ITP survival analysis:   aspirin

Intervention:   aspirin     nonsteroidal anti-inflammatory drug, anti-aging
Trial code: Asp_lo Dose: 60 initiated at age: 11 mo Sex: both Cohort: C2014
Trial code: Asp_hi Dose: 200 initiated at age: 11 mo Sex: both Cohort: C2014
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Asp_lo effect on survival, females, test site = All
Log-rank test chisq = 0.1032 p = 0.7481
Wang-Allison test odds ratio = 0.8645 p = 0.7272
Quantiles Asp_lo Control % difference
25% died before day: 740 764 -3 %
Median lifespan (days) 908 897 +1 %
75% died before day: 1013 1018 0 %
90% died before day: 1095 1109 -1 %
Max lifespan observed (days) 1233 1358
Number of mice at start 135 279
Animal censor events are denoted by + marks in the plot
Asp_hi effect on survival, females, test site = All
Log-rank test chisq = 0.0294 p = 0.8639
Wang-Allison test odds ratio = 0.8847 p = 0.8638
Quantiles Asp_hi Control % difference
25% died before day: 781 764 +2 %
Median lifespan (days) 906 897 +1 %
75% died before day: 1008 1018 -1 %
90% died before day: 1124 1109 +1 %
Max lifespan observed (days) 1319 1358
Number of mice at start 135 279
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Asp_lo effect on survival, males, test site = All
Log-rank test chisq = 0.1084 p = 0.742
Wang-Allison test odds ratio = 1.0369 p = 1.0
Quantiles Asp_lo Control % difference
25% died before day: 625 638 -2 %
Median lifespan (days) 820 832 -1 %
75% died before day: 960 969 -1 %
90% died before day: 1083 1059 +2 %
Max lifespan observed (days) 1315 1272
Number of mice at start 151 273
Animal censor events are denoted by + marks in the plot
Asp_hi effect on survival, males, test site = All
Log-rank test chisq = 0.8274 p = 0.363
Wang-Allison test odds ratio = 1.2351 p = 0.6057
Quantiles Asp_hi Control % difference
25% died before day: 648 638 +2 %
Median lifespan (days) 836 832 0 %
75% died before day: 955 969 -1 %
90% died before day: 1076 1059 +2 %
Max lifespan observed (days) 1281 1272
Number of mice at start 140 273
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Asp_lo effect on survival, females, test site = TJL
Log-rank test chisq = 0.1238 p = 0.7249
Wang-Allison test odds ratio = 0.8107 p = 1.0
Quantiles Asp_lo Control % difference
25% died before day: 833 782 +7 %
Median lifespan (days) 938 904 +4 %
75% died before day: 1013 1010 0 %
90% died before day: 1095 1099 0 %
Max lifespan observed (days) 1201 1358
Number of mice at start 47 96
Animal censor events are denoted by + marks in the plot
Asp_hi effect on survival, females, test site = TJL
Log-rank test chisq = 1.8448 p = 0.1744
Wang-Allison test odds ratio = 3.4281 p = 0.0389
Quantiles Asp_hi Control % difference
25% died before day: 814 782 +4 %
Median lifespan (days) 943 904 +4 %
75% died before day: 1043 1010 +3 %
90% died before day: 1147 1099 +4 %
Max lifespan observed (days) 1319 1358
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Asp_lo effect on survival, males, test site = TJL
Log-rank test chisq = 0.2275 p = 0.6334
Wang-Allison test odds ratio = 1.1654 p = 0.7837
Quantiles Asp_lo Control % difference
25% died before day: 658 572 +15 %
Median lifespan (days) 884 873 +1 %
75% died before day: 994 992 0 %
90% died before day: 1090 1068 +2 %
Max lifespan observed (days) 1315 1272
Number of mice at start 54 93
Animal censor events are denoted by + marks in the plot
Asp_hi effect on survival, males, test site = TJL
Log-rank test chisq = 0.0638 p = 0.8006
Wang-Allison test odds ratio = 1.1103 p = 1.0
Quantiles Asp_hi Control % difference
25% died before day: 630 572 +10 %
Median lifespan (days) 843 873 -3 %
75% died before day: 992 992 0 %
90% died before day: 1078 1068 +1 %
