisq = 1.5096 p = 0.2192
Wang-Allison test odds ratio = 0.4855 p = 0.3867
Quantiles CAPE_lo Control % difference
25% died before day: 714 776 -8 %
Median lifespan (days) 852 896 -5 %
75% died before day: 936 984 -5 %
90% died before day: 1039 1089 -5 %
Max lifespan observed (days) 1204 1281
Number of mice at start 48 99
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival, females, test site = UT
Log-rank test chisq = 0.3605 p = 0.5482
Wang-Allison test odds ratio = 0.6825 p = 0.7746
Quantiles CAPE_hi Control % difference
25% died before day: 749 776 -3 %
Median lifespan (days) 858 896 -4 %
75% died before day: 1001 984 +2 %
90% died before day: 1070 1089 -2 %
Max lifespan observed (days) 1206 1281
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
CAPE_lo effect on survival, males, test site = UT
Log-rank test chisq = 2.6921 p = 0.1008
Wang-Allison test odds ratio = 0.9908 p = 1.0
Quantiles CAPE_lo Control % difference
25% died before day: 662 527 +26 %
Median lifespan (days) 766 722 +6 %
75% died before day: 946 865 +9 %
90% died before day: 1029 1020 +1 %
Max lifespan observed (days) 1221 1176
Number of mice at start 60 119
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival, males, test site = UT
Log-rank test chisq = 0.0031 p = 0.9554
Wang-Allison test odds ratio = 0.859 p = 1.0
Quantiles CAPE_hi Control % difference
25% died before day: 603 527 +14 %
Median lifespan (days) 710 722 -2 %
75% died before day: 871 865 +1 %
90% died before day: 1010 1020 -1 %
Max lifespan observed (days) 1147 1176
Number of mice at start 63 119
Animal censor events are denoted by + marks in the plot


See our ITP data portal page for more information on National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.

Statistical definitions