How it's Made

Recombinant Inbred (RI)

Originating Article

The BXD RI strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.

The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network .

This strain has the wild-type allele of Tlr4. For the subline homozygous for the mutation defective lipopolysaccharide response 2 Jackson, please see stock number 000029.

The BXD set of RI strains was developed in the laboratory of Benjamin Taylor and was transferred to The Jackson Laboratory from Dr. Taylor's research colony upon his retirement. Of 42 BXD RI strains originally derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671), a number have become extinct over the years. The other BXD RI strains now being distributed are listed under "Related Recombinant Inbred Strains." In 1979 the BXD29/Ty strain was cryopreserved, then at generation F39, and was also kept breeding on the shelf as Stock No. 000029. In 2006 Cook et al., reported that a mutation had spontaneously arisin in the Tlr4 sequence, allele Tlr4^lps-2J, in the line that had been maintained on the shelf all those years (Stock No. 000029). The cryopreserved bankstock from 1979 was recovered and found to have no mutation in Tlr4. This Tlr4 wild-type strain (Stock No. 010981) is descended from that 2006 thaw of the 1979 bankstock.

Genetic Background
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Generation
Generation Definitions >
F38p+37
(Last Updated: March 17th 2025)

Allele Symbol Myo5a^d

Allele Name

Gene Symbol

Allele Type

Gene Name

Gene Synonym(s)

Site of Expression

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Expressed Gene(s)

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Strain of Origin

Chromosome

Molecular Note

This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5a^d gene. Reversions of Myo5a^d to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place.

General Note

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Mutations Made By

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