Max lifespan observed (days) 1281 1272
Number of mice at start 48 93
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Asp_lo effect on survival, females, test site = UM
Log-rank test chisq = 0.3284 p = 0.5666
Wang-Allison test odds ratio = 0.8896 p = 1.0
Quantiles Asp_lo Control % difference
25% died before day: 762 748 +2 %
Median lifespan (days) 900 884 +2 %
75% died before day: 1030 1016 +1 %
90% died before day: 1121 1139 -2 %
Max lifespan observed (days) 1233 1210
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
Asp_hi effect on survival, females, test site = UM
Log-rank test chisq = 0.0543 p = 0.8158
Wang-Allison test odds ratio = 0.5477 p = 0.5471
Quantiles Asp_hi Control % difference
25% died before day: 742 748 -1 %
Median lifespan (days) 896 884 +1 %
75% died before day: 1008 1016 -1 %
90% died before day: 1129 1139 -1 %
Max lifespan observed (days) 1268 1210
Number of mice at start 43 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Asp_lo effect on survival, males, test site = UM
Log-rank test chisq = 0.0893 p = 0.7651
Wang-Allison test odds ratio = 1.3539 p = 0.5736
Quantiles Asp_lo Control % difference
25% died before day: 734 756 -3 %
Median lifespan (days) 848 894 -5 %
75% died before day: 1014 1009 0 %
90% died before day: 1129 1084 +4 %
Max lifespan observed (days) 1211 1206
Number of mice at start 48 84
Animal censor events are denoted by + marks in the plot
Asp_hi effect on survival, males, test site = UM
Log-rank test chisq = 0.0666 p = 0.7964
Wang-Allison test odds ratio = 0.9016 p = 1.0
Quantiles Asp_hi Control % difference
25% died before day: 721 756 -5 %
Median lifespan (days) 841 894 -6 %
75% died before day: 932 1009 -8 %
90% died before day: 1082 1084 0 %
Max lifespan observed (days) 1188 1206
Number of mice at start 41 84
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Asp_lo effect on survival, females, test site = UT
Log-rank test chisq = 2.5503 p = 0.1103
Wang-Allison test odds ratio = 0.9007 p = 1.0
Quantiles Asp_lo Control % difference
25% died before day: 652 768 -15 %
Median lifespan (days) 839 882 -5 %
75% died before day: 966 1046 -8 %
90% died before day: 1094 1109 -1 %
Max lifespan observed (days) 1174 1238
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
Asp_hi effect on survival, females, test site = UT
Log-rank test chisq = 4.8155 p = 0.0282
Wang-Allison test odds ratio = 0.1427 p = 0.0362
Quantiles Asp_hi Control % difference
25% died before day: 788 768 +3 %
Median lifespan (days) 863 882 -2 %
75% died before day: 977 1046 -7 %
90% died before day: 1019 1109 -8 %
Max lifespan observed (days) 1147 1238
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Asp_lo effect on survival, males, test site = UT
Log-rank test chisq = 0.0477 p = 0.8272
Wang-Allison test odds ratio = 0.6886 p = 0.774
Quantiles Asp_lo Control % difference
25% died before day: 490 570 -14 %
Median lifespan (days) 687 743 -8 %
75% died before day: 849 892 -5 %
90% died before day: 940 977 -4 %
Max lifespan observed (days) 1228 1167
Number of mice at start 49 96
Animal censor events are denoted by + marks in the plot
Asp_hi effect on survival, males, test site = UT
Log-rank test chisq = 2.187 p = 0.1392
Wang-Allison test odds ratio = 1.743 p = 0.3914
Quantiles Asp_hi Control % difference
25% died before day: 583 570 +2 %
Median lifespan (days) 810 743 +9 %
75% died before day: 924 892 +4 %
90% died before day: 1047 977 +7 %
Max lifespan observed (days) 1201 1167
Number of mice at start 51 96
Animal censor events are denoted by + marks in the plot


See our ITP data portal page for more information on National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.

Statistical definitions