ITP survival analysis:   acarbose

Intervention:   acarbose     a-glucosidase inhibitor, anti-aging
Trial code: ACA Dose: 1000 ppm initiated at age: 16 mo Sex: both Cohort: C2012
This compound had a significant effect on survival:   males p < 0.0001

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
ACA effect on survival, females, test site = All
Log-rank test chisq = 3.2299 p = 0.0723
Wang-Allison test odds ratio = 1.9159 p = 0.0579
Quantiles ACA Control % difference
25% died before day: 772 770 0 %
Median lifespan (days) 903 877 +3 %
75% died before day: 1022 1006 +2 %
90% died before day: 1166 1100 +6 %
Max lifespan observed (days) 1365 1301
Number of mice at start 136 279
Animal censor events are denoted by + marks in the plot
All test sites combined – male
ACA effect on survival, males, test site = All
Log-rank test chisq = 16.1801 p < 0.0001
Wang-Allison test odds ratio = 3.3119 p = 0.0003
Quantiles ACA Control % difference
25% died before day: 682 620 +10 %
Median lifespan (days) 877 816 +7 %
75% died before day: 1042 960 +9 %
90% died before day: 1183 1055 +12 %
Max lifespan observed (days) 1306 1260
Number of mice at start 148 284
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
ACA effect on survival, females, test site = TJL
Log-rank test chisq = 0.4052 p = 0.5244
Wang-Allison test odds ratio = 1.8693 p = 0.2594
Quantiles ACA Control % difference
25% died before day: 776 801 -3 %
Median lifespan (days) 882 924 -5 %
75% died before day: 1030 1014 +2 %
90% died before day: 1240 1092 +14 %
Max lifespan observed (days) 1365 1301
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
ACA effect on survival, males, test site = TJL
Log-rank test chisq = 8.9223 p = 0.0028
Wang-Allison test odds ratio = 3.6481 p = 0.0231
Quantiles ACA Control % difference
25% died before day: 756 624 +21 %
Median lifespan (days) 876 844 +4 %
75% died before day: 1044 960 +9 %
90% died before day: 1170 1006 +16 %
Max lifespan observed (days) 1303 1163
Number of mice at start 53 101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
ACA effect on survival, females, test site = UM
Log-rank test chisq = 1.868 p = 0.1717
Wang-Allison test odds ratio = 2.2285 p = 0.227
Quantiles ACA Control % difference
25% died before day: 768 745 +3 %
Median lifespan (days) 904 843 +7 %
75% died before day: 1021 988 +3 %
90% died before day: 1133 1084 +5 %
Max lifespan observed (days) 1261 1243
Number of mice at start 44 90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
ACA effect on survival, males, test site = UM
Log-rank test chisq = 6.9285 p = 0.0085
Wang-Allison test odds ratio = 4.2781 p = 0.0239
Quantiles ACA Control % difference
25% died before day: 747 719 +4 %
Median lifespan (days) 957 872 +10 %
75% died before day: 1070 1022 +5 %
90% died before day: 1191 1111 +7 %
Max lifespan observed (days) 1306 1204
Number of mice at start 44 84
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
ACA effect on survival, females, test site = UT
Log-rank test chisq = 1.2376 p = 0.2659
Wang-Allison test odds ratio = 1.6709 p = 0.3771
Quantiles ACA Control % difference
25% died before day: 800 738 +8 %
Median lifespan (days) 912 873 +4 %
75% died before day: 1018 1008 +1 %
90% died before day: 1160 1116 +4 %
Max lifespan observed (days) 1243 1255
Number of mice at start 44 93
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
ACA effect on survival, males, test site = UT
Log-rank test chisq = 1.8773 p = 0.1706
Wang-Allison test odds ratio = 2.4293 p = 0.1481
Quantiles ACA Control % difference
25% died before day: 500 577 -13 %
Median lifespan (days) 792 751 +5 %
75% died before day: 951 886 +7 %
90% died before day: 1133 994 +14 %
Max lifespan observed (days) 1285 1260
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions